ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)


Volume 23, 46 Issues, 2017


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Current Pharmaceutical Design

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Abstracts Ahead of Print

Protein kinases as tumor biomarkers and therapeutic targets


Chuntao Quan, Juanjuan Xiao, Lin Liu, Qiuhong Duan, Ping Yuan and Feng Zhu.


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Molecular Tests for the Choice of Cancer Therapy


Anna P. Sokolenko and Evgeny N Imyanitov.


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Management Of Blood Pressure And Heart Rate In Patients With Acute Stroke


Carlo Maida, Antonino Tuttolomondo, Domenico Di Raimondo and Antonio Pinto.


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Application Of Kinase Inhibitors For Anti-Aging Intervention


Mercedes Cano, Antonio Ayala, Francesco Marotta and Sandro Argüelles.


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Biomaterials and Supercritical Fluid technologies: which perspectives to fabricate Artificial Extracellular Matrix?


Della Porta Giovanna, E. Reverchon and N Maffulli.


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Role of the immune component of tumor microenvironment in the efficiency of cancer treatment: perspectives for the personalized therapy


Marina Stakheyeva, Vladimir Riabov, Irina Mitrofanova, Nikolai Litviakov, Evgeny Choynzonov, Nadezhda Cherdyntseva and Julia Kzhyshkowska.


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Pharmacology and literature review based on related death and non-fatal case reports of the benzofurans and benzodifurans designer drugs.


Bernardino Barceló Martín and Isabel Gomila.


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Update of Standard Practices for New Method Validation in Forensic Toxicology


Sarah M.R. Wille, Wim Coucke, Thierry De Baere and Frank T Peters.


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Regulation Mechanism of MicroRNAs in Non-Small Cell Lung Cancer


Feng-Yun Gong, Tao Bai, Ding-Yu Zhang, Chao-lin Huang, Jing Lv, Jing-Li Wang, Xu-Dong Hu, Juan Wang and Wei Liu.


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MiRNA-based therapeutics for lung cancer


Miaowei Wu, Guosheng Wang, Wei Tian, Yongchuan Deng and Yibing Xu.


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Role of miRNA in lung cancer-potential biomarkers and therapies


Xiaohong Du, Jitai Zhang, Juping Wang, Xiaoming Lin and Feng Ding.


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Aquaporin 4 in astrocytes is a target for therapy in Alzheimer's disease


Yu-Long Lan, Jian-Jiao Chen, Gang Hu, Jun Xu, Ming Xiao and Shao Li.


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Molecular Targeting of ERKs/RSK2 signaling in cancers


Yong-Yeon Cho.


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GSK3 inhibitors in the therapeutic development of diabetes, cancer and Neurodegeneration: Past, present and future


Mudasir Maqbool and Nasimul Hoda.


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Emerging targets to relieve fat stress-induced liver diseases: UDCA, tocotrienol, -3 PUFAs, and IgY targeted NPC1L1 cholesterol transporter


Ji-Young Cha, Jong-Min Park, Ho-Jae Lee, Jin-Sik Bae, Young-Min Han, Byung-Chul Oh, Kwang Hyun Ko and Ki-Baik Hahm.


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Current and emerging strategies in osteoporosis management


Stefka Ivanova and Liliya Vasileva.


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AMPK: therapeutic target for diabetes and cancer prevention


Shotaro Umezawa , Takuma Higurashi and Atsushi Nakajima.


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New strategies for the prevention and treatment of systemic and local bone loss; from pathophysiology to clinical application


A. Fassio, Maurizio Rossini , Ombretta Viapiana, Luca Idolazzi, Camilla Benini, Elisabetta Vantaggiato and Davide Gatti.


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Virtual screening and statistical analysis in the design of new caffeine analogues molecules with potential epithelial anticancer activity


Josivan da Silva Costa, Karina da Silva Lopes Costa, Josiane Viana Cruz, Ryan da Silva Ramos, Luciane Barros Silva, Davi Do Socorro Barros Brasil, Carlos Henrique Tomich de Paula da Silva, Cleydson Breno Rodrigues dos Santos and Williams Jorge da Cruz Macêdo.


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Nano-sized Ultrasound Contrast Agents for Cancer Therapy and Theranostics


Hao Li, Shenglong Gan, Shi-Ting Feng, Guofu Zhou, Zhi Dong, Rongqin Zheng and Zi-Ping Li.


