E-Pub Articles Ahead of Print ::: Current Pharmaceutical Design

ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)

Volume 21, 42 Issues, 2015

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Current Pharmaceutical Design

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E-Pub Articles Ahead of Print

The Combined Impact of Exhaled Nitric Oxide and Sputum Eosinophils Monitoring in Asthma Treatment: A Prospective Cohort Study
Mario Malerba, Alessandro Radaeli, Alessia Olivini, Beatrice Ragnoli, Fabio Ricciardolo and Paolo Montuschi
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Astrocytes: New Targets for the Treatment of Neurodegenerative Diseases
Charles Finsterwald, Pierre J. Magistretti and Sylvain Lengacher
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The Innate Immunity in Alzheimer Disease- Relevance to Pathogenesis and Therapy
Zofia Blach-Olszewska, Ewa Zaczynska, Kasia Gustaw-Rothenberg, Marco Avila-Rodrigues, George E. Barreto, Jerzy Leszek and Gjumrakch Aliev
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Nicotine-Derived Compounds as Therapeutic Tools Against Posttraumatic Stress Disorder
George Barreto, Alexander Yarkov and Valentina Echeverria
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Hypothalamic Leptin and Ghrelin Signaling as Targets for Improvement in Metabolic Control
Laura M. Frago and Julie A. Chowen
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Antidiabetic Drugs: Mechanisms of Action and Potential Outcomes on Cellular Metabolism
Maria J. Meneses, Branca M. Silva, Mário Sousa, Rosália Sá, Pedro F. Oliveira and Marco G. Alves
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Impact of Metformin on Male Reproduction
Carolina Ferreira, Ana Rabaca, Mario Sousa, Pedro F Oliveira, Marco G Alves and Rosalia Sa
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The Function and Regulation of BMP6 in Various Kinds of Stem Cells
Ruinan Shen, Ruobing Jia, Wenjie Liu, Qisheng Lin, Yanan Hai and Zuping He
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The Metaboloepigenetic Dimension of Cancer Stem Cells: Evaluating the Market Potential for New Metabostemness-Targeting Oncology Drugs
Javier A. Menendez
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Myocardial Energy Substrate Metabolism in Heart Failure : from Pathways to Therapeutic Targets
Arata Fukushima, Kenneth Milner, Abhishek Gupta and Gary D. Lopaschuk
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Disruption of Circadian Rhythms and Sleep in Critical Illness and its Impact on the Development of Delirium
Benjamin K. Scott
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The Role of Circadian Rhythms in Fatal Arrhythmias and the Potential Impact of Intervention for Sleep-Disordered Breathing
Yoshiyasu Aizawa, Takashi Kohno, Shinsuke Yuasa and Keiichi Fukuda
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Disruption of Circadian Rhythms and Sleep in Critical Illness and its Impact on Innate Immunity
Viola Dengler, Kristin Westphalen and Michael Koeppen
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Disruption of Circadian Rhythms in Critical Illness – A Role of Hyperoxia-Induced Lung Injury
Alex Czachor, Zachary Krueger, Young Cho, Sarvadaman Pathak, Yashwant Pathak and Narasaiah Kolliputi
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Disruption of Circadian Rhythms and Delirium, Sleep Impairment and Sepsis in Critically ill Patients. Potential Therapeutic Implications for Increased Light-Dark Contrast and Melatonin Therapy in an ICU Environment
Madrid-Navarro CJ, Sanchez-Galvez R, Martinez-Nicolas A, Ros Marina, Garcia JA, Madrid JA and Rol MA
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Disruption of Circadian Rhythms and Sleep on Critical Illness and the Impact on Cardiovascular Events
Cristine J. Reitz and Tami A. Martino
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Obstructive Sleep Apnea and Cardiovascular Disease - A New Target for Treatment
Giuseppe Schillaci, Francesca Battista, Giuseppe Fiorenzano, Maria Cristina Basili, Mariano Crapa, Yahya al-Rashdi and Giacomo Pucci
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Disruption of Circadian Rhythms and Sleep in Critical Illness: Potential Implications for Angiogenesis After Myocardial Infarction. A Review
Yuan-Yuan Sun, Zhan-Hui Du and Yu-Xia Zhao
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Repurposing Non-Antimicrobial Drugs and Clinical Molecules to Treat Bacterial Infections
