E-Pub Articles Ahead of Print ::: Current Pharmaceutical Design

ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)


Volume 22, 46 Issues, 2016


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Current Pharmaceutical Design

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  • 73rd of 253 in Pharmacology & Pharmacy

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Editor-in-Chief:
William A. Banks
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E-Pub Articles Ahead of Print

Antiepileptic Drugs Based on the α-Substituted Amide Group Pharmacophore: From Chemical Crystallography to Molecular Pharmaceutics


Arcadius V Krivoshein.


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Structural Aspects of Solid Solutions of Enantiomers


Clément Brandel, Samuel Petit, Yohann Cartigny and Gérard Coquerel.


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Benefits and Limitations of Polymorphic and Amorphous Forms of Active Pharmaceutical Ingredients


Alicja Talaczyńska, Jakub Dzitko and Judyta Cielecka-Piontek.


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Non-ambient Conditions in the Investigation and Manufacturing of Drug Forms


Elena Boldyreva.


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Altered Steroid Metabolism And Insulin Signaling In Pcos Endometria: Impact In Tissue Function


Lorena Oróstica, Carlos Rosas, Francisca Plaza-Parrochia, Isis Astorga, Fernando Gabler, Víctor García, Carmen Romero and Margarita Vega.


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Advanced Applications of Raman Imaging for Deeper Understanding and Better Quality Control of Formulations


Kei Moriyama.


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Follicular Cysts: A Single Sign and Different Diseases. A View from Comparative Medicine


Hugo H. Ortega, Pablo U. Diaz, Natalia R. Salvetti, Gustavo J. Hein, Belkis E. Marelli, Fernanda M. Rodríguez, Antonela Stassi and Florencia Rey.


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The Role of Solid State Characterization in Predicting Stability of Solid Dosage Forms


Péter Szabó, Romána Zelkó and István Antal.


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Solid Dispersions for Oral Administration: An Overview of the Methods for their Preparation


François Hallouard, Lyes Mehenni, Malika Lahiani-Skiba, Youssef Anouar and Mohamed Skiba.


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Investigation of Polymorphism and Cocrystallization of Active Pharmaceutical Ingredients using Vibrational Spectroscopic Techniques


Yong Du and Jiadan Xue.


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Application of Vibrational Spectroscopy to Study Solid-state Transformations of Pharmaceuticals


Andrea Erxleben.


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Mechanochemical Approaches to Pharmaceutical Cocrystal Formation and Stability Analysis


Shan-Yang Lin.


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Blood-Brain Barrier ABC-transporter P-glycoprotein in Alzheimer’s Disease: still a suspect?


D.M.E. van Assema and BNM van Berckel.


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Kinetic models for measuring P-glycoprotein function at the blood-brain barrier with Positron Emission Tomography


Mark Lubberink.


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Carrier Mediated Systemic Delivery of Protein and Peptide Therapeutics


Rahela Zaman, Iekhan Othman and Ezharul Hoque Chowdhury.


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Potential Pathways for CNS Drug Delivery across the Blood-Cerebrospinal Fluid Barrier


Nathalie Strazielle and Jean-François Ghersi-Egea.


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Formation, Physicochemical Characterization, and Thermodynamic Stability of the Amorphous State of Drugs and Excipients


Piera Di Martino, Federico Magnoni, Dolores Vargas Peregrina, Maria Rosa Gigliobianco, Roberta Censi and Ledjan Malaj.


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Pharmacological Targeting of the Epidermal Barrier


L. Kemény, N. Nagy, Zs. Csoma, K. Szabó and G Erős.


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Membrane Transporters in Physiological Barriers of Pharmacological Importance


Ildikó Nagy, Beáta Tóth, Zsuzsanna Gáborik, Franciska Erdő and Péter Krajcsi.


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Plant-Derived Biomolecules and Drug Delivery Systems in the Treatment of Liver and Kidney Diseases


Anca Hermenean, Claudia Ghiozdan, Sami Gharbia, Istvan A. Krizbai and Aurel Ardelean.


