E-Pub Articles Ahead of Print ::: Letters in Drug Design & Discovery

ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)


Volume 13, 10 Issues, 2016


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Letters in Drug Design & Discovery

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Editor-in-Chief:
Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK
Email: lddd@benthamscience.org

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E-Pub Articles Ahead of Print

Design, Synthesis and Antidepressant and Anticonvulsant Effect of 1-Alkoxy-1H-Benzo[d]-1,2,3-Triazole Derivatives


Yu Sun and Qing-Hao Jin.


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Anti-biofilm and Antibacterial Effects of Novel Metal-coordinated Sulfamethoxazole Against Escherichia coli


Caren Rigon Mizdal, Sílvio Terra Stefanello, Pauline Cordenonsi Bonez, Vanessa Albertina Agertt, Vanessa da Costa Flores, Grazielle Guidolin Rossi, Fallon dos Santos Siqueira, Lenice de Lourenço Marques and Marli Matiko Anraku Campos.


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Quorum Sensing Inhibitor Activities of Celecoxib Derivatives in Pseudomonas aeruginosa


Seyhan Ulusoy, Sevil Aydın, İnci Coşkun, Gülgün Boşgelmez-Tınaz, Laurent Soulere, Yves Queneau and Ş Güniz Küçükgüzel.


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Synthesis, Antibacterial, Antifungal, Antimycobacterial Activity Evaluation of Novel 1,2,4-triazole Derivatives Bearing 4-aminophenyl Moiety Biological Evaluation of New Triazole Derivatives


Betül Kaya, Leyla Yurttas, Meral Yılmaz Cankılıç and Zafer Asım Kaplancıklı.


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Polyphenolic Compound from Vitis vinifera L. Have Potential for the Alzheimer Disease Treatment


Soukup Ondrej, Stralkova Radomira, Mistova Tereza, Popov Marek, Hejtmankova Alena, Lachman Jaromir, Klimova Blanka and Kuca Kamil.


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A Facile Synthesis and Drug Design of Some New Heterocyclic Compounds Incorporating Pyridine Moiety and Their Antimicrobial Evaluation


Sobhi M. Gomha, Fathy M. Abdelrazek, Aly H. Abdelrahman, Peter Metz and Mohsen A Sayed.


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A Two QSAR Way for Antidiabetic Agents Targeting Using α-Amylase and α-Glucosidase Inhibitors: Model Parameters Settings in Artificial Intelligence Techniques


Karel Diéguez-Santana, Hai Pham-The, Oscar Miguel Rivera-Borroto, Amilkar Puris, Huong Le-Thi-Thu and Gerardo M Casañola-Martin.


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Synthesis, Enzyme Assays and Molecular Docking Studies of Fluorinated Bioisosteres of Santacruzamate A as Potential HDAC Tracers


Muneer Ahamed, Koen Vermeulen, Michael Schnekenburger, Lise Román Moltzau, Finn Olav Levy, János Marton, Mathy Froeyen, Dag Erlend Olberg, Marc Diederich and Guy Bormans.


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Synthesis, Computational Study, and Evaluation of In vitro Antimicrobial, Antibiofilm, and Anticancer Activities of New Sulfanyl Aminonaphthoquinone Derivatives


Nilüfer Bayrak, Hatice Yıldırım, Amaç Fatih Tuyun, Emel Mataraci Kara, Berna Ozbek Celik, Girish Kumar Gupta, Halil I. Ciftci, Mikako Fujita, Masami Otsuka and Hamid R Nasi.


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Synthesis and Herbicidal Activity of Some Novel Pyrazole Derivatives


Hai-Qin He, Xing-Hai Liu, Jian-Quan Weng and Cheng-Xia Tan.


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Computational Analysis of Pyridopyrimidine-based Polo Like Kinase 2 (PLK2) Inhibitors: Examining the Structural Basis for Anticancer Activity


Anand Balupuri, Pavithra K. Balasubramanian and Seung Joo Cho.


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Quinoline Derivatives as Novel Depigmenting and Antioxidant Agents


Rebeca Mól Lima, Jordana de Abreu Lazzarini, Isabela Oliveira Souza, Adilson David Silva, Nádia Rezende Barbosa Raposo and Kauana Cristina de Souza.


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Pentoxifylline Alleviates Proteinuria in Fructose Model of Metabolic Syndrome


Hany M. El-Bassossy, Basma Eid and Ahmad Azhar.


