ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)


Volume 22, 46 Issues, 2016


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Current Pharmaceutical Design

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  • 62nd of 254 in Pharmacology & Pharmacy

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Upcoming Articles (E-Pub Abstracts ahead of Print)

NEURONAL ACETYLCHOLINE NICOTINIC RECEPTORS AS NEW TARGETS FOR LUNG CANCER TREATMENT


Vanessa Mucchietto, Arianna Crespi, Francesca Fasoli, Francesco Clementi and Cecilia Gotti.


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Xanthine oxidase pathway and muscle damage. Insights from McArdle disease


Helios Pareja-Galeano, Alejandro Santos-Lozano, María Morán, Fabian Sanchis-Gomar, Rafael Alis, Alfredo Santalla, Alejandro F. San Juan, Jorge Díez, Miguel Ángel Martín, Joaquín Arenas and Alejandro Lucia.


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MicroRNA-208a Potentiates Angiotensin II-triggered Cardiac Myoblasts Apoptosis via Inhibiting Nemo-like kinase (NLK)


Ying Huang, Yang Yang, Yong He, Cheng Huang, Xiaoming Meng and Jun Li.


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Inhaled biologics: from preclinical to product approval


Kristin Fathe, Silvia Ferrati, Daniel Moraga-Espinoza, Ash Yazdi and Hugh D C Smyth.


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Mitochondrial Signaling And Hepatocellular Carcinoma: Molecular Mechanisms And Therapeutic Implications


Antonio Facciorusso, Rosanna Villani, Francesco Bellanti, Domenica Mitarotonda, Gianluigi Vendemiale and Gaetano Serviddio.


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Use of lipoprotein like nanoparticles used in drug and gene delivery


Jaleh Varshosaz, Hamed Vakilzadeh and Erfaneh Ghassami.


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Nanoparticles Based on Plasma Proteins for Drug Delivery Applications


Ayşen Tezcaner, Erkan Türker Baran and Dilek Keskin.


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Dextran-based Nanocarriers for Delivery of Bioactives


Rania A.H. Ishak, Rihab Osman and Gehanne AS Awad.


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Advances on magnetic nanocarriers based on natural polymers.


Rita Muzzalupo and Lorena Tavano.


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Mitochondrial dysfunction and endoplasmic reticulum stress in diabetes


Milagros Rocha, Noelia Diaz-Morales, Susana Rovira-Llopis, Irene Escribano-Lopez, Celia Bañuls, Antonio Hernandez-Mijares, Evanthia Diamanti-Kandarakis and Victor M Victor.


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Bioactivity of Hybrid Polymeric Magnetic Nanoparticles and Their Applications in Drug Delivery


Leena Mohammed, Doaa Ragab and Hassan Gomaa.


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Natural polymeric nanoparticles for brain-targeting: Implications on drug and gene delivery


Ahmed O. Elzoghby, Mahmoud M. Abd-Elwakil, Kholod Abd-Elsalam, Mustafa T. Elsayed, Yosra Hashem and Ola Mohamed.


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The prominent role of protein-based delivery systems on the development of cancer treatment


Hasan Kouchakzadeh, Seyed and Abbas Shojaosadati.


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Site-Specific Thiol-mediated PEGylation of Streptokinase Leads to Improved Properties with Clinical Potential


Pooja Sawhney, Shekhar Kumar, Neeraj Maheshwari, Sumeet Singh Guleria, Neelam Dhar, Radhika Kashyup and Girish Sahni.


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Endoplasmic reticulum and mitochondria: independent roles and crosstalk in fatty liver diseases and hepatic inflammation


Ana Blas-García, Nadezda Apostolova, Victoria Valls-Bellés and Juan V Esplugues.


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Macrocyclic Compounds: Emerging Opportunities for Current Drug Discovery


Lisha You, Rui An, Kun Liang, Bo Cui and Xinhong Wang.


