Title:Meitner-Auger Electron Emitters for Targeted Radionuclide Therapy: Mercury-197m/g and Antimony-119
Volume: 14
Issue: 4
Author(s): Parmissa Randhawa, Aeli P. Olson, Shaohuang Chen, Kaley Lexi Gower-Fry, Cornelia Hoehr*, Jonathan W. Engle*, Caterina F. Ramogida*Valery Radchenko*
Affiliation:
- Department of Life Sciences Division, TRIUMF, Vancouver, BC,Canada
- Department of Medical Physics and Radiology, University of Wisconsin, Madison, WI,United States
- Department of Chemistry, Simon Fraser University, Burnaby, BC,Canada
- Department of Life Sciences Division, TRIUMF, Vancouver, BC,Canada
Keywords:
Targeted radionuclide therapy (TRT), auger electrons, mercury-197 (197Hg), antimony-119 (119Sb), production, radiochemicalseparation, coordination, imaging, dosimetry.
Abstract: Targeted Radionuclide Therapies (TRTs) based on Auger emitting radionuclides have
the potential to deliver extremely selective therapeutic payloads on the cellular level. However, to
fully exploit this potential, suitable radionuclides need to be applied in combination with appropriate
delivery systems. In this review, we summarize the state-of-the-art production, purification, chelation
and applications of two promising candidates for Targeted Auger Therapy, namely antimony-
119 (119Sb) and mercury-197 (197Hg). Both radionuclides have great potential to become efficient
tools for TRT. We also highlight our current progress on the production of both radionuclides
at TRIUMF and the University of Wisconsin.