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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Natural Products as a Paradigm for the Treatment of Coxsackievirus - induced Myocarditis

Author(s): Madhu Khanna*, Anju Gautam, Roopali Rajput and Latika Sharma

Volume 20, Issue 8, 2020

Page: [607 - 616] Pages: 10

DOI: 10.2174/1568026620666200129094516

Price: $65


Coxsackievirus B3 (CVB3), a member of the Picornaviridae family, is considered to be one of the most important infectious agents to cause virus-induced myocarditis. Despite improvements in studying viral pathology, structure and molecular biology, as well as diagnosis of this disease, there is still no virus-specific drug in clinical use. Structural and nonstructural proteins produced during the coxsackievirus life cycle have been identified as potential targets for blocking viral replication at the step of attachment, entry, uncoating, RNA and protein synthesis by synthetic or natural compounds. Moreover, WIN (for Winthrop) compounds and application of nucleic-acid based strategies were shown to target viral capsid, entry and viral proteases, but have not reached to the clinical trials as a successful antiviral agent. There is an urgent need for diverse molecular libraries for phenotype-selective and high-throughput screening.

Keywords: Natural Products, Coxsackievirus, Myocarditis, Picornaviridae, Viral pathology, Antiviral agent.

Graphical Abstract
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