ISSN: 1875-533X (Online)
ISSN: 0929-8673 (Print)


Volume 22, 38 Issues, 2015


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Current Medicinal Chemistry

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 6th of 59 in Chemistry & Medicinal
  • 47th of 254 in Pharmacology & Pharmacy
  • 81st of 289 in Biochemistry & Molecular Biology

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Editor-in-Chief:
Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK


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Current: 3.853
5 - Year: 4.115

Upcoming Articles (E-Pub Abstracts ahead of Print)

Chemical disruption of Wnt-dependent cell fate decision-making mechanisms in cancer and regenerative medicine


Lawrence Lum and Chuo Chen.


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Synthetic Small Molecule Inhibitors of Hh Signaling as Anti-Cancer Chemotherapeutics


Chad A. Maschinot, Jennifer R. Pace and M Kyle Hadden.


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Potential relevance of melatonin against some infectious agents: A Review and Assessment of Recent Research


Ehab Kotb Elmahallawy, Javier Ortega Luque, Abdelkarim Saleh Aloweidi, José Gutiérrez Fernández, Antonio Sampedro Martínez, Javier Rodriguez-Granger, Abdullah Kaki and Ahmad Agil.


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Exosomes: a promising factor involved in cancer hypoxic microenvironments


Yuehua Yang, Xi Yang, Yan Yang, Hongcheng Zhu, Xiaochen Chen, Hao Zhang, Feng Wang, Qin Qin, Hongyan Cheng and Xinchen Sun.


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Rational Development of Nucleoside Diphosphate Prodrugs: DiPPro-Compounds


C. Meier, H.J. Jessen, T. Schulz, L. Weinschenk and J Balzarini.


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Endosome Escape Strategies for Improving the Efficacy of Oligonucleotide Delivery Systems


Yu Wan, Peter M. Moyle and Istvan Toth.


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Sesterterpenoids with Anticancer Activity


Antonio Evidente, Alexander Kornienko, Florence Lefranc, Alessio Cimmino, Ramesh Dasari, Marco Evidente, Véronique Mathieu and Robert Kiss.


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The Immucillins: Design, Synthesis and Application of Transition State Analogues


Gary B. Evans, Vern L. Schramm and Peter C Tyler.


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Nicotinamide Adenine Dinucleotide Based Therapeutics, Update


K.W. Pankiewicz, R. Petrelli, R. Singh and K Felczak.


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Nalmefene: a novel drug for an old disorder


Donatella Marazziti, Silvio Presta, Stefano Baroni, Francesco Mungai, Armando Piccinni, Federico Mucci and Liliana Dell’Osso.


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Angiotensin II Type 1 Receptor Binding Molecule ATRAP as A Possible Modulator of Renal Sodium Handling and Blood Pressure in Pathophysiology


Kouichi Tamura, Hiromichi Wakui, Kengo Azushima, Kazushi Uneda, Sona Haku, Ryu Kobayashi, Kohji Ohki, Kotaro Haruhara, Sho Kinguchi, Miyuki Matsuda, Akio Yamashita and Satoshi Umemura.


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Novel drug therapies for fertility preservation in men undergoing chemotherapy: clinical relevance of protector agents


A. Rabaça, M. Sousa, M.G. Alves, P.F. Oliveira and R Sá.


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Current and Future Trends in Early Detection of Pancreatic Cancer: Molecular Targets and PET Probes


Mian M. Alauddin and Louis De Palatis.


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Unfolded Protein Response and PERK kinase as a new therapeutic target in the pathogenesis of Alzheimer’s disease


Wioletta Rozpędek, Lukasz Markiewicz, J.Alan Diehl, Dariusz Pytel and Ireneusz Majsterek.


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Recent Progress in Chemical Modifications of Chlorophylls and Bacteriochlorophylls for the Applications in Photodynamic Therapy


Jakub Staroń, Leszek Fiedor, Dariusz Karcz, Bożena Boroń and Małgorzata Szczygiel.


