From Nucleic Acids to Drug Discovery: Nucleobases as Emerging Templates for Drug Candidates

Chronic diseases such as malignant tumors and rheumatoid arthritis have long plagued a large number of patients. Currently, the management of chronic diseases has entered a new stage of targeted regulation, precise intervention and integrated treatment. The traditional diagnosis and treatment model is undergoing profound changes due to new drugs ...read more

This thematic issue highlights recent advances in computational strategies applied to neurodegenerative disorders, cancer, and infectious diseases. It focuses on the use of artificial intelligence, machine learning, molecular modeling, molecular dynamics simulations, bioinformatics, and multi-omics data analysis to understand disease mechanisms and accelerate drug discovery. The contributions demonstrate how computational ...read more

Central nervous system (CNS) diseases are among the leading causes of chronic disability and mortality worldwide. According to the World Health Organization (WHO), neurological disorders affect over 1 billion people, and the cost of their treatment increases annually. However, advances in neuroscience and medicine are enabling fundamentally new approaches to ...read more

This thematic issue focuses on cutaneous and musculoskeletal tissue biology, spanning traumatic repair, pathological disorders, and regenerative medicine across both systems. We welcome original studies integrating epidemiological analysis, disease prediction models, multi-omics integration, genetic dissection, virtual cell technology, organoid models, advanced biomaterials, clinical efficacy evaluation, and pharmacological mechanism research to ...read more