Title:Role of Subclinical Iatrogenic Hyperthyroidism in the Setting of Heart Disease and Arrhythmic Burden
Volume: 20
Issue: 6
Author(s): Sandra Mastroianno, Giuseppe Di Stolfo*, Angela Maggio, Michele Pacilli, Domenico Rosario Potenza, Raimondo Massaro, Giovanni De Luca and Aldo Russo
Affiliation:
- Cardiovascular Department, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo,Italy
Keywords:
Subclinical hyperthyroidism, heart disease, arrhythmia, mitral valve insufficiency, accessory pathway, l-thyroxine.
Abstract:
Background: Subclinical hyperthyroidism is defined by a subnormal serum thyroidstimulating
hormone (TSH) level with normal free thyroxine (FT4) and free triiodothyronine (FT3)
levels. Its prevalence varies from 0.6% to 16% in the elderly and can increase to 20% in patients receiving
thyroid hormone replacement therapy. Thyroid disease and/or replacement therapy are frequently
associated with cardiovascular involvement.
Cases Presentation: We report three clinical cases of patients with initial subclinical hyperthyroidism
and cardiological manifestations, including supraventricular and ventricular extrasystoles, prolapse of
the mitral valve with severe regurgitation, higher mean heart rate and deterioration of the arrhythmias
on arrhythmogenic dysplasia substrate.
Conclusion: We discuss the role of appropriate and early correction of thyroid dysfunction in improving
cardiological manifestations.
