ISSN: 1873-5592 (Online)
ISSN: 1389-4501 (Print)


Volume 16, 14 Issues, 2015


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Current Drug Targets

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  • 77th of 254 in Pharmacology & Pharmacy

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Editor-in-Chief:
Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA


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Current: 3.021
5 - Year: 3.260

Upcoming Articles (E-Pub Abstracts ahead of Print)

Standard first-line immunosuppression for acquired severe aplastic anemia in adults
Hubert Schrezenmeier, Sixten Korper and Britta Hochsmann
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Epigenetic Regulation of Myocardial Homeostasis, Self-Regeneration and Senescence
Marco Matteucci, Gaia Papini, Enrica Ciofini, Lucio Barile and Vincenzo Lionetti
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Wnt Signaling in Rhabdomyosarcoma – a Potential Targeted Therapy Option
Eleanor Chen
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SIRT1 as a promising novel therapeutic target for myocardial ischemia reperfusion injury and cardiometabolic disease
Dong Han, Jinda Wang, Sai Ma, Yundai Chen and Feng Cao
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Release of Soluble Ligands for the Activating NKG2D Receptor: One More Immune Evasion Strategy Evolved by HIV-1 ?
Erica Giuliani, Lia Vassena, Cristina Cerboni and Margherita Doria
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CXCL8 as a Potential Therapeutic Target for HIV-Associated Neurocognitive Disorders
Manmeet K. Mamika and Anuja Ghorpadeb
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AMPK as a New Attractive Therapeutic Target for Disease Prevention: the Role of Dietary Compounds
Massimiliano Gasparrini, Francesca Giampieri, Jose M. Alvarez Suarez, Luca Mazzoni, Tamara Y. Forbes Hernandez, Jose L. Quiles, Pedro Bullon and Maurizio Battino
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Targeting TNF-alpha in HIV-1 infection
Amit Kumar, Laurie Coquard and Georges Herbein
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Structural and Functional Aspects of Extended-Spectrum AmpC cephalosporinases
Rachel A. Powers
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Anaplastic Lymphoma Kinase Inhibitors in Non-Small Cell Lung Cancer: A Review of the Literature
David M. Straughan, Said C. Azoury and Vivek Shukla
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IL-17 Axis Driven Inflammation in Non-alcoholic Fatty Liver Disease Progression
Daniel A Giles, Maria E Moreno-Fernandez and Senad Divanovic
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HIV-1 Tat-mediated calcium dysregulation and neuronal dysfunction in vulnerable brain regions
Xiu-Ti Hu
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Antioxidant and antimicrobial properties of Veronica spicata L. (Plantaginaceae)
Valerija Dunkić, Ivan Kosalec, Iztok Joze Kosir, Tanja Potocnik, Andreja Cerenak, Marijana Zovko Koncic, Dubravka Vitali, Ivna Dragojevic Muller, Martina Kopricanec, Nada Bezic, Sinisa Srecec and Dario Kremer
View Abstract
Apolipoprotein A5: extracellular and intracellular roles in triglyceride metabolism
Trudy M. Forte and Robert O. Ryan
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Microscopies at the nanoscale for nano-scale drug delivery systems
Luciana Dini, Elisa Panzarini, Stefania Mariano, Daniele Passeri, Melania Reggente, Marco Rossi and Cristian Vergallo
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Natural Products on Nonalcoholic Fatty Liver Disease
Jiao-Ya Xu, Li Zhang, Zhong-Ping Li and Guang Ji
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Advances in hyaluronic acid-based drug delivery systems
Yan Jiao, Xin Pang and Guangxi Zhai
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Eph receptors as drug targets: single-chain antibodies and beyond
Urpo Lamminmäki, Dimitar Nikolov and Juha Himanen
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Tuning T cell activation: the function of CD6 at the immunological synapse and in T cell responses
Rita F. Santos, Liliana Oliveira and Alexandre M. Carmo
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Chronic exposure to low-level cadmium in diabetes: role of oxidative stress and comparison with polychlorinated biphenyls.