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Current Advances in Antitubercular Drug Discovery: Potent Prototypes and New Targets


Guilherme Felipe dos Santos Fernandes, Daniela Hartmann Jornada, Paula Carolina de Souza, Chung Man Chin, Fernando Rogério Pavan and Jean Leandro dos Santos.


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Flexibility as a Strategy in Nucleoside Antiviral Drug Design


H.L. Peters, T.C. Ku and KL Seley-Radtke.


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Antibacterial Nucleoside Natural Products Inhibiting Phospho-MurNAc-Pentapeptide Translocase; Chemistry and Structure-Activity Relationship.


S. Ichikawa, M. Yamaguchi and A Matsuda.


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Mycobacterium tuberculosis low molecular weight phosphatases (MPtpA and MPtpB): from biological insight to inhibitors


Luisa Fanzani, Federica Porta, Fiorella Meneghetti, Stefania Villa, Arianna Gelain, Anna Paola Lucarelli and Emilio Parisini.


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From bitopic inhibitors to multitarget drugs for Alzheimer’s disease future treatment


Daniel I. Pérez, Ana Martínez, Carmen Gil and Nuria E Campillo.


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Progress in the search for new dopamine transporter inhibitors


Beata Gryzło, Paula Zaręba, Katarzyna Malawska, Anna Jakubowska and Katarzyna Kulig.


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Quercetin in cancer treatment, alone or in combination with conventional therapeutics?


Ana Filipa Brito, Marina Ribeiro, Ana Margarida Abrantes, Ana Salomé Pires, Ricardo Jorge Teixo, José Guilherme Tralhão and Maria Filomena Botelho.


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Quinoxalines Potential to Target Pathologies


María Tristán-Manzano, Antonio Guirado, María Martínez-Esparza, Jesús Gálvez, Pilar García-Peñarrubia and Antonio J Ruiz-Alcaraz.


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Mitochondria-mediated oxidative stress: old target for new drugs


Lyakhovich A and Graifer D.


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Why anticancer nanomedicine needs sugars?


E. Bouffard, K. El Cheikh, A. Gallud, A. Da Silva, M. Maynadier, I. Basile, M. Gary-Bobo, A. Morere and M Garcia.


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PET and SPECT radiotracers for Alzheimer’s disease


Killian Oukoloff, Monika Cieslikiewicz-Bouet, Sovy Chao, Emilie Da Costa Branquinho, Cedric Bouteiller and Ludovic Jean.


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The Case for Development of 11-Aza-artemisinins for Malaria


Rozanne Harmse, Ho Ning Wong, Frans Smit, Richard K. Haynes and David D N'Da.


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Flavonoids, breast cancer chemopreventive and/or chemotherapeutic agents


Chantal Beatrice Magne Nde, Stephane Zingue, Evelyn Winter, Tania Beatriz Creczynski-Pasa, Thomas Michel, Xavier Fernandez, Dieudonne Njamen and Colin Clyne.


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Chalcones as Promising Lead Compounds on Cancer Therapy


Antonio J. Leon-Gonzalez, Nuria Acero, Dolores Munoz-Mingarro, Inmaculada Navarro and Carmen Martin-Cordero.


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The interest of folic acid in targeted photodynamic therapy


Aurelie Stallivieri, Francis Baros, Gulim Jetpisbayeva, Bauyrzhan Myrzakhmetov and Celine Frochot.


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Synthesis of Porphyrin, Chlorin and Phthalocyanine Derivatives by Azide-Alkyne Click Chemistry


Samir Acherar, Ludovic Colombeau, Celine Frochot and Regis Vanderesse.


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Effects of natural products on Mcl-1 expression and function


Florian Muller, Claudia Cerella, Flavia Radogna, Mario Dicato and Marc Diederich.


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Phomoxanthone A – From Mangrove Forests to Anticancer Therapy


Marian Frank, Hendrik Niemann, Philip Bohler, Bjorn Stork, Sebastian Wesselborg, Wenhan Lin and Peter Proksch.


