ISSN: 1873-5592 (Online)
ISSN: 1389-4501 (Print)


Volume 17, 16 Issues, 2016


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Current Drug Targets

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  • 74th of 253 in Pharmacology & Pharmacy

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Editor-in-Chief:
Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA


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Current: 3.029
5 - Year: 3.341

Upcoming Articles (E-Pub Abstracts ahead of Print)

Life and Death Partners in Post-PCI Restenosis: Apoptosis, Autophagy, and The Cross-talk Between Them


Hong Zhu and Yingmei Zhang.


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Cytosolic mRNA Target and Bioavailability of Nanoparticulate siRNA delivery systems for gene silencing


Sorin Emilian Leucuta.


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Pancreatic Neoplasms and Autophagy


Linzi A. Barton and Jun Ren.


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EBMT Educational Meeting from the Severe Aplastic Anemia and Infectious Diseases Working Parties


Andre Tichelli and Alicia Rovó.


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Targeting Apelinergic System in Cardiometabolic Disease


Rui Guo, Olivia Rogers and Sreejayan Nair.


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Aptamer-mediated polymeric vehicles for enhanced cell-targeted drug delivery


Kei Xian Tan, Michael K. Danquah, Amandeep Sidhu, Lau Sie Yon and Clarence M Ongkudon.


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Mechanism of Action of Novel Glibenclamide Derivatives on Potassium and Calcium Channels for Insulin Secretion


Marisa Jádson Silva Frederico, Allisson Jhonatan Gomes Castro, Danusa Menegaz, Cahuê De Bernardis Murat, Camila Pires Mendes, Alessandra Mascarello, Ricardo José Nunes and Fátima Regina Mena Barreto Silva.


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Aligning animal models of clinical germinal matrix hemorrhage, from basic correlation to therapeutic approach


Tim Lekic, Damon William Klebe, Pilar Pichon, Katarina Brankov, Sally Sultan, Devin William McBride, Darlene Casel, Alhamza Al-Bayati, Yan Ding, Jiping Tang and John He Zhang.


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Cellular and Molecular Networks in Chronic Myeloid Leukemia: the leukemic stem, progenitor and stromal cell interplay


Danilo Perrotti, Giovannino Silvestri, Lorenzo Stramucci, Justine Yu and Rossana Trotta.


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Current Perspectives on Novel Drug Delivery Systems and Therapies for Management of Prostate Cancer: An Inclusive Review


Rohit Rajendra Bhosale, H V Gangadharappa, Umme Hani, Riyaz Ali M Osmani, Rudra Vaghela, K Sairam Venkata and P K Kulkarni.


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Non Coding RNAs: a new avenue for the self-tailoring of blood cancer treatment


Gabriella Misso, Mayra Rachele Zarone, Anna Grimaldi, Maria Teresa Di Martino, Angela Lombardi, Hiromichi Kawasaki, Paola Stiuso, Pierfrancesco Tassone, Pierosandro Tagliaferri and Michele Caraglia.


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Current approach for the diagnosis of Aplastic Anemia


Alicia Rovo and Andre Tichelli.


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Targeted mesoporous silica nanocarriers in oncology


Alejandro Baeza and Maria Vallet-Regí.


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Recent Advances in pH-Sensitive Polymeric Nanoparticles for Smart Drug Delivery in Cancer Therapy


Eun-Kyung Lim, Bong Hyun Chung and Sang J Chung.


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Bioinspired Platform Conjugated Active Drug Delivery


Jingxin Shao, Mingjun Xuan, Qiang He and Luru Dai.


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Predictive Pathology in the Target Therapy Era in Breast Cancer


Anna Sapino.


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The connections among autophagy, inflammasome and mitochondria


Isabel de Lavera, Ana Delgado Pavón, Marina Villanueva Paz, Manuel Oropesa-Ávila, Mario de la Mata, Elizabet Alcocer-Gómez, Juan Garrido-Maraver, David Cotán, Mónica Álvarez-Córdoba and José A Sánchez-Alcázar.


