ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)


Volume 22, 46 Issues, 2016


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Current Pharmaceutical Design

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  • 62nd of 254 in Pharmacology & Pharmacy

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Editor-in-Chief:
William A. Banks
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Current: 3.452
5 - Year: 3.504

Upcoming Articles (E-Pub Abstracts ahead of Print)

ARE THE MYOKINES THE MEDIATORS OF PHYSICAL ACTIVITY-INDUCED HEALTH BENEFITS?


Domenico Di Raimondo, Antonino Tuttolomondo, Giuseppe Miceli, Gaia Musiari, Caterina Schimmenti, Fabio Balistreri and Antonio Pinto.


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Neurotrophic and Neuroprotective effects of muscle contraction


Valentina Arnao, Domenico Di Raimondo, Antonino Tuttolomondo and Antonio Pinto.


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Are sex differences in outcomes of patients with ACS from observational registries similar to the findings from randomized clinical trials?


CP Gale and O Bebb.


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The multifaceted roles of molecular dynamics simulations in drug discovery


Stephen John Fox, Jianguo Li, Tan Yaw Sing, Minh N. Nguyen, Arumay Pal, Zohra Ouaray, Shilpa Yadahalli and Srinivasaraghavan Kannan.


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Modelling DNA Repair Pathways: Recent Advances and Future Directions


Francesco Gentile, Jack A. Tuszynski and Khaled H Barakat.


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Therapeutic development of interrelated metabolic and neurodegenerative disorders


Xuan Thi-Anh Nguyen and Ly Le.


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A Perspective on Rational Designs of a Hemagglutinin Based Universal Influenza Vaccine.


Thanh D. Van, Nhut Tran, Ly Le and Frank Eisenhaber.


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Modulation of energy intake and expenditure due to habitual physical exercise


Matoulek Martin, Slabý Kryštof, Radvanský Jiří, Daňková Martina, Větrovská Renata, Mikeš Ondřej, Svačina Štěpán and Tuka Vladimír.


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Nanocarriers made from non-ionic surfactants or natural polymers for pulmonary drug delivery


K.C. Carter and M Puig-Sellart.


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Systems pharmacology: A unified framework for prediction of drug-target interactions


Duc-Hau Le and Ly Le.


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Miscellaneous topics in computer-aided drug design: Synthetic accessibility and GPU computing, and other topics


Yoshifumi Fukunishi, Tadaaki Mashimo, Kiyotaka Misoo, Yoshinori Wakabayashi, Toshiaki Miyaki, Seiji Ohta, Mayu Nakamura and Kazuyoshi Ikeda.


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Insights into the conformational ensemble of human islet amyloid polypeptide from molecular simulations


Linh Tran and Tap Ha-Duong.


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Virtual screening techniques and current computational infrastructures


Jason H. Haga, Kohei Ichikawa and Susumu Date.


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In Silico Approach to Finding New Active Compounds from Histone Deacetylase (HDAC) Family


Arry Yanuar, Azminah, Andika, Linda Erlina and Rezi Riadhi Syahdi.


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Hypertension and Ischemic Heart Disease in Women


Maria Dorobantu, Sebastian Onciul, Oana Florentina Tautu and Edina Cenko.


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Oxidative stress modulation through habitual physical activity


A. Boccatonda, R. Tripaldi, G. Davì and F Santilli.


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Nano-precipitation: preparation and application in the field of pharmacy


Thao Truong-DinhTran, Phuong Ha-Lien Tran, Khanh Tu Nguyen and Van-Thanh Tran.


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Endoplasmic stress inhibitors for homocysteine induced Cardiovascular disease


Anthony Zulli.


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Computational Drug Repositioning by Target Hopping: A Use Case in Chagas Disease


VJ Haupt, Jesús E. Aguilar Uvalle, Sebastian Salentin, Simone Daminelli, Franziska Leonhardt, Janez Konc and Michael Schroeder.


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From Mars to Venus: Gender Differences in the Management and Outcomes of Acute Coronary Syndromes


Nigel S. Tan and Andrew T Yan.


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Exploring polypharmacology in drug discovery and repurposing using the CANDO platform


Gaurav Chopra and Ram Samudrala.