Adeline Jacquet, Faycal Ounnas, Marine Lenon, Josiane Arnaud, Christine Demeilliers and Jean-Marc Moulis
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Perspectives on membrane-associated progesterone receptors as prospective therapeutic targets
Sae Hasegawa, Mayu Kasubuchi, Kazuya Terasawa and Ikuo Kimura
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ISCHEMIRs: Finding a way through the obstructed cerebral arteries
Sreekala S. Nampoothiri, Hari Vinayak Menon, Debashish Das and Rajanikant G. K.
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Antimuscarinics in the treatment of OAB: is there a first-line and a second-line choice?
Apostolos Apostolidis
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Endogenous retroelements in cellular senescence and related pathogenic processes: promising drug targets in age-related diseases.
Maurizio Cardelli, Robertina Giacconi, Marco Malavolta and Mauro Provinciali
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An integrative review on role and mechanisms of ghrelin in stress, anxiety and depression
Anjana Bali and Amteshwar Singh Jaggi
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Targeting the Bone Microenvironment in Metastatic Castration-Resistant Prostate Cancer
Pavlos Msaouel, Jose Nahun Galeas, Alejandro Recio Boiles, Ramiro Rancier Ruiz and Michael Koutsilieris
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Antioxidants as a Potential Preventive and Therapeutic Strategy for Cadmium
Malgorzata M. Brzóska, Sylwia Borowska and Michal Tomczyk
View Abstract
Targeting The Noradrenergic System In Posttraumatic Stress Disorder: A Systematic Review And Meta-Analysis Of Prazosin Trials
Domenico De Berardis, Stefano Marini, Nicola Serroni, Felice Iasevoli, Carmine Tomasetti, Andrea de Bartolomeis, Monica Mazza, Daniela Tempesta, Alessandro Valchera, Michele Fornaro, Maurizio Pompili, Gianna Sepede, Federica Vellante, Laura Orsolini, Giovanni Martinotti and Massimo Di Giannantonio
View Abstract
Redox-Related Mechanisms to Rebalance Cancer-Deregulated Cell Growth The Anticarcinogenic Mechanisms of Regeneration
An-Sofie Stevens, Nicky Pirotte, Annelies Wouters, Andromeda Van Roten, Frank Van Belleghem, Maxime Willems, Ann Cuypers, Tom Artois and Karen Smeets
View Abstract
Gastric Carcinoma at the Era of Targeted Therapies
Johann DREANIC, Marion DHOOGE, Elena SION, Catherine BREZAULT, Stanislas CHAUSSADE and Romain CORIAT
View Abstract
Current Perspectives on Novel Drug Delivery Systems and Approaches for Management of Cervical Cancer: A Comprehensive Review
Umme Hani, Riyaz Ali M Osmani, Rohit R Bhosale, Parthasarathi K. Kulkarni and Hosakote G Shivakumar
View Abstract
Interfering with Hedgehog Pathway: New Avenues for Targeted Therapy in Rhabdomyosarcoma
Gabriele Manzella and Beat W. Schäfer
View Abstract
A Review of Pharmacological Treatment Options for Lung Cancer: Emphasis on Novel Nanotherapeutics and Associated Toxicity
Christopher G. England, Chin F. Ng, Victor van Berkel and Hermann B. Frieboes
View Abstract
Antioxidant Mechanisms in Nonalcoholic Fatty Liver Disease
Liu Wensheng, Susan S Baker, Robert D Baker and Lixin Zhu
View Abstract
New advances in the molecular mechanisms driving biliary fibrosis and emerging molecular targets
A Santos-Laso, P Munoz-Garrido, M Felipe-Agirre, L Bujanda, J M Banales and M J Perugorria
View Abstract
Nanoparticles-Based Treatment for Bone Metastasis
Rossana Saracino, Rosa Luciano, Giulia Battafarano, Antonio Perrotta, Maurizio Muraca and Andrea Del Fattore
View Abstract
Functional genomics of cardioprotection by ischemic conditioning and the influence of comorbid conditions: implications in target identification
Z V Varga, Z Giricz, P Bencsik, R Madonna, M Gyöngyösi, R Schulz, M Mayr, T Thum, L G Puskás and P Ferdinandy
View Abstract
Loop Diuretics Strategies in Acute Heart Failure: from Clinical Trials to Practical Application
Alberto Palazzuoli, Gaetano Ruocco, Marco Pellegrini, Matteo Beltrami, Gabriele Del Castillo and Ranuccio Nuti
View Abstract
Targeted drug delivery for cardiovascular and cerebrovascular diseases
Jingjing Luan and Guangxi Zhai
View Abstract
Doxorubicin action on mitochondria: relevance to osteosarcoma therapy?