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Smart Drug-Delivery Systems for Cancer Nanotherapy


Paola Sánchez-Moreno, Juan Luis Ortega-Vinuesa, José Manuel Peula-García, Juan Antonio Marchal and Houria Boulaiz.


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The Smart Programmable CRISPR Technology: A Next Generation Genome Editing Tool for Investigators


Chiranjib Chakraborty, Teoh Seong Lin and Srijit Das.


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Targeting Hsp90-Cdc37: a promising therapeutic strategy by inhibiting Hsp90 chaperone function


Lei Wang, Li Li, Kai Gu, Xiao-Li Xu, Qi-Dong You and Hao-Peng Sun.


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Functional components from nature-derived drugs for the treatment of rheumatoid arthritis


Qin Ma and Jian-Guo Jiang.


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Molecular targets and angiogenesis in renal cell carcinoma, a multi-target approach: mini review


Simone A.M. Badal, William D. Aiken and Sheray N Chin.


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SMALL-CELL LUNG CANCER: CLINICAL MANAGEMENT AND UNMET NEEDS, New perspectives for an old problem


Giuseppe Lo Russo, Marianna Macerelli, Marco Platania, Nicoletta Zilembo, Milena Vitali, Diego Signorelli, Claudia Proto, Monica Ganzinelli, Rosaria Gallucci, Francesco Agustoni, Gianpiero Fasola, Filippo de Braud and Marina Chiara Garassino.


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Mechanism and potential inhibitors of GlmU: a novel target for antimicrobial drug discovery


Rashmi Sharma and Inshad Ali Khan.


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Antiangiogenics and Hypoxic Response: Role of Fatty Acid Synthase Inhibitors


Maria Bueno, Jesus Sanchez, Ramon Colomer and Miguel Quintela-Fandino.


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The molecular concept of atheromatous plaques


Zar Chi Thent, Chiranjib Chakraborty, Pasuk Mahakkanukrauh, Nik Kosai, Reynu Rajan and Srijit Das.


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Future targets in endothelial biology: Endothelial cell to mesenchymal transition


Pei-Yu Chen and Michael Simons.


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Chemical modifications and biological activities of polysaccharides


Gangliang Huang, Hualiang Huang and Xin Chen.


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Editorial: Embryonic signaling pathways as potential targets for the treatment of rhabdomyosarcoma


Soledad Gallego and Josep Roma.


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Rational Design of Multi-Target Estrogen Receptors ERα and ERβ by QSAR Approaches


Qi Zhao, Yuxi Lu, Yan Zhao, Rongchao Li, Feng Luan and M Natália D S Cordeiro.


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Modelling chemotherapy-induced cardiotoxicity by human pluripotent stem cells


Rosalinda Madonna, Christian Cadeddu, Martino Deidda, Paolo Spallarossa, Concetta Zito and Giuseppe Mercuro.


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Smart triggered release in controlled drug delivery


Paul Cătălin Balaure, Dragos Gudovan and Iulia Alexandra Gudovan.


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Phytometabolites Targeting Warburg Effect in Cancer Cells: A Mechanistic Review


Mohadeseh Hasanpourghadi, Chung Yeng Looi, Ashok Kumar Pandurangan, Gautam Sethi, Won Fen Wong and Mohd Rais Mustafa.


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Smart Drug Delivery Systems in Cancer Therapy


Gozde UNSOY and Ufuk GUNDUZ.


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Nosocomial infections and antimicrobial treatment in coiled patients with aneurysmal subarachnoid hemorrhage


Peter Lackner, Christoph Mueller, Ronny Beer, Gregor Broessner, Marlene Fischer, Raimund Helbok, Alois Schiefecker, Erich Schmutzhard and Bettina Pfausler.


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Recent Advances in Nanosystems and Strategies for Managing Leishmaniasis


Rudra Vaghela, Parthasarathi K. Kulkarni, Riyaz Ali M. Osmani, Rohit R. Bhosale and V Naga Sravan Kumar Varma.


