Title:The Hydroxamic Acids as Potential Anticancer and Neuroprotective Agents
Volume: 28
Issue: 39
Author(s): Margarita E. Neganova, Sergey G. Klochkov, Yulia R. Aleksandrova and Gjumrakch Aliev*
Affiliation:
- Institute of Physiologically Active Compounds of Russian Academy of Sciences, Chernogolovka,Russian Federation
Keywords:
Hydroxamic acids, cancer, neurodegenerative diseases, oxidative stress, mitochondria, histone deacetylase.
Abstract: Hydroxamic acids are a promising class of chemical compounds with proven
antitumor potential, primarily due to their ability to inhibit the activity of histone deacetylase
enzymes. The analysis of modern experimental data shows a wide range of biological
activities of hydroxamic acids, which make them equally worthy candidates for the
fight against neuropathologies. A characteristic feature of hydroxamic acids is their ability
to act simultaneously on several promising molecular targets for the correction of both
neuropathologies and oncological diseases, thereby exhibiting multifunctionality. This review
discusses the effect of hydroxamic acids on key parts of cancer and neurodegenerative
disorders' pathogenesis. Pathological changes in the processes associated with oxidative
stress, the functioning of mitochondria, and the activity of metal enzymes of the
class of histone deacetylases, as the main links in the epigenetic regulation of pathological
conditions, are such molecular targets.
