ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)


Volume 20, 42 Issues, 2014


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Current Pharmaceutical Design

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Upcoming Articles (E-Pub Abstracts ahead of Print)

The Case for Using Higher Doses of First Line Anti-Tuberculosis Drugs to Optimize Efficacy
Sylvain Goutelle, Laurent Bourguignon, Pascal Maire, Roger W. Jelliffe and Michael N. Neely
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Editorial Combined Cancer Therapy
Jasminka Pavelic
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Combined Modality Therapy in Pancreatic Adenocarcinoma: Review and Updates on a Controversial Issue
Ludimila Cavalcante, David P. Kelsen and Kenneth H. Yu
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Curcumin in Combined Cancer Therapy
Koraljka Gall Troselj and Renata Novak Kujundzic
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Mechanism-based Combinations with Pim Kinase Inhibitors in Cancer Treatments
Qingshan Yang, Lisa S. Chen and Varsha Gandhi
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Pancreatic Cancer: Systemic Combination Therapies for a Heterogeneous Disease
Davide Melisi, Lorenzo Calvetti, Melissa Frizziero and Giampaolo Tortora
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Pharmaco-therapeutic challenges in cancer biology with focus on the immune-system related risk factors
Zlatko Dembic
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A Comprehensive Review of Poorly Differentiated Neuroendocrine Carcinomas (pdNECs): a Niche to Find Novel Opportunities
Pablo Reguera, Ainhoa Madariaga and Enrique Grande
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Immunotoxins constructed with ribosome-inactivating proteins and their enhancers: a lethal cocktail with tumor specific efficacy
Roger Gilabert-Oriol, Alexander Weng, Benedicta von Mallinckrodt, Matthias F. Melzig, Hendrik Fuchs and Mayank Thakur
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Combined Cancer Therapy: Strategies to Overcome Acquired Aromatase Inhibitor Resistance
Susan B. Kesmodel, Gauri J. Sabnis, Saranya Chumsri and Angela MH Brodie
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NCRNA COMBINED THERAPY AS FUTURE TREATMENT OPTION FOR CANCER
Cornelia Braicu, Cristina Catana, George A. Calin and Ioana Berindan-Neagoe
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The Exploitation of Toll-like Receptor 3 Signaling in Cancer Therapy
Tanja Matijevic Glavan and Jasminka Pavelic
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Attacking c-Myc: Targeted and Combined Therapies for Cancer
Huilin Huang, Hengyou Weng, Hui Zhou and Lianghu Qu
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Oxidative Stress and Antioxidants in Carcinogenesis and Integrative Therapy of Cancer
Lidija Milkovic, Werner Siems, Renate Siems and Neven Zarkovic
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Anti-metastatics: an Overview of Drug Candidates in Current Pipelines
Anne Schaap-Nutt, Dane A. Thyssen, David W. Drell and Frank Entschladen
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Combining oncolytic virotherapy and cytotoxic therapies to fight cancer
Cristina Fillat, Maria Victoria Maliandi, Ana Mato-Berciano and Ramon Alemany
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Utility of Anti-Arrhythmic Medications in ‘Lone Atrial Fibrillation
Ramanan Kumareswaran and Paul Dorian
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Editorial: ‘Lone’ atrial fibrillation: No longer lone or even alone
Tatjana S. Potpara and Gregory Y.H. Lip
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Phosphodiesterase: An Interface Connecting Cognitive Deficits to Neuropsychiatric and Neurodegenerative Diseases
Zhen-Zhen Wang, Yi Zhang, Han-Ting Zhang and Yun-Feng Li
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The roles of phosphodiesterase 2 in the central nervous and peripheral systems
Chong Zhang, Yingcong Yu, Lina Ruan, Chuang Wang, Jianchun Pan, Jonathan Klabnik, Lindsay Lueptow, Han-Ting Zhang, James M. O’Donnell and Ying Xu
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Does Phosphodiesterase 11A (PDE11A) Hold Promise as a Future Therapeutic Target?
