The Open Nitric Oxide Journal is an Open Access online journal, which publishes Research articles, Reviews and Letters in the field of Nitric Oxide, aiming at providing the most complete and reliable source of information on current developments in the field.

Manuscripts may be submitted directly to tonoj@benthamopen.org. Each peer-reviewed article that is published in a Bentham OPEN Journal is universally and freely accessible via the Internet in an easily readable and printable PDF format.

ONLINE MANUSCRIPT SUBMISSION: An online submission and tracking service via Internet facilitates a speedy and cost-effective submission of manuscripts.¹ The full manuscript has to be submitted online via Bentham's Content Management System (CMS) at http://www.bentham-editorial.org/ View Instructions

Alternatively, you may also submit your full manuscript by e-mail to tonoj@benthamopen.org

Manuscripts must be submitted by one of the authors of the manuscript, and should not be submitted by anyone on their behalf. The principal/corresponding author will be required to submit a Covering Letter along with the manuscript, on behalf of all the co-authors (if any). The author(s) will confirm that the manuscript (or any part of it) has not been published previously or is not under consideration for publication elsewhere. Furthermore, any illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained.

For all online submissions, please provide your complete manuscript in the form of a single zipped folder containing soft copies of all the materials (main text in MS Word or Tex/LaTeX), figures/illustrations in TIFF, PDF or JPEG, and chemical structures drawn in ChemDraw (CDX)/ISISDraw (TGF) as separate files, while a PDF version of the entire manuscript must also be included, embedded with all the figures/illustrations/tables/chemical structures etc.

It is imperative that before submission, authors should carefully proofread the files for special characters, mathematical symbols, Greek letters, equations, tables and images, to ensure that they appear in proper format.

A successful electronic submission of a manuscript will be followed by a system-generated acknowledgement to the principal/corresponding author within 72 hours of the dispatch of the manuscript. Any questions with regards to the preparation of and submission of your manuscript to the journal should be addressed to tonoj@benthamopen.org and copied to managingeditor@benthamopen.org

NOTE: Any queries therein should be addressed to oa@benthamscience.org and copied to Jalil@benthamscience.org

Manuscript Preparation: The manuscript should be written in English in a clear, direct and active style. All pages must be numbered sequentially, facilitating in the reviewing and editing of the manuscript.

For further convenience, the customer support team available at Bentham Publishing Services (www.benthampublishingservices.com) can provide assistance to authors for the preparation of manuscripts.

Manuscript Length:

Research Articles: The total number of words for a published research article is from 4000 to 8000 words.

Review Articles: The total number of words for a published comprehensive review article article is from 8000 to 40000 words, and for mini-review articles from 3000 to 6000 words.

Letter Articles: The total number of words for a published letter/short communication article is from 3000 to 6000 words.

There is no restriction on the number of figures, tables or additional files e.g. video clips, animation and datasets, that can be included with each article online. Authors should include all relevant supporting data with each article.

Manuscripts Published: The Journal accepts letters/short communications, original research articles, and mini- and full-length review articles written in English. Supplements, proceedings of conferences and book reviews may also be considered for publication.

Supplements/Single Topic Issues: The journal also considers Supplements/Single topic issue for publication. A Supplements/Single topic will be a collection of articles (minimum of 6, maximum of 20 articles) based on a contemporary theme or topic of great importance to the field. Mini-supplements consisting of between 3 to 5 articles are also welcome. A Supplement can consist of either all review articles or a mixture of review and research articles. The Guest Editors' main editorial task is to invite the contributors to the Supplement and to manage the peer review of submitted manuscripts. A short summary or proposal for editing a supplement should be submitted to the Editor-in-Chief at e-mail to tonoj@benthamopen.org with a copy to specialissue@benthamopen.org

Conference Proceedings: Authors are welcome to publish their conference proceedings in ‘The Open Conference Proceedings (www.benthamscience.com/open/toprocj)’ or alternatively in ‘The Open Nitric Oxide Journal’. Proposals for publishing relevant conference proceedings should be submitted to the Editor at e-mail tonoj@benthamopen.org with a copy to oa@benthamscience.org

Open Access Book Reviews: This journal publishes open access reviews on recently published books (both print and electronic) relevant to the journal. Publishers and authors of books are invited to contact our book reviews editor at tonoj@benthamopen.org with book review requests. All submitted books will be reviewed by an independent expert in the field.

