ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)

Volume 12, 8 Issues, 2016

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Medicinal Chemistry

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Upcoming Articles (E-Pub Abstracts ahead of Print)

Synthesis and evaluation of phenyliminoindolin-containing phenylacetamide derivatives with the antidepressant and anticonvulsant effects

Li-Ping Guan, Bing-Yu Liu, Ying-Chun Quan, Li-Ye Yang, Xing-Hua Zhen and Si-Hong Wang.

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Synthesis, Antibacterial Activity, Interaction with Nucleobase and Molecular Docking Studies of 4-Formylbenzoic Acid Based Thiazoles

Krzysztof Z. Łączkowski, Anna Biernasiuk, Angelika Baranowska-Łączkowska, Konrad Misiura, Anna Malm, Tomasz Plech and Agata Paneth.

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Ether and carbamate derivatives of 3-quinuclidinol and 3-hydroxymethylquinuclidine: synthesis and evaluation as nicotinic ligands

Sivakumar Annadurai, Min Zhang, Jerome L. Gabriel, Merouane Bencheriff and Daniel J Canney.

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In-Vitro Anticancer Evaluation and Docking Study of Novel benzo[g] quinazoline-sulfonamide Derivatives

Mostafa M. Ghorab, Mansour S. Alsaid, Mohamed S. Al-Dosary and Marwa G El-Gazzar.

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Synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives incorporating benzisoselenazolone scaffold as potential antitumor agents

Xiaoyun Fu, Sha Li, Fen Jing, Xuefeng Wang, Baolin Li, Jijun Zhao, Yuming Liu and Baoquan Chen.

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Efficient Synthesis and Discovery of Schiff Bases as Potent Cholinesterase Inhibitors

Basma M. Abd Razik, Hasnah Osman, Mohammed Oday Ezzat, Alireza Basiri, Abdussalam Salhin, Yalda Kia and Vikneswaran Murugaiyah.

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Nitazoxanide Analogues as Antimicrobial Agents against Nosocomial Pathogens

Jia-Suey Gau, Wen-Pao Lin, Li-Ching Kuo and Ming-Kuan Hu.

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Synthesis, in vivo anticoagulant evaluation and molecular docking studies of bicoumarins obtained from furocoumarin peucedanin

Alla V. Lipeeva, Mikhail V. Khvostov, Dmitry S. Baev, Makhmut M. Shakirov, Tatijana G. Tolstikova and Elvira E Shults.

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Biologically Active New N, N', N''-Tri-Substituted Ferrocenyl Phenylguanidines and their Characterization

Rukhsana Gul, Ataf Ali Altaf, Azim Khan, Amin Badshah, Afzal Shah, Zia ur Rehman, Rabia Naz, Muhammad Nawaz Tahir and Asif Junaid.

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Preliminary Studies on the Activity of Mixed Polyphenol-Heterocyclic systems against B16-F10 Melanoma Cancer Cells

Duc Duy Vo, Isabelle Rouaud, Francoise Le Devehat, Fabien Gautier, Sophie Barillé-Nion, Philippe Juin, Nicolas Levoin, Joël Boustie and René Grée.

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Competitive Interaction Between Plasma Omega-3 Fatty Acids and Arachidonic Acid is Related to Down-Regulation of A Signaling Mediator

Kunio Yui, George Imataka and Yohei Kawasaki.

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Synthesis, Biological Evaluation and Pharmacokinetic Studies of Mefenamic Acid - N-Hydroxymethylsuccinimide Ester Prodrug as Safer NSAID

Asif Husain, Priyanka Ahuja, Aftab Ahmad and Shah Alam Khan.

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Design, Synthesis and Antiproliferative Activity of Novel Benzothiazole Derivatives Conjugated with Semicarbazone Scaffold

Guanglong Bao, Baoquan Du, Yuxiu Ma, Meng Zhao, Ping Gong and Xin Zhai.

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Facing Chagas’ disease: trypanocidal properties of new coumarin-chalcone scaffolds

Saleta Vazquez-Rodriguez, Roberto Figueroa Guíñez, Maria João Matos, Claudio Olea-Azar, Juan Diego Maya, Eugenio Uriarte and Lourdes Santana.

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Identification of New Inhibitors for Human SIRT1: An in-silico Approach

Balasundaram Padmanabhan, Manjula Ramu, Sruti Mathur, Sruthi Unni and Saravanamuthu Thiyagarajan.

