Title:Intracranial Cerebrospinal Fluid Volume Evaluation in Healthy People and Hydrocephalus Patients using SPACE Sequence
Volume: 17
Author(s): Xiaofeng Wu, Seidu A. Richard, Xu Xiangdong, Zhang Lirong and Wu Min*
Affiliation:
- Department of Neurosurgery, Jiangyin Hospital, Southeast University, Jiangyin, 214400, Jiangsu province,China
Keywords:
CSF, hydrocephalus, intracranial, ICP, SPACE, volunteers.
Abstract:
Introduction: Cerebrospinal Fluid (CSF) is produced mainly by the choroid plexus but
with a substantial influence by the ependymal lining of the ventricles in the brain. Hydrocephalus
occurs as a result of discrepancy in the production as well as circulation of CSF as a result of congenital
and acquired conditions. Nevertheless, studies on the differences between CSF dynamics according
to age and gender are still insufficient. Thus, this study evaluated the volume of intracranial
CSF in healthy people and hydrocephalus patients taking into account the differences between
CSF dynamics according to age and gender using Sampling Perfection with Application optimised
Contrast using different flip-angle Evolution (SPACE) sequence.
Methods: 120 healthy volunteers and 60 patients with hydrocephalus were included in this study.
SPACE sequence was used to evaluate intracranial CSF with a 3.0T magnetic resonance machine.
The total volume of intracranial CSF and the amount of CSF in the ventricle were obtained using a
software, and the volume ratio of CSF in the subarachnoid space, the ventricle and the subarachnoid
space were calculated.
Results: The mean volume of intracranial CSF, ventricular CSF, and subarachnoid CSF of male
volunteers were (206.9±47.7) cm3, (33.0±10.7) cm3, (173.9±37.9) cm3 respectively. The average
volume of intracranial CSF, ventricular CSF, and subarachnoid CSF of female volunteers were
(199.7±44.9) cm3, (30.8±9.4) cm3, and (168.9±37.0) cm3, respectively. Thus, no significant statistically
(P>0.05) difference between males and females was found. (3) The mean values of intracranial
CSF, ventricle CSF and subarachnoid CSF, ventricle and subarachnoid CSF volume ratio in patients
with hydrocephalus were significantly greater than health volunteers. Thus, the difference between
the two groups was statistically significant (P<0.05).
Conclusion: SPACE sequence can quantitatively determine the content of CSF. The change of
CSF volume has nothing to do with gender but with age. It is feasible to use SPACE sequence to
evaluate the spatial distribution and volume of intracranial CSF.