MANUSCRIPT SECTIONS FOR PAPERS: Manuscripts for research articles and letters submitted to the respective journals should be divided into the following sections; however, there can be an extension in the number of sections in review articles in accordance with the requirements of the topic.

Covering letter
Abstract
Keywords
Text organization
Tables
List of abbreviations (if any)
Conflict of interest (if any)
Acknowledgements (if any)
References
Appendices
Figures/illustrations (if any)
Chemical structures (if any)
Tables and captions (if any)
Supportive/supplementary material (if any)

COVERING LETTER: It is a mandatory requirement that a signed covering letter also be submitted along with the manuscript by the author to whom correspondence is to be addressed, delineating the scope of the submitted article declaring the potential competing interests, acknowledging contributions from authors and funding agencies, and certifying that the paper is prepared according to the 'Instructions for Authors'. All inconsistencies in the text and in the reference section, and any typographical errors must be carefully checked and corrected before the submission of the manuscript. The article contains no such material or information that may be unlawful, defamatory, fabricated, plagiarized, or which would, if published, in any way whatsoever, violate the terms and conditions as laid down in the agreement. The authors acknowledge that the publishers have the legal right to take appropriate action against the authors for any such violation of the terms and conditions as laid down in the agreement. Download the Covering letter

TITLE: The title should be precise and brief and must not be more than 120 characters. Authors should avoid the use of non-standard abbreviations. The title must be written in title case except for articles, conjunctions and prepositions.

Authors should also provide a short ‘running title’.

ABSTRACT: The abstract should not exceed 250 words for review and research papers and should be limited to only 150 words for letters, summarizing the essential features of the article. The use of abbreviations should be reduced to a minimum and the references should not be cited in the abstract.

KEYWORDS: Provide 6 to 8 keywords in alphabetical order.

TEXT ORGANIZATION: The main text should begin on a separate page and should be divided into title page, abstract and the main text. The text may be subdivided further according to the areas to be discussed, which should be followed by the Acknowledgement (if any) and Reference sections. The review article should mention any previous important reviews in the field and contain a comprehensive discussion starting with the general background of the field. It should then go on to discuss the salient features of recent developments. The authors should avoid presenting material which has already been published in a previous review.

Greek Symbols and Special Characters: Greek symbols and special characters often undergo formatting changes and get corrupted or lost during preparation of manuscript for publication. To ensure that all special characters used are embedded in the text, these special characters should be inserted as a symbol but should not be a result of any format styling (Symbol font face) otherwise they will be lost during conversion to PDF/XML².

Authors are encouraged to consult reporting guidelines. These guidelines provide a set of recommendations comprising a list of items relevant to their specific research design. Chemical equations, chemical names, mathematical usage, unit of measurements, chemical and physical quantity & units must conform to SI and Chemical Abstracts or IUPAC.

All kinds of measurements should be reported only in International System of Units (SI).

LIST OF ABBREVIATIONS: If abbreviations are used in the text either they should be defined in the text where first used, or a list of abbreviations can be provided.

CONFLICT OF INTEREST: Financial contributions to the work being reported should be clearly acknowledged, as should any potential conflict of interest.

ACKNOWLEDGEMENTS: Please acknowledge anyone (individual/company/institution) who has contributed to the study by making substantial contributions to conception, design, acquisition of data, or analysis and interpretation of data, or who was involved in drafting the manuscript or revising it critically for important intellectual content. Please list the source(s) of funding for the study, for each author, and for the manuscript preparation in the acknowledgements section.