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Phytocannabinoids for Cancer Therapeutics: Recent Updates and Future Prospects


Kalpesh R. Patil, Sameer N. Goyal, Charu Sharma, Chandragouda R. Patil and Shreesh Ojha.


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Dendrogenin A: a Mammalian Metabolite of Cholesterol with Tumor Suppressor and Neurostimulating Properties.


Florence Dalenc, Marc Poirot and Sandrine Silvente-Poirot.


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A Novel Class of Emerging Anticancer Compounds: Oxyprenylated Secondary Metabolites from Plants and Fungi


Salvatore Genovese, Serena Fiorito, Francesco Epifano and Vito Alessandro Taddeo.


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Lipoprotein-related and Apolipoprotein-mediated Delivery Systems for Drug Targeting and Imaging


Gunter Almer, Harald Mangge, Andreas Zimmer and Ruth Prassl.


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Current advances in DOPA and DOPA-peptidomimetics: chemistry, applications and biological activity.


Bruno Mattia Bizzarri, Luca Rotelli, Giorgia Botta and Raffaele Saladino.


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CURIOUS (OLD AND NEW) ANTIVIRAL NUCLEOSIDE ANALOGUES WITH INTRIGUING THERAPEUTIC POTENTIAL


Erik De Clercq.


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Molecular and cellular pathways as treatment targets for biologic therapies in systemic sclerosis


Theodoros Dimitroulas, Dimitris Daoussis, A. Garyfallos, Petros P. Sfikakis and George D Kitas.


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Oxidative stress and post-stroke depression: possible therapeutic role of polyphenols?


Seyed Fazel Nabavi, Olivia M. Dean, Alyna Turner, Antoni Sureda, Maria Daglia and Seyed Mohammad Nabavi.


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Neuronanomedicine - (Part II)


Wei-Yi Ong and Eng-Ang Ling.


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PARP1: a promising target for the development of PARP1-based candidates for anticancer intervention


Yongzhou Hu.


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Title Body mass index, lipid metabolism and estrogens: their impact on coronary heart disease


Genovefa D. Kolovou, Vana Kolovou, Peggy M. Kostakou and Sophie Mavrogeni.


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Tumor Antigen-Derived Peptides Delivery for Cancer Immunotherapy


Ma Wenxue.


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Interaction of Crotamine and Protamine, Small Cationic Peptides, With The Retinal Spreading Depression


EmptyYN="Y" Fernandes de Lima V M, P Spencer and W Hanke.


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Editorial: Current status and progress of radiopharmaceuticals for molecular imaging and targeted therapy


Junbo Zhang.


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On the Physiological Role of Cytosolic 5’-Nucleotidase II (Cn-II): Pathological and Therapeutical Implications


Maria Grazia Tozzi, Rossana Pesi and Simone Allegrini.


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The role of soluble 5`-nucleotidases in the conversion of nucleotide analogs. Metabolic and therapeutic aspects


Andrzej C Składanowski.


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The Enzymology of Cytosolic Pyrimidine 5’-Nucleotidases: Functional Analysis and Physiopathological Implications


Giulio Magni, Adolfo Amici and Giuseppe Orsomando.


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5'-Nucleotidases, Nucleosides and their Distribution in the Brain: Pathological and Therapeutic Implications


Zsolt Kovács, Árpád Dobolyi, Katalin A. Kékesi and Gábor Juhász.


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Therapeutic Perspectives for CN-II in Cancer


Lars Petter Jordheim.


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Enzymatic Properties and Physiological Roles of Cytosolic 5’-Nucleotidase II


Roichi Itoh.


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Is The Expression Of Deoxynucleoside Kinases And 5´-Nucleotidases In Animal Tissues Related To The Biological Effects Of Nucleoside Analogs?


Staffan Eriksson.


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Editorial “ Metabolic, pathological, and therapeutic perspectives intracellular 5’-nucleotidases”


Piero Luigi Ipata.


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