ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)


Volume 13, 10 Issues, 2016


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Letters in Drug Design & Discovery

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Editor-in-Chief:
Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK
Email: lddd@benthamscience.org

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Upcoming Articles (E-Pub Abstracts ahead of Print)

Nano conjugated PLGA-Chlorambucil: Synthesis In Vitro anti non- Hodgkin's lymphoma Cellular Assay


Fatemeh Monnavari, Artin Assadi, Hossein Heidari, Rahimeh Rasouli, Mostafa Saffari, Seyed Ataollah Sadat Shandiz, Mohammad Reza Aghasadeghi, Peyman Keyhanvar, Farnoor Davachi Omoomi, Mohammad saffari, Seyed Esmaeil Sadat Ebrahimi, Morteza Pirali Hamedani and Mehdi Shafiee Ardestani.


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Synthesis, antibacterial, antifungal, antimycobacterial activity evaluation of novel 1,2,4-triazole derivatives bearing 4-aminophenyl moiety Biological evaluation of new triazole derivatives


Betül Kaya, Leyla Yurttas, Meral Yılmaz Cankılıç and Zafer Asım Kaplancıklı.


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A Two QSAR Way for Antidiabetic Agents Targeting using α-Amylase and α-Glucosidase Inhibitors: Model Parameters Settings in Artificial Intelligence Techniques


Karel Diéguez-Santana, Hai Pham-The, Oscar Miguel Rivera-Borroto, Amilkar Puris, Huong Le-Thi-Thu and Gerardo M Casañola-Martin.


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Synthesis of Mannich bases by two different methods and evaluation of their acetylcholine esterase and carbonic anhydrase inhibitory activities


Halise Inci Gul, Alkan Demirtas, Gokbay Ucar, Parham Taslimi and İlhami Gulcin.


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A facile Synthesis and Drug Design of Some New Heterocyclic Compounds Incorporating Pyridine Moiety and Their Antimicrobial Evaluation


Sobhi M. Gomha, Fathy M. Abdelrazek, Aly H. Abdelrahman, Peter Metz and Mohsen A Sayed.


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Hydroxamate Inhibitor Profiling of Both Zn2+- and Ni2+-Activated Glyoxalase I Metalloenzymes Having Diverse Quaternary Structures


John F. Honek and Uthaiwan Suttisansanee.


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Quorum Sensing Inhibitor Activities of Celecoxib Derivatives in Pseudomonas aeruginosa


Seyhan Ulusoy, Sevil Aydın, İnci Coşkun, Gülgün Boşgelmez-Tınaz, Laurent Soulere, Yves Queneau and Ş Güniz Küçükgüzel.


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Novel Chromeno[2,3-d]pyrimidines - Design, Synthesis and Antioxidant Activity


Kotiah Yalagala, Sreekantha B. Jonnalagadda, Suresh Maddila, Surjyakanta Rana and Surya Narayana Maddila.


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Benzopentathiepine derivative, 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride (TC-2153), as a promising antidepressant of new generation


Elizabeth A. Kulikova, Konstantin Volcho, Nariman Salakhutdinov and Alexander V Kulikov.


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Withania somnifera phytochemicals confer neuroprotection by inhibition of the catalytic domain of human matrix metalloproteinase-9


Gaurav Kumar, Pankaj Paliwal and Ranjana Patnaik.


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Synthesis, Antiproliferative, and Antiangiogenic Activities of Benzochromene and Benzoquinoline Derivatives on Prostate Cancer in vitro


Gricelda Mata, Juan Rodrigues, Neira Gamboa, Katiuska Charris, Gricela Lobo, Melina Monasterios, Milagros Avendaño, Michael Lein, Klaus Jung Claudia Abramjuk and Jaime Charris.


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Synthesis and Evaluation of Anti-Tuberculosis and Anti-Cancer Activities of Hydrazones and N-Acylhydrazones by Using Sonochemistry, a New General Procedure


Ligia Souza da Silveira Pinto, Marcus Vinicius Nora De Souza and Carlos Roland Kaiser.


