Title:SIRT1 Promotes Neuronal Fortification in Neurodegenerative Diseases through Attenuation of Pathological Hallmarks and Enhancement of Cellular Lifespan
Volume: 19
Issue: 7
Author(s): Priya Mishra, Amit Kumar Mittal, Harikesh Kalonia, Swati Madan, Shampa Ghosh, Jitendra Kumar Sinha*Satyendra Kumar Rajput*
Affiliation:
- Amity Institute of Neuropsychology and Neurosciences (AINN), Amity University, Noida, Uttar Pradesh 201313,India
- Amity Institute of Indian System of Medicine (AIISM), Amity University, Noida, Uttar Pradesh 201313,India
Keywords:
SIRT1, neurogenesis, genomic stability, oxidative stress, neuoroprotection, neurodegenerative disease.
Abstract: Neurodegeneration is a complex neurological phenomenon characterized by disturbed
coherence in neuronal efflux. Progressive neuronal loss and brain damage due to various age-related
pathological hallmarks perturb the behavioral balance and quality of life. Sirtuins have been
widely investigated for their neuroprotective role, with SIRT1 being the most contemplated member
of the family. SIRT1 exhibits significant capabilities to enhance neurogenesis and cellular lifespan
by regulating various pathways, which makes it an exciting therapeutic target to inhibit neurodegenerative
disease progression. SIRT1 mediated neuronal fortification involves modulation of
molecular co-factors and biochemical pathways responsible for the induction and sustenance of
pro-inflammatory and pro-oxidative environment in the cellular milieu. In this review, we present
the major role played by SIRT1 in maintaining cellular strength through the regulation of genomic
stability, neuronal growth, energy metabolism, oxidative stress, inhibiting mechanisms and anti-inflammatory
responses. The therapeutic significance of SIRT1 has been put into perspective
through a comprehensive discussion about its ameliorating potential against neurodegenerative stimuli
in a variety of diseases that characteristically impair cognition, memory and motor coordination.
This review enhances the acquaintance concerned with the neuroprotective potential of SIRT1
and thus promotes the development of novel SIRT1 regulating therapeutic agents and strategies.
