Title:The Role of Heat Shock Protein -90 (HSP-90) in Inflammatory Disorders
Volume: 14
Issue: 1
Author(s): Chiranjib Bhattacharjee and Lokesh Deb*
Affiliation:
- Institute of Bioresources and Sustainable Development - Sikkim Centre (Department of Biotechnology, Government of India), 5th Mile, NH-10A, Near Metro Point, Tadong, Gangtok, Sikkim, North-East, 795001,India
Keywords:
Heat shock protein-90 (HSP-90), autoimmune diseases, cancer, HSP inhibitor, viral HSP-90,
fungal HSP-90.
Abstract: In human cells, Heat Shock Protein-90 (HSP-90) is present in the cytosol, nucleoplasm,
endoplasmic reticulum, and mitochondria. The eukaryotic HSP-90 is multifunctionary
and essential for cell viability, signal transduction, cell-cycle control as well as
transcriptional regulation. The intracellular environment does not restrict HSP-90. It has a
vital role in all types of inflammatory disorders, including cancer, autoimmune diseases, infectious
inflammatory conditions. Hence, pharmacological inhibition of HSP-90 is currently
a choice of therapeutic target for the treatment of autoimmune diseases, cancer, and infectious
diseases. Based on the biology of HSP-90, several COOH-terminal ATPase sites of
HSP-90, NH2-terminal ATPase sites of HSP-90, and Histone deacetylase inhibitors are
evaluated and classified under various groups. For the treatment of different inflammatory
disorders, HSP-90 identified as a promising therapeutic target. The present review may guide
researchers for evaluating the HSP-90 targeted pathway as a useful therapeutic target for inflammatory
diseases, including cancers.
