E-Pub Articles Ahead of Print ::: Current Pharmaceutical Design

ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)


Volume 20, 42 Issues, 2014


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Current Pharmaceutical Design

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  • 62nd of 254 in Pharmacology & Pharmacy

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E-Pub Articles Ahead of Print

Macrophages in Immunopathology of Atherosclerosis: a Target for Diagnostics and Therapy
Alexander N. Orekhov, Igor A. Sobenin, Mikhail A. Gavrilin, Alexei Gratchev, Svetlana Y. Kotyashova, Nikita G. Nikiforov and Julia Kzhyshkowska
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Modular Nanotransporters for Targeted Intracellular Delivery of Drugs: Folate Receptors as Potential Targets
Tatiana A. Slastnikova, Andrey A. Rosenkranz, Michael R. Zalutsky and Alexander S. Sobolev
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Assessment and Relevance of Carotid Intima-Media Thickness (C-IMT) in Primary and Secondary Cardiovascular Prevention
Alessio Ravani, José Pablo Werba, Beatrice Frigerio, Daniela Sansaro, Mauro Amato, Elena Tremoli and Damiano Baldassarre
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Fibrillar, Fibril-associated and Basement Membrane Collagens of the Arterial Wall: Architecture, Elasticity and Remodeling Under Stress
M. S Osidak, E. O Osidak, M. A, S. P Domogatsky and A S Domogatskaya
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Mutations of Mitochondrial DNA in Atherosclerosis and Atherosclerosis-Related Diseases
Igor A. Sobenin, Andrey V. Zhelankin, Konstantin Y. Mitrofanov, Vasily V. Sinyov, Margarita A. Sazonova, Anton Y. Postnov and Alexander N. Orekhov
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Therapies Targeting Innate Immunity for Fighting Inflammation in Atherosclerosis
Itzhak Mendel, Niva Yacov, Dror Harats and Eyal Breitbart
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Adverse Effects of Statins - Myths and Reality
Iveta Šimić and Željko Reiner
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Overview of Green Tea Interaction with Cardiovascular Drugs
José P. Werba, Shingen Misaka, Monica G. Giroli, Shizuo Yamada, Viviana Cavalca, Keisuke Kawabe, Isabella Squellerio, Federica Laguzzi, Satomi Onoue, Fabrizio Veglia, Veronika Myasoedova, Kazuhiko Takeuchi, Eisuke Adachi, Naoki Inui, Elena Tremoli and Hiroshi Watanabe
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Oleacein. Translation from Mediterranean diet to potential antiatherosclerotic drug
Marek Naruszewicz, Monika E. Czerwinska and Anna K. Kiss
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Regulatory T Cells and Tolerogenic Dendritic Cells as Critical Immune Modulators in Atherogenesis
Naoto Sasaki, Tomoya Yamashita, Kazuyuki Kasahara, Masafumi Takeda and Ken-ichi Hirata
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Development of Anti-Atherosclerosis Therapy Based on the Inflammatory and Proliferative Aspects of the Disease
Raul C. Maranhão and Antonio C. A. Leite
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Implementation of Cardiovascular Disease Prevention Guidelines into Clinical Practice: an Unmet Challenge?