Jo Armstrong and Crispin R. Dass
View Abstract
Endoplasmic Reticulum Stress, Calcium Dysregulation and Altered Protein Translation: Intersection of Processes that Contribute to Cancer Cachexia Induced Skeletal Muscle Wasting
S. T. Isaac, T. C. Tan and P. Polly
View Abstract
Mechanisms of bacterial acetohydroxyacid synthase (ahas) and specific inhibitors of Mycobacterium tuberculosis ahas as potential drug candidates against tuberculosis
Kunal Gokhale and Bhargav Tilak
View Abstract
Heat shock proteins: Mediators of atherosclerotic development
Justin F. Deniset and Grant N. Pierce
View Abstract
Cancellers - Exploring the Possibility of Receptor Decoy Traps as a Superior Anti-Retroviral Strategy
Sundararaj Stanley Jeremiah, Kenji Ohba and Naoki Yamamoto
View Abstract
Pharmacological interference with protein-protein interactions of A-kinase anchoring proteins as a strategy for the treatment of disease
Veronika A. Deak and Enno Klussmann
View Abstract
Bridging the Gap: The Potential Role of Corticosteroid Binding Globulin in Cardiac Steroid Facilitation
Hans Hendrik Schäfer, Thomas Dieterle, Aaron Trachsler, Mikael Gencay and Edelgard Anna Kaiser
View Abstract
Identification of Lipid Species Linked to the Progression of Non-alcoholic Fatty Liver Disease
Yuki Kawano, Shin Nishiumi, Masaya Saito, Yoshihiko Yano, Takeshi Azuma and Masaru Yoshida
View Abstract
Statins and epilepsy: preclinical studies, clinical trials and statin-anticonvulsant drug interactions
Francesca Scicchitano, Andrew Constanti, Rita Citraro, Giovambattista De Sarro and Emilio Russo
View Abstract
Intravital Microscopy Imaging Approaches for Image-Guided Drug Delivery Systems
Dickson K. Kirui and Mauro Ferrari
View Abstract
PET and SPECT imaging for the acceleration of anti-cancer drug development
Christopher RT Hillyar, James C. Knight, Katherine A. Vallis and Bart Cornelissen
View Abstract
ABC transporter inhibitors in reversing multidrug resistance to chemotherapy
Haigang Cui, Anna J. Zhang, Mingwei Chen and Johnson J. Liu
View Abstract
Lipophilic statins as anticancer agents: molecular targeted actions and proposal in advanced gynaecological malignancies.
Salvatore Gizzo, M.D, Michela Quaranta, M.D, Giovanni Battista Nardelli, M.D. & Marco Noventa and M.D.