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Synthesis of Novel 4-(Dimethylaminoalkyl)piperazine-1-carbodithioate Derivatives as Cholinesterase Inhibitors


Ulviye Acar, Serkan Levent, Begüm Nurpelin Sağlık, Yusuf Özkay and Zafer Asım Kaplancıklı.


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Synthesis and Cytotoxicity of Amino-Pyrazole Derivatives with Preliminary SAR


Chunqi Hu, Jianfeng Shen and Wenting Du.


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Caffeic Acid Phenethyl Ester Restores Adipocyte Function Following Lipopolysaccharide treatment


Ignazio Barbagallo, Giovanni Li Volti, Valeria Sorrenti, Claudia Di Giacomo, Rosaria Acquaviva, Marco Raffaele, Fabio Galvano and Luca Vanella.


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Novel Second Generation HIV Integrase Inhibitor- DOLUTEGRAVIR : an emerging weapon against HIV


Vivek Jain, Diksha Gupta, Ashutosh Pareek and Yashumati Ratan Bhardwaj.


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Sequential Therapy For Helicobacter Pylori In Elderly Patients: Effectiveness, Safety And Predictors Of Success


Giuseppe Losurdo, Andrea Iannone, Floriana Giorgio, Michele Barone, Mariabeatrice Principi, Enzo Ierardi and Alfredo Di Leo.


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3D-QSAR studies of novel cytotoxic bufadienolides via CoMFA and CoMSIA approaches


Jian Jie, Hui Lin, Kangjia Liu, Yushui Han, Jialiang Guo, Longxin Lin, Yiqun Chang, Gaokeng Xiao, Weimin Chen and Pinghua Sun.


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Synthesis of New Benzofuran-Pyrazole Hybrids as Potential Antibiofilm Agents


Gejjalagere S Lingaraju, Somashekaraiah Rakesh, Koravangala S Vinay Kumar, Kanchepalli Poornachandra Rao, Marikunte Y Sreenivasa and Maralinganadoddi P Sadashiva.


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In Vivo Antimalarial and In Vitro Antileishmanial Activity of 4-Aminoquinoline Derivatives Hybridized to Isoniazid or Sulfa or Hydrazine Groups


Clarice Abramo, Roberta R. Soares, Luciana MR Antinarelli, Isabela de Oliveira Souza, Fernanda V. Lopes, Kézia Katiani Gorza Scopel and Adilson D da Silva.


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Identification of thiazoloquin(az)olin(on)es Derivatives as CD38 Inhibitors Through 3D-QSAR and Molecular Docking Simulations


Xiaodong Gao and Jie Yu Ren.


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In silico Modeling for the Design of 2-substitted Benzimidazole Derivatives, and Prediction of Activity as Procaspase-3 Activators and Apoptosis Inducer


Vivek K. Vyas, Manjunath Ghate and Prajakta Kulkarni.


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Cytotoxic, Apoptotic and DNA Synthesis Inhibitory Effects of Some Thiazole Derivatives


Gülşen Akalın Çiftçi, Mehlika Dilek Altıntop, Halide Edip Temel, Ahmet Özdemir and Zafer Asım Kaplancıklı.


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In Vitro and In Vivo Investigations into the Carbene Gold Chloride and Thioglucoside Anticancer Drug Candidates NHC-AuCl and NHC-AuSR


Wolfgang Walther, Oyinlola Dada, Cillian O'Beirne, Ingo Ott, Goar Sánchez-Sanz, Claudia Schmidt, Carsta Werner, Xiangming Zhu and Matthias Tacke.


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Synthesis, Molecular Docking and Pharmacological Study of Pyrimidothiadiazinones and its bis-derivatives


Sobhi M. Gomha, Ikhlass Abbas, Mohamed Elneairy, Mahmoud Elaasser and bazada khamis.


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The Synthesis of (Iodobenzyl)oxybenzaldehydes, Useful Intermediates for Biologically Active Targets


Hedvig Bölcskei, Andrea Német-Hanzelik, István Greiner, Zsófia Dubrovay, Viktor Háda and György Keglevich.


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Design, Synthesis and Bioactivity of Phenoxy Carboxylate(amide) Derivatives Containing 4,6-Dimethoxypyrimidine


zhiqiang huang, chenpeng feng, jun tong, qiang bian and Zhao Yu.


