ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)


Volume 23, 46 Issues, 2017


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Current Pharmaceutical Design

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Editor-in-Chief:
William A. Banks
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Abstracts Ahead of Print

A review of Chinese herbal medicine for the treatment of chronic heart failure


Yong Wang, Qiyan Wang, Chun Li, Linghui Lu, Qian Zhang, Ruixin Zhu and Wei Wang.


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Optimising β-lactam Dosing in Neonates: A Review of Pharmacokinetics, Drug Exposure and Pathogens


Aline Fuchs, Grace Li, Johannes Van Den Anker and Julia Bielicki.


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Development of Peptide Vaccines in Dengue


Kavita Reginald, Yanqi Chan, Magdalena Plebanski and Chit Laa Poh.


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Effects Of Excitotoxic Lesion With Inhaled Anesthetics On Nervous System Cells Of Rodents


Maria Fernanda Quiroz-Padilla, Gemma Guillazo-Blanch, Magdy Y Sanchez, Maria Andrea Dominguez-Sanchez and Rosa Margaria Gomez.


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Neonatal plasticity of the nociceptive system: mechanisms, effects, and treatment of repetitive painful procedures during NICU admittance


N J Van den Hoogen, J Patijn , D Tibboel and E A Joosten.


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Intravenous paracetamol dosing guidelines for pain management in (pre)term neonates using the paediatric study decision tree


P. Mian, C.A.J. Knibbe, E.A.M. Calvier, D. Tibboel and K Allegaert.


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Big data analyses for continuous evaluation of pharmacotherapy: A proof of principle with doxapram in preterm infants


Robert B. Flint, Willem van Weteringen, Swantje Völler, Jarinda A Poppe, Birgit CP Koch, Ronald de Groot, Dick Tibboel, Catherijne AJ Knibbe, Irwin KM Reiss, Sinno HP Simons and DINO Research group.


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Natural active compounds from plant food and Chinese herbal medicine for nonalcoholic fatty liver disease


Qian Liu, Lixin Zhu, Chen Cheng, Yiyang Hu and Qin Feng.


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Chinese herbal medicine for the treatment of depression: applications, efficacies and mechanisms


Yuanyuan Wang, Menglin Li, Yan Liang, Yiting Yang, Zhe Liu, Keyu Yao, Zijie Chen and Shuangqing Zhai.


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The use of hemodynamic and cerebral monitoring to study pharmacodynamics in neonates


A. Smits, L. Thewissen, A. Dereymaeker, E. Dempsey, A. Caicedo and Gunnar Naulaers.


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Allopurinol: old drug, new indication in neonates?


Kim V Annink, Axel R Franz, Jan B Derks, Mario Rüdiger, Frank van Bel and Manon JNL Benders.


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Cardiovascular Drug Therapy for Human Newborn: Review of Pharmacodynamic Data


Ebru Ergenekon, Héctor Rojas-Anaya, María Carmen Bravo, Charalampos Kotidis, Liam Mahoney and Heike Rabe.


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Aerosol: a novel vehicle in pharmacotherapy in neonates


Ronan MacLoughlin, Colin Telfer, Andy Clark and James Fink.


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The transport mechanism of extracellular vesicles at the blood-brain barrier


Junichi Matsumoto, Tessandra Stewart, William A. Banks and Jing Zhang.


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Statins and contrast-induced nephropathy: a systematic review and meta-analysis


Alexandros Briasoulis, Mohan Pala , Tesfaye Telila , Obsinet Merid, Emmanuel Akintoye, Georgia Vogiatzi , Evangelos Oikonomou and Dimitris Tousoulis.


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Role of pharmacogenomics in antiepileptic drug therapy: current status and future perspectives.


Antonio Gambardella, Angelo Labate, Laura Mumoli, Iscia Lopes-Cendes and Fernando Cendes.


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Alzheimer’s disease and Parkinson’s disease: a review of current treatment adopting a nanotechnology approach


Adriana Trompetero, Aldemar Gordillo, Carolina del Pilar Mora, María Cristina Velasquillo and Rosa Helena Bustos.


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Modulation of both Insulin Resistance and Cancer Growth by Inositol


Mariano Bizzarri, Simona Dinicola and Alessandra Cucina.


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Pharmacological aspects of neuro-immune interactions


Vadim V. Tarasov, Nikita V. Kudryashov, Vladimir N. Chubarev, Tatiana S. Kalinina, George E. Barreto, Ghulam Md Ashraf and Gjumrakch Aliev.


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The effect of physical exercise on neurogenesis factor production in glial cells


Jorge M. Moreno-Collazos and Eva S Orti.


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Genetic aspects of glial cells regarding neurodegenerative diseases


Julio Cesar Martinez Lozano, Rosa Margarita Gómez, Andres Gabriel Zarate Sanabria, Giovanny Jubiz and Sonia Del Pilar Otalora Valderrama.


