Title:COVID-19 Invades Several Important Organs other than the Lungs: Organs Crosstalk
Volume: 2
Issue: 10
Author(s): Manal A. Hamed*
Affiliation:
- Department of Therapeutic Chemistry, National Research Centre, Dokki, Giza,Egypt
Keywords:
COVID-19, viral detection, organs crosstalk, organs dysfunction, prognosis, clinical care.
Abstract: In December 2019, a new severe acute respiratory coronavirus (SARS- COV-2) had
caused outbreaks of pneumonia in Wuhan city, China. It was known as coronavirus infected disease-2019 (COVID-19). COVID-19 patients typically have a fever and respiratory syndrome,
where the lung is the main target organ affected by this virus. The objective of this review is to
monitor and evaluate injuries caused by the SARS-COV-2 virus on multiple organs other than the
lung as the gastrointestinal tract, liver, kidney, heart, ovary, ocular, olfactory, gonad, skin, central
nervous system, and sense organs. As SARS- COV-2 virus enters host cells via cell receptor angiotensin circulating enzyme-2 (ACE2), so it is important to identify the main target cells attacked
by SARS- COV-2 virus by comparing the ACE2 expression and viral upload in different organs. In
conclusion, the definite role of body organs is explored in the manifestation of COVID-19 infection and crosstalk between other organs are useful tools to find any correlation between disease
severity and organs dysfunction, exact prognosis, disease prevention measures, clinical care, and
treatment strategies.