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THERMODYNAMIC AND KINETIC ASPECTS INVOLVED IN THE DEVELOPMENT OF NANOCARRIERS AND DRUG DELIVERY SYSTEMS BASED ON CATIONIC IOPOLYMERS


Ismael D. Bianco, Roxana V. Alasino, Victoria Leonhard and Dante M Beltramo.


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Biomimetic approach to stimulate osteogenesis on titanium implant surfaces using fibronectin derived oligopeptide


Young-Dan Cho, Sung-Jun Kim, Han-Sol Bae, Won-Joon Yoon, Kyung-Hwa Kim, Hyun-Mo Ryoo, Yang-Jo Seol, Yong-Moo Lee, In-Chul Rhyu and Young Ku.


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Aptamers to hemagglutinin: a novel tool for influenza virus recognition and neutralization


Elena Zavyalova and Alexey Kopylov.


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Pharmacotherpy and Alzheimer’s disease: The M-drugs (Melatonin, Minocycline, Modafinil, and Memantine) Approach


Mak Adam Daulatzai.


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Dendritic Cells in Colorectal Cancer and a Potential for their Use in Therapeutic Approaches


Dimitry A. Chistiakov, Alexander N. Orekhov and Yuri V Bobryshev.


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Scaffolds for bone regeneration: state of the art


M. Moreno, M.H. Amaral, J.M. Sousa Lobo and AC Silva.


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The heat stress response and diabetes: more room for mitochondrial implication


Biljana Miova, Maja Dimitrovska, Suzana Dinevska-Kjovkarovska, Juan V. Esplugues and Nadezda Apostolova.


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In Vitro Pulmonary Cell Culture in Pharmaceutical Inhalation Aerosol Delivery: 2-D, 3-D, and In Situ Bioimpactor Models.


Maria F. Acosta, Priya Muralidharan, Samantha A. Meenach, Don Hayes Jr., Stephen M. Black and Heidi M Mansour.


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Activation of the dsRNA-Activated Protein Kinase PKR in Mitochondrial Dysfunction and Inflammatory Stress in Metabolic Syndrome


Neetu Sud, Angela C. Rutledge, Kaichao Pan and Qiaozhu Su.


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Thermostable Subunit Vaccines for Pulmonary Delivery: How Close Are We?


Camilla Foged.


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Mitochondrial proteases as emerging pharmacological targets


Lara Gibellini, Sara De Biasi, Milena Nasi, Anna Iannone, Andrea Cossarizza and Marcello Pinti.


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Αlpha-2 adrenergic and opioids receptors participation in mice gastroprotection of Abelmoschus esculentus lectin


Kátia A. Ribeiro, Hellíada V. Chaves, Samuel Mateus Pereira Filho, Isabela Ribeiro Pinto, Dina Andressa Martins Monteiro, Samuel Oliveira Matos, Tatiane Santi-Gadelha, Carlos Alberto de Almeida Gadelha, José Thalles Jocelino Gomes de Lacerda, Lissiana M. V. Aguiar, Karuza M. A. Pereira, Norma M. B. Benevides, Vicente de Paulo T. Pinto, Gerardo Cristino Filho, Mirna M. Bezerra and Antonio A R Silva.


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Prospects of Developing Medicinal Therapeutic Strategies and Pharmaceutical Design for Effective Gluten Intolerance Treatment


Lyudmila V. Savvateeva and Andrey A Zamyatnin Jr.


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Allosteric modulation of nicotinic acetylcholine receptors: the concept and therapeutic trends.


Victor V Uteshev.


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Opportunities and Challenges for Host-Directed Therapies in Tuberculosis


Madhur Sachan, Ashish Srivastava, Rajeev Ranjan, Anuradha Gupta, Sanketkumar Pandya and Amit Misra.


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Dry powder form of polymeric nanoparticles for pulmonary drug delivery


Farideh Shiehzadeh and Mohsen Tafaghodi.


