Title:The Synthesis of Nano-Doxorubicin and its Anticancer Effect
Volume: 21
Issue: 18
Author(s): Lusha Zhu and Mei Lin*
Affiliation:
- Department of Science and Research, Taizhou People’s Hospital, The Fifth Affiliated Hospital of Nantong University, Taizhou 225300,China
Keywords:
Doxorubicin, nanotechnology, nanoparticles, synthesis, nanocarrier, drug delivery systems.
Abstract: Doxorubicin (DOX) is widely used as a clinical first-line anti-cancer drug. However, its clinical
application is severely limited due to the lack of tumor specificity of the drug and severe side effects such as
myelosuppression, nephrotoxicity, dose-dependent cardiotoxicity, and multi-drug resistance. To improve the
bioavailability of DOX, maximize the therapeutic effect, and reduce its toxicity and side effects, many studies
have been done on the nanoformulations of DOX, such as liposomes, polymer micelles, dendrimer, and nanogels.
Herein, we review the latest progress of DOX nano-preparations and their anti-tumor effects, hoping to provide
theoretical references and new research ideas for the development of new dosage forms of the drug and the
technical methods available for clinical application.
