Title:A Review of the Effects of Gold, Silver, Selenium, and Zinc Nanoparticles on Diabetes Mellitus in Murine Models
Volume: 21
Issue: 14
Author(s): Fernando Martínez-Esquivias , Juan Manuel Guzmán-Flores*, Alejandro Pérez-Larios, José Luis Rico and Julieta Saraí Becerra-Ruiz
Affiliation:
- Instituto de Investigacion en Biociencias, Centro Universitario de Los Altos, Universidad de Guadalajara, Tepatitlan de Morelos, Jalisco,Mexico
Keywords:
metal nanoparticles, diabetes, gold, silver, selenium, zinc.
Abstract: Diabetes mellitus is a disease that presents great challenges for healthcare systems worldwide,
and the identification of alternative therapies for the treatment of this disease is of vital importance.
Metallic nanoparticles (gold, silver, and selenium) and metallic oxide (ZnO) have been studied
in different areas such as medicine, biotechnology, the environment, and the food industry with
promising results. In medicine, current research has revealed these nanoparticles' anti-diabetic properties
thanks to the implementation of animal models. This review will address the existing antecedents
and the effects of gold, silver, selenium, and zinc oxide nanoparticles in diabetes administered alone,
functionalized with other molecules, or combined with drugs that have shown promising therapeutic
effects. The anti-diabetic effects of these nanoparticles are related to the regulation of glucose, insulin,
and lipid profiles. In addition, oxidative stress markers, liver and kidney markers, the reduction of inflammation,
apoptosis of the pancreas, and the restoration of normal liver and kidney histology are
also reported in the literature after using these nanoparticles. However, the therapeutic effects that
these nanoparticles provide are limited due to the lack of specific protocols dictated by international
organizations to evaluate the risks of using these nanoparticles.