Michy P. Kelly
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‘Emerging Biology of PDE10A’
Lindsay S. Wilson and Nicholas J. Brandon
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Phosphodiesterase inhibitors as a target for cognition enhancement in aging and Alzheimer’s disease: a translational overview
P.R.A. Heckman, C. Wouters and J. Prickaerts
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Role of Phosphodiesterase 4-mediated cyclic AMP signaling in pharmacotherapy for substance dependence
Rui-Ting Wen, Wan-Yu Feng, Jian-Hui Liang and Han-Ting Zhang
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Phosphodiesterase-4 modulation as a potential therapeutic for cognitive loss in pathological and non-pathological aging: Possibilities and Pitfalls
Rolf T. Hansen III and Han-Ting Zhang
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‘Phosphodiesterases as therapeutic targets for Huntington’s disease.’
Francesca R. Fusco and Carmela Giampà
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Phosphodiesterase Inhibitors as Therapeutics for Traumatic Brain Injury
David J. Titus, Anthony A. Oliva, Nicole M. Wilson and and Coleen M. Atkins
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Genetic Signatures in the Treatment of Stroke
Anjana Munshia and Vandana Sharma
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Vitamin D3, D2 and Arterial Wall Properties in Coronary Artery Disease
Gerasimos Siasos, Dimitris Tousoulis, Evangelos Oikonomou, Konstantinos Maniatis, Stamatios Kioufis, Eleni Kokkou, Marina Zaromitidou, Eva Kassi, Antigoni Miliou, Christodoulos Stefanadis and Manolis Vavuranakis
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PATHOPHYSIOLOGY OF IDIOPATHIC ATRIAL FIBRILLATION-PROGNOSTIC AND TREATMENT IMPLICATIONS
Crijns HJGM, Schotten U and Weijs B
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CATHETER ABLATION OF LONE ATRIAL FIBRILLATION
Milan M. Marinković, Tatjana S. Potpara, László Gellér and Nebojša M. Mujović
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Genetic Aspects of Lone Atrial Fibrillation: What Do We Know?
Laura Andreasen, Jonas B. Nielsen and Morten S. Olesen
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ENDOTHELIAL (DYS)FUNCTION IN LONE ATRIAL IBRILLATION
Tatjana S. Potpara, Gregory Y.H. Lip and Marija M. Polovina
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ASYMPTOMATIC LONE ATRIAL FIBRILLATION ­ HOW CAN WE DETECT THE ARRHYTHMIA?
Cinzia Valzania, Mauro Biffi, Igor Diemberger, Matteo Ziacchi, Cristian Martignani and Giuseppe Boriani
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Lone atrial fibrillation- a diagnosis of exclusion
Antonio Tello-Montoliu, Diana Hernandez-Romero, Marianela Sanchez-Martinez, Mariano Valdes and Francisco Marin
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Biomarkers in Lone Atrial Fibrillation-An Additional ‘Fine Tuning’ of Risk?
Darae Ko, Jared Magnani and Elaine M. Hylek
View Abstract
The Heart And Brain Imaging In Lone Atrial Fibrillation – Are We Surprised?
Karl Georg Haeusler, Jochen B. Fiebach, Günter Breithardt, Paulus Kirchhof and Eduard Shantsila
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Lone Atrial Fibrillation: Electrophysiology, Risk Factors, Catheter Ablation and Other Non-pharmacologic Treatments
Arun Kanmanthareddy, Martin P. Emert, Rhea C. Pimentel, Yeruva Madhu Reddy, Sudharani Bommana, Donita Atkins and Dhanunjaya Lakkireddy
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BEST PRACTICE FOR ATRIAL FIBRILLATION PATIENT EDUCATION
Rachel V Barker, Gregory Y H Lip and Deirdre A Lane
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Psychological factors associated with response to treatment in rheumatoid arthritis
Santiago T, Geenen R, Jacobs WG and Da Silva JAP
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Are patient self-report questionnaires as “scientific” as biomarkers in “treat-to-target” and prognosis in rheumatoid arthritis?