Richard Češka and Tomáš Štulc
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Tissue Factor And Atherothrombosis
D Saha, S Saha, E. G Sergeeva, Z. I Ionova and A. V Gorbach
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Dendritic Cells: A double-edge Sword in Atherosclerotic Inflammation
Dimitry A. Chistiakov, Igor A. Sobenin, Alexander N. Orekhov and Yuri V. Bobryshev
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Reactive Oxygen Species in Pathogenesis of Atherosclerosis
Nikolay V. Goncharov, Pavel V. Avdonin, Alexander D. Nadeev, Irina L. Zharkikh and Richard O. Jenkins
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Novel Anti-inflammatory Interleukin-35 as an Emerging Target for Anti-atherosclerotic Therapy
Yuri V. Bobryshev, Igor A. Sobenin, Alexander N. Orekhov and Dimitry A. Chistiakov
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Melatonin and Renal Protection: Novel Perspectives from Animal Experiments and Human Studies (review )
Jaroslav Hrenak, Ludovit Paulis, Kristina Repova, Silvia Aziriova, Elsbeth J Nagtegaal, Russel J Reiter and Fedor Simko
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The Role of White Matter Abnormalities in Treatment-Resistant Depression: a Systematic Review
Gianluca Serafini, Maurizio Pompili, Stefan Borgwardt, Enrico Giuffra, Oliver Howes, Paolo Girardi and Mario Amore
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Novel Dual Small-Molecule HIV inhibitors: Scaffolds and Discovery Strategies
Anran Song, Haiqing Yu, Changyuan Wang, Xingqi Zhu, Kexin Liu and Xiaodong Ma
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Strategies for Skeletal Muscle Targeting in Drug Discovery
David C. Ebner, Peter Bialek, Ayman F. El-Kattan, Catherine M. Ambler and Meihua Tu
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The Heart And Brain Imaging In Lone Atrial Fibrillation – Are We Surprised?
Karl Georg Haeusler, Jochen B. Fiebach, Günter Breithardt, Paulus Kirchhof and Eduard Shantsila
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Best Practice for Atrial Fibrillation Patient Education
Deirdre A. Lane, Rachel V. Barker and Gregory Y. H. Lip
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Clinical Applications of Choline PET/CT in Brain Tumors
Elisabetta Giovannini, Patrizia Lazzeri, Amelia Milano, Maria Chiara Gaeta and Andrea Ciarmiello
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Molecular Mechanisms Involved in the Control of Neurohypophyseal Hormones Secretion
M Iovino, E Guastamacchia, V A Giagulli, B Licchelli, E Iovino and V Triggiani
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Editorial: ‘Lone’ atrial fibrillation: No longer lone or even alone
Tatjana S. Potpara and Gregory Y.H. Lip
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Bacteriophages and their Enzymes in Biofilm Control
Benjamin K. Chan and Stephen T. Abedon
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Nitric Oxide: a Key Mediator of Biofilm Dispersal with Applications in Infectious Diseases
Nicolas Barraud, Michael J. Kelso, Scott A. Rice and Staffan Kjelleberg
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Quorum Sensing and Biofilms in the Pathogen, Streptococcus Pneumoniae
Joana Galante, Alfred C-Y Ho, Sarah Tingey and Bambos M Charalambous
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Quorum Sensing Inhibitors as Anti-Biofilm Agents
Gilles Brackman and Tom Coenye
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Strategies for Antimicrobial Drug Delivery to Biofilm
Claire Martin, Wan Li Low, Abhishek Gupta, Mohd Cairul, Iqbal Mohd Amin, Iza Radecka, Stephen T. Britland, Prem Raj and Ken MA Kenward
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Current and Future Approaches to the Prevention and Treatment of Staphylococcal Medical Device-Related Infections
S Hogan, N T Stevens, H Humphreys, J P O’Gara and E. O’Neill
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Potential Application of Antimicrobial Peptides in the Treatment of Bacterial Biofilm Infections
Nikola Strempel, Janine Strehmel and Joerg Overhage
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Targeting Cyclic di-GMP Signalling: a Strategy to Control Biofilm Formation?
Delphine L. Caly, Domenico Bellini, Martin A. Walsh, J Maxwell Dow and Robert P. Ryan
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Phosphodiesterase Inhibitors as a Target for Cognition Enhancement in Aging and Alzheimer’s Disease: A Translational Overview
P.R.A. Heckman, C. Wouters and J. Prickaerts
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The Roles of Phosphodiesterase 2 in the Central Nervous and Peripheral Systems
Chong Zhang, Yingcong Yu, Lina Ruan, Chuang Wang, Jianchun Pan, Jonathan Klabnik, Lindsay Lueptow, Han-Ting Zhang, James M. O’Donnell and Ying Xu
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Editorial: Emerging Concepts in Management of Bacterial Biofilm Infections
Brendan Gilmore
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Role of synovial fibroblasts in rheumatoid arthritis
S Lefèvre, FMP Meier, E Neumann and U Muller-Ladner
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Role of T lymphocytes in the development of rheumatoid arthritis. Implications for treatment.