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Supramolecular self-assembled nanogels a new platform for anticancer drug delivery


Jaleh Varshosaz, Somayeh Taymouri and Erfaneh Ghassami.


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Therapeutic Strategy of Targeting Astrocytes for Neuroprotection in Parkinson's Disease


Ikuko Miyazaki and Masato Asanuma.


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The Tat/P-TEFb Protein-protein interaction determining transcriptional activation of HIV


Kaori Asamitsu and Takashi Okamoto.


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Astrocyte: an innovative approach for Alzheimer's disease therapy


Maria Rosanna Bronzuoli, Roberta Facchinetti, Luca Steardo and Caterina Scuderi.


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Targeting Human Astrocytes’ Calcium-sensing Receptors for Treatment of Alzheimer’s Disease


Anna Chiarini, Ubaldo Armato, James F. Whitfield and Ilaria Dal Pra.


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Altered Homeostatic Functions in Reactive Astrocytes and Their Potential as a Therapeutic Target After Brain Ischemic Injury


Helena Pivonkova and Miroslava Anderova.


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Biohybrid Membrane Systems for Testing Molecules and Stem Cell Therapy in Neuronal Tissue Engineering


Sabrina Morelli, Antonella Piscioneri, Simona Salerno, Enrico Drioli and Loredana De Bartolo.


View Abstract


Hybrid Materials and Nanocomposites as Multifunctional Biomaterials


Heveline D. M. Follmann, Alliny F. Naves, Rafael A. Araujo, Viktor Dubovoy, Xiaoxi Huang, Tewodros Asefa, Rafael Silva and Osvaldo N Oliveira.


View Abstract


Hydrogel-based cell therapies for kidney regeneration: current trends in biofabrication and in vivo repair


Katja Jansen, Carl C.L. Schuurmans, Jitske Jansen, Rosalinde Masereeuw and Tina Vermonden.


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Bioinformatics approaches to profile the tumor microenvironment for immunotherapeutic discovery


Trevor Clancy, Ruth Dannenfelser, Olga Troyanskaya, Karl Johan Malmberg, Eivind Hovig and Vessela Kristensen.


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Identification of antineoplastic targets with systems approaches, using resveratrol as an in-depth case study


Nivedita Singh, Sherry Freiesleben, Shailendra K. Gupta, Yogeshwer Shukla and Olaf Wolkenhauer.


View Abstract


Modulation of heart rate by acute or chronic aerobic exercise. Potential effects on blood pressure control


Carme Perez-Quilis, J. Derek Kingsley, Kabir Malkani, Gianfranco Cervellin, Giuseppe Lippi and Fabian Sanchis-Gomar.


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Class A GPCRs: Structure, Function, Modeling and Structure-based Ligand Design


Xiaojing Cong, Jérémie Topin and Jérôme Golebiowski.


View Abstract


Discovery and Development of ATP-Competitive mTOR Inhibitors Using Computational Approaches


Yao Luo and Ling Wang.


View Abstract


Protein kinases as targets for Opisthorchis viverrini- associated cholangiocarcinoma therapy


Watcharin Loilome and Hasaya Dokduang.


View Abstract


Targeting CD147 is a novel strategy for antitumor therapy


ChengXiang Lian, Yeye Guo, Jianglin Zhang, Xiang Chen and Cong Peng.


View Abstract


Targeting Protein Kinases for the Treatment of Glioblastoma Multiforme:Linking Basic Studies to Clinical Applications


Aidong Zhou.


View Abstract


Induction of synthetic lethality by natural compounds targeting cancer signaling


Lee Farrand and Sanguine Byun.


View Abstract


Recent advances in the function of the 67 kDa laminin receptor and its targeting for personalized therapy in cancer


Ada Pesapane, Pia Ragno, Carmine Selleri and Nunzia Montuori.


View Abstract


Gene Delivery with Organic Electronic Biomaterials


Kathryn Frances Anne Clancy and John George Hardy.


View Abstract


DNA base excision repair: the Achilles’ heel of tumour cells and their microenvironment?


M Poletto , A J Legrand and G L Dianov.


View Abstract


Protein Kinase Inhibitors as Potential Antimicrobial Drugs against Tuberculosis, Malaria and HIV


Yong Cheng, Jeffrey S. Schorey, Cheng-Cai Zhang and Xuejuan Tan.


