Generic placeholder image

Current Vascular Pharmacology

Editor-in-Chief

ISSN (Print): 1570-1611
ISSN (Online): 1875-6212

Research Article

Paget’s Disease of Bone and Cardiovascular Risk: A Pilot Study

Author(s): Agostino Gaudio*, Luca Zanoli, Anastasia Xourafa, Rosario Rapisarda, Antonino Catalano, Salvatore Santo Signorelli and Pietro Castellino

Volume 19, Issue 4, 2021

Published on: 09 June, 2020

Page: [423 - 428] Pages: 6

DOI: 10.2174/1389450121666200609151555

Price: $65

conference banner
Abstract

Background: The association between Paget’s disease of bone (PDB) and increased cardiovascular (CV) risk has been suggested, but the literature is conflicting.

Objective: Our study aimed to evaluate two markers of CV risk, namely, common carotid artery intimamedia thickness (cIMT) and the aortic pulse wave velocity (PWV) in patients with PDB.

Methods: We enrolled 12 patients with PDB and 58 control subjects, matched for age. The diagnosis of PDB was based on clinical, radiological and biochemical parameters.

Results: Patients with PDB showed higher PWV values than the controls, whereas cIMT was slightly but not significantly increased.

Conclusion: These findings, although limited by the small study population, represent an original observation that deserves further study. The higher arterial stiffness in PDB could be related to the increased bone turnover or the high levels of oxidative stress that characterize this population.

Keywords: Paget's disease of bone, carotid intima-media thickness, pulse wave velocity, cardiovascular risk, disorder bone.

