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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Natural Sirtuin Modulators in Drug Discovery: A Review (2010 -2020)

Author(s): Yuin Chang and Keng Yoon Yeong*

Volume 28, Issue 37, 2021

Published on: 29 March, 2021

Page: [7749 - 7766] Pages: 18

DOI: 10.2174/0929867328666210329124415

Price: $65


There have been intense research interests in sirtuins since the establishment of their regulatory roles in a myriad of pathological processes. In the last two decades, many research efforts have been dedicated to the development of sirtuin modulators. Although synthetic sirtuin modulators are the focus, natural modulators remain an integral part to be further explored in this area as they are found to possess therapeutic potential in various diseases, including cancers, neurodegenerative diseases, and metabolic disorders. Owing to the importance of this cluster of compounds, this review gives a current stand on the naturally occurring sirtuin modulators, associated molecular mechanisms, and their therapeutic benefits. Furthermore, comprehensive data mining resulted in detailed statistical data analysis pertaining to the developmental trend of sirtuin modulators from 2010-2020. Lastly, the challenges and future prospects of natural sirtuin modulators in drug discovery will also be discussed.

Keywords: Sirtuins, natural product, modulators, drug discovery, inhibitors, activators.

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