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Synthesis of Some New 1(2H)-phthalazinone Derivatives and Evaluation of Their Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activities


Burcu Kılıç, Hayrettin Ozan Gülcan, Mertcan Yalçın, Fatma Aksakal, Anatoli Dimoglo, Mustafa Fethi Şahin and Deniz Songül Doğruer.


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Synthesis and Evaluation of Morpholinoethylester Conjugate of N-acetylcysteine in Ovalbumin- Induced Airway Hyperresponsiveness in Sprague Dawley Rats


Suneela S Dhaneshwar and Neha V Bhilare.


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Molecular Docking, Molecular Dynamics, and In Silico Prediction of the Toxic Potential of Primaquine Thiazolidinone Derivatives


Andre Silva Pimentel and Erika Murce.


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Field Based 3D-QSAR model of KATP channel activation by 4, 6 disubstituted Benzopyran Derivatives


Kamlesh Asotra, yaseen gigani, Andrew Lynn and Swati Gupta.


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Synthesis, Docking and Antidiabetic Activity of Some Newer Benzamide Derivatives as Glucokinase Activators


Rohit Singh, Viney Lather, Deepti Pandita, Vikramjeet Judge, Karthikeyan N. Arumugam and Ajmer Singh Grewal.


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Structural studies of aminopeptidase P from Plasmodium falciparum: a novel target against malaria


P Snigdha, P Lakshmana Rao, N Prakash Prabhu and Insaf Ahmed Qureshi.


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Anti-inflammatory Potential of Alkaloids as a Promising Therapeutic Modality


HAROON KHAN.


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Zinc tetrafluoroborate Catalyzed Synthesis, Molecular Docking and Cytotoxicity of Pyrrolidinyl aminophosphonates


Cirandur Suresh Reddy, Santhisudha Sarva, Madhu Kumar Reddy Kandula, Nanda Kumar Yellapu, Selvarajan Ethiraj, Mohanasrinivasan Vaithiyalingam and Sandip Kumar Nayak.


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The Summation of Atomic Contributions is an Overly Simplified Characterization of the Holistic Molecular Behavior


Yoan Martínez-López, Yovani Marrero-Ponce, Gustavo Echeverri Jaramillo and Stephen J Barigye.


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Discovery of 6-benzamide containing 4-phenylquinazoline derivatives as novel PI3Kδ Inhibitors


Minhang Xin, Yuan-Yuan Hei, Hao Zhang, Xiao-Xiao Xie, Shuai Mao, Sai-Jie Zuo and San-Qi Zhang.


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Design, Synthesis and Biological Evaluation of Novel Tetrahydroquinoline Based Propanehydrazides as Antitubercular Agents


Subhash Chander, Penta Ashok, Bidart de Macedo Maira, Cappoen Davie and Sankaranarayanan Murugesan.


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Biologically Potent Pyrazoline Derivatives from Versatile (2)-1-(4-Chlorophenyl)-3-[4-(propan-2-yl)phenyl]prop-2-en-1-one


Badiadka Narayana.


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Estrogen catechols detection as biomarkers in schistosomiasis induced cancer and infertility


Monica Catarina Botelho, Helena Alves and Joachim Richter.


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Synthesis and Antioxidant Evaluation of Some Novel Benzimidazole Derivatives Containing a Triazole Nucleus


Emre Mentese, Nimet Baltaş and Fatih YILMAZ.


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Model for Classification of ChEMBL Dataset of Anti-breast cancer Compounds According to Multiple Pharmacological Parameters, Biological Assays, and Receptors


Francisco J. Prado-Prado, Angel G. Arguello-Chan, Coraima I. Estrada-Domínguez, Alejandra Aguirre-Crespo, Francisco J. Aguirre-Crespo and Xerardo García-Mera.


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Preparation and Characterization of CS/(β-CD)/PAA Composite Hydrogels for Controlled Drug Delivery


Jie Ren, Xiaoci Yang, Mengqi Yao, Jinfen Gu, Xiaohua Tang and Wu Yang.


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Synthesis, Antitumor of New Pyrimidineand Caffeine Derivatives


Ameen Ali Abu-Hashem and Hoda Abdel Raouf Hussein.


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Synthesis and Biological Evaluation of New Tubulin Inhibitors: Shikonin Thio-glycoside Derivatives


Xiao-Ming Wang, Hong-Yan Lin, Jin-Liang Qi, Li-Fei Bai and Yong-Hua Yang.


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