Open Veterinary Science Journal
Equine Herpes Virus-1: Virus, Immunity and Vaccines
R. Paillot, R. Case, J. Ross, R. Newton and J. Nugent Pp
Equine Herpes virus-1 (EHV-1) is one of the most common respiratory
pathogens of the horse. EHV-1 induces several clinical signs of
disease ranging in severity, from mild respiratory distress to abortion
in pregnant mares, neonatal foal death and neuropathogenic disorders.
This review details some aspects of EHV-1 biology, its life cycle
and pathogenicity in the natural host. Protective immunity stimulated
by natural EHV-1 infection, which is short lived and depends of
both humoral and cellular immune responses, will also be treated
here. Vaccination remains today one of the best options to fight
EHV-1 infection and several different strategies of vaccination
that have been investigated and developed over the past decades
will be presented in this report.