Title:Design, Synthesis and Anticancer Evaluation of Acetamides Comprising 1,2,3-triazole, 1,3,4-thiadiazole and Isothiazolo[4,3-b]pyridine Rings
Volume: 17
Issue: 11
Author(s): Shaik Shahinshavali, Nuthalapati Poojith, Venkat Rao Guttikonda, Reddymasu Sreenivasulu and Mandava Venkata Basaveswara Rao*
Affiliation:
- Department of Chemistry, Krishna University, Machilipatnam, Andhra Pradesh, 521001,India
Keywords:
1, 2, 3-triazole, 1, 3, 4-thiadiazole, anticancer activity, azetepa, Carboxyamido triazole (CAI), isothiazolo[4, 3-
b]pyridine.
Abstract: We have synthesized a library of new 1,2,3-triazole incorporated 1,3,4-thiadiazoleisothiazolo[
4,3-b]pyridine derivatives 12a-j and have screened these products for their anticancer
activities against four human cancer cell lines such as MCF-7 (breast cancer), A549 (lung cancer),
DU-145 (prostate cancer), and MDA MB-231 (breast cancer) using MTT assay with etoposide as a
positive control. Among them, compound 12e has shown excellent activities against MCF-7, A549,
DU-145, and MDA-MB-231 with IC50 values of 0.53±0.055 μM, 0.18±0.077 μM, 0.10±0.082 μM, and
0.92±0.041 μM, respectively.