Title:Sepsis-Associated Encephalopathy: Insight into Injury and Pathogenesis
Volume: 20
Issue: 2
Author(s): Lina Zhao, Yanxia Gao, Shigong Guo, Xin Lu, Shiyuan Yu, Zeng Zheng Ge, Hua Dong Zhu and Yi Li*
Affiliation:
- Emergency Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing,China
Keywords:
Hyperammonemia, intestinal flora imbalance, inflammatory medium, neurotransmitters, sepsis-associated encephalopathy,
mitochondrial dysfunction.
Abstract: Sepsis-associated encephalopathy causes long-term health problems in patients with sepsis.
This review explores the pathogenesis of sepsis-associated encephalopathy, including its effects
on the blood-brain barrier, microglia activation, mitochondrial dysfunction, the inflammatory
medium and neurotransmitters and its roles in amino acid balance disorders, hyperammonemia,
and intestinal flora imbalance. Understanding the etiology of sepsis-associated encephalopathy
may allow the development of adjunctive therapies targeting its underlying mechanism and help develop
preventative strategies.