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Pharmacokinetic considerations of inhaled pharmaceuticals for systemic delivery


Xiao Hu, Fei-Fei Yang and Yong-Hong Liao.


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Selected Engineering and Physicochemical Aspects of Systemic Drug Delivery by Inhalation


Tomasz R Sosnowski.


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Aerosol Processing of Crumpled Graphene Oxide-based Nanocomposites for Drug Delivery


Wei-Ning Wang and Xiang He.


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Large Porous Hollow Particles: Lightweight Champions of Pulmonary Drug Delivery


Sachin Gharse and Jennifer Fiegel.


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The role of anionic polysaccharides in the preparation of nanomedicines with anticancer applications”.


Ana M. Martínez, Marta Benito, Elena Pérez, José María Teijón and María Dolores Blanco.


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Neuroprotective Strategies in Glaucoma


CA Gossman, J Christie, MK Webster, DM Linn and CL Linn.


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Cholinergic Targets in Lung Cancer


Eliot R Spindel.


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The recent development of α7 nicotinic acetylcholine receptor (nAChR) ligands as therapeutic candidates for the treatment of central nervous system (CNS) diseases


Corinne Beinat, Samuel D. Banister, Marco Herrera and Michael Kassiou.


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THE CHOLINERGIC SYSTEM: AN EMERGING DRUG TARGET FOR SCHIZOPHRENIA


Andrew Gibbons and Brian Dean.


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Targeting Functional Biomarkers in Schizophrenia with Neuroimaging


Korey P. Wylie, Jason Smucny, Kristina T. Legget and Jason R Tregellas.


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Serotonergic and cholinergic strategies as potential targets for the treatment of schizophrenia.


Agnieszka Nikiforuk.


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Targeting The Cholinergic System For Neuroprotection And/Or Enhancement Of Functional Recovery Following Neurotrauma


Kathleen B. Germany, Victor V. Uteshev and James R Pauly.


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Serotonergic Drugs: Agonists/Antagonists at Specific Serotonergic Subreceptors for the Treatment of Cognitive, Depressant and Psychotic Symptoms in Alzheimer’s Disease


Felix-Martin Werner and Rafael Coveñas.


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Desformylflustrabromine: A novel positive allosteric modulator for beta2 subunit containing nicotinic receptor sub-types.


Anshul A Pandya.


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The Role Of α7 Nicotinic Acetylcholine Receptors And α7-Specific Antibodies In Neuroinflammation Related To Alzheimer Disease


Maryna Skok and Olena Lykhmus.


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Nicotinic acetylcholine receptors in the pathophysiology of Alzheimer’s disease: The role of protein-protein interactions in current and future treatment


Morten Skøtt Thomsen, Jesper Tobias Andreasen, Maria Arvaniti and Kristi Anne Kohlmeier.


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Role of Nicotinic and Muscarinic Receptors on Synaptic Plasticity and Neurological Diseases


Marco Fuenzalida, Miguel Ángel Pérez and Hugo R Arias.


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Regulation of Gait and Balance: The Underappreciated Role of Neuronal Nicotinic Receptor Agonists


Michael F. Young and Lynn Wecker.


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The cholinergic potential, the vagus nerve and challenges in treatment of traumatic brain injury


Victor V. Uteshev, Olli Tenovuo and Nikhil Gaidhani.


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Obstacles and opportunities for cholinergic drug development in the treatment of cognitive disorders


Rachel A. Schroeder, Lynn Wecker and Rex M Philpot.


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Albumin-Based Nanodevices as Drug Carriers


Ana Loureiro, Nuno G. Azoia, Andreia C. Gomes and Artur Cavaco-Pauloa.


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Liposome-Nanogel Structures for Future Pharmaceutical Applications: An Updated Review


Sergey Kazakov.


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Statins and Type 2 Diabetes Mellitus: An Update After 1 Year


Niki Katsiki, Vasilios G. Athyros, Asterios Karagiannis and Dimitri P Mikhailidis.


