Title:Advances on the Anti-Inflammatory Activity of Oleanolic Acid and Derivatives
Volume: 21
Issue: 15
Author(s): Xiaofan Zhang, Huiyun Wang, Yangrong Xu, Mingzhu Luan, Fenglan Zhao and Qingguo Meng*
Affiliation:
- School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005,China
Keywords:
oleanolic acid, derivative, anti-inflammatory, mechanism, inhibitory activity, signaling pathway.
Abstract: Oleanolic acid can inhibit edema and exhibit obvious inhibitory activity to inflammatory by
activating of the pituitary-adrenal cortical system, inhibiting the synthesis or release of PGs, inhibiting
endotoxin-mediated release of HMGB1 by endothelial cells or regulating MAPK, PI3K/Akt/NF-
κB/ICAM-1/JAK/STAT signaling pathways, etc. In recent years, an increased number of interesting
research work has been carried out on the anti-inflammatory activity and mechanisms of OA derivatives,
such as acyloxyimino derivative, 3-acetylated derivatives, novel 3,5-disubstituted isoxazoles
derivatives, acetate, ester derivatives and oximes derivatives. The review summaries and highlights the
updated advances on the anti-inflammatory activity and mechanism of OA and its derivatives.