View Abstract
Macrophages and Dendritic Cells: The Usual Suspects in Atherogenesis
Christina Kassiteridi and Claudia Monaco
View Abstract
A Comprehensive Review on miR-200c, a Promising Cancer Biomarker with Therapeutic Potential
Suresh Kumar, Alo Nag and Chandi C. Mandal
View Abstract
Pattern Recognition by CD6: a Scavenger-Like Lymphocyte Receptor
Adelaida Sarukhan, Mario Martinez-Florensa, Cristina Escoda-Ferran, Esther Carrasco, Esther Carreras and Francisco Lozano
View Abstract
MicroRNAs and the Response of Prostate Cancer to Anti-Cancer Drugs
Marzia Pennati, Marco Folini, Paolo Gandellini and Nadia Zaffaroni
View Abstract
Nano Traditional Chinese Medicine: Current Progresses and Future Challenges
Songqing Liu, Y i Huang, Fang Liu and Yinglan Zhao
View Abstract
Dormant Circulating Tumor Cells In Prostate Cancer: Biological, Clinical And Therapeutic Implications
M. J. Alvarez-Cubero, F Vázquez-Alonso, I Puche-Sanz, F. G. Ortega, M. Martin-Prieto, J L Garcia-Puche, M. Pascual-Geler, J A. Lorente, J. M. Cozar-Olmo and M. J. Serrano-Fernández
View Abstract
Heterocyclic Scaffolds: Centrality in Anticancer Drug Development
Imran Ali, Mohammad Nadeem Lone, Zeid A. Al-Othman and Abdulrahman Al-Warthan
View Abstract
Endogenous Cardioprotective Agents: Role in Pre and Postconditioning
C Penna, R Granata, C G Tocchetti, M P Gallo, G Alloatti and P Pagliaro
View Abstract
Mini Review: Pathophysiology of Erectile Dysfunction
Hotaka Matsui, Nikolai A. Sopko, Johanna L. Hannan and Trinity J. Bivalacqua
View Abstract
Metformin for Prevention and Treatment of Colon Cancer: a Reappraisal of Experimental and Clinical Data
Vladimir N. Anisimov
View Abstract
Hemoglobin degradation pathway of Plasmodium falciparum as antimalarial drug target
Tabish Qidwai
View Abstract
Do we need full donor chimerism? How alloreactive cell therapies without substantial engraftment might treat hematologic cancers
Elizabeth F. Krakow, Hui-Sheng Ai, Brian Shaffer, Jean-Sébastien Delisle, Kai-Xun Hu and Anthony D. Sung
View Abstract
Nitroso-Redox Balance and Modulation of Basal Myocardial Function: an Update from the Italian Society of Cardiovascular Research (SIRC)
Carlo G Tocchetti, Marilisa Molinaro, Tommaso Angelone, Vincenzo Lionetti, Rosalinda Madonna, Fabio Mangiacapra, Francesco Moccia, Claudia Penna, Laura Sartiani, Federico Quaini and Pasquale Pagliaro
View Abstract
The Impact of Combination Therapy with a-Blockers and 5ARIs on the Progression of BPH
Petros Sountoulides
View Abstract
Primary Cilia in Tumor Biology: The Primary Cilium as a Therapeutic Target in Cholangiocarcinoma
Sergio A Gradilone, María J Lorenzo Pisarellob and Nicholas F LaRussob
View Abstract
Docetaxel/2-Hydroxypropyl β-Cyclodextrin Inclusion Complex Increases Docetaxel Solubility and Release from a Nanochannel Drug Delivery System
Silvia Ferrati, Eugenia Nicolov, Shyam Bansal, Sharath Hosali, Melissa Landis and Alessandro Grattoni
View Abstract
Molecular Bases Of Chemoresistance In Cholangiocarcinoma
J JG Marin, E Lozano, O Briz, R Al-Abdulla, M A Serrano and R IR Macias
View Abstract
MicroRNAs in breast cancer: one More Turn in Regulation
P Eroles, E Tormo, B Pineda, E Espin and A Lluch
View Abstract
