E-Pub Articles Ahead of Print ::: Current Pharmaceutical Design

ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)


Volume 21, 42 Issues, 2015


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Current Pharmaceutical Design

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E-Pub Articles Ahead of Print

History and Milestones of Mouse Models of Autoimmune Diseases
Xinhua Yu, Qiaoniang Huang and Frank Petersen
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Mouse Models of Autoimmune Diseases - Autoimmune Myocarditis
Anna-Maria Muller, Andrea Fischer, Hugo A. Katus and Ziya Kaya
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Mouse Models of Autoimmune Diseases: Immune Thrombocytopenia
Anton Neschadim and Donald R. Branch
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Mouse Models of Myasthenia Gravis
Joanne Ban and William D Phillips
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Mouse Models of Autoimmune Uveitis
Izabela P. Klaska and John V. Forrester
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Mouse Models of Multiple Sclerosis: Lost in translation?
David Baker and Sandra Amor
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Animal Models to Investigate Pathomechanisms and Evaluate Novel Treatments for Autoimmune Bullous Dermatoses
Hiroaki Iwata, Katja Bieber, Misa Hirose and Ralf J. Ludwig
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Preclinical Models of Graves’ Disease and Associated Secondary Complications
Sajad Moshkelgosha, Po-Wah So, Salvador Diaz-Cano and J Paul Banga
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Mouse Models of Primary Biliary Cirrhosis
Axel R. Concepcion and Juan F. Medina
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An Update on Animal Models of Autoimmune Hepatitis: Are we There Yet?
Urs Christen and Edith Hintermann
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Mouse Models of anti-Neutrophil Cytoplasmic Antibody-associated Vasculitis
Poh-Yi Gan, Joshua D Ooi, A. Richard Kitching and Stephen R Holdsworth
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Animal Models of Systemic Sclerosis
F. Morin, N. Kavian and F. Batteux
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Mouse Models of Primary Sj
Young-Seok Park, Adrienne E. Gauna and Seunghee Cha
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Animal Models of Lupus and Lupus Nephritis
Yong Du, Soomro Sanam, Krause Kate and Chandra Mohan
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The Contribution of Transcriptomics to Biomarker Development in Systemic Vasculitis and SLE
Shaun M Flint, Eoin F McKinney, Paul A Lyons and Kenneth G Smith
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Editorial: Autoimmune diseases: What have we learned from mice?
Xinhua Yu
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MicroRNAs in Esophageal Adenocarcinoma: Functional Significance and Potential for the Development of New Molecular Disease Markers
Yuri V. Bobryshev, Alexander N. Orekhov and Dmitry A. Chistiakov
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Predicting the Druggability of Protein-Protein Interactions Based on Sequence and Structure features of active pockets
X u Dai, Run Yu Jing, Yanzhi Guo, Yong Cheng Dong, Yue Long Wang, Yuan Liu, Xue Mei Pu and Menglong Li
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Editorial: Rheumatology: An Evolutionary force in Biologics
Matthew A. Sleeman
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Inhibition of quorum sensing in Staphylococcus spp.
