Title:Gut Microbiota as a Link between Modern Lifestyle and Alzheimer’s Disease
Volume: 14
Issue: 3
Author(s): Yi Wang*Gary Dykes
Affiliation:
- School of Agriculture and Food Sciences, University of Queensland, Keyhole Road, St Lucia, Queensland 4067,Australia
Keywords:
Gut microbiota, Alzheimer's disease, modern lifestyle, dietary pattern, exercise, mental stress.
Abstract: It is established that the gut microbiota has a significant influence on Alzheimer’s disease.
In turn, both the disease and the microbiota are affected by biological variables associated
with modern lifestyles. Examination of the potential interrelationship among these three factors
and on the role played by lifestyles in gut dysbiosis-induced pathologies of Alzheimer’s disease are
limited. Deciphering these connections will provide insights into the pathogenesis and therapeutic
strategies for Alzheimer’s disease. Specifically, based on this trilateral relationship, various nonpharmacological
interventive strategies targeting the gut microbiota can be developed. This review
fills this gap by presenting the latest evidence for the modulative role of modern lifestyle on the gut
microbiota and its relevance to Alzheimer’s disease, with a discussion on the limitations of current
research and future directions.
