Title:A Systematic Review on Synthetic Drugs and Phytopharmaceuticals Used to Manage Diabetes
Volume: 16
Issue: 4
Author(s): Mayukh Banerjee, Rubiya Khursheed, Ankit Kumar Yadav, Sachin Kumar Singh*, Monica Gulati, Devendra Kumar Pandey, Pranav Kumar Prabhakar, Rajesh Kumar, Omji Porwal, Ankit Awasthi, Yogita Kumari, Gurmandeep Kaur, Clarisse Ayinkamiye, Rahul Prashar, Diksha Mankotia and Narendra Kumar Pandey
Affiliation:
- School of Pharmaceutical Sciences, Lovely Professional University, Phagwara – 144411, Punjab,India
Keywords:
Diabetes, combination therapy, probiotics, herbal drugs, synthetic drugs, phytopharmaceuticals.
Abstract:
Background: Diabetes is a multifactorial disease and a major cause for many microvascular
and macrovascular complications. The disease will ultimately lead to high rate mortality if it is not
managed properly. Treatment of diabetes without any side effects has always remained a major challenge
for health care practitioners.
Introduction: The current review discusses the various conventional drugs, herbal drugs, combination
therapy and the use of nutraceuticals for the effective management of diabetes mellitus. The biotechnological
aspects of various antidiabetic drugs are also discussed.
Methods: Structured search of bibliographic databases for previously published peer-reviewed research
papers was explored and data was sorted in terms of various approaches that are used for the treatment
of diabetes.
Results: More than 170 papers including both research and review articles, were included in this review
in order to produce a comprehensive and easily understandable article. A series of herbal and synthetic
drugs have been discussed along with their current status of treatment in terms of dose, mechanism of
action and possible side effects. The article also focuses on combination therapies containing synthetic
as well as herbal drugs to treat the disease. The role of pre and probiotics in the management of diabetes
is also highlighted.
Conclusion: Oral antihyperglycemics which are used to treat diabetes can cause many adverse effects
and if given in combination, can lead to drug-drug interactions. The combination of various phytochemicals
with synthetic drugs can overcome the challenge faced by the synthetic drug treatment.
Herbal and nutraceuticals therapy and the use of probiotics and prebiotics are a more holistic therapy
due to their natural origin and traditional use.