REFERENCES: References must be listed in the ACS Style only. All references should be numbered sequentially [in square brackets] in the text and listed in the same numerical order in the reference section. The reference numbers must be finalized and the bibliography must be fully formatted before submission.

See below few examples of references listed in the ACS Style:

Journal Reference:
[1] Thomsen, R.; Christensen, M.H. MolDock: a new technique for high-accuracy molecular docking. J. Med. Chem., 2006, 49, 3315-21.

Book Reference:
[2] Crabtree, R.H. The organometallic chemistry of the transition metals, 3rd ed.; Wiley & Sons: New York, 2001.

Book Chapter Reference:
[3] Wheeler, D.M.S.; Wheeler, M.M. In Studies in Natural Products Chemistry; Atta-ur-Rahman, Ed.; Elsevier Science B. V: Amsterdam, 1994; Vol. 14, pp. 3-46.

Conference Proceedings:
[4] Jakeman, D.L.; Withers, S.G. E. In Carbohydrate Bioengineering: Interdisciplinary Approaches, Proceedings of the 4th carbohydrate bioengineering meeting, Stockholm, Sweden, June 10-13, 2001; Teeri, T.T.; Svensson, B.; Gilbert, H.J.; Feizi, T., Eds.; Royal Society of Chemistry: Cambridge, UK, 2002; pp. 3-8.

URL(Web Page):
[5] National Library of Medicine. Specialized Information Services: Toxicology and Environmental Health. http://sis.nlm.nih.gov/Tox/ToxMain.html (accessed May 23, 2004).

Patent:
[6] Hoch, J.A.; Huang, S. Screening methods for the identification of novel antibiotics. U.S. Patent 6,043,045, March 28, 2000.

Thesis:
[7] Kirby, C.W. Thesis, University of Waterloo, 2000.

E-citations:
[8] Citations for articles/material published exclusively online or in open access (free-to-view) , must contain the exact Web addresses (URLs) at the end of the reference(s), except those posted on an author’s Web site unless editorially essential, e.g. ‘Reference: Available from: URL’.

Some important points to remember:

*All references must be complete and accurate.
*All authors must be cited and there should be no use of the phrase et al (the term “et al.” should be in italics).
*Online citations should include the date of access.
*Journal abbreviations should follow the Index Medicus/MEDLINE.
*Take special care of the punctuation convention as described in the above-mentioned examples.
*Avoid using superscript in the in-text citations and reference section.
*Abstracts, unpublished data and personal communications (which can only be included if prior permission has been obtained) should not be given in the reference section but they may be mentioned in the text and details provided as footnotes.
*The authors are encouraged to use a recent version of EndNote (version 5 and above) or Reference Manager (version 10) when formatting their reference list, as this allows references to be automatically extracted.

APPENDICES: In case there is a need to present lengthy, but essential methodological details, use appendices, which can be a part of the article. An appendix must not exceed three pages (Times New Roman, 12 point fonts, 900 max. words per page).The information should be provided in a condensed form, ruling out the need of full sentences. A single appendix should be titled APPENDIX, while more than one can be titled APPENDIX A, APPENDIX B, and so on.

FIGURES/ILLUSTRATIONS: The authors should provide the illustrations as separate files, as well as embedded in the text file, numbered consecutively in the order of their appearance. Each figure should include a single illustration. No charges will be levied on the use of color figures except in the reprints. Each figure should be closely cropped to minimize the amount of white space surrounding the illustration.

If a figure consists of separate parts, it is important that a single composite illustration file be submitted, containing all parts of the figure.

Photographs should be provided with a scale bar if appropriate, as well as high-resolution component files.

Scaling/ Resolution:

For Line Art image type, which is generally an image based on lines and text and does not contain tonal or shaded areas, the preferred file format is TIFF or EPS, with colour mode being Monochrome 1-bit or RGB, in a resolution of 900-1200 dpi.