Gilles Brackman and Tom Coenye
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Staphylococcus Aureus: Current State of Prevalence, Impact, and Vaccine Development
Meghan Brett and Steven B. Bradfute
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Therapeutic Options and Emerging Alternatives for Multidrug Resistant Staphylococcal Infections
Maria Magana, Anastasios Ioannidis, Emmanouil Magiorkinis, Oleg Ursu, Cristian G. Bologa, Stylianos Chatzipanagiotou, Michael R Hamblin and George P. Tegos
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Harnessing the Power of Light to Treat Staphylococcal Infections Focusing on MRSA
Tanupriya Agrawal, Pinar Avci, Gaurav K. Gupta, Ardeshir Rineh, Shanmugamurthy Lakshmanan, Vincent Batwala, George P Tegos and Michael R. Hamblin
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Antimicrobial Peptides and Peptidomimetics – Potent Therapeutic Allies for Staphylococcal Infections
Haroon Mohammad, Shankar Thangamani and Mohamed N. Seleem
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Significant Differences Characterise the Correlation Coefficients between Biocide and Antibiotic Susceptibility Profiles in Staphylococcus aureus
Marco R. Oggioni, Joana Rosado Coelho, Leonardo Furi, Daniel R Knight, Carlo Viti, Graziella Orefici, Jose-Luis Martinez, Ana Teresa Freitas, Teresa M Coque and Ian Morrissey
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Driving Forces of Mechanisms Regulating Oxacillin-Resistance Phenotypes of MRSA: Truly Oxacillin-Susceptible MecA-Positive Staphylococcus Aureus Clinical Isolates also Exist
Spyros Pournaras, Artur J. Sabat, Hajo Grundmann, Ron Hendrix, Athanassios Tsakris and Alexander W. Friedrich
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Beyond Numbers: The Informative Patterns of Immuno-Staphylococcal Dynamics
Ariel L. Rivas, Almira L. Hoogesteyn and Renata Piccinini
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Drug Repurposing for the Treatment of Staphylococcal Infections
Shankar Thangamani, Haroon Mohammad, Waleed Younis and Mohamed N. Seleem
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Rheumatoid Arthritis: an Evolutionary Force in Biologics
Philip M Brown and John D Isaacs
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Rheumatology: A Force for Change in Monoclonal Antibodies
David C. Lowe
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Interleukin-6 In Rheumatoid Arthritis – From The Laboratory To The Bedside
Xiao Liu, Andrew J. Teichtahl and P. Wicks
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Finding a Place for Interleukin-1 Inhibitors in the Treatment of Rheumatologic Diseases
Donna Finch and Matthew Sleeman
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Biological Therapies in Osteoarthritis
Claire YJ Wenham, Michael McDermott and Philip G Conaghan
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Towards a Stratified Targeted Approach with Biologic Treatments in Rheumatoid Arthritis: Role of Synovial Pathobiology
Elisa Astorri, Alessandra Nerviani, Michele Bombardieri and Costantino Pitzalis
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Versatile Approaches to Target Staphylococcal Infections
George P. Tegos
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Anti-Cancer Cytotoxic Effects of Multiwalled Carbon Nanotubes
Lorena García-Hevia, Rafael Valiente, Jesús González, Héctor Terán, José Luís Fernández-Luna, Juan C. Villegas and Mónica L. Fanarraga
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Nanofibers Based Antibacterial Drug Design, Delivery and Applications
Kezban Ulubayram, Semih Calamak, Reza Shahbazi and Ipek Eroglu
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Smart Electrospun Nanofibers for Controlled Drug Release: Recent Advances and New Perspectives
Lin Weng and Jingwei Xie
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Drug-Incorporated Electrospun Fibers Efficiently Prevent Postoperative Adhesion
Bo Shi, Jianxun Ding, Junchao Wei, Changfeng Fu, Xiuli Zhuang and Xuesi Chen
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Immobilization and Application of Electrospun Nanofiber Scaffold-based Growth Factor in Bone Tissue Engineering
Guobao Chen and Yonggang Lv
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Scaffold-based Drug Delivery for Cartilage Tissue Regeneration
K. T. Shalumon and Jyh-Ping Chen
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Controlled Bioactive Molecules Delivery Strategies for Tendon and Ligament Tissue Engineering using Polymeric Nanofibers
Thomas Kok Hiong TEH, James Cho Hong GOH and Siew Lok TOH
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Nanofibers based Tissue Engineering and Drug Delivery Approaches for Myocardial Regeneration
Jyotsna Joshi and Chandrasekhar R. Kothapalli
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Implication of Nanofibers in Oral Drug Delivery
Himani Kapahi, Nikhat Mansoor Khan, Ankur Bhardwaj and Neeraj Mishra