Erik Lubberts
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Biomarkers for radiographic progression in rheumatoid arthritis
A. Krabben, T.W.J. Huizinga and A.H.M. van der Helm-van Mil
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Biomarkers predicting a need for intensive treatment in patients with early arthritis
I. Gonzalez-Alvaro, A. Mª. Ortiz, I. V. Seoane, R. García-Vicuna, C. Martínez and R. P. Gomariz
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Rheumatoid Arthritis: Genetic Variants as Biomarkers of Cardiovascular Disease
Luis Rodriguez-Rodriguez, Raquel Lopez-Mejias, Benjamín Fernandez-Gutiérrez, Alejandro Balsa, Miguel A. González-Gay and Javier Martín
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Laboratory biomarkers for guiding therapy with methotrexate in rheumatoid arthritis
Carlos Abud-Mendoza, Marco U. Martínez-Martínez, Adriana Monsiváis-Urenda and Roberto González-Amaro
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Response to rituximab: has the original hypothesis been confirmed?
Geraldine Cambridge and Inmaculada De La Torre
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Predictors of Response to TNF Antagonists
Eva Salgado, Jose Ramon Maneiro and Juan J. Gomez-Reino
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Predicting toxicity: biomarkers and the value of the patient’s opinion
MJ Garcia de Yebenes, E Loza and L Carmona
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Are patient self-report questionnaires as “scientific” as biomarkers in “treat-to-target” and prognosis in rheumatoid arthritis?
Theodore Pincus and Isabel Castrejón
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Psychological factors associated with response to treatment in rheumatoid arthritis
Santiago T, Geenen R, Jacobs WG and Da Silva JAP
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Genetic Signatures in the Treatment of Stroke
Anjana Munshia and Vandana Sharma
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Phosphodiesterase Inhibitors as Therapeutics for Traumatic Brain Injury
David J. Titus, Anthony A. Oliva, Nicole M. Wilson and and Coleen M. Atkins
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‘Phosphodiesterases as therapeutic targets for Huntington’s disease.’
Francesca R. Fusco and Carmela Giampà
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Phosphodiesterase-4 modulation as a potential therapeutic for cognitive loss in pathological and non-pathological aging: Possibilities and Pitfalls
Rolf T. Hansen III and Han-Ting Zhang
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Role of Phosphodiesterase 4-mediated cyclic AMP signaling in pharmacotherapy for substance dependence
Rui-Ting Wen, Wan-Yu Feng, Jian-Hui Liang and Han-Ting Zhang
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‘Emerging Biology of PDE10A’
Lindsay S. Wilson and Nicholas J. Brandon
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Does Phosphodiesterase 11A (PDE11A) Hold Promise as a Future Therapeutic Target?
Michy P. Kelly
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Phosphodiesterase: An Interface Connecting Cognitive Deficits to Neuropsychiatric and Neurodegenerative Diseases
Zhen-Zhen Wang, Yi Zhang, Han-Ting Zhang and Yun-Feng Li
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Editorial: Mitochondrial Biogenesis: Pharmacological Approaches
Teresa Valero
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Mechanisms of Inflammatory Response and Organ Dysfunction: Organ-Protective Strategy by Anesthetics
Noboru Hatakeyama and Naoyuki Matsuda
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VEGF and Colon Cancer Growth Beyond Angiogenesis: Does VEGF Directly Mediate Colon Cancer Growth Via a Non-angiogenic Mechanism?
