ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)


Volume 13, 10 Issues, 2016


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Letters in Drug Design & Discovery

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Editor-in-Chief:
Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK
Email: lddd@benthamscience.org

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Upcoming Articles (E-Pub Abstracts ahead of Print)

Design and prediction of activity of 2-substituted benzimidazole derivatives as procaspase-3 activators and apoptosis inducer: 3D QSAR and in silico ADMET study


Vivek K. Vyas, Manjunath Ghate and Prajakta Kulkarni.


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Design, synthesis and antidepressant and anticonvulsant effect of 1-alkoxy -1H-benzo[d][1,2,3]triazole derivatives


Qinghao Jin, yingchun quan, yan han, di yu, qiuping dai and zhoujun zheng.


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In Vitro and In Vivo Investigations into the Carbene Gold Chloride and Thioglucoside Anticancer Drug Candidates NHC-AuCl and NHC-AuSR


Wolfgang Walther, Oyinlola Dada, Cillian O'Beirne, Ingo Ott, Goar Sánchez-Sanz, Claudia Schmidt, Carsta Werner, Xiangming Zhu and Matthias Tacke.


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Facile Synthesis and Nitric Oxide Inhibitory Activity of Aurones, Rugaurone A, Gramflavonoid A and Their Derivatives


Jong-Gab Jun, Kongara Damodar and Jin-Kyung Kim.


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Synthesis of Some New 1(2H)-phthalazinone Derivatives and Evaluation of Their Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activities


Burcu Kılıç, Hayrettin Ozan Gülcan, Mertcan Yalçın, Fatma Aksakal, Anatoli Dimoglo, Mustafa Fethi Şahin and Deniz Songül Doğruer.


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Synthesis and antimicrobial evaluation of amino-guanidine and 3-amino-1,2,4-triazole derivatives as potential antibacterial agents


Chao Li, Ya-Ru Li, Tian-Yi Zhang, Xiao-Zhen Li, Liang-Peng Sun, Chang-Ji Zheng and Hu-Ri Piao.


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Synthesis, Docking and Antidiabetic Activity of Some Newer Benzamide Derivatives as Glucokinase Activators


Rohit Singh, Viney Lather, Deepti Pandita, Vikramjeet Judge, Karthikeyan N. Arumugam and Ajmer Singh Grewal.


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Design, Synthesis and Bioactivity of Phenoxy Carboxylate(amide) Derivatives Containing 4,6-Dimethoxypyrimidine


zhiqiang huang, chenpeng feng, jun tong, qiang bian and Zhao Yu.


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Synthesis, molecular docking and pharmacological study of Pyrimido-thiadiazinones and its bis-derivatives


Sobhi M. Gomha, Ikhlass Abbas, Mohamed Elneairy, Mahmoud Elaasser and bazada khamis.


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Novel Artemisinin-Derived Dimers: Synthesis and Evaluation of Anticancer Activities


Tran Khac Vu, Vu Tuan Kien, Le Huy Binh, Phan Hai Phong, Doan Thi Hien, Nguyen Thi Thuy My, Nguyen Hai Nam, Do Thi Thao and Michael Baltas.


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Field Based 3D-QSAR model of KATP channel activation by 4, 6 disubstituted Benzopyran Derivatives


Kamlesh Asotra, yaseen gigani, Andrew Lynn and Swati Gupta.


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Novel Dual Inhibitors of Secretory Phospholipase A2 and Sphingomyelin Synthase: Design, Synthesis and Evaluation


De-Yong Ye, Lu Zhou, Hao-jun Gong, Xing Gao, Ya-li Li, Xiang-yu Qi and Yong Chu.


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Synthesis and herbicidal activity of some novel pyrazole derivatives


Xing-Hai Liu, Hai-Qing He, Jian-Quan Weng and Cheng-Xia Tan.


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Structure-based Virtual Screening to Get New Scaffold Inhibitors of the Ser/Thr Protein Kinase PknB from Mycobacterium tuberculosis


Antonio Coluccia, Giuseppe La Regina, Nathalie Barilone, María-Natalia Lisa, Andrea Brancale, Gwenaëlle André-Lerouxb, Pedro M. Alzari and Romano Silvestri.


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Molecular Docking, Molecular Dynamics, and In Silico Prediction of the Toxic Potential of Primaquine Thiazolidinone Derivatives


Andre Silva Pimentel and Erika Murce.


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Synthesis and evaluation ofmorpholinoethylesterconjugate of N-acetylcysteine in ovalbumin- induced airway hyperresponsivenessin Sprague dawley rats


Suneela S Dhaneshwar and Neha V Bhilare.


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The Synthesis of (Iodobenzyl)oxybenzaldehydes, Useful Intermediates for Biologically Active Targets


Hedvig Bölcskei, Andrea Német-Hanzelik, István Greiner, Zsófia Dubrovay, Viktor Háda and György Keglevich.


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3D-QSAR modeling and molecular docking study on Small Molecule Src Homology 2 Domain Inhibitors


Jing Li Wang, Li Ping Cheng, Yang Ping Quan and Zhen Wang.


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Structural studies of aminopeptidase P from Plasmodium falciparum: a novel target against malaria


P Snigdha, P Lakshmana Rao, N Prakash Prabhu and Insaf Ahmed Qureshi.


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Synthesis and Biological Evaluation of a Novel Apogossypolone Derivative


Yonghua Zhan, Xu Cao, Yingchao Li, Xueli Chen and Xiaofeng Huang.


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Design, Synthesis and Molecular Docking Studies of 2-Aryl/Heteroaryl-Ethyl 6-Chloroquinoline-4-Carboxylates as Potential Antimalarial Agents


K.M Mahadevan, T.O Shrungesh Kumar, P. S Sujan Ganapathy and MN Kumara.


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Preparation of Edible Zein Hybrid Particles and Its Controlled Release Behaviors


Jie Liu, Lv Si Yao, Fei Pei, He Yu Feng and Rong-Min Wang.


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Binding Free Energy-Based Footprint Pharmacophore Model to Enhance Virtual Screening and Drug Discovery: A Case on Glycosidases as Anti-influenza Drug Targets


Ndumiso Mhlongo and Mahmoud Soliman.


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Anti-inflammatory potential of alkaloids as a promising therapeutic modality


HAROON KHAN.


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Synthesis and antiviral activity of 2-Phenyl-4H-chromen-4-one derivatives against chikungunya virus


Vishnu Nayak Badavath, Surender Singh Jadava, Boris Pastorino, Xavier de Lamballerie, Barij Nayan Sinha and Venkatesan Jayaprakash.


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Fe3+-Tryptophan-3-Hydroxy-2-Methyl or ethyl pyridinones Towards Novel Molecular Tumor Nuclear Resonance Imaging Agents


Ali Khalaj, Shadi Hosseini, Rahimeh Rasouli, Artin Assadi, Seyedeh Ghoreishi and Mehdi Shafiee Ardestani.


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Identification of novel IRAK-4 inhibitors through pharmacophore modeling, atom-based 3D-QSAR, docking strategies and molecular dynamics simulation


Lu Zhou.


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