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Vitamin B12 controlled release with crosslinked poly(acrylic acid) and poly(methacrylic acid) based on Chitosan and Starch as pH sensitive hydrogels


Massomeh Ghorbanloo and Somaieh Tarasi.


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Polyphenolic Compound from Vitis vinifera L. Have Potential for the Alzheimer Disease Treatment


Kamil Kuca.


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Structure-Based Hybridization, Conventional and Microwave Irradiated Synthesis, Biological Evaluation and Molecular Docking Studies of New Compounds Derived from Thiomorpholine


Serpil Demirci, Fatma Aksakal, Nesrin Colak, Serdar Ulker, Ahmet Demirbas and Neslihan DEMİRBAS.


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Homology Modeling of Human Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 2: Insights into Isoenzyme-Specific Differences Using Molecular Docking Simulatons


Gokcen Eren.


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Copper Complexes of 8-Aminoquinoline and Uracils as Novel Aromatase Inhibitors


Nujarin Sinthupoom, Veda Prachayasittikul, Ratchanok Pingaew, Apilak Worachartcheewan, Supaluk Prachayasittikul, Somsak Ruchirawat and Virapong Prachayasittikul.


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3D-QSAR and molecular docking studies of pyrazole derivatives as inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis


Sheshagiri R. Dixit, Shrinivas D. Joshi, V. H. Kulkarni and Tejraj M Aminabhavi.


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Antitubercular and antimicrobial activity of NH4VO3 promoted 1,4-dihydropyridine incorporated 1,3,4-trisubstituted pyrazole


Harikrishna Nandam, Arun M. Isloor, Ananda Kulal, Tanya Parish, Joazaizulfazli Jamalis, Hazem A. Ghabbour and Hoong-Kun Fun.


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Synthesis and Evaluation of New Thiazolyl Hydrazone Derivatives as Potential Anticancer Agents


Zafer Asim Kaplancikli, Belgin Sever, Mehlika Dilek Altıntop, Özlem Atlı, Merve Baysal and Ahmet Özdemir.


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The decisive role of mutual arrangement of hydroxy and methoxy groups in (3(4)-hydroxy-4(3)-methoxyphenyl)-4,7-dimethyl-3,4,4a,5,8,8a-hexahydro-2H-chromene-4,8-diols in their biological activity


Alla Pavlova, Oksana Patrusheva, Irina Il'ina, Konstantin Volcho, Tat'yana Tolstikova and Nariman Salakhutdinov.


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Development of Xanthine based inhibitors targeting Phosphodiesterase 9A


Sanjukta Patra, Nivedita Singh and M S Thakur.


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Synthesis, Enzyme Assays and Molecular Docking Studies of Fluorinated Bioisosteres of Santacruzamate A as Potential HDAC Tracers


Muneer Ahamed, Koen Vermeulen, Michael Schnekenburger, Lise Román Moltzau, Finn Olav Levy, János Marton, Mathy Froeyen, Dag Erlend Olberg, Guy Bormans and Marc Diederich.


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3D-QSAR studies of HDAC6 inhibitors using docking-based alignment


Chunqi Hu, Liang Hong, Jun Li and Wenting Du.


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Design, Synthesis and Insecticidal Activity of Diamides with Oxydibenzene or Diphenylamine Subunits


Ye Liu, Xusheng Shao, Xinfei Chen, Xiaoyong Xu, Zhong Li and Jiagao Cheng.


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Design, synthesis, antioxidant and anticancer activity of new coumarin derivatives linked with thiazole, isoxazole or pyrazole moiety


Khaled Abdellatif, Mohamed Abdelgawad, Heba Elshemy and Nesma Kahk.


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Synthesis, Computational Study, and Evaluation of in vitro Antimicrobial, Antibiofilm, and Anticancer Activities of New Sulfanyl Aminonaphthoquinone Derivatives


Nilüfer Bayrak, Hatice Yıldırım, Amaç Fatih Tuyun, Emel Mataraci Kara, Berna Ozbek Celik, Girish Kumar Gupta, Halil I. Ciftci, Mikako Fujita, Masami Otsuka and Hamid R Nasi.