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Phytochemicals as prototypes for pharmaceutical leads for drug development against diabetic cardiomyopathy


Shreesh Ojha, Amani Kurdi, Bassem Sadek, M Kaleem, Lu Cai, M A Kamal and Mohanraj Rajesh.


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The immunomodulatory effects of physical activity


Krüger Karsten, Mooren Frank-Christoph and Pilat Christian.


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Intra-renal hemodynamic changes after habitual physical activity in patients with Chronic Kidney Disease


Kaltsatou Antonia, Karatzaferi Christina, Mitrou Georgia I, P Poulianiti Konstantina and K Sakkas George.


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Regular physical activity and vascular aging


Bárbara M.M. Antunes, Fabrício E. Rossi, Jason M. Cholewa and Fábio S Lira.


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Biological rationale for regular physical exercise as an effective intervention for the prevention and treatment of depressive disorders


Helios Pareja-Galeano, Sara Mayero, María Perales, Nuria Garatachea, Alejandro Santos-Lozano, Carmen Fiuza-Luces, Enzo Emanuele, Beatriz G. Gálvez, Fabian Sanchis-Gomar and Alejandro Lucia.


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Cellulose acetate based nanocomposites for biomedical applications: A review


Elham N. Bifari, Sher Bahadar Khan, Khalid A. Alamry, Abdullah M. Asiri and Kalsoom Akhtar.


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Electrocardiographic and cardiac autonomic indices - Implications of sex-specific risk stratification in women after acute myocardial infarction


Romy Ubrich, Petra Barthel, Anna Berkefeld, Katerina Hnatkova, Katharina M Huster, Michael Dommasch, Daniel Sinnecker, Alexander Steger, Georg Schmidt and Marek Malik.


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Barriers to risk stratification accuracy in ischemic heart disease in women: the role of non-obstructive coronary artery disease


Edina Cenko and Raffaele Bugiardini.


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Polypharmacological Properties and Therapeutic Potential of β-Caryophyllene: a Dietary Phytocannabinoid of Pharmaceutical Promise


Charu Sharma, Juma Al Kaabi, Syed M. Nurulain, Sameer N. Goyal, M. A. Kamal and Shreesh Ojha.


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Revascularization vs. optimal medical therapy in women with NSTE-ACS


Piera Capranzano, Claudia Tamburino and Corrado Tamburino.


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Risk Factors for Myocardial Infarction in Women and Men: A Review of the Current Literature


Lene Rørholm Pedersen, Daria Frestad, Marie Mide Michelsen, Naja Dam Mygind, Hanne Rasmusen, Hannah Elena Suhrs and Eva Prescott.


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Atypical chest pain in ACS: a trap especially for women.


Beatrice Ricci, Edina Cenko, Elisa Varotti, Paolo Emilio Puddu and Olivia Manfrini.


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Atheroma Burden and Morphology in Women


Lina Badimon, María Borrell-Pagès and Teresa Padró.


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Tailored Multi-target Agents. Applications and Design Considerations


Alan Talevi.


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Formulation and application of biodegradable nanoparticles based biopharmaceutical delivery - an efficient delivery system


Surajit Bhattacharjee, Biplab Sarkar, Ashish Ranjan Sharma, Priya Gupta, Garima Sharma, Sang-Soo Lee and Chiranjib Chakraborty.


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Natural products towards the discovery of potential future antithrombotic drugs


Asiful Islam, Fahmida Alam, Ibrahim Khalil, Teguh Haryo Sasongko and Siew Hua Gan.


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Association of Oxidative Stress with Psychiatric Disorders


Waseem Hassan, Hamsa Noreen, Vitor Castro-Gomes, Imdadullah Mohammadzai, Joao Batista Teixeira da Rocha and J Landeira-Fernandez.


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Metabolic Control of Type 2 Diabetes by Targeting the GLUT4 Glucose Transporter: Intervention Approaches


Fahmida Alam, Asiful Islam, Ibrahim Khalil and Siew Hua Gan.


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The potential use of piglets as human pediatric surrogate for preclinical pharmacokinetic and pharmacodynamic drug testing


Elke Gasthuys, Tim Vandecasteele, Pauline De Bruyne, Johan Vande Walle, Patrick De Backer, Pieter Cornillie, Mathias Devreese and Siska Croubels.