Waleed Younis, Shankar Thangamani and Mohamed N. Seleem
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Editorial: Health Impact and Management of a Disrupted Circadian Rhythm and Sleep in Critical Illnesses
Tobias Eckle
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Neuropeptide Receptor Ligands for the Treatment of Schizophrenia: Focus on Neurotensin and Tachykinins
Guy Griebel
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When is a Proof-of-Concept (POC) not a POC? Pomaglumetad (LY2140023) as a Case Study for Antipsychotic Efficacy
Gerard J. Marek
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5-HT6 Receptor Antagonists: Potential Efficacy for the Treatment of Cognitive Impairment in Schizophrenia
Natasja M.W.J. de Bruin and Chris G. Kruse
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Bone Recuperation after rhBMP-2 Insertion in Alcoholic Animals-Experimental Study
Bruna Gabriela dos Santos Kotake, Leda Maria Pescinini Salzedas, Edilson Ervolino, Ricardo Alexandre, Junqueira Calzzani, Walter Sebald and João Paulo Mardegan Issa
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Treatment of Cognitive Impairment in Schizophrenia: Potential Value of Phosphodiesterase Inhibitors in Prefrontal Dysfunction
Van Duinen MA, Reneerkens OAH, Lambrecht L, Sambeth A, Rutten BPF, Van Os J, Blokland A and Prickaerts J
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Targeting of α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a Translational Biomarker
Kenji Hashimoto
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Editorial: The Pathogenesis of Inflammation and Cancer in the Gastrointestinal Tract: From Basic Science to Translational Medicine
C.H. Cho and H.Y. Wang
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Efficacy of Andolast in Mild to Moderate Asthma: A Randomized, Controlled, Double-Blind Multicenter Study (The Andast Trial)
Mario Malerba, Massimo D`Amato, Alessandro Radaeli, Giampaolo Giacovelli, Lucio Rovati, Sayed H. Arshad and Stephen T. Holgate
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Editorial: Breaking the Skin Barrier: Achievements and the Future
Yasser Shahzad
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Atrial Fibrillation and Gastro-Oesophageal Reflux Disease - Controversies and Challenges
Mariana Floria, Oana Bărboi, Ciprian Rezuș, Valentin Ambărus, Cristina Cijevschi-Prelipcean, Gheorghe Balan and Vasile Liviu Drug
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Anti-VEGF Drugs in Eye Diseases: Local Therapy with Potential Systemic Effects
Markus van der Giet, Cornelia Henkel, Mirjam Schuchardt and Markus Tölle
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The Potential Effect of Fluorinated Compounds in the Treatment of Alzheimer’s Disease
Bárbara Gomes, Joana A. Loureiro, Manuel A.N. Coelho and Maria do Carmo Pereira
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Anticancer Advances of Matrine and Its Derivatives
Jianping Yong, Xiaoyuan Wu and Canzhong Lu
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Skeletal Muscle Cell Behavior After Physical Agent Treatments
Michela Battistelli, Sara Salucci, Michele Guescini, Davide Curzi, Vilberto Stocchi and Elisabetta Falcieri
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Analysis of Edg-Like LPA Receptor-Ligand Interactions
Balazs Balogh, Tamas Pazmany and Peter Matyus
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Evaluation of the In Vivo Safety Profiles of Rictor Inhibition Using a Zebrafish Model
Yang Cao, Lijun Jiang, Lei Zhao, Xiaoxi Zhou, Na Wang, Peilin Zhang, Yuting Tang and Jianfeng Zhou
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Applications of Important Polysaccharides in Drug Delivery
Gangliang Huang, Xinya Mei, Feng Xiao, Xin Chen, Qilin Tang and Daquan Peng
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The Molecular Mechanisms of TRAIL Resistance in Cancer Cells: Help in Designing New Drugs
Feng Wang, Junsheng Lin and Ruian Xu
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Editorial: Mitochondrial Biogenesis: Pharmacological Approaches
Teresa Valero
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Mechanisms of Inflammatory Response and Organ Dysfunction: Organ-Protective Strategy by Anesthetics
Noboru Hatakeyama and Naoyuki Matsuda
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VEGF and Colon Cancer Growth Beyond Angiogenesis: Does VEGF Directly Mediate Colon Cancer Growth Via a Non-angiogenic Mechanism?