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Recent Advancements in Carbon Nanofiber and Carbon Nanotube Applications in Drug Delivery and Tissue Engineering
David A. Stout
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Anti-VEGF Drugs in Eye Diseases: Local Therapy with Potential Systemic Effects
Markus van der Giet, Cornelia Henkel, Mirjam Schuchardt and Markus Tölle
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The Potential Effect of Fluorinated Compounds in the Treatment of Alzheimer’s Disease
Bárbara Gomes, Joana A. Loureiro, Manuel A.N. Coelho and Maria do Carmo Pereira
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Anticancer Advances of Matrine and Its Derivatives
Jianping Yong, Xiaoyuan Wu and Canzhong Lu
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Skeletal Muscle Cell Behavior After Physical Agent Treatments
Michela Battistelli, Sara Salucci, Michele Guescini, Davide Curzi, Vilberto Stocchi and Elisabetta Falcieri
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Nanofiber-based Drug Design, Delivery and Application
Yonggang Lv
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Analysis of Edg-Like LPA Receptor-Ligand Interactions
Balazs Balogh, Tamas Pazmany and Peter Matyus
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Multiple Roles of Fibroblast Growth Factor 21 in Metabolism
Li Li and Liling Tang
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Evaluation of the In Vivo Safety Profiles of Rictor Inhibition Using a Zebrafish Model
Yang Cao, Lijun Jiang, Lei Zhao, Xiaoxi Zhou, Na Wang, Peilin Zhang, Yuting Tang and Jianfeng Zhou
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Therapeutic Effect of Ghrelin in the Course of Ischemia/Reperfusion-induced Acute Pancreatitis
J Bukowczan, Z Warzecha, P Ceranowicz, B Kusnierz-Cabala, R Tomaszewska and A Dembinski
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Application of Molecular Imaging Technologies in Antitumor Drug Development and Therapy
Yan Lin, Zhi-Yi Chen, Feng Yang, Jin-Shan Zhang, Yi-Xiang Wang, Jin-Bing Liu, Jian-Yi Liao, Yang-Ying Liao, Qiu-Lan Zhou, Bing-Cheng Li and Hui-Ying Liang
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Sarcosine-Based Glycine Transporter Type-1 (GlyT-1) Inhibitors Containing Pyridazine Moiety: A Further Search for Drugs with Potential to Influence Schizophrenia Negative Symptoms
Laszlo G. Harsing, Julia Timar, Geza Szabo, Szabolcs Udvari, Katalin M. Nagy, Bernadett Marko, Gabriella Zsilla, Andrea Czompa, Pal Tapolcsanyi, Akos Kocsis and Peter Matyus
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Applications of Important Polysaccharides in Drug Delivery
Gangliang Huang, Xinya Mei, Feng Xiao, Xin Chen, Qilin Tang and Daquan Peng
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CXCR4 and CXCL12 Expression in Rectal Tumors of Stage IV Patients Before and After Local Radiotherapy and Systemic Neoadjuvant Treatment
Karin Tamas, Urszula M. Domanska, Tonnis H. van Dijk, Hetty Timmer-Bosscha, Klaas Havenga, Arend Karrenbeld, Wim J. Sluiter, Jannet C. Beukema, Marcel A.T.M. van Vugt, Elisabeth G.E. de Vries, Geke A.P. Hospers and Annemiek M.E. Walenkamp
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Phenylbutyric Acid: Simple Structure – Multiple Effects
Magdalena Kusaczuk, Marek Bartoszewicz and Marzanna Cechowska-Pasko
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25OH-Vitamin D3 Levels in Obesity and Metabolic Syndrome—Unaltered in Young and not Correlated to Carotid IMT in all Ages
Harald Mangge, Sieglinde Zelzer, Andreas Meinitzer, Ingeborg Stelzer, Wolfgang J Schnedl, Daniel Weghuber, Dietmar Fuchs, Teodor T Postolache, Elmar Aigner, Christian Datz and Eva Z Reininghaus
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Novel kynurenic Acid Analogues in the Treatment of Migraine and Neurodegenerative Disorders: Preclinical Studies and Pharmaceutical Design
János Tajti, Zsófia Majláth, Délia Szok, Anett Csáti, József Toldi, Ferenc Fülöp and László Vécsei
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Microrna-21: A Central Regulator of Fibrotic Diseases Via Various Targets
Ying Huang, Yong He and Jun Li
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Treatment of Leishmaniasis: A Review and Assessment of Recent Research
Ehab Kotb Elmahallawy and Ahmad Agil
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The Molecular Mechanisms of TRAIL Resistance in Cancer Cells: Help in Designing New Drugs
Feng Wang, Junsheng Lin and Ruian Xu
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Editorial: Mitochondrial Biogenesis: Pharmacological Approaches
Teresa Valero
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Mechanisms of Inflammatory Response and Organ Dysfunction: Organ-Protective Strategy by Anesthetics
Noboru Hatakeyama and Naoyuki Matsuda
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VEGF and Colon Cancer Growth Beyond Angiogenesis: Does VEGF Directly Mediate Colon Cancer Growth Via a Non-angiogenic Mechanism?
