Title:Regenerative Medicine Under the Control of 3D Scaffolds: Current State and Progress of Tissue Scaffolds
Volume: 16
Issue: 2
Author(s): Ali Golchin, Sina Farzaneh, Bahareh Porjabbar, Fatemeh Sadegian, Masoumeh Estaji, Parviz Ranjbarvan, Mohammad Kanafimahbob, Javad Ranjbari, Nasim Salehi-Nik and Simzar Hosseinzadeh*
Affiliation:
- Department of Tissue engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran,Iran
Keywords:
Stem cells, regenerative medicine, tissue engineering, biocompatible materials, 3D scaffold, dimensional.
Abstract: Currently, combining stem cells (SCs) with biomaterial scaffolds provides a promising strategy
for the future of biomedicine and regenerative medicine (RG). The cells need similar substrates of
the extracellular matrix (ECM) for normal tissue development, which signifies the importance of
three dimensional (3D) scaffolds to determine cell fate. Herein, the importance and positive contributions
of corresponding 3D scaffolds on cell functions, including cell interactions, cell migrations,
and nutrient delivery, are presented. Furthermore, the synthesis techniques which are recruited to
fabricate the 3D scaffolds are discussed, and the related studies of 3D scaffold for different tissues
are also reported in this paper. This review focuses on 3D scaffolds that have been used for tissue
engineering purposes and directing stem cell fate as a means of producing replacements for biomedical
applications.