Steps and Routes of HCV Infection: the Great Promise of new Anti-Viral Targets
Annalisa Crema, Antonio Ponzetto, Massimo Clementi and Guido Carloni
View Abstract
Multiscale Imaging of Nanoparticle Drug Delivery
Lawrence W. Dobrucki, Dipanjan Pan and Andrew M. Smith
View Abstract
Antimicrobial and Antioxidant Properties of Satureja Montana L. and S. Subspicata Vis. (Lamiaceae)
Dario Kremer, Iztok Jože Košir, Marijana Zovko Končić, Andreja Čerenak, Tanja Potočnik, Siniša Srečec, Marko Randić and Ivan Kosalec
View Abstract
Roles of Apoptosis and Cellular Senescence in Cancer and Aging
Claudia Cerella, Cindy Grandjenette, Mario Dicato and Marc Diederich
View Abstract
The Role of JNK Signalling in Responses to Oxidative DNA Damage
Zeeshan Shaukat, Dawei Liu, Rashid Hussain, Mahwish Khan and Stephen L. Gregory
View Abstract
Cardioprotection by Targeting the Pool of Resident and Extracardiac Progenitors
Konrad Urbanek, Caterina Frati, Gallia Graiani, Denise Madeddu, Angela Falco, Stefano Cavalli, Bruno Lorusso, Andrea Gervasi, Lucia Prezioso, Monia Savi, Francesca Ferraro, Federica Galaverna, Pietro Rossetti, Costanza Annamaria Lagrasta, R e Fancesca, Eugenio Quaini, Francesco Rossi, Antonella De Angelis and Federico Quaini
View Abstract
(1→3)-α-D-Glucans from Aspergillus spp.: Structural Characterization and Biological Study on Their Carboxymethylated Derivatives
Adrian Wiater, Roman Paduch, Adam Choma, Stączek Sylwia, Małgorzata Pleszczyńska, Michał Tomczyk, Marcello Locatelli and Szczodrak Janusz
View Abstract
The Impact of the Emerging Genomics Data on the Management of Age-Related Phenotypes in the Context of Cellular Senescence
Alberto Montesanto, Silvana Geracitano, Sabrina Garasto, Sergio Fusco, Fabrizia Lattanzio, Giuseppe Passarino and Andrea Corsonello
View Abstract
Architectural Clones in Aplastic Anaemia- Lessons Learned from High Throughput Sequencing
Austin G Kulasekararaj and Judith C W Marsh
View Abstract
Phosphonate Emerging Zinc Binding Group in Matrix Metalloproteinase Inhibitors
Cristina Campestre, Mariangela Agamennone, Marilena Tauro and Paolo Tortorella
View Abstract
Hyaluronic Acid as a Protein Polymeric Carrier: an Overview and a Report on Human Growth Hormone
Anna Mero, Monica Campisi, Michele Caputo, Christian Cuppari, Antonio Rosato, Oddone Schiavon and Gianfranco Pasut
View Abstract
Protective Effect of Aronia Melanocarpa Polyphenols on Cadmium Accumulation in the Body: a Study in a Rat Model of Human Exposure to this Metal
Malgorzata M. Brzóska, Malgorzata Galażyn-Sidorczuk, Maria Jurczuk and Michal Tomczyk
View Abstract
OPA1 in Cardiovascular Health and Disease
N Burke, A R Hall and D J Hausenloy
View Abstract
Recent Advances in Optical Molecular Imaging and its Applications in Targeted Drug Delivery
Xibo Ma, Hui Hui, Wenting Shang, Xiaohua Jia and Jie Tian
View Abstract
Matched Sibling Donor Hematopoietic Stem Cell Transplant in Patients with Acquired Aplastic Anemia
André Tichelli and Jakob R. Passweg
View Abstract
Molecular Imaging of Therapeutic Potential of Reporter Probes
Bhushan Thakur, Subhoshree Chatterjee, Smrita Chaudhury and Pritha Ray
View Abstract
Intracellular Ca2+ Signals to Reconstruct a Broken Heart: Still a Theoretical Approach?
Francesco Moccia, Federico Alessandro Ruffinatti and Estella Zuccolo
View Abstract
Image Guidance in Stem Cell Therapeutics: Unfolding the Blindfold
Amirali B. Bukhari, Shruti Dutta and Abhijit De
View Abstract
Aqueous Extracts of Selected Potentilla Species Modulate Biological Activity of Human Normal Colon Cells
Roman Paduch, Adrian Wiater, Marcello Locatelli, Małgorzata Pleszczyńska and Michał Tomczyk
View Abstract
Stem cell aging and age-related cardiovascular disease: Perspectives of treatment by ex-vivo stem cell rejuvenation
Madonna Rosalinda, Engel B. Felix, M Davidson Sean, Ferdinandy Péter, Görbe Anikó, P.G. Sluijter Joost and W Van Laake Linda
View Abstract
Biomedical Imaging in Implantable Drug Delivery Systems
Haoyan Zhou, Christopher Hernandez, Monika Goss, Anna Gawlik and Agata A. Exner
View Abstract
Bioactive Food Components as Dietary Intervention for Cystic Fibrosis
Nualpun Sirinupong and Zhe Yang
View Abstract
Polymeric Aggregates in Ionic Liquids: the Green Future of the Delivery Systems
Guido Angelini and Carla Gasbarri
View Abstract
Proteomic profiling of a biomimetic drug delivery platform
Claudia Corbo, Alessandro Parodi, Michael Evangelopoulos, David A. Engler, Risë K. Matsunami, Anthony C. Engler, Roberto Molinaro, Shilpa Scaria, Francesco Salvatore and Ennio Tasciotti
View Abstract
Preparation of Multifunctional Nanoprobes for Tumor-Targeted Fluorescent Imaging and Therapy
Mi Zhou, Xiao Xiao, Adnan A. Kadi, Hoong-kun Fun, Jinbo Li and Yan Zhang
View Abstract
Multistage Nanovectors Enhance the Delivery of Free and Encapsulated Drugs
Jonathan O. Martinez, Michael Evangelopoulos, Rohan Bhavane, Stefania Acciardo, Francesco Salvatore, Xuewu Liu, Mauro Ferrari and Ennio Tasciotti
View Abstract
Systemic Delivery of Free Chitosan Accelerates Femur Fracture Healing in Rats
Peng Shao, Yongzhong Wei, Crispin R. Dass, Guoying Zhang and Zhisheng Wu
View Abstract
Image-Guided Drug Delivery with Single-Photon Emission Computed Tomography: A Review of Literature
Rubel Chakravarty, Hao Hong and Weibo Cai
View Abstract
Silencing of Tumor Necrosis Factor Receptor-1 in Human Lung Microvascular Endothelial Cells using Particle Platforms for siRNA Delivery
Litao Bai, Helen A. Andersson, Kellie McConnell, Diana Chan, Michael Hernandez, Javier Gonzalez, Xuewu Liu, Saverio La Francesca, Jason Sakamoto and Rita E. Serda
View Abstract
Penetration Enhancer-Containing Vesicles: Does the Penetration Enhancer Structure Affect Topical Drug Delivery?
Anna Maria Fadda
View Abstract
Supramolecular Nanomedicine - An Overview
Bhupinder Singh Sekhon
View Abstract
αIIbβ3-Integrin Ligands: Abciximab and Eptifibatide as Proapoptotic Factors in MCF-7 Human Breast Cancer Cells
Joanna Kononczuk, Arkadiusz Surazynski, Urszula Czyzewska, Izabela Prokop, Michal Tomczyk, Jerzy Palka and Wojciech Miltyk
View Abstract
Safety of Nanoparticles in Medicine
Joy Wolfram, Motao Zhu, Yong Yang, Jianliang Shen, Emanuela Gentile, Donatella Paolino, Massimo Fresta, Guangjun Nie, Chunying Chen, Haifa Shen, Mauro Ferrari and Yuliang Zhao
View Abstract
Non-small Cell Lung Carcinoma: An Overview on Targeted Therapy
Ana Vanessa Nascimento, Hassan Bousbaa, Domingos Ferreira and Bruno Sarmento
View Abstract
Genomic identification of potential targets unique to Candida albicans for the discovery of antifungal agent
Himanshu Tripathi, Suaib Luqman, Abha Meena and Feroz Khan
View Abstract
A Review on Skin Targeted Delivery of Bioactives as 2 Ultradeformable Vesicles: Overcoming the Penetration Problem
Priyanka Karunanidhi and Singh Sanjay
View Abstract
Editorial:Mirnas as Legitimate Targets for Cancer Therapy
Wang Z
View Abstract
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