Theodore Pincus and Isabel Castrejón
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Predicting toxicity: biomarkers and the value of the patient’s opinion
MJ Garcia de Yebenes, E Loza and L Carmona
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Predictors of Response to TNF Antagonists
Eva Salgado, Jose Ramon Maneiro and Juan J. Gomez-Reino
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Response to rituximab: has the original hypothesis been confirmed?
Geraldine Cambridge and Inmaculada De La Torre
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Laboratory biomarkers for guiding therapy with methotrexate in rheumatoid arthritis
Carlos Abud-Mendoza, Marco U. Martínez-Martínez, Adriana Monsiváis-Urenda and Roberto González-Amaro
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Rheumatoid Arthritis: Genetic Variants as Biomarkers of Cardiovascular Disease
Luis Rodriguez-Rodriguez, Raquel Lopez-Mejias, Benjamín Fernandez-Gutiérrez, Alejandro Balsa, Miguel A. González-Gay and Javier Martín
View Abstract
Biomarkers predicting a need for intensive treatment in patients with early arthritis
I. Gonzalez-Alvaro, A. Mª. Ortiz, I. V. Seoane, R. García-Vicuna, C. Martínez and R. P. Gomariz
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Role of T lymphocytes in the development of rheumatoid arthritis. Implications for treatment.
Erik Lubberts
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Biomarkers for radiographic progression in rheumatoid arthritis
A. Krabben, T.W.J. Huizinga and A.H.M. van der Helm-van Mil
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Role of synovial fibroblasts in rheumatoid arthritis
S Lefèvre, FMP Meier, E Neumann and U Muller-Ladner
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Editorial: Optimizing treatment in Rheumatoid Arthritis
Rosa P. Gomariz and Isidoro Gonzalez-Alvaro
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SPARC in Tumor Pathophysiology and as a Potential Therapeutic Target
Liling Tang and Jianguo Feng
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PET Radioligands for in Vivo Visualization of Neuroinflammation
Dieter Ory, Sofie Celen, Alfons Verbruggen and Guy Bormans
View Abstract
Models And Methods In Cardiac Imaging For Metabolism Studies
M F Santarelli, N Martini, P Positano and L Landini
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Hyperpolarized Metabolic MR in the Study of Cardiac Function and Disease
M. H. Lauritzen, L. V. Sogaard, P. L. Madsen and J. H. Ardenkjaer-Larsen
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Cardiological Ultrasound Imaging
Johan M. Thijssen and Chris L. de Korte
View Abstract
Imaging of Organ Metabolism in Obesity and Diabetes: Treatment Perspectives
J Hannukainen, MA Guzzardi, KA Virtanen, E Sanguinetti, P Nuutila and P Iozzo
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Treating Arterial Stiffness in Young and Elderly Patients with the Metabolic Syndrome
Konstantinos Tziomalos, Vasilios G. Athyros and Asterios Karagiannis
View Abstract
Modification of Lifestyle Factors are Needed to Improve the Metabolic Health of Patients with Cardiovascular Disease Risk
Linda Landini