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The current use of mass spectrometry in combination with other separation techniques in drug discovery arena

Piotr Kawczak and Tomasz Bączek.

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Design, Synthesis, and Cytotoxicity of Novel 2,4,6-Trisubstituted 1,3,5-triazines Bearing Aryl Hydrazone Moiety as Potent Antitumor Agent

Limei Wang, Sijia Zhao, Guanglong Bao, Yu Zhang, Shuancheng Xi, Guolin Zhou, Xin Zhai and Ping Gong.

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Antiplasmodial Limonoids from Trichilia rubescens (Meliaceae)

Tsamo Tontsa Armelle, Nangmo Kemda Pamela, Mkounga Pierre, Ingrid B. Müller, Kirk Marat, Gabriele Sass and Nkengfack Augustin Ephrem.

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Discovery and optimization of 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-(amino)pyridin-3-yl)ureas as novel KDR kinase inhibitors

Yu Jiao, Fei Huang, Pengfei Xu, Yanmin Zhang, Shangyan Yang, Danfeng Zhang, Tao Lu and Weifang Tang.

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Antimicrobial and Anti-Biofilm Activity of Thiourea Derivatives Bearing 3-Amino-1H-1, 2, 4-Triazole Scaffold

Joanna Stefanska, Karolina Stepien, Anna Bielenica, Daniel Szulczyk, Barbara Miroslaw, Anna E Koziol, Giuseppina Sanna, Filippo Iuliano, Silvia Madeddu, Michal Jozwiak and Marta Struga.

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Mining ZINC Database to Discover Potential Phosphodiesterase 9 Inhibitors Using Structure-Based Drug Design Approach

Engi A. Hassaan, Sara C. Sigler, Tamer M. Ibrahim, Kevin J. Lee, Lauren K. Cichon, Bernard D. Gary, Joshua C. Canzoneri, Gary A. Piazza and Ashraf HAbadi.

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Serum Tumor Markers in Stage I-II Breast Cancer

Renato Tozzoli, Federica D'Aurizio, Flavio Falcomer, Stefano M.M. Basso and Franco Lumachi.

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Adjuvant Treatment of Early Breast Cancer in the Elderly

Giovanni M. Fadda, Davide A. Santeufemia, Stefano M.M. Basso, Renato Tozzoli, Flavio Falcomer and Franco Lumachi.

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Advances in the Treatment of Triple-negative Early Breast Cancer

Stefano M.M. Basso, Davide A. Santeufemia, Giovanni M. Fadda, Renato Tozzoli, Federica D'Aurizio and Franco Lumachi.

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Chemosensitization of prostate carcinoma cells with a receptor-directed Smac conjugate

Alexander Sturzu, Sumbla Sheikh, Hartmut Echner, Martin Deeg, Thomas Nägele, Christopher Weidenmaier, Christian Schwentner, Marius Horger, Ulrike Ernemann and Stefan Heckl.

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Synthesis, structural characterization of a novel ferrocene derivative and preliminarily anticancer activity

Jianping Yong, Xiaoyuan Wu, Jianzhen Liao, Canzhong Lu and Xiaolong Liu.

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Synthesis, Molecular Docking Study, and Cytotoxic Activity of 3,4-diaryl-5-(4-pyridinyl)-1,2,4-oxadiazole

Bita Zareian, Sajad Ghadbeighi, Amirali Amirhamzeh, Seyed Nasser Ostad, Abbas Shafiee and Mohsen Amini.

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Design, Synthesis, and Fungicidal Activities of Novel 5-Methyl-1H-1,2,3-trizole-4-carboxyl Amide Analogues

Zhen-Jun Wang, Hui-Hui Yang, Lei Tian and Wei-Guang Zhao.

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DNA Hybridization on Chitosan-Functionalized Silicon Substrate

Amina Omar, El-Sayed M. El-Sayed, Mona S. Talaat and Medhat Ibrahim.

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Design, Synthesis and Structure-Activity Relationship Studies of Novel 4-(1-adamantyl) Phenyl Analogues as HIF-1α Inhibitors

Yan Xia, Qiong Duan, Bao-Hua Zhao, Dong-Feng Li and Rui-Bin Hou.

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Withanolides: Biologically Active Constituents in the Treatment of Alzheimer Disease

Shahid Ali Khan, Sher Bahadar Khan, Zarbad Shah and Abdullah M Asiri.