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Statins in Stable Angina Pectoris


Adam Ioannou, Nikolaos Papageorgiou , Vincent McVaughan , Marietta Charakida , Dimitris Bertsias , Fay Zacharia, Gerasimos Siasos, George Latsios, Spyridon Papaioannou, Evangelos Oikonomou and Dimitris Tousoulis.


View Abstract


Graphene-based nanomaterials: potential tools for neurorepair


Qing Wang , Yan-Hua Li, Wei-Jia Jiang, Jian-Guo Zhao, Bao-Guo Xiao , Guang-Xian Zhang and Cun-Gen Ma.


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Analgesics in Pregnancy: An Update on Use, Safety and Pharmacokinetic Changes in Drug Disposition.


Hayley R Price and Abby C Collier.


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Preterm Birth and Neonatal Injuries: Importance of Interleukin-1 and Potential of Interleukin-1 Receptor Antagonists


Mathieu Nadeau-Vallée, Dima Obari, Alexandra Beaudry-Richard, Estefania Marin Sierra, Alexandre Beaulac, Noémie Maurice, David M. Olson and Sylvain Chemtob.


View Abstract


Instrumenting a Fetal Membrane on a Chip as Emerging Technology for Preterm Birth Research


Juan S. Gnecco, Anjali P. Anders, David Cliffel, Virginia Pensabene, Lisa M. Rogers, Kevin Osteen and David M Aronoff.


View Abstract


An overview of cardenolides in Digitalis - more than a cardiotonic compound


Ekrem Gurel, Serhan Karvar, Buhara Yucesan, Ismail Eker and Muhammad Sameeullah.


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Nasal Delivery of Antioxidants by Cholesterol-incorporated Liposomes Extends the Neuroprotective Time Window in Cerebral Ischemia


Seul Ki Min, Yeo Seon Kwon, Myung Kwon Cho and Hwa Sung Shin.


View Abstract


The Food and Drug Addiction Epidemic: Targeting Dopamine Homeostasis


Kenneth Blum, Panayotis K Thanos, Gene-Jack Wang, Marcelo Febo, Zsolt Demetrovics, Edward Justin Modestino, Eric R. Braverman, David Baron, Rajendra D. Badgaiyan and Mark S Gold.


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The Efficacy and Potential Mechanisms of Chinese Herbal Medicine on Irritable Bowel Syndrome


Zijuan Bi, Yu Zheng, Jianye Yuan and Zhaoxiang Bian.


View Abstract


Danshen (Salvia miltiorrhiza Bunge): A Prospective Healing Sage for Cardiovascular Diseases


Wei Chen and Guoxun Chen.


View Abstract


A novel danshensu-tetramethylpyrazine conjugate DT-018 provides cardioprotection by preserving mitochondrial function through the MEF2D/PGC-1α pathway


Xiaojing Zhang, Jingxiong Luo, Yali Huang, Huixing Deng, Huihui Hu, Pei Yu, Yewei Sun, Luchen Shan and Yuqiang Wang.


View Abstract


Genetic variants of PEAR1 are associated with platelet function and antiplatelet drug efficacy: a systematic review and meta-analysis


Qian Xiang, Shuang Zhou, Joshua P. Lewis, Alan R. Shuldiner, Guanhua Ren and Yimin Cui.


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Biomarkers of cardiovascular risk in haemodialysis patients


Beata Franczyk, Anna Gluba-Brzózka and Jacek Rysz.


View Abstract


Statins in acute coronary syndromes


Manolis Vavuranakis, Maria Kariori, Gerasimos Siasos, Konstantinos Kalogeras and Dimitris Tousoulis.


View Abstract


Statins in Diabetes Mellitus


Charalambos Vlachopoulos, Nikolaos Ioakeimidis, Konstantinos Aznaouridis, George Lazaros and Dimtris Tousoulis.


View Abstract


Statins in Aortic Stenosis


Karl Norrington, Emmanuel Androulakis, Evangelos Oikonomou, Georgia Vogiatzi and Dimitris Tousoulis.


View Abstract


Imaging Biomarkers of Anti-Epileptic Drug Action: Insights from Magnetic Resonance Imaging


Lorenzo Caciagli, Fenglai Xiao, Britta Wandschneider and Matthias J Koepp.


View Abstract


Neuroprotection in hypoxic-ischemic brain injury targeting glial cells


María Inés Herrera, Sofia Mucci, George E. Barreto, Rodolfo Kolliker-Frers and Francisco Capani.


View Abstract


The therapeutical effect of Chinese medicine for the treatment of atherosclerotic coronary heart disease


Jian Zhang , Hui Meng, Yi Zhang , Xuefeng Zhang , MingYan Shao, Chun Li and Pengfei Tu.