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Strategies that Target Tight Junctions for Enhanced Drug Delivery


Lorenza González-Mariscal, Yanahi Posadas-Torrentera, Jael Miranda, Perla Uc, José Mario Ortega-Olvera and Sandra Hernández.


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Pharmacological Targeting of the Inflamed Intestinal Barrier


Attila E. Farkas and Asma Nusrat.


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Pharmaceutical Targeting of the Brain


István A. Krizbai, Ádám Nyúl-Tóth, Hans-Christian Bauer, Attila E. Farkas, Andreas Traweger, János Haskó, Hannelore Bauer and Imola Wilhelm.


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Targeted Vascular Drug Delivery in Cerebral Cancer


Nanna Humle, Kasper Bendix Johnsen, Gitte Abildgaard Arendt, Rikke Paludan Nielsen, Torben Moos and Louiza Bohn Thomsen.


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Polycystic Ovary Syndrome as a Proinflammatory State: The Role of Adipokines


Georgios K. Dimitriadis, Ioannis Kyrou and Harpal S Randeva.


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Metabolic Features Across The Female Life Span In Women With PCOS


Teresa Sir-Petermann, Bárbara Echiburú, Nicolás Crisosto, Manuel Maliqueo and Francisco Pérez Bravo.


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Cardiovascular Risk in the Different Phenotypes of Polycystic Ovary Syndrome


Konstantinos Tziomalos.


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Current Insights about Inositol Isoforms, Mediterranean and Ketogenic Diets for Polycystic Ovary Syndrome: From Bench to Beside


Giovanna Muscogiuri, Stefano Palomba, Antonio Simone Laganà and Francesco Orio.


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Insulin Resistance and Polycystic Ovary Syndrome


Paolo Moghetti.


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Hirsutism in Polycystic Ovary Syndrome: Pathophysiology and Management


Poli Mara Spritzer, Carolina Rocha Barone and Fabiana Bazanella de Oliveira.


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Adrenal Hyperandrogenism and Polycystic Ovary Syndrome


Manuel Luque-Ramírez and Héctor F Escobar-Morreale.


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Duration of Dual Antiplatelet Therapy after Coronary Stenting


Gerasimos Siasos, Konstantinos Mourouzis, Evangelos Oikonomou, Manolis Vavuranakis, Georgia Vogiatzi, Alexandros Briasoulis, Nikolaos Papageorgiou, Theodore G. Papaioannou, Thodoris Zografos, Aggeliki Papapanagiotou, Athanasios G. Papavassiliou, Christodoulos Stefanadis and Dimitris Tousoulis.


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Cubic Phases, Cubosomes and Ethosomes for Cutaneous Application


Elisabetta Esposito, Markus Drechsler, Claudio Nastruzzi and Rita Cortesi.


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Advances in the Diagnosis and Treatment of PCOS


Enrico Carmina, Ettore Guastella and Rosa Alba Longo.


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Quinolones in the Search for New Anticancer Agents


Pedro Netto Batalha Netto Batalha, Maria Cecília Bastos Vieira de Souza, Eduardo Peña-Cabrera, David Cruz Cruz and Fernanda da Costa Santos Boechat.


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Translational Insight Into Polycystic Ovary Syndrome (PCOS) From Female Monkeys With PCOS-like Traits


David H. Abbott, Levine JE and Dumesic DA.


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Editorial: Recent Advances in Cancer Research: Targets and New Ligands


Marcela Cristina de Moraes and Fernando de Carvalho da Silva.


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Gastric Cancer: Nanoparticles as Tools to Improve Treatment Efficacy


Ariel R. Guerrero, Felipe Oyarzún-Ampuero, Natalia Hassan, Alejandro H. Corvalán, Andrew F.G. Quest and Marcelo J Kogan.


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Determinants of Anti-Cancer Effect of Mitochondrial Electron Transport Chain Inhibitors: Bioenergetic Profile and Metabolic Flexibility of Cancer Cells


Félix A. Urra, Boris Weiss-López and Ramiro Araya-Maturana.


