Title:Natural Products Containing Olefinic Bond: Important Substrates for Semi-synthetic Modification Towards Value Addition
Volume: 24
Issue: 7
Author(s): Meenakshi Singh, V. Ravichandiran, Yogesh P. Bharitkar*Abhijit Hazra*
Affiliation:
- National Institute of Pharmaceutical Education and Research (NIPER), Chunilal Bhawan, 168 Maniktala Main Road, Kolkata - 700 054,India
- National Institute of Pharmaceutical Education and Research (NIPER), Chunilal Bhawan, 168 Maniktala Main Road, Kolkata - 700 054,India
Keywords:
Semi-synthesis, double bond, sesquiterpene lactone, michael addition, heck reaction, dipolar cycloaddition.
Abstract: Semi-synthesis, the way of preparing novel bioactive molecules via modification
of compounds isolated from natural sources is very much useful nowadays in the drug discovery
process. The modification is based on the reaction of functional group(s) present in a
natural compound. Among the examples of functional group transformation, double bond
modification is also common in the literature. Several reactions like hydrogenation, cyclopropanation,
epoxidation, addition reaction (halogenations, hydroxylation), Michael addition,
Heck reaction, cycloaddition, dipolar cycloaddition, etc. are employed for this purpose.
In this review, we have tried to gather the reactions performed with several double bond
containing classes of natural products like diterpenes, xanthones, sesquiterpene exomethylene lactones, diaryl
heptanoids, steroidal lactones, triterpenoids, limonoids, and alkamides. Where available, the effects of transformations
on the biological activities of the molecules are also mentioned.