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Current Nutrition & Food Science

Editor-in-Chief

ISSN (Print): 1573-4013
ISSN (Online): 2212-3881

Research Article

Does the Vitamin D Deficiency Have Any Role in Severity or Prolongation of Seizure? A Pilot Study in Iran

Author(s): Mohammad Vafaee-Shahi , Reza S. Badv , Alinaghi Kazemi , Samileh Noorbakhsh *, Koorosh Kamali, Shahin Teimourtash and Leila Tahernia

Volume 16, Issue 5, 2020

Page: [781 - 787] Pages: 7

DOI: 10.2174/1573401315666190912091832

Price: $65

Abstract

Background: Based on previous studies, vitamin D deficiency could lead to nerve stimulation. The purpose of the present study was to determine frequency and duration of seizures in children with idiopathic epilepsy in two groups; normal level of vitamin D versus decreased level of vitamin D.

Methods: This pilot, comparative study was carried out in Zanjan University of Medical Sciences on total 40 children aging between 2 to 12 years old (23 male and 17 female) with the diagnosis of idiopathic epilepsy. All patients were receiving anti-epileptic drugs. The initial questionnaire was completed by each parent. Total 40 epileptic cases were examined in close follow-ups every three months, during total 9 months. Meanwhile, the frequency and duration of each seizure were recorded in questionnaire at every three-month period. Vitamin D blood samples were analyzed at the beginning of the study and after 9 months following the study. Serum levels of Vitamin D were analyzed by ELISA method (Elecsys2010, RocheCo, Germany; STAR FAX; 2100), simultaneously, Vitamin D level <30 ng/ml (nanogram per milliliter) was defined as Vitamin D deficiency. Cases were divided into two groups based on Vitamin D level. The frequency and duration of convulsions were compared in patients with normal level of vitamin D versus children with decreased level of vitamin D. Data were analyzed by Chi-square and t-test methods.

Results: In all 40 patients, vitamin D level less than 30 ng/ml was detected in 32% (13 patients) at the beginning of study and 35% (14 patients) in 9 months later (13 patients were common between the two groups). There was no significant relationship between the frequency of seizures, the duration of seizures and vitamin D levels in patients. The relationship between positive family history of epilepsy and the number of seizures was reported significant. The frequency of vitamin D deficiency was higher in female cases in final evaluation.

Conclusion: In the present study, a considerable correlation was detected between the frequency of seizures and positive history of seizure in the family. The frequency of vitamin D deficiency was higher in female cases in final analysis. No significant relationship was detected between the number of seizures, the mean duration of seizures and serum level of Vitamin D in children who received anticonvulsant drugs. However, vitamin D deficiency in patients was not overlooked in order to prevent known complications. We recommend a randomized clinical trial in the future with an adequate sample size. Moreover, a non-epileptic control group in study would be useful.

Keywords: Children, epilepsy, prolongation, seizure, severity, vitamin D.

