Title:COVID-19: Epidemiology, Pathology, Diagnosis, Treatment, and Impact
Volume: 27
Issue: 33
Author(s): Saimon Shahriar, Md. Sohel Rana, Md. Sabbir Hossain, Ariful Karim, Tasneem N. Mredula, Nadia Nourin, Md. Sahab Uddin*Md. Shah Amran*
Affiliation:
- Department of Pharmacy, Southeast University, Dhaka,Bangladesh
- Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka 1000,Bangladesh
Keywords:
SARS-CoV-2, COVID-19, coronavirus, drug targets, second wave, mental health.
Abstract: The pandemic, well-known as COVID-19, has been caused by the coronavirus SARS-CoV-2 and it
has distinct characteristics from other coronavirus-related epidemics. This pandemic has been ravaging the
whole world for more than a year now, and no drugs or vaccines have been found to eliminate this virus from
the infected people effectively; only physical measures like social distancing, hand washing and face-mask
wearing have been taken to reduce its spread and very recently Veklury (remdesivir) has been permitted by the
USFDA to manage the critical patients. This disease can be asymptomatic, but when it is symptomatic, it presents
with respiratory problems and cold- or flu-like symptoms, which can be diagnosed with a chest CT and
confirmed with RT-PCR tests. In this review, the taxonomy and structure of SARS-CoV-2 and history, transmission,
epidemiology, pathology, clinical features and impacts of the COVID-19 have been discussed. A summary
of possible drug targets, attempted physical and chemical measures, as well as vaccine candidates, has also
been provided. How this coronavirus is different from other coronaviruses, the obstacles in managing this
disease and the possibility of a second wave have also been reviewed. This review represents a wide range of information
regarding COVID-19 and intends to be used as a comprehensive overview in this regard.