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Synthesis and antioxidant activity of indole derivatives containing 4-substituted piperazine moieties


Tuncagül Altuntaş, Nilüfer Yilmaz, Tülay Çoban, Zühal Kilic-Kurt and Sureyya Olgen.


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Synthesis and Antiproliferative Activities of Novel O-Benzyl Salicylamide Derivatives


Jan Dušek, Aleš Imramovský, Karel Pauk, Radek Jorda, Eva Řezníčková and Vladimír Kryštof.


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Synthesis, Phosphorylated Derivatives of 2′, 3′-O-Isopropylidene Adenosine, thier In Ovo Antiviral Activity


Naga Raju Chamarthi, rasheed syed, Madhava Golla, Subramanyam Chennamsetty, Janardhan Avila and Narasimha Golla.


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Novel Indole-Isoxazole Hybrids: Synthesis and In Vitro Anti-cholinesterase Activity


Fahimeh Vafadarnejad, Mina Saeedi, Mohammad Mahdavi, Ali Rafinejad, Elahe Karimpour-Razkenari, Bilqees Sameem, Mahnaz Khanavi and Tahmineh Akbarzadeh.


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Design and synthesis of novel orotic acid amide derivatives as potent Glucokinase activators


Leilei Zhang and Zhiqiang Feng.


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Chronobiotic Hormone Melatonin: Comparative in vitro Release Studies from Matrix Tablets and Liposomal Formulations


Androniki Zampakola, Angeliki Siamidi, Natassa Pippa, Costas Demetzos and Marilena Vlachou.


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Synthesis and nematocidal activity of novel pyrazole carboxamide derivatives against Meloidogyne incognita


Wen Zhao, Zhong-Hua Shen, Jia-Hua Xing, Tian-Ming Xu, Wei-Li Peng and Xing-Hai Liu.


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3D-QSAR, molecular docking and molecular dynamics studies of 2,4-diarylaminopyrimidine analogues (DAAP analogues) as potent ALK inhibitors


Fu long Wu, Qian qian Lv, Zhong hua Wang, Dan dan Li, Peng Peng, Yan Yin, Si heng Cui and Fan hong Wu.


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Anti-biofilm and antibacterial effects of novel metal-coordinated sulfamethoxazole against Escherichia coli.


Caren Rigon Mizdal, Sílvio Terra Stefanello, Pauline Cordenonsi Bonez, Vanessa Albertina Agertt, Vanessa da Costa Flores, Grazielle Guidolin Rossi, Fallon dos Santos Siqueira, Lenice de Lourenço Marques and Marli Matiko Anraku Campos.


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NF-kappaB Inhibitors in Head and Neck Cancer


Siddavaram Nagini, Kranthi Kiran Kishore Tanagala and Indranil Chattopadhyay.


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Possible Binding Mode Analysis of Pyrazolo-triazole Hybrids as Potential Anticancer Agents through Validated Molecular Docking and 3D-QSAR Modeling Approaches


Sk. Abdul Amin, Nilanjan Adhikari, Ramkishore Agrawal, Tarun Jha and Shovanlal Gayen.


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Improved Anti-inflammatory Activity and Potential Cytoprotective Properties of Tolfenamic Acid, Naproxen and Indomethacin Derivatives


Panagiotis Theodosis-Nobelos, Theodora C Politou, Chrysoula Athanasekou and Eleni A Rekka.


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Design, synthesis and antidepressant and anticonvulsant effect of 1-alkoxy -1H-benzo[d][1,2,3]triazole derivatives


Qinghao Jin, yingchun quan, yan han, di yu, qiuping dai and zhoujun zheng.


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Fe3+-Tryptophan-3-Hydroxy-2-Methyl or ethyl pyridinones Towards Novel Molecular Tumor Nuclear Resonance Imaging Agents


Ali Khalaj, Shadi Hosseini, Rahimeh Rasouli, Artin Assadi, Seyedeh Ghoreishi and Mehdi Shafiee Ardestani.


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