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Current Pharmaceutical Biotechnology

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ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

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The Impact of Physical Exercise on the Hippocampus in Physiological Condition and Ageing-Related Decline: Current Evidence from Animal and Human Studies

Author(s): Giovanni Laurettaorcid of author, Silvia Ravalliorcid of author, Grazia Maugeriorcid of author, Velia D’Agataorcid of author, Michelino Di Rosaorcid of author and Giuseppe Musumeci*

Volume 23, Issue 2, 2022

Published on: 05 April, 2021

Page: [180 - 189] Pages: 10

DOI: 10.2174/1389201022666210405142611

Price: $65

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Abstract

Physical exercise (PE), notoriously, promotes a state of general well-being, throughout the entire human lifespan. Moreover, maintaining an adequate and regular PE habit results in a powerful preventive factor towards many diseases and may also help in managing existing pathological conditions. PE induces structural and functional changes in various parts of the body, determining biological and psychological benefits. Additionally, in the elderly, PE might represent a remarkable tool reducing cognitive impairments related to the normal aging processes and it has also been found to have an impact on neurodegenerative diseases such as Alzheimer’s disease. The present review aims to provide an overview of PE effects on the hippocampus, since it is one of the brain regions most susceptible to aging and, therefore, involved in diseases characterized by cognitive impairment.

Keywords: Physical exercise, cognitive impairment, cognitive decline, aging, hippocampus, neurogenesis, neurotrophic factors.

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Graphical Abstract

Graphical abstract illustrating key findings of the study

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