For Halftone image type, which is generally a continuous tone photograph and contains no text, the preferred file format is TIFF, with colour mode being or RGB or Grayscale, with a minimum resolution of 300 dpi.

For Combination image type, which is generally an image containing halftone in addition to text or line art elements, the preferred file format is TIFF, with colour mode being or RGB or Grayscale, in a resolution of 500-900 dpi.

Formats:

For illustrations, the following file formats are acceptable:

• Illustrator
• EPS (preferred format for diagrams)
• PDF (also especially suitable for diagrams)
• PNG (preferred format for photos or images)
• Microsoft Word (version 5 and above; figures must be a single page)
• PowerPoint (figures must be a single page)
• TIFF
• JPEG (conversion should be done using the original file)
• BMP
• CDX (ChemDraw)
• TGF (ISISDraw)

Bentham OPEN does not process figures submitted in GIF format.

If the large size of TIFF or EPS figures acts as an obstacle to online submission, authors may find that conversion to JPEG format before submission results in significantly reduced file size and upload time, while retaining acceptable quality. JPEG is a 'lossy' format, however. In order to maintain acceptable image quality, it is recommended that JPEG files are saved at High or Maximum quality.

Files should not be compressed with tools such as Zipit or Stuffit prior to submission as these tools will in any case produce negligible file-size savings for JPEGs and TIFFs, which are already compressed.

Please do not:

1. Supply embedded graphics in your word processor (spreadsheet, presentation) document;
2. Supply files that are optimized for screen use (like GIF, BMP, PICT, WPG); the resolution is too low;
3. Supply files that are too low in resolution;
4. Submit graphics that are disproportionately large for the content
.
Image Conversion Tools:

There are many software packages, many of them freeware or shareware, capable of converting to and from different graphics formats, including PNG.

Good general tools for image conversion include GraphicConverter on the Macintosh, PaintShop Pro, for Windows, and ImageMagick, which is available on Macintosh, Windows and UNIX platforms.

Note that bitmap images (e.g. screenshots) should not be converted to EPS, since this will result in a much larger file size than the equivalent JPEG, TIFF, PNG or BMP, with no increase in quality. EPS should only be used for images produced by vector-drawing applications such as Adobe Illustrator or CorelDraw. Most vector-drawing applications can be saved in, or exported as, EPS format. In case the images have been originally prepared in an Office application, such as Word or PowerPoint, then the original Office files should be directly uploaded to the site, instead of being converted to JPEG or another format that may be of low quality.

Chemical Structures: Chemical structures MUST be prepared according to the guidelines below.

Structures should be prepared in ChemDraw and provided as separate file, submitted both on disk and in printed formats.

Structure Drawing Preferences:

[As according to the ACS style sheet]

Drawing Settings:

Chain angle         120°

Bond spacing       18% of width

Fixed length         14.4 pt (0.500cm, 0.2in)

Bold width            2.0 pt (0.071cm, 0.0278in)

Line width            0.6 pt (0.021cm, 0.0084in)

Margin width        1.6 pt (0.096cm)

Hash spacing     2.5 pt (0.088cm, 0.0347in)

Text settings:

Font                    Times New Roman

Size                     8 pt

Under the Preference Choose:

Units                    points

Tolerances          3 pixels

Under Page Setup Use:

Paper                  US letter

Scale                   100%

TABLES:

*Data Tables should be submitted in Microsoft Word table format.
*Each table should include a title/caption being explanatory in itself with respect to the details discussed in the table. Detailed legends may then follow.
*Table number in bold font i.e. Table 1, should follow a title. The title should be in small case with the first letter in caps. A full stop should be placed at the end of the title.
*Tables should be embedded in the text exactly according to their appropriate placement in the submitted manuscript.
*Columns and rows of data should be made visibly distinct by ensuring that the borders of each cell are displayed as black lines.
*Tables should be numbered in Arabic numerals sequentially in order of their citation in the body of the text.
*If a reference is cited in both the table and text, please insert a lettered footnote in the table to refer to the numbered reference in the text.
*Tabular data provided as additional files can be submitted as an Excel spreadsheet.