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Circulating microRNAs in hepatocellular carcinoma: potential diagnostic and prognostic biomarkers


Hamid Reza Mirzaei, Amirhossein Sahebkar, Foad Yazdi, Hosein Salehi, Mohammad Hasan Jafari, Afshin Namdar, Ehsan Khabazian, Mahmoud Reza Jaafri and Hamed Mirzaei.


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ABC transporters in the development of multidrug resistance in cancer therapy


Angelika Długosz and Anna Janecka.


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Ligand-Based Virtual Screening Using Tailored Ensembles: A Prioritization Tool for Dual A2A Adenosine Receptor Antagonists / Monoamine Oxidase B Inhibitors


Aliuska Morales Helguera, Yunierkis Perez-Castillo, M. Natália D. S. Cordeiro, Eduardo Tejera, Cesar Paz-y-Miño, Aminael Sánchez-Rodríguez, Marta Teijeira Bautista, Evys Ancede-Gallardo, Fernando Cagide, Fernanda Borges and Maykel Cruz-Monteagudo.


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Imidazole Derivatives as Potential Therapeutic Agents


Archana Sharma, Vipin Kumar, Rajeev Kharb, Sunil Kumar, Prabodh Chander Sharma and Dharam Pal Pathak.


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Polypharamocological drugs in the treatment of Epilepsy: The comprehensive review of marketed and new emerging molecules


Shikha Kumari, Chandrabhushan Mishra and Manisha Tiwari.


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Polypharmacology in drug discovery: a review from systems pharmacology perspective


Wenjuan Zhang, Yaofei Bai, Yonghua Wang and Wei Xiao.


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1, 2-Benzisoxazole: a privileged structure with a potential for polypharmacology”


Uto Yoshikazu.


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Multi-target drugs for Neglected Diseases


L. Scotti, F.J.B. Mendonça Júnior, R. O. De Moura, F.F. Ribeiro, H. Ishiki, M. S. Da Silva, J.M. Barbosa Filho and MT Scotti.


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Drugs Polypharmacology by in Silico Methods: New Opportunities in Drug Discovery


Antonino Lauria, Riccardo Bonsignore, Roberta Bartolotta, Ugo Perricone, Annamaria Martorana and Carla Gentile.


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Label-free cell phenotypic assays for assessing drug polypharmacology


Jixia Wang, Xiuli Zhang, Ye Fang and Xinmiao Liang.


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Harnessing Polypharmacology with Computer-Aided Drug Design and Systems Biology


Henri Wathieu, Naiem T. Issa, Stephen W Byers and Sivanesan Dakshanamurthy.


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Progress in the rational design for polypharmacology drug


Jinming Zhou, Quanjie Li, Meng Wu, Chao Chen and Shan Cen.


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Oxidative stress, Sarcopenia, Antioxidant strategies and Exercise: Molecular aspects


Thomas Brioche and Lemoine-Morel Sophie.


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Nanoscale Polymersomes as Anti-cancer Drug Carriers Applied for Pharmaceutical Delivery


Ruslan G. Tuguntaev, Chukwunweike Ikechukwu Okeke, Jing Xu, Chan Li, Paul C. Wang and Xing-Jie Liang.


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Polymeric based therapeutic delivery systems prepared using electrohydrodynamic processes


M Rasekh, K Nazari, MS Arshad, I Kucuk, R Haj-Ahmad, A Hussain, MA Morris, N Abbas, M-w Chang, X Li and Z Ahmad.


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Converting human proteins into precision polymer therapeutics


Felix Boldt, Weina Liu, Yuzhou Wu and Tanja Weil.


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Polymer self-assembled nanostructures as innovative drug nanocarrier platforms


Natassa Pippa, Stergios Pispas and Costas Demetzos.


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The Production of Solid Dosage Forms from Non-Degradable Polymers


Ian Major, Evert Fuenmayor and Christopher McConville.


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Nanoparticulate drug delivery to colorectal cancer: formulation strategies and surface engineering


Thao Truong-Dinh Tran, Phuong Ha-Lien Tran, Yichao Wang, Puwang Li and Lingxue Kong.