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Targeting the EGF/HER Ligand-Receptor System in Cancer


Azucena Esparís-Ogando, Juan Carlos Montero, Joaquín Arribas, Alberto Ocaña and Atanasio Pandiella.


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RNAi-Based Therapy in Experimental Ischemia-Reperfusion Injury: The New Targets


Laura de Ramon, Marta Jarque, Elia Ripoll, Oriol Bestard, Josep M. Grinyo and Juan Torras.


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Gut-Brain Axis and Metabolism in Polycystic Ovary Syndrome


Basak Ozgen Saydam and Bulent O Yildiz.


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Targeted Nanosystems to Prostate Cancer


Luiz Cláudio Rodrigues Pereira da Silva, Flávia Almada do Carmo, Luiz Eurico Nasciutti, Patrícia Zancan, Plínio Cunha Sathler and Lucio Mendes Cabral.


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Latest Results for Anti-Angiogenic Drugs in Cancer Treatment


Sofie Frandsen, Sascha Kopp, Markus Wehland, Jessica Pietsch, Manfred Infanger and Daniela Grimm.


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Writers and Erasers of Histone Lysine Methylation with Clinical Applied Modulators: Promising Target for Cancer Therapy


Yi-Chao Zheng, Jin-Lian Ma, Ying Liu and Hong M Liu.


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Do Advanced Glycation End Products (AGEs) Contribute to the Comorbidities of Polycystic Ovary Syndrome (PCOS)?


Aleksandra Zofia Rutkowska and Evanthia Diamanti-Kandarakis.


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Insulin-Like Growth Factor 2 – The Oncogene and its Accomplices


Sonja M. Kessler, Johannes Haybaeck and Alexandra K Kiemer.


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The 9p21 Locus and its Potential Role in Atherosclerosis Susceptibility; Molecular Mechanisms and Clinical Implications


Amir Tajbakhsh, Seyed Mahdi Hassanian, Mohammad Sadegh Khorrami, Alireza Pasdar, Ehsan Tabatabai, Seyed Mohammad Reza Parizadeh, Mostafa Fazeli, Sharareh Gholamin, Gordon A. Ferns, Majid Ghayour-Mobarhan and Amir Avan.


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Natalizumab Modifies Catecholamines Levels Present in Patients with Relapsing-Remitting Multiple Sclerosis


Begoña M. Escribano, Macarena Aguilar, Carmen Bahamonde, Cristina Conde, Rafael Lillo, Fernando Sánchez-López, Ana I. Giraldo, Antonio H. Cruz, Evelio Luque, Félix Gascón, Eduardo Agüera and Isaac Tunez.


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Emerging Role for RBM20 and Its Splicing Substrates in Cardiac Function and Heart Failure


Jipeng Ma, Linhe Lu, Jun Ren and Jian Yang.


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The Novel Antipsychotic Cariprazine (RGH-188): State-of-the-Art in the Treatment of Psychiatric Disorders


Domenico De Berardis.


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Energy Remodeling, Mitochondrial Disorder and Heart Failure


Peng Wang, Lei Xu and Aijun Sun.


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Targeting Mitochondrial Dysfunction in Chronic Heart Failure: Current Evidence and Potential Approaches


A Aimo, C Borrelli, G Vergaro, MF Piepoli, AR De Caterina, G Mirizzi, A Valleggi, V Raglianti, C Passino, M Emdin and A Giannoni.


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Lipids, Statins and Heart Failure: An update


Niki Katsiki, Michael Doumas and Dimitris P Mikhailidis.


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Design and Synthesis of 2-(Arylmethylideneamino) Isoindolines as New Potential Analgesic and Anti-Inflammatory Agents: A Molecular Hybridization Approach


Maryam Iman, Hamed Shafaroodi, Asghar Davood, Masoud Abedini, Pouyan Pishva, Mehrnoush Taherkhani, Ahmad Reza Dehpour and Abbas Shafiee.


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Application of Mitochondria-Targeted Pharmaceuticals for the Treatment of Heart Disease


Ryan J Mailloux.


