Generic placeholder image

Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Biological Signatures of Alzheimer’s Disease

Author(s): Poornima Sharma, Anjali Sharma, Faizana Fayaz, Sharad Wakode* and Faheem H. Pottoo

Volume 20, Issue 9, 2020

Page: [770 - 781] Pages: 12

DOI: 10.2174/1568026620666200228095553

Price: $65

conference banner
Abstract

Alzheimer’s disease (AD) is the most prevalent and severe neurodegenerative disease affecting more than 0.024 billion people globally, more common in women as compared to men. Senile plaques and amyloid deposition are among the main causes of AD. Amyloid deposition is considered as a central event which induces the link between the production of β amyloid and vascular changes. Presence of numerous biomarkers such as cerebral amyloid angiopathy, microvascular changes, senile plaques, changes in white matter, granulovascular degeneration specifies the manifestation of AD while an aggregation of tau protein is considered as a primary marker of AD. Likewise, microvascular changes, activation of microglia (immune defense system of CNS), amyloid-beta aggregation, senile plaque and many more biomarkers are nearly found in all Alzheimer’s patients. It was seen that 70% of Alzheimer’s cases occur due to genetic factors. It has been reported in various studies that apolipoprotein E(APOE) mainly APOE4 is one of the major risk factors for the later onset of AD. Several pathological changes also occur in the white matter which include dilation of the perivascular space, loss of axons, reactive astrocytosis, oligodendrocytes and failure to drain interstitial fluid. In this review, we aim to highlight the various biological signatures associated with the AD which may further help in discovering multitargeting drug therapy.

Keywords: Alzheimer's disease, Neurodegenerative disorders, Dementia, Neurofibrillary tangles, Microvascular degeneration, Cerebral amyloid angiopathy.

Graphical Abstract
[1]
Nagel, E. The Structure of science: problems in the logic of scienific explanation; Hackett Publishing Company: Indianapolis, 1979.
[2]
Di Nicola, V.; Stoyanov, D. Psychiatry in crisis: at the crossroads of social science, the humanities, and neuroscience; Springer Publishing: New York, 2016.
[3]
Place, U.T. Identifying the mind: Selected papers of UT place; Oxford University Press: Oxford, 2004.
[4]
Kherif, F.; Muller, S. Neuro-clinical signatures of language impairments: a theoretical framework for function-to-structure mapping in clinics. Curr. Top. Med. Chem., 2020, 20(9), 800-811.
[5]
Sharma, P.; Sharma, A.; Fayaz, F.; Wakode, S.; Pottoo, F.H. Biological signatures of Alzheimer disease. Curr. Top. Med. Chem., 2020, 20(9), 770-781.
[6]
Kakanakova, A.; Popov, S.; Maes, M. Immunological disturbances and neuroimaging findings in Major Depressive Disorder (MDD) and Alcohol Use Disorder (AUD) comorbid patients. Curr. Top. Med. Chem., 2020, 20(9), 759-769.
[7]
Muller, S.; Dauyey, K.; Ruef, A.; Lorio, S.; Eskandari, A.; Schneider, L. Neuro-Clinical signatures of language impairments after acute stroke: a VBQ analysis of quantitative native CT scans. Curr. Top. Med. Chem., 2020, 20(9), 792-799.
[8]
Zufferey, V.; von Gunten, A.; Kherif, F. Interactions between personality, depression/anxiety and cognition to understand early stage of Alzheimer’s disease. Curr. Top. Med. Chem., 2020, 20(9), 782-791.

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy