ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)


Volume 20, 42 Issues, 2014


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Current Pharmaceutical Design

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  • 65th of 261 in Pharmacology & Pharmacy

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Editor-in-Chief:
William A. Banks
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Current: 3.311
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Upcoming Articles (E-Pub Abstracts ahead of Print)

SPARC in Tumor Pathophysiology and as a Potential Therapeutic Target
Liling Tang and Jianguo Feng
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Vitamin D3, D2 and Arterial Wall Properties in Coronary Artery Disease
Gerasimos Siasos, Dimitris Tousoulis, Evangelos Oikonomou, Konstantinos Maniatis, Stamatios Kioufis, Eleni Kokkou, Marina Zaromitidou, Eva Kassi, Antigoni Miliou and Christodoulos Stefanadis
View Abstract
PET Radioligands for in Vivo Visualization of Neuroinflammation
Dieter Ory, Sofie Celen, Alfons Verbruggen and Guy Bormans
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Models And Methods In Cardiac Imaging For Metabolism Studies
M F Santarelli, N Martini, P Positano and L Landini
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Hyperpolarized Metabolic MR in the Study of Cardiac Function and Disease
M. H. Lauritzen, L. V. Sogaard, P. L. Madsen and J. H. Ardenkjaer-Larsen
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Cardiological Ultrasound Imaging
Johan M. Thijssen and Chris L. de Korte
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Imaging of Organ Metabolism in Obesity and Diabetes: Treatment Perspectives
J Hannukainen, MA Guzzardi, KA Virtanen, E Sanguinetti, P Nuutila and P Iozzo
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Treating Arterial Stiffness in Young and Elderly Patients with the Metabolic Syndrome
Konstantinos Tziomalos, Vasilios G. Athyros and Asterios Karagiannis
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New Insight into Urate-Related Mechanism of Cardiovascular Damage
Davide Grassi, Giovambattista Desideri and Claudio Ferri
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Modification of Lifestyle Factors are Needed to Improve the Metabolic Health of Patients with Cardiovascular Disease Risk
Linda Landini
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Effects of Remifentanil on the Cardiac Conduction System. Our Experience in the Study of Remifentanil Electrophysiological Properties
Brezo B. Del Blanco Narciso, Concepción Jimeno, Jesús Almendral Garrote and M Jose Anadon Baselga
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Study on Gluco-Regulatory Potential of Glimepiride Sulfonamide using in Silico, in Vitro and in Vivo Approaches
Hamendra Singh Parmar, Mahesh Kumar Bhinchar, Muskan Bhatia, Nikita Chordia, Ishan Raval, Digvijay Singh Chauhan, E. Manivannan, Rameshwar Jatwa and Anil Kumar
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Activated Immune System and Inflammation in Healthy Ageing: Relevance for Tryptophan and Neopterin Metabolism
Lucile Capuron, Simon Geisler, Katharina Kurz, Friedrich Leblhuber, Barbara Sperner-Unterweger and Dietmar Fuchs
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Pain and Obesity in the Older Adult
Robert Taylor, Joseph V. Pergolizzi, Robert B. Raffa, Srinivas Nalamachu and Philip J. Balestrieri
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Beyond Acetylcholinesterase Inhibitors for Treating Alzheimer's Disease: 7-nAChR Agonists in Human Clinical Trials
Patrizia Russo, Alessandra Del Bufalo, Alessandra Frustaci, Massimo Fini and Alfredo Cesario
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Use of Trastuzumab for Breast Cancer: the Role of Age
Walter Mazzucco, Marta Rossi, Rosanna Cusimano, Matteo Franchi, Martina Bonifazi, Alessandro Mistretta, Francesco Vitale, Walter Ricciardi, Eva Negri, Stefania Boccia and Carlo La Vecchia
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Determinants of Longevity: Genetics, Biomarkers and Therapeutic Approaches
Juulia Jylhava
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MicroRNA Therapeutics in Neurological Disease
David S. Greenberg and Hermona Soreq
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P4 Medicine Needs P4 Education
Alfredo Cesario, Charles Auffray, Patrizia Russo and Leroy Hood
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Therapeutic Application of Intrabodies Against Age-Related Neurodegenerative Disorders
Alessio Cardinale, Daniela Merlo, Paolo Giunchedi and Silvia Biocca
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Hyper-Longevity, a Late-Modern Paradigm for Understanding Longevity and Ageing in Western Developed Globalised Countries
Roberto Alzetta
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Biological Carrier Molecules of Radiopharmaceuticals for Molecular Cancer Imaging and Targeted Cancer Therapy
A Aerts, N Impens, M Gijs, M D’Huyvetter, H Vanmarcke, B Ponsard, T Lahoutte, A Luxen and S Baatout
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Metabolic Reprogramming of Human Cells in Response to Oxidative Stress: Implications in the Pathophysiology and Therapy of Mitochondrial Diseases
Yu-Ting Wu, Shi-Bei Wu and Yau-Huei Wei
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Phytoestrogens and Mitochondrial Biogenesis in Breast Cancer. Influence of Estrogen Receptors Ratio
Pilar Roca, Jorge Sastre-Serra, Mercedes Nadal-Serrano, Daniel Gabriel Pons, M del Mar Blanquer-Rossello and Jordi Oliver
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Mitochondrial Biogenesis: Regulation By Endogenous Gases during Inflammation and Organ Stress
Hagir B. Suliman and Claude A. Piantadosi
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Mitochondrial Biogenesis in Health and Disease. Molecular and Therapeutic Approaches
Sanchis-Gomar Fabian, García Giménez, José Luis, Gómez Cabrera, Mari Carmen and V Federico Pallardo
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Healthspan and Longevity in Mammals: A Family Game for Cellular Organelles?
Enzo Nisoli and Alessandra Valerio
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Regulation And Quantification Of Cellular Mitochondrial Morphology And Content
Karl J. Tronstad, Marco Nooteboom, Linn I. H. Nilsson, Julie Nikolaisen, Maciek Sokolewicz, Sander Grefte, Ina K.N. Pettersen, Sissel Dyrstad, Fredrik Hoel, Peter H.G.M. Willems and Werner J.H. Koopman
View Abstract
Mitochondria: Prospective Targets for Neuroprotection in Parkinson’s Disease
Anuradha Yadav, Swati Agrawal, Shashi Kant Tiwari and Rajnish K. Chaturvedi
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Editorial : Targeting vascular calcification: Up-date
Yuri V Bobryshev
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Mechanisms of Medial Arterial Calcification in Diabetes
Dimitry A. Chistiakov, Igor A. Sobenin, Alexander N. Orekhov and Yuri V. Bobryshev
View Abstract
Mechanisms of Vascular Calcification and Associated Diseases
Juliana Marulanda, Saleh Alqarni and Monzur Murshed
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New Therapeutic Approaches to Arterial Calcification Via Inhibition of Transglutaminase and B-Catenin Signaling
Mikhail Konoplyannikov and Maria Nurminskaya
View Abstract
Abdominal Aortic Calcification: Clinical Significance, Mechanisms and Therapies
Jonathan Golledge
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Vascular Calcification in Chronic Kidney Disease: Role of Disordered Mineral Metabolism
Shyamal Palit and Jessica Kendrick
View Abstract
Blood Serum Atherogenicity and Coronary Artery Calcification
Igor A. Sobenin, Veronica A. Myasoedova, Elena V. Anisimova, Xenia N. Pavlova, Stefan Möhlenkamp, Axel Schmermund, Rainer Seibel, Sina Berenbein, Nils Lehmann, Susanne Moebus, Jöckel Karl-Heinz, Alexander N. Orekhov and Raimund Erbel
View Abstract
Circulating Cellular Players in Vascular Calcification
Mattia Albiero, Angelo Avogaro and Gian Paolo Fadini
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Editorial : Novel Insights into the Role of Anesthetics and Opioids in Organ or Tissue Protection
Hiroyuki Kinoshita
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Mechanistic View of Renal Protective Action of Calcium Channel Blockade
N Sugano
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Editorial: Crosstalk between the nervous and the immune systems in health and sickness
Monica De la Fuente
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The Pivotal Role of Nitric Oxide: Effects on the Nervous and Immune Systems
Milagros Rocha, Susana Rovira-Llopis, Jose R Herance, Celia Bañuls, Miriam Polo, Ana Blas-Garcia, Antonio Hernandez-Mijares and Victor M Victor
View Abstract
Role of the Endocannabinoid System in the Neuroendocrine Responses to Inflammation
Andrea De Laurentiis, Hugo A. Araujo and Valeria Rettori
View Abstract
Physiology And Therapeutic Potential Of The Thymic Peptide Thymulin
Paula C. Reggiani, Jose I. Schwerdt, Gloria M. Console, Eduardo A. Roggero, Mireille Dardenne and Rodolfo G. Goya
View Abstract
The Effect of Psychological Stress and Social Isolation on Neuroimmunoendocrine Communication
Julia Cruces, César Venero, Inmaculada Pereda-Pérez and Mónica De la Fuente
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Crosstalk Between Behavior and Immune System During the Prodromal Stages of Alzheimer’s Disease
Lydia Giménez-Llort, Virginia Torres-Lista and Mónica De la Fuente
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Neuroendocrine Stimulation Of Mucosal Immune Cells In Inflammatory Bowel Disease
Jose M. Martin-Villa
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Neuroimmune Interactions And Psychologycal Stress Induced By Cohabitation With A Sick Partner: A Review
Joao Palermo-Neto and Glaucie Jussilane Alves
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Physiologic Versus Diabetogenic Effects of Interleukin-1: a Question of Weight
Hugo O. Besedovsky and Adriana del Rey
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Host Neuro- Immuno-Endocrine Responses In Periodontal Disease
Elisa Rettori, Andrea De Laurentiis, W. Les Dees, Axel Endruhn and Valeria Rettori
View Abstract
Neuroimmune aspects of Sjögren´s Syndrome: Role of VIP/VPAC System in Immune and Salivary Gland Epithelial Cell Function
Hauk Vanesa, Calafat Mario, Grasso Esteban, Fraccaroli Laura, Paparini Daniel, Ramhorst Rosanna and Perez Leiros Claudia
View Abstract
Inflammation, Infection and Preterm Birth
Juliana Burdet, Ana Paula Dominguez Rubio, Ana Ines Salazar, Maria Laura Ribeiro, Cristina Ibarra and Ana M. Franchi
View Abstract
Increase of Oxidation and Inflammation in Nervous and Immune Systems with Aging and Anxiety
Carmen Vida, Eva M Gonzalez and Monica De la Fuente
View Abstract
Chronobiology of the Neuroimmunoendocrine System and Aging
Ianire Mate, Juan Antonio Madrid and Mónica De la Fuente
View Abstract
Genistein Inhibits Cell Growth and Invasion Through Regulation of MiR-27a in Pancreatic Cancer Cells
Jun Xia, Long Cheng, Chuanzhong Mei, Jia Ma, Ying Shi, Fanpeng Zeng, Zhenghuan Wang and Zhiwei Wang
View Abstract
MicroRNAs (miRNA) as Biomarker(s) for Prognosis and Diagnosis of Gastrointestinal (GI) Cancers
Muzafar A. Macha, Parthasarathy Seshacharyulu, Shiv Ram Krishn, Priya Pai, Satyanarayana Rachagani, Maneesh Jain and Surinder K. Batra
View Abstract
Oncogenic MicroRNAs in the Genesis of Leukemia and Lymphoma
Yanyan Pan, Mei Meng, Gaochuan Zhang, Hongyan Han and Quansheng Zhou
View Abstract
MicroRNAs in Cancer Stem Cells: New Regulators of Stemness
Fei Xing, Kerui Wu and Kounosuke Watabe
View Abstract
MicroRNAs in Breast Cancer Therapy
Joy Tang, Aamir Ahmad and Fazlul H. Sarkar
View Abstract
MiRNAs in Human Cancers: The Diagnostic and Therapeutic Implications
Qiong Wu, Zhiping Yang, Yongquan Shi and Daiming Fan
View Abstract
The miRNAs and Epithelial-Mesenchymal Transition in Cancers
Lin Ching-Wen, Kao Shih-Han and Yang Pan-Chyr
View Abstract
Arsenic Trioxide Targets miR-125b in Glioma Cells
Sulian Chen, Lihua Zhu, Jing Huang, Ying Cai, Xiaohui Lu, Qingling Yang, Qiong Wu, Changjie Chen and Zhiwei Wang
View Abstract
Regulation of KRAS–PAK4 Axis by MicroRNAs in Cancer
Zeshan S. Choudhry, Vraj Tripathi, Mike Sutton, Bin Bao, Ramzi M. Mohammad and Asfar S. Azmi
View Abstract
Assessing Schizophrenia-Relevant Cognitive and Social Deficits in Mice: a Selection of Mouse Behavioral Tasks and Potential Therapeutic Compounds
Wen-Sung Lai, Chia-Yuan Chang, Wan-Rong Wong, Ju-Chun Pei, Ya-Shan Chen and Wei-li Hong
View Abstract
Frontal Lobe Synaptic Plasticity in Development and Disease: Modulation by the Dopamine D1 Receptor
Lynn D. Selemon
View Abstract
The Co-Agonist Site of NMDA-Glutamate Receptors: a Novel Therapeutic Target for Age-Related Cognitive Decline
Rogério Panizzutti, Linda Scoriels and Marcos Avellar
View Abstract
NMDA Neurotransmission Dysfunction in Mild Cognitive Impairment and Alzheimer’s Disease
Chieh-Hsin Lin, Yu-Jhen Huang, Hsien-Yuan Lane and Guochuan E. Tsai
View Abstract
Predicting Protein-Ligand Interactions Based on Chemical Preference Features with its Application to New D-Amino Acid Oxidase Inhibitor Discovery
Mingzhu Zhao, Hao-Teng Chang, Qiang Zhou, Tao Zeng, Zhi-Ping Liu, Luonan Chen and Dong-Qing Wei
View Abstract
Inhibitory Effects of Water Caltrop Pericarps on the Growth of Human Gastric Cancer Cells In Vitro
Qiusheng Lin, Junhui Shen, Ying Ning, Shengrong Shen and Undurti N. Das
View Abstract
Editorial: Current Pro-Cognitive Therapeutic Strategies for Improved Pharmacological Treatment in Schizophrenia
G Wadenberg Marie-Louise
View Abstract
The Attentional Set-Shifting Test Paradigm in Rats for the Screening of Novel Pro-Cognitive Compounds with Relevance for Cognitive Deficits in Schizophrenia
Pascal Jean Denis Goetghebeur and Rebecca Dias
View Abstract
The Role of α5 GABAA Receptor Agonists in the Treatment of Cognitive Deficits in Schizophrenia
Kathryn M. Gill and Anthony A. Grace
View Abstract
Editorial: Managing the Cardiovascular Risk Associated with the Metabolic Syndrome
Giuseppe Montalto, Manfredi Rizzo and Dimitri P. Mikhailidis
View Abstract
Beneficial Effects of the Mediterranean Diet on Metabolic Syndrome
Giuseppe Grosso, Antonio Mistretta, Stefano Marventano, Agata Purrello, Paola Vitaglione, Giorgio Calabrese, Filippo Drago and Fabio Galvano
View Abstract
Pharmacologic Therapy for Cardiovascular Risk Reduction in Patients with the Metabolic Syndrome
Ioanna Gouni-Berthold and Heiner K. Berthold
View Abstract
The Metabolic Syndrome and Chronic Liver Disease
Matteo Rosselli, Sophie Lotersztajn, Francesco Vizzutti, Umberto Arena, Massimo Pinzani and Fabio Marra
View Abstract
The Metabolic Syndrome and HIV Infection
Valentina Li Vecchi, Paolo Maggi, Manfredi Rizzo and Giuseppe Montalto
View Abstract
The Role of the Heme Oxygenase System in the Metabolic Syndrome
Ignazio Barbagallo, Anna Nicolosi, Giorgio Calabrese, Sabrina David, Sebastiano Cimino, Massimo Madonia and Francesco Cappello
View Abstract
Resistin: An Inflammatory Cytokine. Role In Cardiovascular Diseases, Diabetes And The Metabolic Syndrome
Nicola Abate, Hanaa S. Sallam, Manfredi Rizzo, Dragana Nikolic, Milan Obradovic, Predrag Bjelogrlic and Esma R. Isenovic
View Abstract
Metabolic Syndrome and Non-Cardiac Vascular Diseases: an Update from Human Studies
Niki Katsiki, Vasilios G. Athyros, Asterios Karagiannis and Dimitri P. Mikhailidis
View Abstract
Editorial: Targeting Neuregulin1 and ErbB Receptor Tyrosine Kinases for Therapy of Breast Cancer and Heart Failure
Xinhua Yan
View Abstract
Editorial: From gut inflammation to gastrointestinal disorders Current update on pathophysiology, molecular mechanism and pharmacological treatment modalities
Predrag Sikiric
View Abstract
The Developing Role of Neuregulin1 In Cardiac Regenerative Stem Cell Therapy
Christopher P. Blomberg, Juyong Lee and James P. Morgan
View Abstract
Neuregulin Signaling in Pieces—Evolution of the Gene Family
Mark A. Marchionni
View Abstract
Heregulin in Breast Cancer: Old Story, New Paradigm
Ashwani Khurana, Anatilde Gonzalez-Guerrico and Ruth Lupu
View Abstract
Mathematical Modeling of Tumor Growth and Treatment
Heiko Enderling and Mark A.J. Chaplain
View Abstract
Breast Cancer Biomarkers: Risk Assessment, Diagnosis, Prognosis, Prediction of Treatment Efficacy and Toxicity, and Recurrence
Amy M. Braden, Rachel V. Stankowski, Jessica M. Engel and Adedayo A. Onitilo
View Abstract
Manifestations In Course Of Celiac Disease: Case Report And Review Of The Literature
Skroza Nevena, Proietti Ilaria, Bernardini Nicoletta, La Viola Giorgio, Mancini Maria Teresa, Nicolucci Francesca, Pampena Riccardo, Tolino Ersilia, Zuber Sara and Potenza Concetta
View Abstract
Editorial: Basic and Clinical Aspects of Melatonin in the Gastrointestinal Tract. New Advancements and Future Perspectives
Thomas Brzozowski and Jolanta Jaworek
View Abstract
Melatonin in the Biliary Tract and Liver: Health Implications
Russel J. Reiter, Sergio A. Rosales-Corral, Lucien C. Manchester, Xiaoyan Liu and Dun-Xian Tan
View Abstract
Detection of Melatonin Production from the Intestinal Epithelium using Electrochemical Methods
Paul P Bertrand, Kate E Polglaz, Rebecca L Bertrand, Shaun L Sandow and Maria J Pozo
View Abstract
The Role Of Melatonin In Pancreatic Protection: Could Melatonin Be Used In The Treatment Of Acute Pancreattis?
Jolanta Jaworek, Anna Leja-Szpak, Michalina Kot, Andrzej Jaworek, Katarzyna Nawrot-Porąbka, Joanna Bonior and Joanna Szklarczyk
View Abstract
Protective Role of Melatonin in Liver Damage
Cezary Chojnacki, Ewa Walecka-Kapica, Marek Romanowski, Jan Chojnacki and Grażyna Klupinska
View Abstract
Melatonin and Glucose Metabolism: Clinical Relevance
PJ Lardone, N Álvarez- Sánchez, JM Guerrero and A Carrillo-Vico
View Abstract
Helicobacter pylori eradication therapy: advantages and disadvantages
Justyna Bien, Maria Bozko, Nisar P. Malek and Przemyslaw Bozko
View Abstract
EDITORIAL:The Multidomain Mobility Lab in Older Persons: From Bench to Bedside
Marcello Maggio, Gian Paolo Ceda and Fulvio Lauretani
View Abstract
Role of brain NUCB2/nesfatin-1 in the regulation of food intake
Andreas Stengel and Yvette Taché
View Abstract
Regulation of Gastric Nesfatin-1/NUCB2
Ziru Li, Michael Mulholland and Weizhen Zhang
View Abstract
Discovery of Nesfatin-1 and Overview of Biological Actions and New Developments
Masatomo Mori, Masanobu Yamada, Shuichi Okada, Koshi Hashimoto, Tesurou Satoh, Hiroyuki Shimizu and Toshihiko Yada
View Abstract
Role of NUCB2/nesfatin-1 in glucose control: diverse functions in islets, adipocytes and brain
Masanori Nakata and Toshihiko Yada
View Abstract
Central and peripheral expression and distribution of NUCB2/nesfatin-1
Miriam Goebel-Stengel and Lixin Wang
View Abstract
Role of NUCB2/nesfatin–1 as a possible biomarker
Suleyman Aydin
View Abstract
Editorial: Rational Design of Antiviral Compounds
Vladimir Frecer and Stanislav Miertus
View Abstract
EDITORIAL Advances in Computational Structure Based Drug Discovery
Gergely Tóth
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Editorial Cardio-Metabolic Complications: Current Perspective and Future Developments.
Joseph Fomusi Ndisang
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EDITORAL Novel strategies for cardiac repair post-myocardial infarction
Simeon Agathopoulos and Theofilos M. Kolettis
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EDITORIAL: NEUROBIOLOGICAL AND NEUROCOGNITIVE BASIS OF THE EFFECTS OF CANNABINOIDS IN ANIMALS AND MAN: THERAPEUTIC POTENTIAL OF CANNABINOIDS IN PSYCHIATRY
Sagnik Bhattacharyya
View Abstract
Dietary Interventions for Atopic Disorders
Despoina Mavrommati and Theoharis C. Theoharides
View Abstract
Editorial Leptin and the cardiovascular system – a target for therapeutic interventions
Jerzy Bełtowski
View Abstract
EDITORIAL Structure-based Drug Design: Strategies and Challenges
Guang-Fu Yang
View Abstract
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