Title:Effects of Exosomes on Major Pathways Promote Tumor
Formation and Progression
Volume: 22
Issue: 6
Author(s): Mehmet Emin Köse, Beste Aydin, Caner Geyik, Öykü Gönül Geyik and Engin Ulukaya*
Affiliation:
- ISUMKAM Molecular Cancer Research Center, Istinye University, Istanbul, Turkey
- Medical Biochemistry
Department, Faculty of Medicine, Istinye University, Istanbul, Turkey
Keywords:
Extracellular vesicles, oncosome, EMT, cancer metabolism, drug resistance, survival, proliferation, exosomal crosstalk.
Abstract: Exosomal vesicles enclose and carry a broad range of biological molecules,
such as nucleic acids, lipids, and proteins, and transfer them between cells. In cancer,
cells being mentioned could be neighbors in the same tumor microenvironment
communicating with each other, or they could be localized at distant sites of the body,
enabling suitable conditions for metastasis. Either way, it is a concrete fact that cells
under physiological or pathological conditions make crosstalk via exosomal secretion.
This review looks at the relation between exosomal cargo and mechanisms of cancer
through recent research.