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Insights into Effects of Ellagic Acid on the Nervous System: A Mini Review


Touqeer Ahmed, William N. Setzer, Seyed Fazel Nabavi, Ilkay Erdogan Orhan, Nady Braidy, Eduardo Sobarzo-Sanchez and Seyed Mohammad Nabavi.


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Opioid and Cannabinoid System in Food Intake


Dorota Katarzyna Pomorska, Jean-Claude do-Rego, Jean-Luc do-Rego, Maria Zubrzycka and Anna Janecka.


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Editorial: The Kynurenine and Melatonergic Pathways in Psychiatric and CNS Disorders


George Anderson.


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Pathophysiology of Metastatic Bone Disease and the Role of the Second Generation of Bisphosphonates:From Basic Science to Medicine


Reham F. Barghash and Wafaa M Abdou.


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Multiple Roles of Biosurfactants in Biofilms


Surekha K. Satpute, Arun G. Banpurkar, Ibrahim M. Banat, Jaiprakash N Sangshetti, Rajendra R. Patil and Wasudev N Gade.


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Nanomaterials in the pharmaceuticals: Occurrence, behaviour and applications


Imran Uddin, Siddarthan Venkatachalam, Arka Mukhopadhyay and Mohd Amil Usmani.


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Natural Product-Based Antibiotics: Synthesis and SAR-Studies.


Evgeny V Prusov.


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Mycobacterium tuberculosis-secreted tyrosine phosphatases as targets against tuberculosis: exploring natural sources in searching for new drugs


Alessandra Mascarello, Louise Domeneghini Chiaradia-Delatorre, Mattia Mori, Hernán Terenzi and Bruno Botta.


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One hundred faces of cyclopamine


Valentina Iovine, Mattia Mori, Andrea Calcaterra, Simone Berardozzi and Bruno Botta.


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Synthesis of Tetracyclic Diterpenoids with Pharmacologic Relevance


Miroslav Sisa and Tomas Vanek.


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Biomimetic Approaches Towards The Synthesis of Complex Dimeric Natural Products


Paul A. Stanley, Christian Spiteri, Jonathan C. Moore, Andrew S. Barrow, Pallavi Sharma and John E Moses.


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Transcatheter aortic valve implantation infective endocarditis: Current data and implications on prophylaxis and management


Jeremy Ben-Shoshan, Sharon Amit and Ariel Finkelstein.


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Mechanisms And Prevention Of TAVI-Related Cerebrovascular Events


Alexander Ghanem, Amir S. Naderi, Christian Frerker, Georg Nickenig and Karl-Heinz Kuck.


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Innovative formulations for controlled drug delivery to the lungs and the technical and toxicological challenges to overcome#


Leticia Aragão-Santiago, Adam Bohr, Mathilde Delaval, Alexandra C. Dalla-Bona, Tobias Gessler, Werner Seeger and Moritz Beck-Broichsitter.


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Relevant Physicochemical Descriptors of “Soft Nanomedicines” to Bypass Biological Barriers


Amaya Niño-Pariente, Vicent J. Nebot and María J Vicent.


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The Role of Carrier Geometry in Overcoming Biological Barriers to Drug Delivery


C. Jordan, V. V. Shuvaev, M. Bailey, V. R. Muzykantov and T D Dziubla.


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DNA-Based Drug Carriers: The Paradox of a Classical “Cargo” Material Becoming a Versatile “Carrier” to Overcome Barriers in Drug Delivery


Robert Getts and Silvia Muro.


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Journey to the Center of the Cell: Current Nanocarrier Design Strategies Targeting Biopharmaceuticals to the Cytoplasm and Nucleus


Erik V. Munsell, Nikki L. Ross and Millicent O Sullivan.


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Intracellular drug delivery: mechanisms for cell entry


Carmen Garnacho.


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Lymphatic Targeting of Nanosystems for Anticancer Drug Therapy


Raquel Abellán-Pose, Noémi Csaba and María José Alonso.