View Abstract


The role of statins in heme oxygenase-1 activation in cardiovascular diseases


A. Piechota-Polanczyk and A Jozkowicz.


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Advances in Drug Delivery Systems, from 0 to 3D superstructures


Marius RADULESCU, Simona Popescu, Denisa FICAI, Maria SONMEZ, Ovidiu OPREA, Angela SPOIALĂ, Anton FICAI and Ecaterina ANDRONESCU.


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Oxidative stress and antioxidants in neurological diseases: is there still hope?


Andreia Neves Carvalho, Omidreza Firuzi, Maria João Gama, Jack van Horssen and Luciano Saso.


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Natural small molecules as stabilizers and activators of cancer-associated NQO1 polymorphisms


AL Pey, CF Megarity, E Medina-Carmona and DJ Timson.


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Specific Targeting of Akt Kinase Isoforms: Taking the Precise Path for Prevention and Treatment of Cancer


Nand Kishor Roy, Devivasha Bordoloi, Javadi Monisha, Ganesan Padmavathi, Devivasha Bordoloi, Javadi Monisha, Ganesan Padmavathi, Jibon Kotoky, Ramesh Golla and Ajaikumar B Kunnumakkara.


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Antiangiogenic resistance and cancer metabolism: opportunities for synthetic lethality


Simon Lord, Juan M. Funes, Adrian L Harris and Miguel Quintela-Fandino.


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Pharmacoperones as a New Therapeutic Approach: In vitro Identification and In vivo Validation of Bioactive Molecules


Alfredo Ulloa-Aguirre and P Michael Conn.


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Antiangiogenic resistance: Novel angiogenesis axes uncovered by antiangiogenic therapies research


Gabriela Jiménez-Valerio and Oriol Casanovas.


View Abstract


MicroRNAs as Candidate Drug Targets for Cardiovascular Diseases


Pengzhou Hang, Jing Guo, Chuan Sun and Zhimin Du.


View Abstract


Polypharmacology of approved anticancer drugs


Ivano Amelio, Andrey Lisitsa, Richard A. Knight, Gerry Melino and Alexey V Antonov.


View Abstract


Elastin-like recombinamers as smart drug delivery systems


F. Javier Arias, Mercedes Santos, Arturo Ibáñez-Fonseca, Jesús Piña and Sofía Serrano.


View Abstract


Soft Computing Techniques for the Protein Folding Problem on High Performance Computing Architectures.


Antonio Llanes, Andrés Muñoz, Andrés Bueno-Crespo, Teresa García-Valverde, Antonia Sánchez, Francisco Arcas-Túnez, Horacio Pérez-Sánchez and José M Cecilia.


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Rationale and Prospects of Targeting Bacterial Two-component Systems for Antibacterial Treatment of Cystic Fibrosis Patients


Nadya Velikova and Jerry M Wellsa.


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Functionalized magnetic nanostructures for anticancer therapy


Eugenia Dumitra Teodor, Florentina Gatea, Anton Ficai and Gabriel Lucian Radu.


View Abstract


Recent Advancement and Technological Aspects of Pulsatile Drug Delivery System - A Laconic Review


Vinay Pandit, Ajay Kumar, M.S Ashawat, C.P. Verma and Pravin Kumar.


View Abstract


STIMULI-RESPONSIVE SMART LIPOSOMES IN CANCER TARGETING


Ankit Jain and Sanjay K Jain.


View Abstract


Drug Target Validation Methods in Malaria - Protein Interference Assay (PIA) as a Tool for Highly Specific Drug Target Validation


Kamila A. Meissner, Sergey Lunev, Yuan-Ze Wang, Marleen Linzke, Fernando de Assis Batista, Carsten Wrenger and Matthew R Groves.


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Can microRNAs Be Biomarkers or Targets for Therapy of Ischemic Coronary Artery Disease in Metabolic Syndrome?


Petra Rocic.


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Role of interferons in chronic hepatitis C infection


Carolina Scagnolari, Katia Monteleone, Giulia Cacciotti and Guido Antonelli.