Amrita Ahluwalia, Michael K. Jones, Tamara Matysiak-Budnik and Andrzej S. Tarnawski
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The Impact of Computational Structure-Based Methods on Drug Discovery
Charles H. Reynolds
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Anti-miRNA-23a Oligonucleotide Suppresses Glioma Cells Growth by Targeting Apoptotic Protease Activating Factor-1
Shizhong Lian, Ruyi Shi, Tao Bai, Yang Liu, Wang Miao, Hongqin Wang, Xiaodong Liu and Yimin Fan
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Editorial: The SNAP-tag Technology – A Versatile Tool with many Applications
Stefan Barth
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Differential Influences of Gastric Bypass and Sleeve Gastrectomy on Plasma Nesfatin-1 and Obestatin Levels in Patients with Type 2 Diabetes Mellitus
Wei-Jei Lee, Chih-Yen Chen, Kong-Han Ser, Keong Chong, Shu-Chun Chen, Pui-Ching Lee, You-Di Liao and Shou-Dong Lee
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Probiotics for the Prevention and Treatment of Allergies, with an Emphasis on Mode of Delivery and Mechanism of Action
Satya Prakash, Catherine Tomaro-Duchesneau, Shyamali Saha, Laetitia Rodes, Imen Kahouli and Meenakshi Malhotra
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Consumption of Mixed Fruit-juice Drink and Vitamin C Reduces Postprandial Stress Induced by a High Fat Meal in Healthy Overweight Subjects
Ilaria Peluso, Debora V. Villano, Susan A. Roberts, Eleonora Cesqui, Anna Raguzzini, Gina Borges, Alan Crozier, Giovina Catasta, Elisabetta Toti and Mauro Serafini
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Immunomodulating and Anti-allergic Effects of Negroamaro and Koshu Vitis vinifera Fermented Grape Marc (FGM)
Giuseppe Marzulli, Thea Magrone, Luisa Vonghia, Masahiro Kaneko, Hiroaki Takimoto, Yoshio Kumazawa and Emilio Jirillo
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Potential Use of Dietary Natural Products, Especially Polyphenols, for Improving Type-1 Allergic Symptoms
Kumazawa Y, Takimoto H, Matsumoto T and Kawaguchi K
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Omega-6 and Omega-3 Polyunsaturated Fatty Acids and Allergic Diseases in Infancy and Childhood
Elizabeth A. Miles and Philip C. Calder
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Factors Affecting Residual Platelet Aggregation in Prasugrel Treated Patients
Dimitrios Alexopoulos, Ioanna Xanthopoulou, Angelos Perperis, Argyro Siapika, Katerina Stavrou, Evropi Tsoni, Periklis Davlouros and George Hahalis
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What Fans the Fire: Insights into Mechanisms of Leptin in Metabolic Syndrome- Associated Heart Diseases
Maolong Dong and Jun Ren
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Transactivation of ErbB Receptors by Leptin in the Cardiovascular System: Mechanisms, Consequences and Target for Therapy
Jerzy Bełtowski and Anna Jazmroz-Wiśniewska
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Structural Insights into Chitinolytic Enzymes and Inhibition Mechanisms of Selective Inhibitors
Tian Liu, Lei Chen, Qiang Ma, Xu Shen and Qing Yang
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Structure-based Design of Conformationally Flexible Reverse Transcriptase Inhibitors to Combat Resistant HIV
Ge-Fei Hao, Sheng-Gang Yang and Guang-Fu Yang
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Structural Basis of Resistance to Anti-Cytochrome bc1 Complex Inhibitors: Implication for Drug Improvement
Lothar Esser, Chang-An Yu and Di Xia
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ABC Transporters in Multidrug Resistance and Pharmacokinetics, and Strategies for Drug Development