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Delivery of peptides via the oral route: diabetes treatment by peptide-loaded nanoparticles


Oriane Bouttefeux, Ana Beloqui and Véronique Préat.


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Carrier deformability in drug delivery


Maria Jose Morilla and Eder Lilia Romero.


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Transdermal drug delivery mediated by microneedle arrays: Innovations and barriers to success


Ester Caffarel-Salvador and Ryan F Donnelly.


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Nanofibre Based Smart Pharmaceutical Scaffolds For Wound Repair And Regenerations


Charu Dwivedi, Himanshu Pandey, Avinash C. Pandey and Pramod W Ramteke.


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The many neuroprogressive actions of tryptophan catabolites (TRYCATs) that may be associated with the pathophysiology of neuro-immune disorders


Gerwyn Morris, Andre Carvalho, George Anderson, Piotr Galecki and Michael Maes.


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Tryptophan Metabolites and Their Impact on Multiple Sclerosis Progression


Jens O Watzlawik, Bharath Wootla and Moses Rodriguez.


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THE KYNURENINE PATHWAY IN THE ACUTE AND CHRONIC PHASES OF CEREBRAL ISCHEMIA


MI Cuartero, J de la Parra, A García-Culebras, I Ballesteros, I Lizasoain and MA Moro.


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Overlapping the Tryptophan Catabolite (TRYCAT) and Melatoninergic Pathways in Alzheimer's Disease


Michael Maes and George Anderson.


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Melatonin attenuates methamphetamine-induced neurotoxicity


Pawaris Wongprayoon and Piyarat Govitrapong.


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Bipolar Disorder: The Role of the Kynurenine and Melatonergic Pathways


George ANDERSON, Aude JACOB, Frank BELLIVIER and Pierre Alexis GEOFFROY.


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Glioma: Tryptophan Catabolite and Melatoninergic Pathways link microRNA, 14-3-3, Chromosome 4q35, Epigenetic Processes and other Glioma Biochemical Changes


Timothy V. Beischlag, George Anderson and Gianluigi Mazzoccoli.


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Melatonin in Pregnancy: Effects on Brain Development and CNS Programming Disorders


Lucas Sagrillo-Fagundes, Eugênia Maria Assunção Salustiano, Philippe Wong Yen, Ahmed Soliman and Cathy Vaillancourt.


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The therapeutic aspects of the endocannabinoid system (ECS) for cancer and their development: from nature to laboratory


Mohammed I. Khan, Anna A. Sobocińska, Anna M. Czarnecka, Magdalena Król, Bruno Botta and Cezary Szczylik.


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Molecular Recognition of Natural Products by Resorc[4]arene Receptors


Ilaria D'Acquarica, Francesca Ghirga, Deborah Quaglio, Antonella Cerreto, Cinzia Ingallina, Andrea Tafi and Bruno Botta.


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Reactivity of Diterpenoid Quinones: Royleanones.


Diogo Ladeiras, Carlos Monteiro, Filipe Pereira, Catarina P. Reis, Carlos A. M. Afonso and Patrícia Rijo.


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Synthetic glycosides and glycoconjugates of low molecular weight natural products


G. Grynkiewicz and W Szeja.


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An update on natural products with carbonic anhydrase inhibitory activity


Anastasia Karioti, Fabrizio Carta and Claudiu T Supuran.


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Targeted drug delivery and imaging using mobile milli/microrobots: A promising future towards theranostic pharmaceutical design


Ajay Vikram Singh and Metin Sitti.


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Top-down versus bottom-up nanoengineering routes to design advanced oropharmacological products


Ajay V Singh and Krunal Mehta.


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Calcium phosphate system for gene delivery: historical background and emerging opportunities


Babak Mostaghaci, Brigitta Loretz and Claus-Michael Lehr.


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Biosystems engineering of prokaryotes with tumor-killing capacities


Ebuzer Kalyoncu, Tolga T. Olmez, Alper D. Ozkan and Omer F Sarioglu.