View Abstract


Current Strategies to Improve the Target of Cell Penetrating Peptides used for Antitumor Therapeutics


Fang Zhang, Dandan Yang, Shanshan Jiang, Lei Wu, Li Qin, Huiyang He and Peng Zhang.


View Abstract


MiRNA-based therapeutic strategy in lung cancer


Guang Li, Jing Fang, Ying Wang, Hu Wang and Cheng-Cao Sun.


View Abstract


Pharmacology and literature review based on related death and non-fatal case reports of the benzofurans and benzodifurans designer drugs.


Bernardino Barceló Martín and Isabel Gomila.


View Abstract


Update of Standard Practices for New Method Validation in Forensic Toxicology


Sarah M.R. Wille, Wim Coucke, Thierry De Baere and Frank T Peters.


View Abstract


Regulation Mechanism of MicroRNAs in Non-Small Cell Lung Cancer


Feng-Yun Gong, Tao Bai, Ding-Yu Zhang, Chao-lin Huang, Jing Lv, Jing-Li Wang, Xu-Dong Hu, Juan Wang and Wei Liu.


View Abstract


MiRNA-based therapeutics for lung cancer


Miaowei Wu, Guosheng Wang, Wei Tian, Yongchuan Deng and Yibing Xu.


View Abstract


Role of miRNA in lung cancer-potential biomarkers and therapies


Xiaohong Du, Jitai Zhang, Juping Wang, Xiaoming Lin and Feng Ding.


View Abstract


Virtual screening and statistical analysis in the design of new caffeine analogues molecules with potential epithelial anticancer activity


Josivan da Silva Costa, Karina da Silva Lopes Costa, Josiane Viana Cruz, Ryan da Silva Ramos, Luciane Barros Silva, Davi Do Socorro Barros Brasil, Carlos Henrique Tomich de Paula da Silva, Cleydson Breno Rodrigues dos Santos and Williams Jorge da Cruz Macêdo.


View Abstract


Studying Interactions of Drugs with Cell Membrane Nutrient Transporters: New Frontiers of Proteoliposome Nanotechnology


Mariafrancesca Scalise, Michele Galluccio, Lorena Pochini, Lara Console, Maria Barile, Nicola Giangregorio, Annamaria Tonazzi and Cesare Indiveri.


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Current Methods of the Circulating Tumor Cells (CTC) Analysis: A Brief Overview


Natalia Dementeva, Daria Kokova and Oleg A Mayboroda.


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Recent Advances in Targeting the HIV-1 Tat/TAR Complex


Fardokht A. Abulwerdi and Stuart FJ Le Grice.


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Mephedrone Concentrations in Cases of Clinical Intoxication


Esther Papaseit, Eulàlia Olesti, Rafael de la Torre, Marta Torrens and Magí Farré.


View Abstract


Prevalence and surveillance of synthetic cathinones use by hair analysis: an update review


JC. Alvarez, N. Fabresse and IA Larabi.


View Abstract


Good Practices in Forensic Toxicology


Olaf H Drummer.


View Abstract


Nails in Forensic Toxicology: an Update


Renata Solimini, Adele Minutillo, Chrystalla Kyriakou , Simona Pichini, Roberta Pacifici and Francesco Paolo Busardò.


View Abstract


Method development in Forensic Toxicology


Frank T. Peters, Dirk K. Wissenbach, Francesco Paolo Busardò, Emilia Marchei and Simona Pichini.


View Abstract


Role of bradykinin in the regulation of endothelial nitric oxide synthase expression by cardiovascular drugs


Jin Bo Su.


View Abstract


“Stress” is 80 years old: From Hans Selye original paper in 1936 to recent advances in GI ulceration


Sandor Szabo, Masashi Yoshida, Janos Filakovszky and Gyorgy Juhasz.


View Abstract


LSD detection and interpretation in hair


Camille Richeval, Delphine Allorge, X. Vanhoye and Jean-michel Gaulier.


View Abstract


Overview Of Forensic Toxicology, Yesterday, Today And In The Future


Heesun Chung and Sanggil Choe.


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Interest of single hair analysis to document drug exposure: literature review and a case report involving zuclopenthixol


Nathalie Allibe, Pascal Kintz, Amandine Faure, François Paysant, Anne-Pascale Michard-Lenoir, Françoise Stanke-Labesque, Virginie Scolan and Hélène Eysseric-Guerin.


View Abstract


Icariin Attenuates Interleukin-1β-Induced Inflammatory Response in Human Nucleus Pulposus Cells


Wen-bin Hua, Yu-kun Zhang, Xing-huo Wu, Liang Kang, Ji Tu, Kang-cheng Zhao, Shuai Li, Kun Wang, Yu Song, Rong-jin Luo, Zeng-wu Shao and Cao Yang.