SUPPORTIVE/SUPPLEMENTARY MATERIAL: We do encourage to append supportive material, for example a PowerPoint file containing a talk about the study, a PowerPoint file containing additional screenshots, a Word, RTF, or PDF document showing the original instrument(s) used, a video, or the original data (SAS/SPSS files, Excel files, Access Db files etc.) provided it is inevitable or endorsed by the journal's Editor.

Supportive/Supplementary material intended for publication must be numbered and referred to in the manuscript but should not be a part of the submitted paper. In-text citations as well as a section with the heading "Supportive/Supplementary Material" before the "References" section should be provided. Here, list all Supportive/Supplementary Material and include a brief caption line for each file describing its contents.

Any additional files will be linked into the final published article in the form supplied by the author, but will not be displayed within the paper. They will be made available in exactly the same form as originally provided only on our Web site. Please also make sure that each additional file is a single table, figure or movie (please do not upload linked worksheets or PDF files larger than one sheet). Supportive/ Supplementary material must be provided in a single zipped file not larger than 4 MB.

Authors must clearly indicate if these files are not for publication but meant for the reviewers'/editors' perusal only.

PERMISSION FOR REPRODUCTION: Published/reproduced material should not be included unless you have obtained written permission from the copyright holder, which should be forwarded to the Editorial Office in case of acceptance of your article for publication.

For obtaining permission for reproducing any material published in an article by Bentham Science Publishers, please fill in the request FORM and send to tonoj@benthamopen.org for consideration.

AUTHORS AND INSTITUTIONAL AFFILIATIONS: The author will be required to provide their full names, the institutional affiliations and the location, with an asterisk in front of the name of the principal/corresponding author. The corresponding author(s) should be designated and their complete address, business telephone and fax numbers and e-mail address must be stated to receive correspondence and galley proofs.

REVIEWING AND PROMPTNESS OF PUBLICATION: All manuscripts submitted for publication will be immediately subjected to peer-reviewing, usually in consultation with the members of the Editorial Advisory Board and a number of external referees. Authors may, however, provide in their Covering Letter the contact details (including e-mail addresses) of four potential peer reviewers for their paper. Any peer reviewers suggested should not have recently published with any of the authors of the submitted manuscript and should not be members of the same research institution.

All peer-reviewing will be conducted via the Internet to facilitate rapid reviewing of the submitted manuscripts. Every possible effort will be made to assess the manuscripts quickly with the decision being conveyed to the authors in due course.

LANGUAGE AND EDITING: Manuscripts submitted containing many English typographical errors will not be published. Manuscripts which are accepted for publication on condition that the written English submitted is corrected, will be sent a quote by Eureka Science, a professional language editing company. Authors from non-English language countries who have poor English language written skills, are advised to contact the language editing company prior to submitting their manuscript to the journal. Please contact Eureka Science for a language editing quote at e-mail: info@eureka-science.com stating the total number of words of the article to be edited.

PROOF CORRECTIONS: Authors are required to proofread the PDF versions of their manuscripts before submission. To avoid delays in publication, proofs should be checked immediately for typographical errors and returned within 48 hours. Major changes are not acceptable at the proof stage. If unable to send corrections within 48 hours due to some reason, the author(s) must at least send an acknowledgement on receiving the galley proofs or the article will be published exactly as received and the publishers will not be responsible for any error occurring in the manuscript in this regard.

The corresponding author will be solely responsible for ensuring that the revised version of the manuscript incorporating all the submitted corrections receives the approval of all the authors of the manuscript.

COPYRIGHT: Authors who publish in Bentham OPEN Journals retain copyright to their work.  Submission of a manuscript to the respective journals implies that all authors have read and agreed to the content of the Covering Letter or the Terms and Conditions.  It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. Once submitted to the journal, the author will not withdraw their manuscript at any stage prior to publication.