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Effects of Remifentanil on the Cardiac Conduction System. Our Experience in the Study of Remifentanil Electrophysiological Properties
Brezo B. Del Blanco Narciso, Concepción Jimeno, Jesús Almendral Garrote and M Jose Anadon Baselga
View Abstract
Study on Gluco-Regulatory Potential of Glimepiride Sulfonamide using in Silico, in Vitro and in Vivo Approaches
Hamendra Singh Parmar, Mahesh Kumar Bhinchar, Muskan Bhatia, Nikita Chordia, Ishan Raval, Digvijay Singh Chauhan, E. Manivannan, Rameshwar Jatwa and Anil Kumar
View Abstract
Activated Immune System and Inflammation in Healthy Ageing: Relevance for Tryptophan and Neopterin Metabolism
Lucile Capuron, Simon Geisler, Katharina Kurz, Friedrich Leblhuber, Barbara Sperner-Unterweger and Dietmar Fuchs
View Abstract
Pain and Obesity in the Older Adult
Robert Taylor, Joseph V. Pergolizzi, Robert B. Raffa, Srinivas Nalamachu and Philip J. Balestrieri
View Abstract
Beyond Acetylcholinesterase Inhibitors for Treating Alzheimer's Disease: 7-nAChR Agonists in Human Clinical Trials
Patrizia Russo, Alessandra Del Bufalo, Alessandra Frustaci, Massimo Fini and Alfredo Cesario
View Abstract
Use of Trastuzumab for Breast Cancer: the Role of Age
Walter Mazzucco, Marta Rossi, Rosanna Cusimano, Matteo Franchi, Martina Bonifazi, Alessandro Mistretta, Francesco Vitale, Walter Ricciardi, Eva Negri, Stefania Boccia and Carlo La Vecchia
View Abstract
Determinants of Longevity: Genetics, Biomarkers and Therapeutic Approaches
Juulia Jylhava
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MicroRNA Therapeutics in Neurological Disease
David S. Greenberg and Hermona Soreq
View Abstract
P4 Medicine Needs P4 Education
Alfredo Cesario, Charles Auffray, Patrizia Russo and Leroy Hood
View Abstract
Therapeutic Application of Intrabodies Against Age-Related Neurodegenerative Disorders
Alessio Cardinale, Daniela Merlo, Paolo Giunchedi and Silvia Biocca
View Abstract
Hyper-Longevity, a Late-Modern Paradigm for Understanding Longevity and Ageing in Western Developed Globalised Countries
Roberto Alzetta
View Abstract
Biological Carrier Molecules of Radiopharmaceuticals for Molecular Cancer Imaging and Targeted Cancer Therapy
A Aerts, N Impens, M Gijs, M D’Huyvetter, H Vanmarcke, B Ponsard, T Lahoutte, A Luxen and S Baatout
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Metabolic Reprogramming of Human Cells in Response to Oxidative Stress: Implications in the Pathophysiology and Therapy of Mitochondrial Diseases
Yu-Ting Wu, Shi-Bei Wu and Yau-Huei Wei
View Abstract
Phytoestrogens and Mitochondrial Biogenesis in Breast Cancer. Influence of Estrogen Receptors Ratio
Pilar Roca, Jorge Sastre-Serra, Mercedes Nadal-Serrano, Daniel Gabriel Pons, M del Mar Blanquer-Rossello and Jordi Oliver
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Mitochondrial Biogenesis: Regulation By Endogenous Gases during Inflammation and Organ Stress
Hagir B. Suliman and Claude A. Piantadosi
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Mitochondrial Biogenesis in Health and Disease. Molecular and Therapeutic Approaches
Sanchis-Gomar Fabian, García Giménez, José Luis, Gómez Cabrera, Mari Carmen and V Federico Pallardo
View Abstract
Healthspan and Longevity in Mammals: A Family Game for Cellular Organelles?