View Abstract


Studying Interactions of Drugs with Cell Membrane Nutrient Transporters: New Frontiers of Proteoliposome Nanotechnology


Mariafrancesca Scalise, Michele Galluccio, Lorena Pochini, Lara Console, Maria Barile, Nicola Giangregorio, Annamaria Tonazzi and Cesare Indiveri.


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Current Methods of the Circulating Tumor Cells (CTC) Analysis: A Brief Overview


Natalia Dementeva, Daria Kokova and Oleg A Mayboroda.


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Recent Advances in Targeting the HIV-1 Tat/TAR Complex


Fardokht A. Abulwerdi and Stuart FJ Le Grice.


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The HIV-1 Tat protein: mechanism of action and target for HIV-1 cure strategies


Andrew P Rice.


View Abstract


Mephedrone Concentrations in Cases of Clinical Intoxication


Esther Papaseit, Eulàlia Olesti, Rafael de la Torre, Marta Torrens and Magí Farré.


View Abstract


Always Look On the Bright Side: Anti-Tumor Functions of Neutrophils


Sandra Völs, Ronit Vogt Sionov and Zvi Granot.


View Abstract


Prevalence and surveillance of synthetic cathinones use by hair analysis: an update review


JC. Alvarez, N. Fabresse and IA Larabi.


View Abstract


Good Practices in Forensic Toxicology


Olaf H Drummer.


View Abstract


Protein Phosphatase-1 –targeted Small Molecules, Iron Chelators and Curcumin Analogs as HIV-1 Antivirals


Xionghao Lin, Tatyana Ammosova, Namita Kumari and Sergei Nekhai.


View Abstract


Nails in Forensic Toxicology: an Update


Renata Solimini, Adele Minutillo, Chrystalla Kyriakou , Simona Pichini, Roberta Pacifici and Francesco Paolo Busardò.


View Abstract


Oncostatin M: Potential Implications for Malignancy and Metabolism


Jacqueline M. Stephens and Carrie M Elks.


View Abstract


Dual roles of Pin1 in cancer development and progression


Hyeong-jun Han, Bu Young Choi and Young-Joon Surh.


View Abstract


Method development in Forensic Toxicology


Frank T. Peters, Dirk K. Wissenbach, Francesco Paolo Busardò, Emilia Marchei and Simona Pichini.


View Abstract


Role of bradykinin in the regulation of endothelial nitric oxide synthase expression by cardiovascular drugs


Jin Bo Su.


View Abstract


Zein-based nanocarriers as potential natural alternatives for drug and gene delivery: Focus on cancer therapy


Ahmed Elzoghby, May Freag, Hadeer Mamdouh and Kadria Elkhodairy.


View Abstract


“Stress” is 80 years old: From Hans Selye original paper in 1936 to recent advances in GI ulceration


Sandor Szabo, Masashi Yoshida, Janos Filakovszky and Gyorgy Juhasz.


View Abstract


Role of Host Factors on the Regulation of Tat-Mediated HIV-1 Transcription


Guillaume Mousseau and Susana T Valente.


View Abstract


LSD detection and interpretation in hair


Camille Richeval, Delphine Allorge, X. Vanhoye and Jean-michel Gaulier.


View Abstract


Overview Of Forensic Toxicology, Yesterday, Today And In The Future


Heesun Chung and Sanggil Choe.


View Abstract


HIV-1 Transcription Inhibitors Increase the Synthesis of Viral Non-Coding RNA that Contribute to Latency


Yao A. Akpamagbo, Catherine DeMarino, Michelle L. Pleet, Angela Schwab, Myosotys Rodriguez, Robert A. Barclay, Gavin Sampey, Sergey Iordanskiy, Nazira El-Hage and Fatah Kashanchi.


View Abstract


Interest of single hair analysis to document drug exposure: literature review and a case report involving zuclopenthixol


Nathalie Allibe, Pascal Kintz, Amandine Faure, François Paysant, Anne-Pascale Michard-Lenoir, Françoise Stanke-Labesque, Virginie Scolan and Hélène Eysseric-Guerin.


View Abstract


Protein Tyrosine signaling and its potential therapeutic implications in carcinogenesis


Mihwa Kim, Minwoo Baek and Dae Joon Kim.