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Pharmacological drug delivery strategies for improved therapeutic effects: Recent advances


Reema Savaliya, Poornima Singh and Sanjay Singh.


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Fighting Diabetes: Lessons from Xenotransplantation and Nanomedicine


S Hassan, A Bhat, RR Bhonde and MA Lone.


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Gold nanomaterials: from preparation to pharmaceutical design and application


Michele Rossi, Cristina Della Pina and Ermelinda Falletta.


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Jean-Baptiste de Sénac’s (1693-1770) important work on cardiology and valvular disorders


Marianna Karamanou, Gregory Tsoucalas, Elias Gialafos, Dimitris A. Vrachatis, George Androutsos and Effie Poulakou-Rebelakou.


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Periodontitis and Periodontal Disease - innovative strategies for reversing the chronic infectious and inflammatory condition by natural products


Lazar Veronica, Crina-Maria Saviuc and Mariana Carmen Chifiriuc.


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The in-situ one-step synthesis of a PDC macromolecular pro-drug and the fabrication of a novel core-shell micell


Cui-yun Yu, Sa Yang, Zhi-ping Li, Can Huang, Qian Ning, Wen Huang, Wen-tong Yang, Dong-xiu He and Lichun Sun.


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Current And Experimental Pharmacological Approaches In Neonatal Hypoxic-Ischemic Encephalopathy


Teresa Zalewska, Joanna Jaworska and Malgorzata Ziemka-Nalecz.


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Editorial : Novel Insights into the Role of Anesthetics and Opioids in Organ or Tissue Protection


Hiroyuki Kinoshita.


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Inhibitory Effects of Water Caltrop Pericarps on the Growth of Human Gastric Cancer Cells In Vitro


Qiusheng Lin, Junhui Shen, Ying Ning, Shengrong Shen and Undurti N Das.


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Editorial: From gut inflammation to gastrointestinal disorders Current update on pathophysiology, molecular mechanism and pharmacological treatment modalities


Predrag Sikiric.


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Manifestations In Course Of Celiac Disease: Case Report And Review Of The Literature


Skroza Nevena, Proietti Ilaria, Bernardini Nicoletta, La Viola Giorgio, Mancini Maria Teresa, Nicolucci Francesca, Pampena Riccardo, Tolino Ersilia, Zuber Sara and Potenza Concetta.


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Helicobacter pylori eradication therapy: advantages and disadvantages


Justyna Bien, Maria Bozko, Nisar P. Malek and Przemyslaw Bozko.


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EDITORIAL:The Multidomain Mobility Lab in Older Persons: From Bench to Bedside


Marcello Maggio, Gian Paolo Ceda and Fulvio Lauretani.


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Role of brain NUCB2/nesfatin-1 in the regulation of food intake


Andreas Stengel and Yvette Taché.


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Role of NUCB2/nesfatin–1 as a possible biomarker


Suleyman Aydin.


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Editorial: Rational Design of Antiviral Compounds


Vladimir Frecer and Stanislav Miertus.


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EDITORIAL Advances in Computational Structure Based Drug Discovery


Gergely Tóth.


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Editorial Cardio-Metabolic Complications: Current Perspective and Future Developments.


Joseph Fomusi Ndisang.


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EDITORAL Novel strategies for cardiac repair post-myocardial infarction


Simeon Agathopoulos and Theofilos M Kolettis.


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EDITORIAL: NEUROBIOLOGICAL AND NEUROCOGNITIVE BASIS OF THE EFFECTS OF CANNABINOIDS IN ANIMALS AND MAN: THERAPEUTIC POTENTIAL OF CANNABINOIDS IN PSYCHIATRY


Sagnik Bhattacharyya.


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Editorial Leptin and the cardiovascular system – a target for therapeutic interventions


Jerzy Bełtowski.


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EDITORIAL Structure-based Drug Design: Strategies and Challenges


Guang-Fu Yang.


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