Title:Novel Adjuvant Therapy with Zinc Supplementation in Neonatal Respiratory Distress Syndrome
Volume: 21
Issue: 12
Author(s): Mohamed Shawky Elfarargy*, Ghada M Al-Ashmawy, Sally Abu-Risha and Haidy Khattab
Affiliation:
- Department of Pediatrics, Faculty of Medicine, Tanta University,Egypt
Keywords:
Neonate, Zinc, respiratory distress, adjuvant, therapy, supplementation, syndrome.
Abstract:
Background: Neonatal respiratory distress syndrome (RDS) is a common dangerous chest
problem that is caused by a lack of surfactant.
Aim: The aim of this study was to show the role of zinc as an adjuvant anti-inflammatory therapy
in neonatal RDS.
Objective: To study the effect of zinc supplementation in cases of neonatal RDS.
Methods: A prospective randomized controlled trial (RCT) study was done on 90 neonates suffering
from respiratory distress (RD) who had been diagnosed as RDS. The included neonates were
classified into two groups: group 1, which received Zinc (Zn) supplementation, and group 2, which
received a placebo. Down score, grades of RDS Malondialdehyde (MDA), Superoxide Dismutase
(SOD) andInterleukin-8 (IL-8) were estimated on the 1st and 5th day in the presence of incubators.
Results: There were statistically significant differences (SSD) in grades of RDS, Down score,
MDA, SOD and IL-8 on the 5th day between group 1 and 2(p = 0.001), and between 1st and 5th day
in group 1 (p = 0.001) in the presence of an incubator. There was an SSD between groups 1 and 2
in the duration of hospitalization (p = 0.001) and the number of cases that needed mechanical ventilation
(MV) (p = 0.049).
Conclusion: Zn supplementation is associated with clinical and laboratory improvement in cases
of neonatal RDS.
Recommendation: Zn supplementation for RDS neonates.