Graphical Abstract
[1]
Wallace SJ. Epilepsy in children London: chapman & hall Medical. 1996; 2: 23-56.
[2]
Välimäki MJ, Tiihonen M, Laitinen K, et al. Bone mineral density measured by dual-energy x-ray absorptiometry and novel markers of bone formation and resorption in patients on antiepileptic drugs. J Bone Miner Res 1994; 9(5): 631-7.
[http://dx.doi.org/10.1002/jbmr.5650090507] [PMID: 8053391]
[3]
Sato Y, Kondo I, Ishida S, et al. Decreased bone mass and increased bone turnover with valproate therapy in adults with epilepsy. Neurology 2001; 57(3): 445-9.
[http://dx.doi.org/10.1212/WNL.57.3.445] [PMID: 11502911]
[4]
Farhat G, Yamout B, Mikati MA, Demirjian S, Sawaya R, El-Hajj Fuleihan G. Effect of antiepileptic drugs on bone density in ambulatory patients. Neurology 2002; 58(9): 1348-53.
[http://dx.doi.org/10.1212/WNL.58.9.1348] [PMID: 12011279]
[5]
Ecevit C, Aydoğan A, Kavakli T, Altinöz S. Effect of carbamazepine and valproate on bone mineral density. Pediatr Neurol 2004; 31(4): 279-82.
[http://dx.doi.org/10.1016/j.pediatrneurol.2004.03.021] [PMID: 15464641]
[6]
Shiva S, Barzegar M. Antiepileptic drugs effects on vitamin D status in epileptic children. Iran J Pediatr 2008; 60: 167-72.
[7]
M Sonmez F. The role of the vitamin d in neurology: interrelationships between headache, epilepsy and vitamin d deficiency. J Ped Neonatal Care 2016; 4(2): 00132.
[http://dx.doi.org/10.15406/jpnc.2016.04.00132]
[8]
Lee SW, Chung SS. A review of the effects of vitamins and other dietary supplements on seizure activity. Epilepsy Behav 2010; 18(3): 139-50.
[http://dx.doi.org/10.1016/j.yebeh.2010.04.013] [PMID: 20493778]
[9]
Holló A, Clemens Z, Kamondi A, Lakatos P, Szűcs A. Correction of vitamin D deficiency improves seizure control in epilepsy: a pilot study. Epilepsy Behav 2012; 24(1): 131-3.
[http://dx.doi.org/10.1016/j.yebeh.2012.03.011] [PMID: 22503468]
[10]
Shellhaas RA, Barks AK, Joshi SM. Prevalence and risk factors for vitamin D insufficiency among children with epilepsy. Pediatr Neurol 2010; 42(6): 422-6.
[http://dx.doi.org/10.1016/j.pediatrneurol.2010.03.004] [PMID: 20472195]
[11]
Teagarden DL, Meador KJ, Loring DW. Low vitamin d levels are common in patients with epilepsy 2014; 108(8): 1352-6.
[12]
Holic MF. High prevalence of vitamin D inadequacy and implication for health. Mayo Clin Proc 2006; 81: 353-73.
[13]
IOM (Institute of Medicine). Dietary reference intakes for calcium and vitamin D. Washington, DC: The National Academies Press 2011.
[14]
Gordon CM, DePeter KC, Feldman HA, Grace E, Emans SJ. Prevalence of vitamin D deficiency among healthy adolescents. Arch Pediatr Adolesc Med 2004; 158(6): 531-7.
[http://dx.doi.org/10.1001/archpedi.158.6.531] [PMID: 15184215]
[15]
Shin YH, Kim KE, Lee C, et al. High prevalence of vitamin D insufficiency or deficiency in young adolescents in Korea. Eur J Pediatr 2012; 171(10): 1475-80.
[http://dx.doi.org/10.1007/s00431-012-1746-0] [PMID: 22562162]
[16]
field j, trivedi NJ, Horton E, Mechanick ji. Vitamin D in the Persian gulf: integrative physiology and socioeconomic factor. Curr Osteoporos Rep 2011; 9: 243-50.
[http://dx.doi.org/10.1007/s11914-011-0071-2] [PMID: 21901427]
[17]
Arabi A, El Rassi R, El-Hajj Fuleihan G. Hypovitaminosis D in developing countries-prevalence, risk factors and outcomes. Nat Rev Endocrinol 2010; 6(10): 550-61.
[http://dx.doi.org/10.1038/nrendo.2010.146] [PMID: 20852586]
[18]
Kazemi A, Sharifi F, Jafari N, Mousavinasab N. High prevalence of vitamin D deficiency among pregnant women and their newborns in an Iranian population. J Womens Health (Larchmt) 2009; 18(6): 835-9.
[http://dx.doi.org/10.1089/jwh.2008.0954] [PMID: 19514825]
[19]
Moussavi M, Heidarpour R, Aminorroaya A, Pournaghshband Z, Amini M. Prevalence of vitamin D deficiency in Isfahani high school students in 2004. Horm Res 2005; 64(3): 144-8.
[PMID: 16192739]
[20]
Izadi NS, Rahbarimanesh A, Javadnia AA, S Soheilipour. Vitamin A, D & zinc serum levels in children with acute gastroentritis: A case control study: Tehran, Iran. Curr Nutr Food Sci 2016; 12(1): 23-7. [Article].
[http://dx.doi.org/10.2174/1573401311666150930215954]
[21]
Javadi-Nia S, Noorbakhsh S, Izadi A, Shokrollahi MR, Asgarian R, Tabatabaei A. Vitamin A, D and zinc serum levels in children with and without acute respiratory tract infection in two university hospitals Tehran Univ Med J (TUMJ) 2014 March; 71(12): 794-9. (persian).
[22]
Soheilipour F, Noorbakhsh S, Javadnia Sh Jesmi F, Pishgahroudsari M. Mohammadi Gh. Assessing the serum levels of ferritin and selenium in three important infections of childhood, compared to a control group. Curr Nutr Food Sci 2015; 11(4): 263-6.
[http://dx.doi.org/10.2174/1573401311666150729230000]
[23]
Barzegar M, Mahdavi M, Galegolab Behbehani A, Tabrizi A. Refractory convulsive status epilepticus in children: etiology, associated risk factors and outcome. Iran J Child Neurol 2015; 9(4): 24-31.
[PMID: 26664438]
[24]
Sharif MR, Kheirkhah D, Madani M, Kashani HH. The relationship between iron deficiency and febrile convulsion: a case-control study. Glob J Health Sci 2015; 8(2): 185-9.
[http://dx.doi.org/10.5539/gjhs.v8n2p185] [PMID: 26383191]
[25]
Sadeghzadeh M, Khoshnevis Asl P, Mahboubi E. Iron status and febrile seizure- a case control study in children less than 3 years. Iran J Child Neurol 2012; 6(4): 27-31.
[PMID: 24665277]
[26]
Salehi Omran MR, Tamaddoni A, Nasehi MM, Babazadeh H, Alizadeh Navaei R. Iron status in febrile seizure: a case-control study. Iran J Child Neurol 2009; 40-3.
[27]
Talebian A, Momtazmanesh N. Febrile seizures and anemia. Iran J Child Neurol 2007; 31-3.
[28]
Yaghini O, Tonekaboni SH, Amir Shahkarami SM, Ahmad Abadi F, Shariat F, Abdollah Gorji F. Bone mineral density in ambulatory children with epilepsy. Indian J Pediatr 2015; 82(3): 225-9.
[http://dx.doi.org/10.1007/s12098-014-1518-0] [PMID: 25106841]

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