Title:Association of Viruses in the Development of Cardiovascular Diseases
Volume: 27
Issue: 37
Author(s): Bisma Rauff *, Arif Malik, Yasir A. Bhatti , Shafiq A. Chudhary, Kaneez Fatima, Shafquat Rafiq , Aisha Tahir, Sumaira Sharif and Ishtiaq Qadri
Affiliation:
- Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, NSW Sydney,Australia
Keywords:
COVID-19, cardiovirus, echovirus, coxsackievirus, cytomegalovirus, HSV-1 and 2, parvovirus B19, hepatitis viruses, influenza
viruses.
Abstract: Cardiovascular diseases (CVD), primarily inflammatory cardiomyopathy, are characterized by the infiltration
of inflammatory cells into the myocardium. It has a relatively high risk of deteriorating heart function
and has heterogeneous etiologies. Inflammatory cardiomyopathy is mainly mediated by viral infections but can
also be mediated by protozoa, fungal or bacterial infections. Besides that, there are a wide variety of drugs, toxic
substances, and systemic immune-mediated diseases that result in the development of cardiovascular diseases
(CVDs). Despite broad research, inflammatory cardiomyopathy has a poor prognosis. The roles of the pathogens,
host genomic counterparts and environmental triggers in the progression of disease are still under consideration,
including the role of some viruses as active inducers and others as bystanders. In this review article, we
review the available evidence on the types, pathogenesis and treatment of myocarditis, inflammatory cardiomyopathy,
and atherosclerosis with a particular focus on virus-associated cardiac diseases.