Amrita Ahluwalia, Michael K. Jones, Tamara Matysiak-Budnik and Andrzej S. Tarnawski
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The Impact of Computational Structure-Based Methods on Drug Discovery
Charles H. Reynolds
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Anti-miRNA-23a Oligonucleotide Suppresses Glioma Cells Growth by Targeting Apoptotic Protease Activating Factor-1
Shizhong Lian, Ruyi Shi, Tao Bai, Yang Liu, Wang Miao, Hongqin Wang, Xiaodong Liu and Yimin Fan
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Editorial: The SNAP-tag Technology – A Versatile Tool with many Applications
Stefan Barth
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Gender Based Differences in Stress-induced Gastric Ulcer Formation and its Regulation by Nitric Oxide (NO): An Experimental Study
Kavita Gulati, Ayanabha Chakraborti and Arunabha Ray
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Differential Influences of Gastric Bypass and Sleeve Gastrectomy on Plasma Nesfatin-1 and Obestatin Levels in Patients with Type 2 Diabetes Mellitus
Wei-Jei Lee, Chih-Yen Chen, Kong-Han Ser, Keong Chong, Shu-Chun Chen, Pui-Ching Lee, You-Di Liao and Shou-Dong Lee
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Probiotics for the Prevention and Treatment of Allergies, with an Emphasis on Mode of Delivery and Mechanism of Action
Satya Prakash, Catherine Tomaro-Duchesneau, Shyamali Saha, Laetitia Rodes, Imen Kahouli and Meenakshi Malhotra
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Consumption of Mixed Fruit-juice Drink and Vitamin C Reduces Postprandial Stress Induced by a High Fat Meal in Healthy Overweight Subjects
Ilaria Peluso, Debora V. Villano, Susan A. Roberts, Eleonora Cesqui, Anna Raguzzini, Gina Borges, Alan Crozier, Giovina Catasta, Elisabetta Toti and Mauro Serafini
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Immunomodulating and Anti-allergic Effects of Negroamaro and Koshu Vitis vinifera Fermented Grape Marc (FGM)
Giuseppe Marzulli, Thea Magrone, Luisa Vonghia, Masahiro Kaneko, Hiroaki Takimoto, Yoshio Kumazawa and Emilio Jirillo
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Potential Use of Dietary Natural Products, Especially Polyphenols, for Improving Type-1 Allergic Symptoms
Kumazawa Y, Takimoto H, Matsumoto T and Kawaguchi K
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Omega-6 and Omega-3 Polyunsaturated Fatty Acids and Allergic Diseases in Infancy and Childhood
Elizabeth A. Miles and Philip C. Calder
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Factors Affecting Residual Platelet Aggregation in Prasugrel Treated Patients
Dimitrios Alexopoulos, Ioanna Xanthopoulou, Angelos Perperis, Argyro Siapika, Katerina Stavrou, Evropi Tsoni, Periklis Davlouros and George Hahalis
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What Fans the Fire: Insights into Mechanisms of Leptin in Metabolic Syndrome- Associated Heart Diseases
Maolong Dong and Jun Ren
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Transactivation of ErbB Receptors by Leptin in the Cardiovascular System: Mechanisms, Consequences and Target for Therapy
Jerzy Bełtowski and Anna Jazmroz-Wiśniewska
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Structural Insights into Chitinolytic Enzymes and Inhibition Mechanisms of Selective Inhibitors
Tian Liu, Lei Chen, Qiang Ma, Xu Shen and Qing Yang
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Structure-based Design of Conformationally Flexible Reverse Transcriptase Inhibitors to Combat Resistant HIV
Ge-Fei Hao, Sheng-Gang Yang and Guang-Fu Yang
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Structural Basis of Resistance to Anti-Cytochrome bc1 Complex Inhibitors: Implication for Drug Improvement
Lothar Esser, Chang-An Yu and Di Xia