Graphical Abstract
[1]
Ralston SH, Corral-Gudino L, Cooper C, et al. Diagnosis and management of paget’s disease of bone in adults: a clinical guideline. J Bone Miner Res 2019; 34(4): 579-604.
[http://dx.doi.org/10.1002/jbmr.3657] [PMID: 30803025]
[2]
Gaudio A, Zanoli L, Fiore CE. Paget’s bone disease is not always the culprit. Eur J Intern Med 2017; 43: e3-4.
[http://dx.doi.org/10.1016/j.ejim.2017.02.001] [PMID: 28185722]
[3]
Paget J. Remarks on osteitis deformans. Illustr Med News 1889; 2: 181-2.
[4]
Sornberger CF, Smedal MI. The mechanism and incidence of cardiovascular changes in Paget’s disease (osteitis deformans); a critical review of the literature with case studies. Circulation 1952; 6(5): 711-26.
[http://dx.doi.org/10.1161/01.CIR.6.5.711] [PMID: 12988350]
[5]
Wootton R, Reeve J, Spellacy E, Tellez-Yudilevich M. Skeletal blood flow in Paget’s disease of bone and its response to calcitonin therapy. Clin Sci Mol Med 1978; 54(1): 69-74.
[http://dx.doi.org/10.1042/cs0540069] [PMID: 620495]
[6]
Hultgren HN. Osteitis deformans (Paget’s disease) and calcific disease of the heart valves. Am J Cardiol 1998; 81(12): 1461-4.
[http://dx.doi.org/10.1016/S0002-9149(98)00213-6] [PMID: 9645898]
[7]
Laroche M, Delmotte A. Increased arterial calcification in Paget’s disease of bone. Calcif Tissue Int 2005; 77(3): 129-33.
[http://dx.doi.org/10.1007/s00223-005-0250-1] [PMID: 16151674]
[8]
Zanoli L, Lentini P, Boutouyrie P, et al. Pulse wave velocity differs between ulcerative colitis and chronic kidney disease. Eur J Intern Med 2018; 47: 36-42.
[http://dx.doi.org/10.1016/j.ejim.2017.08.020] [PMID: 28830726]
[9]
Van Bortel LM, Laurent S, Boutouyrie P, et al. Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity. J Hypertens 2012; 30(3): 445-8.
[http://dx.doi.org/10.1097/HJH.0b013e32834fa8b0] [PMID: 22278144]
[10]
Chen CH, Nevo E, Fetics B, et al. Estimation of central aortic pressure waveform by mathematical transformation of radial tonometry pressure. Validation of generalized transfer function. Circulation 1997; 95(7): 1827-36.
[http://dx.doi.org/10.1161/01.CIR.95.7.1827] [PMID: 9107170]
[11]
D’Elia L, Mossetti G, McEniery CM, et al. P2.05: Central hemodynamic parameters and arterial stiffness in Paget’s disease. Artery Res 2009; 3: 178.
[http://dx.doi.org/10.1016/j.artres.2009.10.021]
[12]
Laurent S, Cockcroft J, Van Bortel L, et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 2006; 27(21): 2588-605.
[http://dx.doi.org/10.1093/eurheartj/ehl254] [PMID: 17000623]
[13]
Vlachopoulos C, Xaplanteris P, Aboyans V, et al. The role of vascular biomarkers for primary and secondary prevention. A position paper from the European Society of Cardiology Working Group on peripheral circulation: Endorsed by the Association for Research into Arterial Structure and Physiology (ARTERY) Society. Atherosclerosis 2015; 241(2): 507-32.
[http://dx.doi.org/10.1016/j.atherosclerosis.2015.05.007] [PMID: 26117398]
[14]
Laurent S, Boutouyrie P, Asmar R, et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 2001; 37(5): 1236-41.
[http://dx.doi.org/10.1161/01.HYP.37.5.1236] [PMID: 11358934]
[15]
Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol 2010; 55(13): 1318-27.
[http://dx.doi.org/10.1016/j.jacc.2009.10.061] [PMID: 20338492]
[16]
Guerin AP, Blacher J, Pannier B, Marchais SJ, Safar ME, London GM. Impact of aortic stiffness attenuation on survival of patients in end-stage renal failure. Circulation 2001; 103(7): 987-92.
[http://dx.doi.org/10.1161/01.CIR.103.7.987] [PMID: 11181474]
[17]
Sattler AM, Schoppet M, Schaefer JR, Hofbauer LC. Novel aspects on RANK ligand and osteoprotegerin in osteoporosis and vascular disease. Calcif Tissue Int 2004; 74(1): 103-6.
[http://dx.doi.org/10.1007/s00223-003-0011-y] [PMID: 14523602]
[18]
Polyzos SA, Cundy T, Mantzoros CS. Juvenile Paget disease. Metabolism 2018; 80: 15-26.
[http://dx.doi.org/10.1016/j.metabol.2017.10.007] [PMID: 29080812]
[19]
Gaudio A, Fiore V, Rapisarda R, et al. Sclerostin is a possible candidate marker of arterial stiffness: Results from a cohort study in Catania. Mol Med Rep 2017; 15(5): 3420-4.
[http://dx.doi.org/10.3892/mmr.2017.6390] [PMID: 28339088]
[20]
Idolazzi L, Fassio A, Tripi G, et al. Circulating Dickkopf-1 and sclerostin in patients with Paget’s disease of bone. Clin Rheumatol 2017; 36(4): 925-8.
[http://dx.doi.org/10.1007/s10067-016-3497-1] [PMID: 28054306]
[21]
Yavropoulou MP, van Lierop AH, Hamdy NA, Rizzoli R, Papapoulos SE. Serum sclerostin levels in Paget’s disease and prostate cancer with bone metastases with a wide range of bone turnover. Bone 2012; 51(1): 153-7.
[http://dx.doi.org/10.1016/j.bone.2012.04.016] [PMID: 22579776]
[22]
Marshall MJ, Evans SF, Sharp CA, Powell DE, McCarthy HS, Davie MW. Increased circulating Dickkopf-1 in Paget’s disease of bone. Clin Biochem 2009; 42(10-11): 965-9.
[http://dx.doi.org/10.1016/j.clinbiochem.2009.04.007] [PMID: 19389391]
[23]
Zanoli L, Lentini P, Briet M, et al. Arterial stiffness in the heart disease of CKD. J Am Soc Nephrol 2019; 30(6): 918-28.
[http://dx.doi.org/10.1681/ASN.2019020117] [PMID: 31040188]
[24]
Zanoli L, Granata A, Lentini P, Gaudio A, Castellino P. Augmentation index is increased in patients with inflammatory bowel disease, a meta-analysis. Eur J Intern Med 2017; 39: e31-2.
[http://dx.doi.org/10.1016/j.ejim.2016.12.012] [PMID: 28012744]
[25]
Zanoli L, Mikhailidis DP, Bruno RM, et al. Aortic stiffening is an extraintestinal manifestation of inflammatory bowel disease: review of the literature and expert panel statement. Angiology 2020; 71(8): 689-97.
[http://dx.doi.org/10.1177/0003319720918509] [PMID: 32292048]
[26]
Werner de Castro GR, Buss Z, Da Rosa JS, Fröde TS. Inflammatory cytokines in Paget’s disease of bone. Int Immunopharmacol 2014; 18(2): 277-81.
[http://dx.doi.org/10.1016/j.intimp.2013.12.003] [PMID: 24355795]
[27]
Kim JY, Ozato K. The sequestosome 1/p62 attenuates cytokine gene expression in activated macrophages by inhibiting IFN regulatory factor 8 and TNF receptor-associated factor 6/NF-kappaB activity. J Immunol 2009; 182(4): 2131-40.
[http://dx.doi.org/10.4049/jimmunol.0802755] [PMID: 19201866]
[28]
Kattoor AJ, Pothineni NVK, Palagiri D, Mehta JL. Oxidative stress in atherosclerosis. Curr Atheroscler Rep 2017; 19(11): 42.
[http://dx.doi.org/10.1007/s11883-017-0678-6] [PMID: 28921056]
[29]
Numan MS, Jean S, Dessay M, et al. Gene-environment interactions in Paget’s disease of bone. Joint Bone Spine 2019; 86(3): 373-80.
[http://dx.doi.org/10.1016/j.jbspin.2018.12.007] [PMID: 30594595]
[30]
van Staa TP, Selby P, Leufkens HG, Lyles K, Sprafka JM, Cooper C. Incidence and natural history of Paget’s disease of bone in England and Wales. J Bone Miner Res 2002; 17(3): 465-71.
[http://dx.doi.org/10.1359/jbmr.2002.17.3.465] [PMID: 11878305]
[31]
Wermers RA, Tiegs RD, Atkinson EJ, Achenbach SJ, Melton LJ III. Morbidity and mortality associated with Paget’s disease of bone: a population-based study. J Bone Miner Res 2008; 23(6): 819-25.
[http://dx.doi.org/10.1359/jbmr.080215] [PMID: 18269308]
[32]
Reference Values for Arterial Stiffness’ Collaboration. Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: ‘establishing normal and reference values’. Eur Heart J 2010; 31(19): 2338-50.
[http://dx.doi.org/10.1093/eurheartj/ehq165] [PMID: 20530030]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy