Title:The Assessment of Some Metabolic Markers by Combination of Ursolic Acid Supplementation and Resistance Training in Young Older Obese Women
Volume: 21
Issue: 10
Author(s): Ehsan Asghari, Seyyed Reza Attarzadeh Hosseini, Mina Kiania, Tahereh Farkhondeh, Hamid Arazi and Saeed Samarghandian*
Affiliation:
- Healthy Ageing Research Center, Neyshabur University of Medical Sciences, Neyshabur,Iran
Keywords:
Aging, BDNF, cytokine, metabolic markers, Irisin, Ursolic acid, resistance training.
Abstract:
Background: In this study, we explored the impacts of moderate-to-high intensity resistance
circuit training (MHRCT) and Ursolic acid (UA) supplementation to improve these pathological
changes in young older obese women (women between the ages of 50 and 70).
Methods: The study included twenty-five young older women (age > 50 years and ≤70 years) with
stage I-II obesity (BMI ≥ 30 and <40 kg/m2), who received eight weeks placebo with MHRCT, and
MHRCT with UA supplementation. UA or placebo orally was ingested as a capsule three times per day
for eight weeks. The following parameters were evaluated post- and pre-intervention. Data were analyzed
using ANOVA with repeated measures.
Results: Interleukin-15 (IL-15), Interleukin-6 (IL-6), Insulin, and HOMA-IR decreased significantly in
the placebo and UA groups versus control, but the UA group significantly decreased compared with
the placebo (p<0.05). In turn, the Brain-Derived Neurotrophic Factor (BDNF) and Irisin levels showed
a significant increase in the placebo and UA groups versus control. However, the BDNF in the UA
group significantly increased compared with the placebo (p < 0.05).
Conclusion: We demonstrated that applying resistance training can reverse the pathological changes
that may occur with aging and a sedentary lifestyle. Our results showed that UA could enhance the
effects of this type of exercise. Therefore, a combination of the resistance training program and UA
supplementation may be considered as a novel and influential intervention to metabolic derangements
and may also decrease the burden associated with this condition.