View Abstract


Membrane-bound ATP-dependent Energy Systems, as Extra- and Intracellular Key Signals for Gastrointestinal Functions and their Regulations in the Gastrointestinal Mucosa


Gyula Mózsik, Imre László Szabó and József Czimmer.


View Abstract


Icariin Attenuates Interleukin-1β-Induced Inflammatory Response in Human Nucleus Pulposus Cells


Wen-bin Hua, Yu-kun Zhang, Xing-huo Wu, Liang Kang, Ji Tu, Kang-cheng Zhao, Shuai Li, Kun Wang, Yu Song, Rong-jin Luo, Zeng-wu Shao and Cao Yang.


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Albumin nanocarriers, γ - irradiated crosslinked, combined with therapeutic drugs for cancer therapy


Macarena Siri, Estefanía Achilli, Mariano Grasselli and Silvia del V Alonso.


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Management of blood pressure and heart rate in patients with diabetes mellitus


Ioanna Gouni-Berthold, Ruth Hanssen, Lisa Ravarani and Heiner K Berthold.


View Abstract


Sialidases: Therapeutic and Antiatherogenic Potential


Vasily Nikolaevich Sukhorukov , Vasily Petrovich Karagodin , Emile Rustemovich Zakiev , Andrey Vyacheslavovich Grechko and Alexandr Nikolaevich Orekhov.


View Abstract


Tumor Targeting of Polymeric Nanoparticles Conjugated with Peptides, Saccharides, and Small Molecules for Anticancer Drugs


Banu Bayram, Aykut Özgür, Lütfi Tutar and Yusuf Tutar.


View Abstract


Why Not All Hypertensive Patients Are Tachycardic at Rest?


Maciej Siński, Piotr Jędrusik and Jacek Lewandowski.


View Abstract


What Is The Real Efficacy Of Beta-Blockers For The Treatment Of Essential Hypertension?


Christian Höcht, Facundo M Bertera, Julieta S Del Mauro, Yanina Santander Plantamura, Carlos A Taira and Ariel H Polizio.


View Abstract


Role of Protein Kinases and Their Inhibitors in Radiation Response of Tumor Cells


Byeong Mo Kim, Wonsuck Yoon, Jung-Hyun Shim, Haiyoung Jung, Ji Hong Lim, Hyun-Jung Choi, MiRan Seo, Tae Ho Lee and Sang-Hyun Min.


View Abstract


How to treat patients with essential hypertension and peripheral arterial disease.


Salvatore Santo Signorelli.


View Abstract


Formulation, Quality Control and Safety Issues of Nanocarriers Used For Cancer Treatment


Ismael D. Bianco, Marcelo R. Ceballos, Cristian Casado, Viviana G. Dabbene, Carolina Rizzi and R Kiyomi Mizutamari.


View Abstract


Anthocyanins: Possible role as Multitarget therapeutic agents for prevention and therapy of chronic diseases


Swathi Putta, Nagendra Sastry Yarla, Ilaria Peluso, Dinesh Kumar Tiwari, Gorla V.Reddy, Priyanka Voori Giri, Naresh Kumar, Ramarao Malla, Veera Brahma Chari, Rama Sekhara Reddy D, Ramesh Bade, Mastan Mannarapu, George Barretto, Da-Yong Lu, Vadim V. Tarasov, Vladimir N. Chubarev, Frederico Fávaro Ribeiro, Luciana Scotti, Marcus T. Scotti, M. A.Kamal, Gjumrakch Aliev, Chinthalapally V. Rao, George Perry and Anupam Bishayee.


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Synthesis and biological evaluation of new tyrosol-salicylate derivatives as potential anti-inflammatory agents


Rafael P. Aguiar, Fahad S. Aldawsari, Luiz A. M. Wiirzler, Saulo E. Silva- Filho, Francielli M. S. Silva-Comar, Ciomar A. Bersani-Amado, Carlos A. Velázquez-Martínez and Roberto K N Cuman.


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Effect of magnesium supplementation on plasma C-reactive protein concentrations: A systematic review and meta-analysis of randomized controlled trials.


Luis E. Simental-Mendía, Amirhossein Sahebkar, Martha Rodríguez-Morán, Graciela Zambrano-Galván and Fernando Guerrero-Romero.


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Using properties of tumor microenvironments for controlling local, on-demand delivery from biopolymer-based nanocarriers.