Amrita Ahluwalia, Michael K. Jones, Tamara Matysiak-Budnik and Andrzej S. Tarnawski
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The Impact of Computational Structure-Based Methods on Drug Discovery
Charles H. Reynolds
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Human Use of Leucoselect® Phytosome® with Special Reference to Inflammatoryallergic Pathologies in Frail Elderly Patients
Thea Magrone, Vittorio Pugliese, Sergio Fontana and Emilio Jirillo
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Anti-miRNA-23a Oligonucleotide Suppresses Glioma Cells Growth by Targeting Apoptotic Protease Activating Factor-1
Shizhong Lian, Ruyi Shi, Tao Bai, Yang Liu, Wang Miao, Hongqin Wang, Xiaodong Liu and Yimin Fan
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Editorial: The SNAP-tag Technology – A Versatile Tool with many Applications
Stefan Barth
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Gender Based Differences in Stress-induced Gastric Ulcer Formation and its Regulation by Nitric Oxide (NO): An Experimental Study
Kavita Gulati, Ayanabha Chakraborti and Arunabha Ray
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Differential Influences of Gastric Bypass and Sleeve Gastrectomy on Plasma Nesfatin-1 and Obestatin Levels in Patients with Type 2 Diabetes Mellitus
Wei-Jei Lee, Chih-Yen Chen, Kong-Han Ser, Keong Chong, Shu-Chun Chen, Pui-Ching Lee, You-Di Liao and Shou-Dong Lee
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Probiotics for the Prevention and Treatment of Allergies, with an Emphasis on Mode of Delivery and Mechanism of Action
Satya Prakash, Catherine Tomaro-Duchesneau, Shyamali Saha, Laetitia Rodes, Imen Kahouli and Meenakshi Malhotra
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Consumption of Mixed Fruit-juice Drink and Vitamin C Reduces Postprandial Stress Induced by a High Fat Meal in Healthy Overweight Subjects
Ilaria Peluso, Debora V. Villano, Susan A. Roberts, Eleonora Cesqui, Anna Raguzzini, Gina Borges, Alan Crozier, Giovina Catasta, Elisabetta Toti and Mauro Serafini
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Immunomodulating and Anti-allergic Effects of Negroamaro and Koshu Vitis vinifera Fermented Grape Marc (FGM)
Giuseppe Marzulli, Thea Magrone, Luisa Vonghia, Masahiro Kaneko, Hiroaki Takimoto, Yoshio Kumazawa and Emilio Jirillo
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Potential Use of Dietary Natural Products, Especially Polyphenols, for Improving Type-1 Allergic Symptoms
Kumazawa Y, Takimoto H, Matsumoto T and Kawaguchi K
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Omega-6 and Omega-3 Polyunsaturated Fatty Acids and Allergic Diseases in Infancy and Childhood
Elizabeth A. Miles and Philip C. Calder
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Factors Affecting Residual Platelet Aggregation in Prasugrel Treated Patients
Dimitrios Alexopoulos, Ioanna Xanthopoulou, Angelos Perperis, Argyro Siapika, Katerina Stavrou, Evropi Tsoni, Periklis Davlouros and George Hahalis
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What Fans the Fire: Insights into Mechanisms of Leptin in Metabolic Syndrome- Associated Heart Diseases
Maolong Dong and Jun Ren
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Transactivation of ErbB Receptors by Leptin in the Cardiovascular System: Mechanisms, Consequences and Target for Therapy
Jerzy Bełtowski and Anna Jazmroz-Wiśniewska
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Structural Insights into Chitinolytic Enzymes and Inhibition Mechanisms of Selective Inhibitors
Tian Liu, Lei Chen, Qiang Ma, Xu Shen and Qing Yang
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Structure-based Design of Conformationally Flexible Reverse Transcriptase Inhibitors to Combat Resistant HIV
Ge-Fei Hao, Sheng-Gang Yang and Guang-Fu Yang
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Structural Basis of Resistance to Anti-Cytochrome bc1 Complex Inhibitors: Implication for Drug Improvement