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miRNAs as Circulating Biomarkers for Alzheimer’s Disease and Parkinson’s Disease

Gohar Mushtaq, Nigel H. Greig, Firoz Anwar, Mazin A. Zamzami, Hani Choudhry, Munvar Miya Shaik, Ian A. Tamargo and Mohammad A Kamal.

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Recent updates on the association between Alzheimer’s disease and vascular dementia

Ghulam Md Ashraf, Sandesh Chibber, Mohammad, Syed Kashif Zaidi, Shams Tabrez, Ausaf Ahmad, Shazi Shakil, Gohar Mushtaq, Saleh Salem Baeesa and Mohammad Amjad Kamal.

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Antioxidant, Antimicrobial Activity and Medicinal Properties of Grewia asiatica L.

Ritu Shukla, Dinesh C. Sharma, Mohd. Hassan Baig, Shabana Bano, Sudeep Roy, Ivo Provazník and Mohammad Amjad Kamal.

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Chemical Composition and Inhibitory Effects of Hypericum brasiliense and H. connatum on Prolyl oligopeptidase and Acetylcholinesterase Activities

Maura Z. dos Santos, Ionara I. Dalcol, Luciana Adolpho, Meritxell Teixidó, Teresa Tarragó, Ademir Morel and Ernest Giralt.

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Growth Factors and Astrocytes Metabolism: Possible Roles for Platelet Derived Growth Factor

Ricardo Cabezas, Marco Avila-Rodriguez, Nelson Enrique Vega-Vela, Valentina Echeverria, Janneth González, Oscar Alejandro Hidalgo, Altair Brito Santos, Gjumrakch Aliev and George E Barreto.

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Robust Modeling and Scaffold Hopping: Case Study based on HIV Reverse Transcriptase Inhibitors Type-1 Data

Girinath G. Pillai, Laznier Mederos, Chandramukhi S. Panda, Amber Gronski, Peeter Burk, C. Dennis Hall, Alan R. Katritzky, Kaido Tämm and Mati Karelson.

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The Brain Protective Effect of rTMS (Repetitive Transcranial Magnetic Stimulation) in Depression: A Mini-Review in Animal Studies

Burak Yulug, Lütfü Hanoglu, Ahmet Mithat Tavli, Nesrin Helvacı Yılmaz and Ertugrul Kılıc.

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Identification of Bostrycin Derivatives as Potential Inhibitors of Mycobacterium tuberculosis Protein Tyrosine Phosphatase (MptpB)

Dong-ni Chen, Hong Chen, Zhi-gang She and Yong-jun Lu.

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Cytotoxic Effects of Salvinorin A, A Major Constituent of Salvia divinorum

Ana Martinho, Sara M. Silva and Eugenia Gallardo.

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QSRR and QSAR Studies of Antitumor Drugs In View of their Biological Activity Prediction

Paulina Szatkowska-Wandas, Marcin Koba, Grzegorz Smoliński and Jacek Wandas.

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Pharmacophore and QSAR Modeling of Neuronal Nitric Oxide Synthase Ligands and Subsequent Validation and In Silico Search for New Scaffolds

Ghadeer Suaifan, Mayadah Shehadeh, Hebah Al-Ijel, Khuloud Al-Jamal and Mutasem Taha.

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Monooxime Bispyridinium Reactivators Bearing Xylene Linker – Synthesis and In Vitro Evaluation on Model of Organophosphate-Inhibited Acetylcholinesterase

Kamil Musilek, Jan Hambalek, Ondrej Holas, Vlastimil Dohnal and Kamil Kuca.

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Synthesis and Anti-Thyroid Cancer Effect of Iodo-Chrysin Derivatives

Yun Wei, Qutong Zheng, Guotao Tang, Chen Song, Guan Wang, Yinxiang Zhang, Yan Xiao, Xianliang Zeng, Zongbao Wang, Jichang Xiao and Xing Zheng.

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Synthesis, in Vitro Biological Screening and Molecular Docking Studies of Novel Camphor Based Thiazoles

Krzysztof Z. Łączkowski, Konrad Misiura, Anna Biernasiuk, Anna Malm, Agata Siwek, Tomasz Plech, Emilia Ciok-Pater, Krzysztof Skowron and Eugenia Gospodarek.

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