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Development of a Mouse Model of Shiga Toxin 2 (STX2) Intoxication for Testing Therapeutic Agents against Hemolytic Uremic Syndrome (HUS)


Maria Pilar Mejias, Romina Jimena Fernandez-Brando, Maria Victoria Ramos, Maria Jimena Abrey-Recalde, Elsa Zotta, Roberto Meiss and Marina Sandra Palermo.


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Generalized Molecular Descriptors Derived From Event-Based Discrete Derivative


Oscar Martínez-Santiago, Reisel Millán Cabrera, Yovani Marrero-Ponce, Stephen J. Barigye, Huong Le-Thi-Thu, Javier F. Torres, Cesar H. Zambrano, Ivan Yaber-Goenaga, Maykel Cruz-Monteagudo, Yoan Martínez López, Facundo Perez and Francisco Torrens.


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Alkaloids: An Emerging Antibacterial Modality Against Methicillin Resistant Staphylococcus aureus


Aini Pervaiz, Ruqaiyah Khan, Firoz Anwar, Gohar Mushtaq, Mohammad A. Kamal and Haroon Khan.


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Editorial: Antiplatelet Treatment in Cardiovascular Disease: New Insights


Gerasimos Siasos and Dimitris Tousoulis.


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The Past, Current Studies and Future of Organometallic 99mTc(CO)3 Labeled Peptides And Proteins


Majid Piramoon and Seyed Jalal Hosseinimehr.


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From Fangs to Pharmacology: The Future of Snakebite Envenoming Therapy


Andreas H. Laustsen, Mikael Engmark, Christina Milbo, Jónas Johannesen, Bruno Lomonte, José María Gutiérrez and Brian Lohse.


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Selection of Antithrombotic Therapy in Patients with Atrial Fibrillation and Percutaneous Coronary Intervention


Theodoros A. Zografos and Demosthenes G Katritsis.


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Pharmacological Approaches in an Experimental Model of Non-Small Cell Lung Cancer: Effects on Tumor Biology


Mercè Mateu-Jimenez, Clara Fermoselle, Federico Rojo, Javier Mateu, Raúl Peña, Alejandro J. Urtreger, Miriam J. Diament, Elisa D. Bal de Kier Joffé, Lara Pijuan, Antonio García de Herreros and Esther Barreiro.


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Common SAR Derived from Multiple QSAR Models on Vorinostat Derivatives Targeting HDACs in Tumor Treatment


Sugathan Praseetha, Srinivas Bandaru, Mukesh Yadav, Anuraj Nayarisseri and Sivanpillai Sureshkumar.


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Targeting cancer cells with photoactive silica nanoparticles


Wioleta Borzęcka, Tito Trindade, Tomás Torres and João Tomé.


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Editorial: Mitochondrial and Metabolism: Novel Targets for Heart Failure


Lei Xu and Aijun Sun.


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Engineered nanoparticles against MDR in cancer: The state of the art and its prospective


Javed Ahmad, Sohail Akhter, Mohammad Ahmed Khan, Muhammad Wahajuddin, Nigel H. Greig, Mohammad Amjad Kamal, Patrick Midoux and Chantal Pichon.


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Triggering PIK3CA mutations in PI3K/AKT/mTOR axis: Exploration of newer inhibitors and rational preventive strategies


Vivek Asati, Sanjay K. Bharti, Debarshi Kar Mahapatra, Vikas Asati and Ashok Kumar Budhwani.


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Editorial Managing Strategies for Diverse Diseases: Challenges from Bench to Bedside Translation in Successful Drug Discovery and Development (Part C)


Mohammad A. Kamal and Nigel H Greig.


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Energetic Metabolic Roles in Pulmonary Arterial Hypertension and Right Ventricular Remodeling


Rui Zhang and Zhi-Cheng Jing.


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Novel anti-platelets in stable Coronary Artery Disease


Nikolaos Papageorgiou, Effimia Zacharia, Adam Ioannou, Onkar Rehal, Konstantinos Zacharias, Gerasimos Siasos and Dimitris Tousoulis.