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ABC Transporters in Multidrug Resistance and Pharmacokinetics, and Strategies for Drug Development
Young Hee Choi, Ai-Ming Yu and Ai-Ming Yu
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Structure-Based Drug Design to Overcome Drug Resistance: Challenges and Opportunities
Rafaela S. Ferreira1, Adriano D. Andricopulo and Adriano D. Andricopulo
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Novel Next-Generation Sequencing and Networks-Based Therapeutic Targets: Realistic and More Effective Drug Design and Discovery
Dimitrios H. Roukos, Giannis G. Baltogiannis, Christos S. Katsouras, Aris Bechlioulis, Katerina K. Naka, Charalambos Batsis, Theodore Liakakos and Lampros K. Michalis
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Endothelial Dysfunction and the Effects of TNF Inhibitors on the Endothelium in Psoriasis and Psoriatic Arthritis: A Systematic Review
Elizabeth A. Brezinski, Matthew R. Follansbee, Ehrin J. Armstrong and April W. Armstrong
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Effects of Biologic Agents and Other Disease-Modifying Antirheumatic Drugs on Cardiovascular Outcomes in Psoriasis and Psoriatic Arthritis: A Systematic Review
April W. Armstrong, Elizabeth A. Brezinski, Matthew R. Follansbee and Ehrin J. Armstrong
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Ultrasound-Based Multimodal Molecular Imaging and Functional Ultrasound Contrast Agents
Yan Lin, Zhi-Yi Chen and Feng Yang
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Long-term Etanercept Therapy Favors Weight Gain and Ameliorates Cachexia in Rheumatoid Arthritis Patients: Roles of Gut Hormones and Leptin
Chih-Yen Chen, Chang-Youh Tsai, Pui-Ching Lee and Shou-Dong Lee
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The Effect of First-in-Class Small Molecule RhoA Inhibitor, HL07, on the Phenylephrine-induced Artery Contraction
Yan Zhang, Jing Deng, Sheng Ma, Lin Xue, Jin Zhu, Wei-liang Zhu, Hua-liang Jiang, Jian Li and Li-yan Miao
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Non-Systemic Drugs: A Critical Review
Dominique Charmot
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Advancement of Targeted Ultrasound Contrast Agents and their Applications in Molecular Imaging and Targeted Therapy
Feng Yang, Zhi-Yi Chen and Yan Lin
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Atorvastatin Sensitises Vascular Smooth Muscle Cells, but not Endothelial Cells, to TNF-α-induced Cell Death
Arturo Giordano, Simona Romano, Giovanna Nappo, Stefano Messina, Michele Polimeno, Nicola Corcione, Gaetano Calì, Paolo Ferraro, Mario Monaco, Nicola Zambrano and Maria Fiammetta Romano
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Carotenoids and Cardiovascular Risk
Paola Giordano, Pietro Scicchitano, Manuela Locorotondo, Cosimo Mandurino, Gabriella Ricci, Santa Carbonara, Michele Gesualdo, Annapaola Zito, Annamaria Dachille, Paola Caputo, Roberta Riccardi, Giulia Frasso, Giuseppe Lassandro, Antonio Di Mauro and Marco Matteo Ciccone
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A Computational Study of the Oligosaccharide Binding Sites in the Lectin-Like Domain of Tumor Necrosis Factor and the TNF-derived TIP Peptide
Alexander Dulebo, Rüdiger Ettrich, Rudolf Lucas and David Kaftan
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Target-based Anti-angiogenic Therapy in Breast Cancer
Markus Wehland, Johann Bauer, Manfred Infanger and Daniela Grimm
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Preclinical Safety and Pharmacokinetic Profile of 3K3A-APC, a Novel, Modified Activated Protein C for Ischemic Stroke
Patricia D. Williams, Berislav V. Zlokovic, John H. Griffin, Kent E. Pryor and Thomas P. Davis
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