View Abstract


Nuclear Factor Kappa B: A Potential Target to Persecute Head and Neck Cancer


Javadi Monisha, Nand Kishor Roy, Devivasha Bordoloi, Amit Kumar, Ramesh Golla, Jibon Kotoky, Ganesan Padmavathi and Ajaikumar B Kunnumakkara.


View Abstract


Neuroinflammation is Associated with Brain Extracellular TAU-Protein Release after Spontaneous Subarachnoid Hemorrhage


Alois Josef Schiefecker, Anelia Dietmann, Ronny Beer, Bettina Pfausler, Peter Lackner, Mario Kofler, Marlene Fischer, Gregor Broessner, Florian Sohm, Miriam Mulino, Claudius Thomé, Christian Humpel, Erich Schmutzhard and Raimund Helbok.


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Biophysical Screening for Identifying Pharmacological Chaperones and Inhibitors against Conformational and Infectious Diseases


A. Velazquez-Campoy, J. Sancho, O. Abian and S Vega.


View Abstract


Review of the Third Domain Receptor Binding Fragment of Alpha-fetoprotein (AFP): Plausible Binding of AFP to Lysophospholipid Receptor Targets


GJ Mizejewski.


View Abstract


Characterization and Management of Cutaneous Side Effects Related to the Immunosuppressive Treatment in Solid Organ Recipients.


Paola Savoia, Andrea Ranghino and Paolo Fava.


View Abstract


Natural Polyphenols and their Synthetic Analogs as Emerging Anticancer Agents


R Colomer, A Sarrats, R Lupu and T Puig.


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Structure-based drug discovery accelerated by many-core devices


Wei Feinstein and Michal Brylinski.


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Recent advances on protein-protein docking


Qian Zhang, Ting Feng, Lei Xu, Huiyong Sun, Peichen Pan, Youyong Li, Dan Li and Tingjun Hou.


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Astrocytes: adhesion molecules and immunomodulation


Shane Liddelow and Daniel Hoyer.


View Abstract


The challenges of modeling drug resistance to antiangiogenic therapy


Michalis Mastri, Spencer Rosario, Amanda Tracz, Robin E. Frink, Rolf A. Brekken and John M L Ebos.


View Abstract


Targeting MET receptor in rhabdomyosarcoma: rationale and progress


Barbara Szewczyk, Klaudia Skrzypek and Marcin Majka.


View Abstract


Diabetes and Complications: Cellular Signalling Pathways, Current Understanding and Targeted Therapies


Krishna A. Adeshara, Arundhati G. Diwan and Rashmi S Tupe.


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LncRNA HOTAIR as prognostic circulating marker and potential therapeutic target in patients with tumor diseases.


Gerardo Botti, Laura Marra, Maria Gabriella Malzone, Annamaria Anniciello, Chiara Botti, Renato Franco and Monica Cantile.


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The double roles of the prostaglandin E2 EP2 receptor in intracerebral hemorrhage


Xu Luo, Qiquan Zhu, Jie Zhang, Qin Huang, Zongyi Xie and Yuan Cheng.


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Dysregulated Chemokine Signaling in Cystic Fibrosis Lung Disease: A Potential Therapeutic Target


Xiaoqing Guan, Yuning Hou, Fei Sun, Zhe Yang and Chunying Li.


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Targeting Transient Receptor Potential Canonical Channels for Nervous System Diseases


Yibin Wang, Jiyuan Bu, Haitao Shen, Haiying Li, Zhong Wang and Gang Chen.


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Design of lipophilic prodrugs to improve drug delivery and efficacy


Abhirup Mandal, Mitesh Patel, Ye Sheng and Ashim K Mitra.


View Abstract


Proteinase-activated receptor 2: Are common functions in glial and immune cells linked to inflammation-related CNS disorders?


Trevor J. Bushell, Margaret R. Cunningham, Kathryn A. McIntosh, Serge Moudio and Robin Plevin.