View Abstract


Sialidases: Therapeutic and Antiatherogenic Potential


Vasily Nikolaevich Sukhorukov , Vasily Petrovich Karagodin , Emile Rustemovich Zakiev , Andrey Vyacheslavovich Grechko and Alexandr Nikolaevich Orekhov.


View Abstract


Tumor Targeting of Polymeric Nanoparticles Conjugated with Peptides, Saccharides, and Small Molecules for Anticancer Drugs


Banu Bayram, Aykut Özgür, Lütfi Tutar and Yusuf Tutar.


View Abstract


Why Not All Hypertensive Patients Are Tachycardic at Rest?


Maciej Siński, Piotr Jędrusik and Jacek Lewandowski.


View Abstract


Role of Protein Kinases and Their Inhibitors in Radiation Response of Tumor Cells


Byeong Mo Kim, Wonsuck Yoon, Jung-Hyun Shim, Haiyoung Jung, Ji Hong Lim, Hyun-Jung Choi, MiRan Seo, Tae Ho Lee and Sang-Hyun Min.


View Abstract


How to treat patients with essential hypertension and peripheral arterial disease.


Salvatore Santo Signorelli.


View Abstract


Anthocyanins: Possible role as Multitarget therapeutic agents for prevention and therapy of chronic diseases


Swathi Putta, Nagendra Sastry Yarla, Ilaria Peluso, Dinesh Kumar Tiwari, Gorla V.Reddy, Priyanka Voori Giri, Naresh Kumar, Ramarao Malla, Veera Brahma Chari, Rama Sekhara Reddy D, Ramesh Bade, Mastan Mannarapu, George Barretto, Da-Yong Lu, Vadim V. Tarasov, Vladimir N. Chubarev, Frederico Fávaro Ribeiro, Luciana Scotti, Marcus T. Scotti, M. A.Kamal, Gjumrakch Aliev, Chinthalapally V. Rao, George Perry and Anupam Bishayee.


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Synthesis and biological evaluation of new tyrosol-salicylate derivatives as potential anti-inflammatory agents


Rafael P. Aguiar, Fahad S. Aldawsari, Luiz A. M. Wiirzler, Saulo E. Silva- Filho, Francielli M. S. Silva-Comar, Ciomar A. Bersani-Amado, Carlos A. Velázquez-Martínez and Roberto K N Cuman.


View Abstract


Nanovesicular formulations for cancer gene therapy


Lorena Tavano, Elisabetta Mazzotta and Rita Muzzalupo.


View Abstract


Long-lasting insulin treatment via a single subcutaneous administration of liposomes in thermoreversible Pluronic® F127 based hydrogel


Xiaoyu Chen, Blenda Chi Kwan Wong, Hubiao Chen, Shiping Zhang, Zhaoxiang Bian, Ge Zhang, Congcong Lin, Muhammad Kashif Riaz, Deependra Tyagi, Aiping Lu and Zhijun Yang.


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Anti-cancer drug delivery using carbohydrate-based polymers


Javad Ranjbari, Ahad Mokhtarzadeh, Abbas Alibakhshi, Maryam Tabarzad, Maryam Hejazi and Mohammad Ramezani.


View Abstract


Percutaneous treatment of aortic valve disease: contemporary overview and future trends


Marko Banovic, Jozef Bartunek, Serge D. Nikolic, Vladan Vukcevic, Srdjan Aleksandric and Bernard Iung.


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Approaches of the transcriptomic analysis in astrocytes: Potential pharmacological targets


George E. Barreto , Rosa M. Gómez, Rosa Helena Bustos, Diego A. Forero, Gjumrakch Aliev, Jerzy Leszek, Valentina Echeverria and Janneth Gonzalez.


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Synthesis and characterization of a new benzo indole derivative with apoptotic activity against colon cancer cells


Fatemeh Hajiaghaalipou, Fadhil Lafta Faraj, Elham Bagheri, Hamid Khaledi, Hapipah Mohd Ali, Nazia Abdul Majid and Mahmood Ameen Abdulla.


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Diabetes-related neurological implications and pharmacogenomics


Rojas Carranza Camilo Andrés, Bustos Cruz Rosa Helena, Pino Pinzón Carmen Juliana , Ariza Marquez Yeimy Viviana, Gómez Bello Rosa Margarita and Cañadas Garre Marisa.


View Abstract


Medicinal plants as protective strategies against Parkinson’s Disease


Natalia Areiza Mazo, Valentina Echeverria, Ricardo Cabezas, Marco Ávila-Rodriguez, Gjumrakch Aliev, Jerzy Leszek and George E Barreto.


View Abstract


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