Title:The Role of Endostatin in Rheumatoid Arthritis
Volume: 17
Issue: 1
Author(s): Priya Nijhawan and Tapan Behl*
Affiliation:
- Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab,India
Keywords:
Rheumatoid arthritis, angiogenesis, endostatin, matrix metalloproteinases, transcription factor, obesity.
Abstract:
Background: Endostatin by its therapeutic value against rheumatoid arthritis has recently
gained significant interest in biomedical science. A recent study revealed that various approaches
have been made to prevent rheumatoid arthritis by either controlling or inhibiting the progression of
angiogenesis.
Objective: The main objective of the current manuscript is to enumerate the intrinsic role of endostatin
in rheumatoid arthritis.
Methods: A thorough and detailed review of literature from the papers published from the year
1997-2019 was studied for the preparation of the current article.
Results: Endostatin is one such agent of the subfamily of ECM called as multiplexins obtained
from proteolytic cleavage of XVIII and its carboxylic terminal fragments and is known for its antiangiogenic
and antiproliferative property. The exact mechanism of endostatin is still unclear, but it
acts by downregulating or inhibiting the responses of various factors, including Id1, Id3, matrix
metalloproteinase, and Nuclear factor Kappa B that are liable for angiogenesis. The mutual effects
on adipogenesis and angiogenesis, endostatin inhibits dietary-induced obesity and its related metabolic
disorders, such as insulin resistance, glucose intolerance, and hepatic steatosis.
Conclusion: The present review demonstrates the intrinsic usage of endostatin as a novel molecule
in rheumatoid arthritis. It focuses on the status of the therapeutic potential of endostatin in inhibiting
the activity of angiogenesis is also very well explored.
