Title:Nanosponges Encapsulated Phytochemicals for Targeting Cancer: A Review
Volume: 22
Issue: 4
Author(s): Shailaja Dombe*Pramodkumar Shirote
Affiliation:
- Department of Pharmaceutics, Arvind Gavali College of Pharmacy, Satara, Shivaji University, Satara-415004,India
Keywords:
Nanosponges, phytochemicals, cancer therapy, organic nanosystems, targeted drug delivery, conventional chemotherapy,
cytotoxicity.
Abstract: Cancer is the most ruinous disease globally. Natural products have impressive characteristics,
such as exceptional chemical versatility, chemical and biological properties of macromolecular
specificity and less toxicity which make them good leads in finding novel drugs. The
phytochemicals not only help to prevent but also treat chronic cancerous conditions. The present review
attempts to put forth some selected anticancer phytochemicals that had reported omics characteristic
and specifically suppressed cancer with in vitro and in vivo activity. Certain issues pertaining
to anticancer phytochemicals like delivery to target site in the body and achieving controlled release
in order to prevent overdoses have been a major concern for medical researchers worldwide.
The most conventional chemotherapy protocols for the treatment of cancer lead to adverse effects
that limit biological efficacy and compromise patient outcomes. In order to defeat incompetency of
current and upcoming natural anticancer agents and to attain targeted drug delivery with good efficacy
and fewer side effects, there is a special focus on novel nanostructured particles and nano approaches
consisting of carrier system. Recent studies have led to the discovery of mesoporous and
nanoporous drug delivery mechanisms, such as inorganic or organic-based nanosponges. The metal
based inorganic systems have exhibited toxicity and non-biodegradable character in vivo. As a result
of problems related to inorganic systems, major shift of research from inorganic to organic
nanosystems has occurred. About decades ago, researchers developed organic nanosponges to control
the limitation of drug delivery and cancer therapies. This review article discusses the development
and application of nanosponges encapsulated phytochemicals for cancer therapy.
