Title:Interpreting the Mechanisms by which Integrins Promote the Differentiation of Mesenchymal Stem Cells and Integrin Application Prospects
Volume: 16
Issue: 7
Author(s): Liwei Ying, Chenggui Wang, Kesi Shi, Xiaopeng Zhou, Zhe Gong, Jiawei Shu, Jingkai Wang, Kaishun Xia, Shining Xiao, Chao Yu, Wei Yu, Xianpeng Huang, Feng Cheng, Chengzhen Liang*, Fangcai Li*Qixin Chen*
Affiliation:
- Department of Orthopedics Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, Zhejiang,China
- Department of Orthopedics Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, Zhejiang,China
- Department of Orthopedics Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, Zhejiang,China
Keywords:
Integrin, mesenchymal stem cells, differentiation, signalling pathway, multilineage, proliferation.
Abstract: Transmembrane integrin receptors represent a major component of cell-extracellular matrix
(ECM) communications that mediate cellular biological activities, including proliferation and
differentiation. Stem cells, especially mesenchymal stem cells (MSC), have rapidly emerged as
promising therapies for various diseases. Dynamic links exist between extracellular and intracellular
environments that profoundly influence the cellular activities via integrin receptors, such as cell
morphology transformation and differentiation. Interpreting the roles of integrin receptors in the
regulation of MSC differentiation may potentially lead to an amplified therapeutic effect. In this review,
we summarize, for the first time, the potential mechanisms by which integrins promote MSC
multilineage differentiation, including integrin downstream signaling cascades and the interactions
between integrin and ion channels, the cytoskeleton, and nuclear mechanoresponses. Furthermore,
we focus on the current state and future prospects of the application of integrins to promote cell differentiation.