Lothar Esser, Chang-An Yu and Di Xia
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ABC Transporters in Multidrug Resistance and Pharmacokinetics, and Strategies for Drug Development
Young Hee Choi, Ai-Ming Yu and Ai-Ming Yu
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Structure-Based Drug Design to Overcome Drug Resistance: Challenges and Opportunities
Rafaela S. Ferreira1, Adriano D. Andricopulo and Adriano D. Andricopulo
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Novel Next-Generation Sequencing and Networks-Based Therapeutic Targets: Realistic and More Effective Drug Design and Discovery
Dimitrios H. Roukos, Giannis G. Baltogiannis, Christos S. Katsouras, Aris Bechlioulis, Katerina K. Naka, Charalambos Batsis, Theodore Liakakos and Lampros K. Michalis
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Endothelial Dysfunction and the Effects of TNF Inhibitors on the Endothelium in Psoriasis and Psoriatic Arthritis: A Systematic Review
Elizabeth A. Brezinski, Matthew R. Follansbee, Ehrin J. Armstrong and April W. Armstrong
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Effects of Biologic Agents and Other Disease-Modifying Antirheumatic Drugs on Cardiovascular Outcomes in Psoriasis and Psoriatic Arthritis: A Systematic Review
April W. Armstrong, Elizabeth A. Brezinski, Matthew R. Follansbee and Ehrin J. Armstrong
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Ultrasound-Based Multimodal Molecular Imaging and Functional Ultrasound Contrast Agents
Yan Lin, Zhi-Yi Chen and Feng Yang
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Long-term Etanercept Therapy Favors Weight Gain and Ameliorates Cachexia in Rheumatoid Arthritis Patients: Roles of Gut Hormones and Leptin
Chih-Yen Chen, Chang-Youh Tsai, Pui-Ching Lee and Shou-Dong Lee
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The Effect of First-in-Class Small Molecule RhoA Inhibitor, HL07, on the Phenylephrine-induced Artery Contraction
Yan Zhang, Jing Deng, Sheng Ma, Lin Xue, Jin Zhu, Wei-liang Zhu, Hua-liang Jiang, Jian Li and Li-yan Miao
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Non-Systemic Drugs: A Critical Review
Dominique Charmot
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Advancement of Targeted Ultrasound Contrast Agents and their Applications in Molecular Imaging and Targeted Therapy
Feng Yang, Zhi-Yi Chen and Yan Lin
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Atorvastatin Sensitises Vascular Smooth Muscle Cells, but not Endothelial Cells, to TNF-α-induced Cell Death
Arturo Giordano, Simona Romano, Giovanna Nappo, Stefano Messina, Michele Polimeno, Nicola Corcione, Gaetano Calì, Paolo Ferraro, Mario Monaco, Nicola Zambrano and Maria Fiammetta Romano
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Carotenoids and Cardiovascular Risk
Paola Giordano, Pietro Scicchitano, Manuela Locorotondo, Cosimo Mandurino, Gabriella Ricci, Santa Carbonara, Michele Gesualdo, Annapaola Zito, Annamaria Dachille, Paola Caputo, Roberta Riccardi, Giulia Frasso, Giuseppe Lassandro, Antonio Di Mauro and Marco Matteo Ciccone
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A Computational Study of the Oligosaccharide Binding Sites in the Lectin-Like Domain of Tumor Necrosis Factor and the TNF-derived TIP Peptide
Alexander Dulebo, Rüdiger Ettrich, Rudolf Lucas and David Kaftan
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Target-based Anti-angiogenic Therapy in Breast Cancer
Markus Wehland, Johann Bauer, Manfred Infanger and Daniela Grimm
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Preclinical Safety and Pharmacokinetic Profile of 3K3A-APC, a Novel, Modified Activated Protein C for Ischemic Stroke
Patricia D. Williams, Berislav V. Zlokovic, John H. Griffin, Kent E. Pryor and Thomas P. Davis
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