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Hypoxia responsive drug delivery systems in tumor therapy


Houman Alimoradi, Siddharth S Matikonda, Allan B Gamble, Gregory I Giles and Khaled Griesh.


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Polymer Drug conjugates: Recent Advancements In various Diseases


Jasbir Singh, Sapna Desai, Snehlata Yadav, Balasubramanian Narasimhan and Harmeet Kaur.


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Drug Delivery Systems Based on Polymeric Micelles and Ultrasound: A Review


Rafeeq Tanbour, Ana M. Martins, William G. Pitt and Ghaleb A Husseini.


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Polymer-based drug delivery systems, development and pre-clinical status


Jaimes-Aguirre Laura, Gibbens-Bandala Brenda Vianey, Morales-Avila Enrique, Ocampo-García Blanca Eli, Seyedeh Fatemeh Mirshojaei and Amirhosein Ahmadi.


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Perspectives of engineered marine derived polymers for biomedical nanoparticles


Khanh Thi My Tran, Toi Van Vo, Wei Duan, Phuong Ha-Lien Tran and Thao Truong-Dinh Tran.


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Covalently and Ionically Crosslinked Chitosan Nanogels for Drug Delivery


Leyre Pérez-Álvarez, José Manuel Laza and Arturo Álvarez-Bautista.


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Oxidative stress in polycystic ovary syndrome


Olga Papalou, Victor M Victor and Evanthia Diamanti-Kandaraki.


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Passive targeting of cyclophosphamide-loaded carbonate apatite nanoparticles to liver impedes breast tumor growth in a syngeneic model


S Tiash and EH Chowdhury.


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Targeting inflammatory bowel diseases by nanocarriers loaded with small and biopharmaceutical anti-inflammatory drugs


Ana Beloqui, Régis Coco and Véronique Préat.


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Xanthine oxidase pathway and muscle damage. Insights from McArdle disease


Helios Pareja-Galeano, Alejandro Santos-Lozano, María Morán, Fabian Sanchis-Gomar, Rafael Alis, Alfredo Santalla, Alejandro F. San Juan, Jorge Díez, Miguel Ángel Martín, Joaquín Arenas and Alejandro Lucia.


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MicroRNA-208a Potentiates Angiotensin II-triggered Cardiac Myoblasts Apoptosis via Inhibiting Nemo-like kinase (NLK)


Ying Huang, Yang Yang, Yong He, Cheng Huang, Xiaoming Meng and Jun Li.


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Mitochondrial Signaling And Hepatocellular Carcinoma: Molecular Mechanisms And Therapeutic Implications


Antonio Facciorusso, Rosanna Villani, Francesco Bellanti, Domenica Mitarotonda, Gianluigi Vendemiale and Gaetano Serviddio.


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Dextran-based Nanocarriers for Delivery of Bioactives


Rania A.H. Ishak, Rihab Osman and Gehanne AS Awad.


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Advances on magnetic nanocarriers based on natural polymers.


Rita Muzzalupo and Lorena Tavano.


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Bioactivity of Hybrid Polymeric Magnetic Nanoparticles and Their Applications in Drug Delivery


Leena Mohammed, Doaa Ragab and Hassan Gomaa.


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Site-Specific Thiol-mediated PEGylation of Streptokinase Leads to Improved Properties with Clinical Potential


Pooja Sawhney, Shekhar Kumar, Neeraj Maheshwari, Sumeet Singh Guleria, Neelam Dhar, Radhika Kashyup and Girish Sahni.


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THERMODYNAMIC AND KINETIC ASPECTS INVOLVED IN THE DEVELOPMENT OF NANOCARRIERS AND DRUG DELIVERY SYSTEMS BASED ON CATIONIC IOPOLYMERS


Ismael D. Bianco, Roxana V. Alasino, Victoria Leonhard and Dante M Beltramo.


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Biomimetic approach to stimulate osteogenesis on titanium implant surfaces using fibronectin derived oligopeptide


Young-Dan Cho, Sung-Jun Kim, Han-Sol Bae, Won-Joon Yoon, Kyung-Hwa Kim, Hyun-Mo Ryoo, Yang-Jo Seol, Yong-Moo Lee, In-Chul Rhyu and Young Ku.