Enzo Nisoli and Alessandra Valerio
View Abstract
Regulation And Quantification Of Cellular Mitochondrial Morphology And Content
Karl J. Tronstad, Marco Nooteboom, Linn I. H. Nilsson, Julie Nikolaisen, Maciek Sokolewicz, Sander Grefte, Ina K.N. Pettersen, Sissel Dyrstad, Fredrik Hoel, Peter H.G.M. Willems and Werner J.H. Koopman
View Abstract
Mitochondria: Prospective Targets for Neuroprotection in Parkinson’s Disease
Anuradha Yadav, Swati Agrawal, Shashi Kant Tiwari and Rajnish K. Chaturvedi
View Abstract
Editorial : Targeting vascular calcification: Up-date
Yuri V Bobryshev
View Abstract
Mechanisms of Medial Arterial Calcification in Diabetes
Dimitry A. Chistiakov, Igor A. Sobenin, Alexander N. Orekhov and Yuri V. Bobryshev
View Abstract
Mechanisms of Vascular Calcification and Associated Diseases
Juliana Marulanda, Saleh Alqarni and Monzur Murshed
View Abstract
New Therapeutic Approaches to Arterial Calcification Via Inhibition of Transglutaminase and B-Catenin Signaling
Mikhail Konoplyannikov and Maria Nurminskaya
View Abstract
Abdominal Aortic Calcification: Clinical Significance, Mechanisms and Therapies
Jonathan Golledge
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Vascular Calcification in Chronic Kidney Disease: Role of Disordered Mineral Metabolism
Shyamal Palit and Jessica Kendrick
View Abstract
Blood Serum Atherogenicity and Coronary Artery Calcification
Igor A. Sobenin, Veronica A. Myasoedova, Elena V. Anisimova, Xenia N. Pavlova, Stefan Möhlenkamp, Axel Schmermund, Rainer Seibel, Sina Berenbein, Nils Lehmann, Susanne Moebus, Jöckel Karl-Heinz, Alexander N. Orekhov and Raimund Erbel
View Abstract
Circulating Cellular Players in Vascular Calcification
Mattia Albiero, Angelo Avogaro and Gian Paolo Fadini
View Abstract
Editorial : Novel Insights into the Role of Anesthetics and Opioids in Organ or Tissue Protection
Hiroyuki Kinoshita
View Abstract
Mechanistic View of Renal Protective Action of Calcium Channel Blockade
N Sugano
View Abstract
Genistein Inhibits Cell Growth and Invasion Through Regulation of MiR-27a in Pancreatic Cancer Cells
Jun Xia, Long Cheng, Chuanzhong Mei, Jia Ma, Ying Shi, Fanpeng Zeng, Zhenghuan Wang and Zhiwei Wang
View Abstract
MicroRNAs (miRNA) as Biomarker(s) for Prognosis and Diagnosis of Gastrointestinal (GI) Cancers
Muzafar A. Macha, Parthasarathy Seshacharyulu, Shiv Ram Krishn, Priya Pai, Satyanarayana Rachagani, Maneesh Jain and Surinder K. Batra
View Abstract
Oncogenic MicroRNAs in the Genesis of Leukemia and Lymphoma
Yanyan Pan, Mei Meng, Gaochuan Zhang, Hongyan Han and Quansheng Zhou
View Abstract
MicroRNAs in Cancer Stem Cells: New Regulators of Stemness
Fei Xing, Kerui Wu and Kounosuke Watabe
View Abstract
MicroRNAs in Breast Cancer Therapy
Joy Tang, Aamir Ahmad and Fazlul H. Sarkar
View Abstract
MiRNAs in Human Cancers: The Diagnostic and Therapeutic Implications
Qiong Wu, Zhiping Yang, Yongquan Shi and Daiming Fan
View Abstract
The miRNAs and Epithelial-Mesenchymal Transition in Cancers
Lin Ching-Wen, Kao Shih-Han and Yang Pan-Chyr
View Abstract
Arsenic Trioxide Targets miR-125b in Glioma Cells
Sulian Chen, Lihua Zhu, Jing Huang, Ying Cai, Xiaohui Lu, Qingling Yang, Qiong Wu, Changjie Chen and Zhiwei Wang
View Abstract
Regulation of KRAS–PAK4 Axis by MicroRNAs in Cancer
Zeshan S. Choudhry, Vraj Tripathi, Mike Sutton, Bin Bao, Ramzi M. Mohammad and Asfar S. Azmi
View Abstract
Assessing Schizophrenia-Relevant Cognitive and Social Deficits in Mice: a Selection of Mouse Behavioral Tasks and Potential Therapeutic Compounds
Wen-Sung Lai, Chia-Yuan Chang, Wan-Rong Wong, Ju-Chun Pei, Ya-Shan Chen and Wei-li Hong
View Abstract