View Abstract


Vascular Biology Center Medical College of Georgia Georgia Regents University Augusta, GA, USA


Rodolfo Montironi, Matteo Santoni, Liang Cheng, Antonio Lopez-Beltran, Francesco Massari, Marc R. Matrana, Holger Moch and Marina Scarpelli.


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Ubiquitin and ubiquitin-like proteins in cardiac disease and protection


Jie Li, John A. Johnson and Huabo Su.


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Chemical Structure Similarity Search for Ligand-Based Virtual Screening: Methods and Computational Resources


Xin Yan, Chenzhong Liao, Zhihong Liu, Arnold T. Hagler, Qiong Gu and Jun Xu.


View Abstract


Multi-Target Mining of Alzheimer Disease Proteome with Hansch’s QSBR-Perturbation Theory and Experimental-Theoretic Study of New Thiophene Isosters of Rasagiline


Paula Abeijón, Xerardo García-Mera, Olga Caamaño, Matilde Yañez, Edgar López-Castro, Francisco J. Romero-Durán and Humberto González-Díaz.


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Trends in nanomaterials and processing for drug delivery of polyphenols for cancer and other treatments


Joaquim Ciurana and Ciro A Rodríguez.


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Sirtuins: a possible clinical implication in cardio- and cerebro- vascular systems.


Valeria Conti, Maurizio Forte, Graziamaria Corbi, Giusy Russomanno, Luigi Formisano, Alessandro Landolfi, V Izzo, Amelia Filippell, Carmine Vecchione and Albino Carrizzo.


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Metallothionein as a Scavenger of Free Radicals – New Cardioprotective Therapeutic Agent or Initiator of Tumor Chemoresistance?


Zbynek Heger, Miguel Angel Merlos Rodrigo, Sona Krizkova, Branislav Ruttkay-Nedecky, Marta Zalewska, Elena Maria Planells del Pozo, Aurelie Pelfrene, Bertrand Pourrut, Marie Stiborova, Tomas Eckschlager, Gabriella Emri, Rene Kizek and Vojtech Adam.


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New pharmacological approaches to the prevention of myocardial ischemia-reperfusion injury


Kai Yee Chin, Chengxue Qin, Lauren May, Rebecca H Ritchie and Owen L Woodman.


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Effect of Genetic Polymorphisms (SNPs) in CHRNA7 Gene on Response to Acetylcholinesterase Inhibitors (AChEI) in Patients with Alzheimer’s Disease


Patrizia Russo, Aliaksei Kisialiou, Rossana Moroni, Giulia Prinzi and Massimo Fini.


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The chemopreventive activity of β-ionone involves modulation of Rxrα, Rarβ and Coup-Tf1 expression in liver pre-neoplastic lesions in rats


Mônica Testoni Cardozo, Kelly Silva Furtado, Aline De Conti, Fábia de Oliveira Andrade, Laura Helena Gasparini Fernandes, Adriana Campos, Clarissa Scolastici and Fernando Salvador Moreno.


View Abstract


RECENT INSIGHTS INTO NOTCH SIGNALING IN EMBRYONAL RHABDOMYOSARCOMA


Beatrice Conti, Katherine K. Slemmons, Rossella Rota and Corinne M Linardic.


View Abstract


CADD modeling of multi-target drugs against Alzheimer's disease


Pravin Ambure and Kunal Roy.


View Abstract


Vitamin C and Bone Health: Evidence from Cell, Animal and Human Studies


Kok-Yong Chin and Soelaiman Ima-Nirwana.


View Abstract


DOCKING STUDIES FOR MULTI-TARGET DRUGS


L. Scotti, F.J.B. Mendonça Júnior, H. Ishiki, F.F. Ribeiro, Singla Rajeev K, J.M. Barbosa Filho, M.S. Da Silva and MT Scotti.


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Innate and Adaptive Immune Responses in Chronic HCV infection


Lynn B Dustin.


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How Current Direct-Acting Antiviral and Novel Cell Culture Systems for HCV are Shaping Therapy and Molecular Diagnosis of Chronic HCV Infection


Fabrizio Maggi, Daniele Focosi and Mauro Pistello.


