Title:A Comprehensive Review on Pharmacology and Toxicology of Bioactive
Compounds of Lagerstroemia Speciosa(L.) Pers.
Volume: 7
Issue: 4
Author(s): Surya Kant Tripathi, Sunayna Behera, Munmun Panda, Gokhan Zengin and Bijesh K Biswal*
Affiliation:
- Cancer Drug Resistance Laboratory, Department of Life Science, National Institute of Technology Rourkela, Odisha-769008,India
Keywords:
Lagerstroemia speciosa, corosolic acid, pharmacological relevance, phytotherapeutic, bioactive agents.
Abstract: Background: Lagerstroemia speciosa (L.) Pers is one of the most valuable plants due to
its ornamental and pharmacological relevance. It is known for its anti-diabetic activity with proved
potent blood sugar-lowering activity. The anti-diabetic activity is due to the presence of its biologically
active component, corosolic acid. Moreover, L.speciosa and its novel purified compounds are
also well-known for their several biological activities with beneficial health benefit on the human
being.
Objectives: This review provides a summary of pharmacokinetics, toxicity, and pharmacological
properties of L.speciosa and its purified phytochemicals, which may help researchers for building
up new research works in the near future.
Methods: The current article is prepared by collecting data through various online and offline
databases. The preliminary source of study and data collection for outlining the review was research
articles and reviews that have been already published by many reputed publishers, including
Springer, Elsevier, Taylor & Francis imprints, BMC, Willy, The Norwegian Academy of Science
and Letters, Environmental health prospective (EHP), and PLOS One.
Result: The available studies' results suggested that the L.speciosa and its phytochemicals exhibitedantidiabetic,
anticancer, anti-inflammatory, antimicrobial, antioxidant, antiviral, anti-obesity, and
cardio-protective activities. Pharmacokinetic studies suggested the low bioavailability of its purified
compounds. However, nano-encapsulation can improve the bioavailability related issue and effectively
potentiate the medicinal properties of its constituents.
Conclusion: Considering the worthy pharmacological properties, L.speciosa is considered a potent
source of several novel drugs. Though, still preclinical and clinical studies are needed to reveal the
targets, molecular mechanisms, bioavailability, and toxicity of its constituents.
