Title:Potential Role of Bioactive Lipids in Rheumatoid Arthritis
Volume: 27
Issue: 44
Author(s): Wheeler Torres*, Mervin Chávez-Castillo, José L. Peréz-Vicuña, Rubén Carrasquero, María P. Díaz, Yosselin Gomez, Paola Ramírez, Clímaco Cano, Joselyn Rojas-Quintero, Maricarmen Chacín, Manuel Velasco, Juan Bautista de Sanctis and Valmore Bermudez
Affiliation:
- Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo,Venezuela
Keywords:
Rheumatoid arthritis, inflammation, bioactive lipids, resolving, autoimmune disease, cardiovascular disease.
Abstract: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that involves a pathological
inflammatory response against articular cartilage in multiple joints throughout the body. It is a complex disorder
associated with comorbidities such as depression, lymphoma, osteoporosis, and cardiovascular disease
(CVD), which significantly deteriorate patients’ quality of life and prognosis. This has ignited a large initiative
to elucidate the physiopathology of RA, aiming to identify new therapeutic targets and approaches in its multidisciplinary
management. Recently, various lipid bioactive products have been proposed to have an essential
role in this process, including eicosanoids, specialized pro-resolving mediators, phospholipids/sphingolipids,
and endocannabinoids. Dietary interventions using omega-3 polyunsaturated fatty acids or treatment with synthetic
endocannabinoid agonists have been shown to significantly ameliorate RA symptoms. Indeed, the modulation
of lipid metabolism may be crucial in the pathophysiology and treatment of autoimmune diseases.
