Advances in Stem Cells Transplantation for the Therapy of Parkinson’s Disease

Title:Advances in Stem Cells Transplantation for the Therapy of Parkinson’s Disease

Volume: 16 Issue: 8

Author(s): Xiansi Zeng, Wenshuo Geng, Jinjing Jia*Zhanqi Wang

Affiliation:

• Department of Physiology, Jiaxing University Medical College, Jiaxing 314001,China

Keywords: Parkinson's disease, stem cells, cell therapy, neurodegenerative, substantia nigra pars compacta, striatum.

Abstract: Parkinson’s disease (PD) is a common neurodegenerative disease and is a major culprit that harms the health of elderly people. The main pathological feature is the progressive loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain. The current mainstream therapeutic strategies include surgical treatment and medicine substitute therapy. However, these treatment methods sometimes have limitations. Subsequently, the treatment with stem cells (SCs) transplantation has been gradually established. SCs is a kind of cell with self-renewal ability and multi-directional differentiation potential. Transplantation of SCs, including embryonic stem cells, adult stem cells (neural stem cells and mesenchymal stem cells) and induced pluripotent stem cells, have the ability to mediate nerve regeneration and restoration within the lesioned midbrain tissue, bringing hope for the treatment of PD. In this paper, we summarize the progress in therapeutic strategies of different types of SCs in PD treatment, with an emphasis on the advantages and limitations.

Cite this article as:

Zeng Xiansi , Geng Wenshuo , Jia Jinjing *, Wang Zhanqi , Advances in Stem Cells Transplantation for the Therapy of Parkinson’s Disease, Current Stem Cell Research & Therapy 2021; 16 (8) . https://dx.doi.org/10.2174/1574888X16666210309153949