Frontal Lobe Synaptic Plasticity in Development and Disease: Modulation by the Dopamine D1 Receptor
Lynn D. Selemon
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The Co-Agonist Site of NMDA-Glutamate Receptors: a Novel Therapeutic Target for Age-Related Cognitive Decline
Rogério Panizzutti, Linda Scoriels and Marcos Avellar
View Abstract
NMDA Neurotransmission Dysfunction in Mild Cognitive Impairment and Alzheimer’s Disease
Chieh-Hsin Lin, Yu-Jhen Huang, Hsien-Yuan Lane and Guochuan E. Tsai
View Abstract
Predicting Protein-Ligand Interactions Based on Chemical Preference Features with its Application to New D-Amino Acid Oxidase Inhibitor Discovery
Mingzhu Zhao, Hao-Teng Chang, Qiang Zhou, Tao Zeng, Zhi-Ping Liu, Luonan Chen and Dong-Qing Wei
View Abstract
Inhibitory Effects of Water Caltrop Pericarps on the Growth of Human Gastric Cancer Cells In Vitro
Qiusheng Lin, Junhui Shen, Ying Ning, Shengrong Shen and Undurti N. Das
View Abstract
Editorial: From gut inflammation to gastrointestinal disorders Current update on pathophysiology, molecular mechanism and pharmacological treatment modalities
Predrag Sikiric
View Abstract
Manifestations In Course Of Celiac Disease: Case Report And Review Of The Literature
Skroza Nevena, Proietti Ilaria, Bernardini Nicoletta, La Viola Giorgio, Mancini Maria Teresa, Nicolucci Francesca, Pampena Riccardo, Tolino Ersilia, Zuber Sara and Potenza Concetta
View Abstract
Helicobacter pylori eradication therapy: advantages and disadvantages
Justyna Bien, Maria Bozko, Nisar P. Malek and Przemyslaw Bozko
View Abstract
EDITORIAL:The Multidomain Mobility Lab in Older Persons: From Bench to Bedside
Marcello Maggio, Gian Paolo Ceda and Fulvio Lauretani
View Abstract
Role of brain NUCB2/nesfatin-1 in the regulation of food intake
Andreas Stengel and Yvette Taché
View Abstract
Regulation of Gastric Nesfatin-1/NUCB2
Ziru Li, Michael Mulholland and Weizhen Zhang
View Abstract
Discovery of Nesfatin-1 and Overview of Biological Actions and New Developments
Masatomo Mori, Masanobu Yamada, Shuichi Okada, Koshi Hashimoto, Tesurou Satoh, Hiroyuki Shimizu and Toshihiko Yada
View Abstract
Role of NUCB2/nesfatin-1 in glucose control: diverse functions in islets, adipocytes and brain
Masanori Nakata and Toshihiko Yada
View Abstract
Central and peripheral expression and distribution of NUCB2/nesfatin-1
Miriam Goebel-Stengel and Lixin Wang
View Abstract
Role of NUCB2/nesfatin–1 as a possible biomarker
Suleyman Aydin
View Abstract
Editorial: Rational Design of Antiviral Compounds
Vladimir Frecer and Stanislav Miertus
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EDITORIAL Advances in Computational Structure Based Drug Discovery
Gergely Tóth
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Editorial Cardio-Metabolic Complications: Current Perspective and Future Developments.
Joseph Fomusi Ndisang
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EDITORAL Novel strategies for cardiac repair post-myocardial infarction
Simeon Agathopoulos and Theofilos M. Kolettis
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EDITORIAL: NEUROBIOLOGICAL AND NEUROCOGNITIVE BASIS OF THE EFFECTS OF CANNABINOIDS IN ANIMALS AND MAN: THERAPEUTIC POTENTIAL OF CANNABINOIDS IN PSYCHIATRY
Sagnik Bhattacharyya
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Dietary Interventions for Atopic Disorders
Despoina Mavrommati and Theoharis C. Theoharides
View Abstract
Editorial Leptin and the cardiovascular system – a target for therapeutic interventions
Jerzy Bełtowski
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EDITORIAL Structure-based Drug Design: Strategies and Challenges
Guang-Fu Yang
View Abstract
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