ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)


Volume 14, 12 Issues, 2017


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Letters in Drug Design & Discovery

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Editor-in-Chief:
G. Perry
University of Texas
San Antonio, TX
USA


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Upcoming Articles (E-Pub Abstracts ahead of Print)

Development of Novel Selective Pharmacophore for Tankyrase Inhibitors


Xin Qiao, Ting Ran, Yan-Min Zhang, Jing Pan, Ling-Feng Yin, Wei-Neng Zhou, Lu Zhu, Jun-Nan Zhao, Hai-Chun Liu, Shuai Lu, Tao Lu, Ya-Dong Chen and Yu-Lei Jiang.


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Synthesis and Antimicrobial Activities of Hybrid Heterocyclic Molecules Based on 1-(4-Fluorophenyl)piperazine Skeleton


Serap Basoglu Ozdemir, Neslihan Demirbas, Yıldız Uygun Cebeci, Hacer Bayrak, Arif Mermer, Sule Ceylan and Ahmet Demirbas.


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3D-QSAR, Topomer CoMFA, Docking analysis, and ADMET prediction of Thioether Pleuromutilin Derivatives as Antibacterial Agents


Li Ping Cheng, Zhen Wang and Zhi Wang.


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Antiproliferative Activity of Olive Oil Phenolics Against Human Melanoma Cells


A. L.M. Batista de Carvalho, F. Caselli, V. Rodrigues, F. Paiva-Martins and M P Marques.


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Docking-based 3D-QSAR Studies of Phosphodiesterase 9A Inhibitors


Changji Tan, Yinuo Wu, Yongxian Shao, Haibin Luo, Xuehua Zheng and Laiyou Wang.


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Homology Modeling in Drug Discovery - An update on the last decade


Mahmoud E. S. Soliman and Geraldene Munsamy.


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Molecular Docking, Synthesis and CNS activity of Some Novel 1, 4-Benzodiazepine Derivatives


Sunil S. Menghani, Rupesh Chikhale, Amit Pant, Bijo Mathew and Pramod Khedekar.


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Pharmacodynamic evaluation of novel Tetrandrine-loaded Chitosan Microspheres


Jing Cang and kefang guo.


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Antimicrobial and cytotoxicity activities of 2-(aryl)-3-(benzo[d][1,3]dioxol-5-yl)thiazolidin-4-ones


Silvana P. Souza, Hellen G Masteloto, Daniel S. Silva, Juliana H. Azambuja, Elizandra Braganhol, Juliana S Ribeiro, Rafael G Lund and Wilson Cunico.


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Synthesis, Molecular Docking Studies and Biological Evaluation of 3-Iminoaurones as Acetylcholinesterase and Butyrylcholinesterase Inhibitors


Ehsan Ullah Mughal, Amina Sadiq, Bilal Ahmad Khan, Muhammad Naveed Zafar, Ishtiaq Ahmed and Muhammad Zubair.


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Synthesis, structural studies and biological evaluation of halogen derivatives of 1,3 disubstituted thiourea


Anna Bielenica, Karolina Stępień, Aleksandra Sawczenko, Tadeusz Lis, Anna E. Kozioł, Silvia Madeddu, David Collu, Filippo Iuliano, Anita Kośmider and Marta Struga.


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In vitro and in silico Analysis of β-lactam Derivatives as Antimycobacterial Agents


Julieta Luna-Herrera, Edgar E. Lara-Ramirez, Ana R. Muñoz-Duarte, Fabian E. Olazaran-Santibañez, Manuel J. Chan-Bacab, Rosa Moo-Puc, Alondra M. Perez-Vazquez, Cynthia M. Morales-Reyes and Gildardo Rivera.


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Combination of irbesartan with amlodipine enhances nitrate/nitrite generation by angiotensin II-exposed endothelial cells


Yuji Ishibashi, Takanori Matsui, Nobutaka Nakamura and Sho-ichi Yamagishi.


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Design, Synthesis and Evaluation of Dual-targeting Prodrug Co-modified by Organic Amine and L-Ascorbic Acid for CNS Delivery


Shubing Qiu, Yi Zhao, Sha Liu, Xiaocen Li, Li Guo, Li Hai and Yong Wu.


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Tranylcypromine Attenuates Senescence in Dental Pulp Stem Cells


Junjun Liu, Zhi Liu, Chunyan Wang, Fang Yu, Wenping Cai, Xi Lu, Rongbin Wei, Shouliang Zhao, Yumei Zhao and Shangfeng Liu.


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Alzheimer’s disease drugs - in vitro comparison of cholinesterase inhibition and beta-amyloid modulation


Ondrej Holas, Jan Korabecny, Zuzana Gazova, Katarina Siposova, Kamil Musilek, Veronika Opletalova, Lukas Gorecki, Katarina Spilovska, Eva Mezeiova and Kamil Kuca.


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Extended-release formulation attenuates the impacts of fluvastatin on serum PCSK9 levels in humans


Yuan-Lin Guo, Wei Zhang, Qian Dong, Geng Liu, Cheng-Gang Zhu, Jing Sun, Rui-Xia Xu and Jian-Jun Li.


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New N’-Arylidene-2-[(4-Nitrophenyl)Piperazın-1-yl]Acetohydrazide Derivatives: Synthesis And Anticancer Activity Investigation


Leyla Yurttas, Şennur Görgülü Kahyaoğlu and Zafer Asım Kaplancikli.


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Design, synthesis, characterization, molecular docking, ADME properties and in vivo antipsychotic activity of aripiprazole related drugs candidates


Mannathusamy Gopalakrishnan, Selvarasu Sekar, Srinivasan Pazhamalai and Ganesan Ariharasivakumar.


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Effects of Tetrahydroxystilbene Glucoside on Liver P450 Enzyme Expressions in Lipopolysaccharide-Induced Dopamine Neuronal Damage Rats


Feng Zhang, Jing-Shan Shi, Guo-Qing Wang, Yan-Zhen Zhou, Jia-Wei Tian and Jie Liu.


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Hydroxamate Inhibitor Profiling of Both Zn2+- and Ni2+-Activated Glyoxalase I Metalloenzymes Having Diverse Quaternary Structures


John F. Honek and Uthaiwan Suttisansanee.


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Vitamin B12 controlled release with crosslinked poly(acrylic acid) and poly(methacrylic acid) based on Chitosan and Starch as pH sensitive hydrogels


Massomeh Ghorbanloo and Somaieh Tarasi.


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