Abdullah K. Alshememry, Suleiman S. El-Tokhy and Larry D Unsworth.


View Abstract


Effects of oral and non-insulin injectable antidiabetic treatment in hypertension: a systematic review


Vasiliki Katsi, Georgios Georgiopoulos, Georgia Vogiatzi, Dimitrios Oikonomou, Maria Megapanou, John Skoumas, Charalampos Vlachopoulos, Petros Nihoyannopoulos and Dimitris Tousoulis.


View Abstract


Pivotal roles of Interleukin-17 as the Epicenter of Bone Loss Diseases


Chongshan Liao, Chengfei Zhang and Yanqi Yang.


View Abstract


Hybrid polymeric-magnetic nanoparticles in cancer treatments


Alexandra Muñoz Bonilla and Pilar Herrasti González.


View Abstract


Nanovesicular formulations for cancer gene therapy


Lorena Tavano, Elisabetta Mazzotta and Rita Muzzalupo.


View Abstract


Long-lasting insulin treatment via a single subcutaneous administration of liposomes in thermoreversible Pluronic® F127 based hydrogel


Xiaoyu Chen, Blenda Chi Kwan Wong, Hubiao Chen, Shiping Zhang, Zhaoxiang Bian, Ge Zhang, Congcong Lin, Muhammad Kashif Riaz, Deependra Tyagi, Aiping Lu and Zhijun Yang.


View Abstract


Anti-cancer drug delivery using carbohydrate-based polymers


Javad Ranjbari, Ahad Mokhtarzadeh, Abbas Alibakhshi, Maryam Tabarzad, Maryam Hejazi and Mohammad Ramezani.


View Abstract


Percutaneous treatment of aortic valve disease: contemporary overview and future trends


Marko Banovic, Jozef Bartunek, Serge D. Nikolic, Vladan Vukcevic, Srdjan Aleksandric and Bernard Iung.


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The role of exosomes and exosome-derived microRNAs in atherosclerosis


Xinjie Lu.


View Abstract


Approaches of the transcriptomic analysis in astrocytes: Potential pharmacological targets


George E. Barreto , Rosa M. Gómez, Rosa Helena Bustos, Diego A. Forero, Gjumrakch Aliev, Jerzy Leszek, Valentina Echeverria and Janneth Gonzalez.


View Abstract


Vitamins in Heart Failure: Friend or Enemy?


George Georgiopoulos, Christina Chrysohoou, Georgia Vogiatzi , Nikolaos Magkas, Ippokratis Bournelis, Sofia Bampali, Damien Gruson and Dimitris Tousoulis.


View Abstract


Synthesis and characterization of a new benzo indole derivative with apoptotic activity against colon cancer cells


Fatemeh Hajiaghaalipou, Fadhil Lafta Faraj, Elham Bagheri, Hamid Khaledi, Hapipah Mohd Ali, Nazia Abdul Majid and Mahmood Ameen Abdulla.


View Abstract


Diabetes-related neurological implications and pharmacogenomics


Rojas Carranza Camilo Andrés, Bustos Cruz Rosa Helena, Pino Pinzón Carmen Juliana , Ariza Marquez Yeimy Viviana, Gómez Bello Rosa Margarita and Cañadas Garre Marisa.


View Abstract


Medicinal plants as protective strategies against Parkinson’s Disease


Natalia Areiza Mazo, Valentina Echeverria, Ricardo Cabezas, Marco Ávila-Rodriguez, Gjumrakch Aliev, Jerzy Leszek and George E Barreto.


View Abstract


Implications of photophysical and physicochemical factors on successful application of photodynamic therapy


Shubhajit Paul, Paul Wan Sia Heng and Lai Wah Chan.


View Abstract


Mur Ligase Inhibitors as Anti-bacterials: A Comprehensive Review


Jaiprakash N. Sangshetti, Suyog S. Joshi, Rajendra H. Patil and Devanand B Shinde.


View Abstract


Vegetable Organosulfur Compounds and their Health Promoting Effects


Spyridon A. Petropoulos, Francesco Di Gioia and Georgia Ntatsi.


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Optimal Pre-treatment for Acute Exposure to the Organophosphate Dicrotophos


Dietrich Ernst Lorke, Syed M. Nurulain, Mohamed Y. Hasan, Kamil Kuča and Georg A Petroianu.


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