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Is Intake of Flavonoid-based Food Supplements during Pregnancy Safe for the Developing Child? A Literature Review.


Marta Barenys, Stefan Masjosthusmann and Ellen Fritsche.


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Targeting interferon regulatory factor for cardiometabolic diseases: opportunities and challenges


Zhang Yaxing, Zhang Xiao-Jing and Li Hongliang.


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Chemokines in the pathogenesis and as therapeutical markers and targets of HCV chronic infection, and HCV extrahepatic manifestations


Poupak Fallahi, Silvia Martina Ferrari, Dilia Giuggioli, Marco Sebastiani, Michele Colaci, Clodoveo Ferri and Alessandro Antonelli.


View Abstract


Phospholipase A2 Isoforms as Novel Targets for Prevention and Treatment of Inflammatory and Oncologic Diseases


Nagendra Sastry Yarla, Anupam Bishayee, Lakshmipathi Vadlakonda, Ramakrishna Chintala, Govinda Rao Duddukuri, Pallu Reddanna and DSVGK Kaladhar.


View Abstract


HDL as a Target for Glycemic Control


Boris Waldman, Alicia J. Jenkins, David Sullivan, Martin K.C. Ng and Anthony C Keech.


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VIRTUAL SCREENING FOR THE DEVELOPMENT OF DUAL-INHIBITORS TARGETING TOPOISOMERASE IB AND TYROSYL-DNA PHOSPHODIESTERASE 1


Francesca Cardamone, Simone Pizzi, Federico Iacovelli, Mattia Falconi and Alessandro Desideri.


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Wnt Signaling in Rhabdomyosarcoma – a Potential Targeted Therapy Option


Eleanor Chen.


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SIRT1 as a promising novel therapeutic target for myocardial ischemia reperfusion injury and cardiometabolic disease


Dong Han, Jinda Wang, Sai Ma, Yundai Chen and Feng Cao.


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Chronic exposure to low-level cadmium in diabetes: role of oxidative stress and comparison with polychlorinated biphenyls.


Adeline Jacquet, Faycal Ounnas, Marine Lenon, Josiane Arnaud, Christine Demeilliers and Jean-Marc Moulis.


View Abstract


Redox-Related Mechanisms to Rebalance Cancer-Deregulated Cell Growth The Anticarcinogenic Mechanisms of Regeneration


An-Sofie Stevens, Nicky Pirotte, Annelies Wouters, Andromeda Van Roten, Frank Van Belleghem, Maxime Willems, Ann Cuypers, Tom Artois and Karen Smeets.


View Abstract


Gastric Carcinoma at the Era of Targeted Therapies


Johann DREANIC, Marion DHOOGE, Elena SION, Catherine BREZAULT, Stanislas CHAUSSADE and Romain CORIAT.


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Interfering with Hedgehog Pathway: New Avenues for Targeted Therapy in Rhabdomyosarcoma


Gabriele Manzella and Beat W Schäfer.


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Doxorubicin action on mitochondria: relevance to osteosarcoma therapy?


Jo Armstrong and Crispin R Dass.


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Do we need full donor chimerism? How alloreactive cell therapies without substantial engraftment might treat hematologic cancers


Elizabeth F. Krakow, Hui-Sheng Ai, Brian Shaffer, Jean-Sébastien Delisle, Kai-Xun Hu and Anthony D Sung.


View Abstract


Architectural Clones in Aplastic Anaemia- Lessons Learned from High Throughput Sequencing


Austin G Kulasekararaj and Judith C W Marsh.


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Matched Sibling Donor Hematopoietic Stem Cell Transplant in Patients with Acquired Aplastic Anemia


André Tichelli and Jakob R Passweg.


View Abstract


Systemic Delivery of Free Chitosan Accelerates Femur Fracture Healing in Rats


Peng Shao, Yongzhong Wei, Crispin R. Dass, Guoying Zhang and Zhisheng Wu.


View Abstract


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