Young Hee Choi, Ai-Ming Yu and Ai-Ming Yu
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Structure-Based Drug Design to Overcome Drug Resistance: Challenges and Opportunities
Rafaela S. Ferreira1, Adriano D. Andricopulo and Adriano D. Andricopulo
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Novel Next-Generation Sequencing and Networks-Based Therapeutic Targets: Realistic and More Effective Drug Design and Discovery
Dimitrios H. Roukos, Giannis G. Baltogiannis, Christos S. Katsouras, Aris Bechlioulis, Katerina K. Naka, Charalambos Batsis, Theodore Liakakos and Lampros K. Michalis
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Endothelial Dysfunction and the Effects of TNF Inhibitors on the Endothelium in Psoriasis and Psoriatic Arthritis: A Systematic Review
Elizabeth A. Brezinski, Matthew R. Follansbee, Ehrin J. Armstrong and April W. Armstrong
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Effects of Biologic Agents and Other Disease-Modifying Antirheumatic Drugs on Cardiovascular Outcomes in Psoriasis and Psoriatic Arthritis: A Systematic Review
April W. Armstrong, Elizabeth A. Brezinski, Matthew R. Follansbee and Ehrin J. Armstrong
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Ultrasound-Based Multimodal Molecular Imaging and Functional Ultrasound Contrast Agents
Yan Lin, Zhi-Yi Chen and Feng Yang
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Long-term Etanercept Therapy Favors Weight Gain and Ameliorates Cachexia in Rheumatoid Arthritis Patients: Roles of Gut Hormones and Leptin
Chih-Yen Chen, Chang-Youh Tsai, Pui-Ching Lee and Shou-Dong Lee
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The Effect of First-in-Class Small Molecule RhoA Inhibitor, HL07, on the Phenylephrine-induced Artery Contraction
Yan Zhang, Jing Deng, Sheng Ma, Lin Xue, Jin Zhu, Wei-liang Zhu, Hua-liang Jiang, Jian Li and Li-yan Miao
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Non-Systemic Drugs: A Critical Review
Dominique Charmot
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Advancement of Targeted Ultrasound Contrast Agents and their Applications in Molecular Imaging and Targeted Therapy
Feng Yang, Zhi-Yi Chen and Yan Lin
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Atorvastatin Sensitises Vascular Smooth Muscle Cells, but not Endothelial Cells, to TNF-α-induced Cell Death
Arturo Giordano, Simona Romano, Giovanna Nappo, Stefano Messina, Michele Polimeno, Nicola Corcione, Gaetano Calì, Paolo Ferraro, Mario Monaco, Nicola Zambrano and Maria Fiammetta Romano
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Carotenoids and Cardiovascular Risk
Paola Giordano, Pietro Scicchitano, Manuela Locorotondo, Cosimo Mandurino, Gabriella Ricci, Santa Carbonara, Michele Gesualdo, Annapaola Zito, Annamaria Dachille, Paola Caputo, Roberta Riccardi, Giulia Frasso, Giuseppe Lassandro, Antonio Di Mauro and Marco Matteo Ciccone
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A Computational Study of the Oligosaccharide Binding Sites in the Lectin-Like Domain of Tumor Necrosis Factor and the TNF-derived TIP Peptide
Alexander Dulebo, Rüdiger Ettrich, Rudolf Lucas and David Kaftan
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Target-based Anti-angiogenic Therapy in Breast Cancer
Markus Wehland, Johann Bauer, Manfred Infanger and Daniela Grimm
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Preclinical Safety and Pharmacokinetic Profile of 3K3A-APC, a Novel, Modified Activated Protein C for Ischemic Stroke
Patricia D. Williams, Berislav V. Zlokovic, John H. Griffin, Kent E. Pryor and Thomas P. Davis
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