Title:Evaluation of Oxidative Stress Biomarkers in Brain Metastatic and Non-Metastatic Lung Cancer Patients with Different Cell Types
Volume: 21
Issue: 15
Author(s): Emre Bilgin, Gülüzar Atli*, Berna B. Duman and Ali I. Okten
Affiliation:
- Cukurova University, Biotechnology Center, Adana,Turkey
Keywords:
Antioxidant system, metastasis, lung cancer, serum, brain, NSCLC.
Abstract:
Background: Oxidative stress that leads to an imbalanced prooxidant/antioxidant status can be a critical
factor affecting lung cancer etiopathology. The antioxidant system provides primary protection under oxidative
stress.
Objective: The purpose of the study was to investigate the serum antioxidant system status in brain metastatic
and non-metastatic lung cancer patients with different cell types.
Methods: In this prospective study, 33 patients with lung cancer metastasis (metastatic patient group), 36 lung
cancer patients (non-metastatic patient group), and 25 healthy control groups were included. Enzymatic (Superoxide
Dismutase, SOD; Glutathione Peroxidase, GPX; and Glutathione Reductase, GR) and non-enzymatic (Glutathione,
GSH) antioxidant system biomarkers with Thiobarbituric Acid Reactive Substances (TBARS) levels
were studied in the serum samples of the control and patient groups. The oxidative stress biomarkers were measured
spectrophotometrically.
Results: SOD activity increased though TBARS levels and GR activity decreased in both patient groups compared
to the control. GPX activity increased only in the non-metastatic group. Antioxidant biomarkers varied between
small cell and non-small cell group patients. GR activity and GSH levels were significantly higher in the
non-metastatic group compared to the metastatic group. Correlations were also found between antioxidant parameters
in the non-metastatic group.
Conclusion: It was emphasized the imbalanced antioxidant system in the duration of the disease is related to
not only cell type but also the metastatic structure. This is the preliminary study exhibiting the contribution of
antioxidant imbalance in different subtypes with varied prognosis and behavior of lung cancer in the presence
of brain metastasis. Therefore, oxidative stress biomarkers can serve as a useful tool to get information about
the progression of lung cancer. Thus, it may provide fundamental data for further cancer research when considering
the diagnosis of the disease.
