Title:Potential of Antibiotics for the Treatment and Management of Parkinson's Disease: An Overview
Volume: 13
Issue: 3
Author(s): Narayan Yadav, Ajit Kumar Thakur*, Nikhila Shekhar and Ayushi
Affiliation:
- Neuropharmacology Research Laboratory, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi-110 017,India
Keywords:
Antibiotic, neuro-inflammation, neurodegeneration, oxidative damage, parkinson's disease, neuroprotection.
Abstract: Evidence has emerged over the last 2 decades to ascertain the proof of concepts viz. mitochondrial
dysfunction, inflammation-derived oxidative damage and cytokine-induced toxicity
that play a significant role in Parkinson's disease (PD). The available pharmacotherapies for PD are
mainly symptomatic and typically indicate L-DOPA to restrain dopamine deficiency and its consequences.
In the 21st century, the role of antibiotics has emerged at the forefront of medicines in
health and human illness. There are several experimental and pre-clinical evidences that support
the potential use of antibiotics as a neuroprotective agent. The astonishing effects of antibiotics and
their neuroprotective properties against neurodegeneration and neuro-inflammation would be
phenomenal for the development of effective therapy against PD. Antibiotics are also testified as
useful in not only preventing the formation of alpha-synuclein but also acting on mitochondrial dysfunction
and neuro-inflammation. Thus, the possible therapy with antibiotics in PD would impact
both pathways leading to neuronal cell death in substantia nigra and pars compacta in the midbrain.
Moreover, the antibiotic-based pharmacotherapy will open a scientific research avenue to add more
to the evidence-based and rational use of antibiotics for the treatment and management of PD and
other neurodegenerative disorders.
