Title:Self-Emulsifying Drug Delivery System (SEDDS) and its Pharmaceutical Applications
Volume: 7
Issue: 3
Author(s): Sankha Bhattacharya*
Affiliation:
- Department of Pharmaceutics, ISF College of Pharmacy, G.T. Road (NH-95), Ghal Kalan, Moga, Punjab 142001,India
Keywords:
Self-emulsified drug delivery system (SEDDS), aqueous solubility, self-micro emulsifying
drug delivery system (SMEDDS), co-surfactant, solid self-emulsifying drug delivery system (S-SEDDS),
patents of SEDDS.
Abstract: Poor aqueous solubility, oral bioavailability, inter, and inter-subject
variability, and physical stability have always been a concern for pharmaceutical
formulation scientists while formulating an oral dosage form. Self-Emulsifying
Drug Delivery System (SEDDS) is a promising new approach to mitigating those
potential problems. The main advantages of SEDDS are that it increases the solubility
and decreases the bio-degradation of lipophilic drugs. Mostly BCS II & IV
Class drugs are preferable. SEDDS is an admixture of drugs, oil, surfactants, cosolvents,
and stabilizers. With little energy input, they form (o/w) microemulsion
within the G.I. lumen. The present review discusses the various formulations of
SEDDS, selection criteria for surfactants, oils, Patentable SEDDS dosage forms,
solidification technique, characterization, and future approaches.