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Aptamers to hemagglutinin: a novel tool for influenza virus recognition and neutralization


Elena Zavyalova and Alexey Kopylov.


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Αlpha-2 adrenergic and opioids receptors participation in mice gastroprotection of Abelmoschus esculentus lectin


Kátia A. Ribeiro, Hellíada V. Chaves, Samuel Mateus Pereira Filho, Isabela Ribeiro Pinto, Dina Andressa Martins Monteiro, Samuel Oliveira Matos, Tatiane Santi-Gadelha, Carlos Alberto de Almeida Gadelha, José Thalles Jocelino Gomes de Lacerda, Lissiana M. V. Aguiar, Karuza M. A. Pereira, Norma M. B. Benevides, Vicente de Paulo T. Pinto, Gerardo Cristino Filho, Mirna M. Bezerra and Antonio A R Silva.


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The role of anionic polysaccharides in the preparation of nanomedicines with anticancer applications”.


Ana M. Martínez, Marta Benito, Elena Pérez, José María Teijón and María Dolores Blanco.


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Periodontitis and Periodontal Disease - innovative strategies for reversing the chronic infectious and inflammatory condition by natural products


Lazar Veronica, Crina-Maria Saviuc and Mariana Carmen Chifiriuc.


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The in-situ one-step synthesis of a PDC macromolecular pro-drug and the fabrication of a novel core-shell micell


Cui-yun Yu, Sa Yang, Zhi-ping Li, Can Huang, Qian Ning, Wen Huang, Wen-tong Yang, Dong-xiu He and Lichun Sun.


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Current And Experimental Pharmacological Approaches In Neonatal Hypoxic-Ischemic Encephalopathy


Teresa Zalewska, Joanna Jaworska and Malgorzata Ziemka-Nalecz.


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Editorial : Novel Insights into the Role of Anesthetics and Opioids in Organ or Tissue Protection


Hiroyuki Kinoshita.


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Inhibitory Effects of Water Caltrop Pericarps on the Growth of Human Gastric Cancer Cells In Vitro


Qiusheng Lin, Junhui Shen, Ying Ning, Shengrong Shen and Undurti N Das.


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Editorial: From gut inflammation to gastrointestinal disorders Current update on pathophysiology, molecular mechanism and pharmacological treatment modalities


Predrag Sikiric.


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Manifestations In Course Of Celiac Disease: Case Report And Review Of The Literature


Skroza Nevena, Proietti Ilaria, Bernardini Nicoletta, La Viola Giorgio, Mancini Maria Teresa, Nicolucci Francesca, Pampena Riccardo, Tolino Ersilia, Zuber Sara and Potenza Concetta.


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Helicobacter pylori eradication therapy: advantages and disadvantages


Justyna Bien, Maria Bozko, Nisar P. Malek and Przemyslaw Bozko.


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EDITORIAL:The Multidomain Mobility Lab in Older Persons: From Bench to Bedside


Marcello Maggio, Gian Paolo Ceda and Fulvio Lauretani.


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Role of brain NUCB2/nesfatin-1 in the regulation of food intake


Andreas Stengel and Yvette Taché.


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Role of NUCB2/nesfatin–1 as a possible biomarker


Suleyman Aydin.


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Editorial: Rational Design of Antiviral Compounds


Vladimir Frecer and Stanislav Miertus.


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EDITORIAL Advances in Computational Structure Based Drug Discovery


Gergely Tóth.


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Editorial Cardio-Metabolic Complications: Current Perspective and Future Developments.


Joseph Fomusi Ndisang.


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EDITORAL Novel strategies for cardiac repair post-myocardial infarction


Simeon Agathopoulos and Theofilos M Kolettis.


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EDITORIAL: NEUROBIOLOGICAL AND NEUROCOGNITIVE BASIS OF THE EFFECTS OF CANNABINOIDS IN ANIMALS AND MAN: THERAPEUTIC POTENTIAL OF CANNABINOIDS IN PSYCHIATRY


Sagnik Bhattacharyya.


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Editorial Leptin and the cardiovascular system – a target for therapeutic interventions


Jerzy Bełtowski.


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EDITORIAL Structure-based Drug Design: Strategies and Challenges


Guang-Fu Yang.


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