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Antiplatelet Therapy in Acute Coronary Syndromes. Evidence Based Medicine


Evangelos Oikonomou, Georgia Vogiatzi, Georgios-Angelos Papamikroulis, Leon Naar, Gerasimos Siasos, Konstantinos Mourouzis, Theodoros Zografos, Manolis Vavuranakis, Alexis Antonopoulos and Dimitris Tousoulis.


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Targeting Anti-Cancer Active Compounds: Affinity-Based Chromatographic Assays


Marcela Cristina de Moraes, Carmen Lucia Cardoso, Claudia Seidl, Ruin Moaddel and Quezia Bezerra Cass.


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Strategies for Increasing the Solubility and Bioavailability of Anticancer Compounds: β-Lapachone and Other Naphthoquinones


Caroline Deckmann Nicoletti, Vitor Francisco Ferreira, Patricia Garcia Ferreira, Debora Omena Futuro and Fernando de Carvalho da Silva.


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Effects and Role of Multikinase Inhibitors in Thyroid Cancer.


Rasmus Laursen, Markus Wehland, Sascha Kopp, Jessica Pietsch, Manfred Infanger, Jirka Grosse and Daniela Grimm.


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The Role of Mitochondrial Dysfunction in Heart Failure and Potential Therapeutic Targets


Marko Banović and Arsen D Ristić.


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Dry Eye Disease: Present Challenges in the Management and Future Trends


Zahraa Al-Saedi, Allison Zimmerman, Rinda Devi Bachu, Surajit Dey, Zahoor Shah, Reginald Baugh and Sai HS Boddu.


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The Role of Platelets in Cardiovascular Disease: Molecular Mechanisms


A. Papapanagiotou, G. Daskalakis, G. Siasos, A. Gargalionis and AG Papavassiliou.


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DNA Methylation: An Epigenetic Insight into Type 2 Diabetes Mellitus


Fahmida Alam, Md. Asiful Islam, Siew Hua Gan, Mafauzy Mohamed and Teguh Haryo Sasongko.


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Antiphospholipid Antibody-Mediated Thrombotic Mechanisms in Antiphospholipid syndrome: Towards Pathophysiology-Based Treatment


Md. Asiful Islam, Fahmida Alam, Teguh Haryo Sasongko and Siew Hua Gan.


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Challenges and Strategies in Precision Medicine for Non-Small Cell Lung Cancer


Joseph Sacco, Hussein Al-Akhrass and Cornelia M Wilson.


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Dual or Single Antiplatelet Therapy After Transcatheter Aortic Valve Implantation? A Systematic Review and Meta-Analysis


Manolis Vavuranakis, Gerasimos Siasos, Theodoros Zografos, Evangelos Oikonomou, Dimitris Vrachatis, Konstantinos Kalogeras, Theodoros Papaioannou, Michail-Aggelos Kolokathis, Carmen Moldovan and Dimitrios Tousoulis.


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Difluorinated curcumin: A promising curcumin analogue with improved anti-tumor activity and pharmacokinetic profile


Amir Abbas Momtazi and Amirhossein Sahebkar.


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Antiplatelet Treatment in Peripheral Arterial Disease: The Role of Novel Antiplatelet Agents


Chris Klonaris, Nikolaos Patelis, Anja Drebes, Sean Matheiken and Theodoros Liakakos.


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Pharmacological Properties and Therapeutic Potential of Naringenin: a Citrus Flavonoid of Pharmaceutical Promise


Neha Rani, Saurabh Bharti, Bhaskar Krishnamurthy, Jagriti Bhatia, Charu Sharma, Mohammad Amjad Kamal, Shreesh Ojha and Dharamvir Singh Arya.


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Genetics in anti-platelet treatment


Maria Gazouli.


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P2Y12 receptor antagonists: which one to choose? A systematic review and meta-analysis


Alexandros Briasoulis, Tesfaye Telila, Mohan Palla, Gerasimos Siasos and Dimitris Tousoulis.


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Antiplatelet Treatment in Stroke: New Insights


Haralampos Milionis, Angelos Liontos, Kostantinos Vemmos and Konstantinos Spengos.


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Polyketide Natural Products, Acetogenins from Graviola (Annona muricata L), its Biochemical, Cytotoxic Activity and Various Analyses Through Computational and Bio-Programming Methods


Keerthana Prabhakaran, Gnanam Ramasamy, Uma Doraisamy, Jayakanthan Mannu, K Rajamani and Jayadeepa Rajamani Murugesan.


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De novo design of new inhibitor of mutated tyrosine-kinase for the myeloid leukemia treatment


W. Pereira and I Camps.


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Identification of Small Molecule as a High Affinity β2 Agonist Irrespectively Targeting Wild and Mutated (Thr164Ile) β 2 Adrenergic Receptor in the Treatment of Bronchial Asthma


Srinivas Bandaru, Mallika Alvala, Jyothy Akka, Someshwar Rao Sagurthi, Anuraj Nayarisseri, Sanjeev Kumar Singh and Hema Prasad Mundluru.


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How the Protein Architecture of RNases III Influences their Substrate Specificity?


Guillermin Agüero-Chapin, Gisselle Pérez-Machado, Juan Collí Mull, Evys Ancede-Gallardo, Agostinho Antunes and Gustavo A de la Riva de la Riva.


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Probing the Hypothesis of SAR Continuity Restoration by the Removal of Activity Cliffs Generators in QSAR


Maykel Cruz-Monteagudo, José L. Medina-Franco, Yunier Perera-Sardiña, Fernanda Borges, Eduardo Tejera, Cesar Paz-y-Miño, Yunierkis Pérez-Castillo, Aminael Sánchez-Rodríguez, Zuleidys Contreras-Posada and M Natália D S Cordeiro.


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Inflammation, Endothelial Dysfunction and Arterial Stiffness as Therapeutic Targets in Cardiovascular Medicine


Vittoriano Della Corte, Antonino Tuttolomondo, Rosaria Pecoraro and Antonio Pinto.


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Preventive and Therapeutic Role of Muscle Contraction Against Chronic Diseases


Domenico Di Raimondo, Gaia Musiari, Giuseppe Miceli, Valentina Arnao and Antonio Pinto.


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Pathogenetic Pathways of Cardiorenal Syndrome and Their Possible Therapeutic Implications


Kenichi Matsushita.


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Intestinal Barrier Dysfunction in Human Pathology and Aging


Marcel Cerqueira César Machado and Fabiano Pinheiro da Silva.


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A Case Report of IgG4-related Syndrome and Literature Review


Antonino Tuttolomondo, Irene Simonetta, Domenico Di Raimondo, Roberta Conigliaro, Francesca Corpora, Valerio Vassallo and Antonio Pinto.


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Discriminating Drug-like Compounds by Partition Trees with Quantum Similarity Indices and Graph Invariants.


Jesus V. de Julián-Ortiz, Rafael Gozalbes and Emili Besalú.


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Structure- and Ligand-Based Approaches to Evaluate Aporphynic Alkaloids from Annonaceae as Multi-Target Agent Against Leishmania donovani


Vitor Prates Lorenzo, Ana Silvia Suassuna Carneiro Lúcio, Luciana Scotti, Josean Fechine Tavares, José Maria Barbosa Filho, Tatjana Keesen de Souza Lima Clemente, Juliana da Câmara Rocha and Marcus Tullius Scotti.


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The Impact of Antiplatelet Treatment on Endothelial Function


Emmanuel Androulakis, Karl Norrington, Constantinos Bakogiannis, Eirini Lioudaki, Gerasimos Siasos and Dimitris Tousoulis.


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Repositioning the Old Fungicide Ciclopirox for New Medical Uses


Tao Shen and Shile Huang.


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Biomimetic approach to stimulate osteogenesis on titanium implant surfaces using fibronectin derived oligopeptide


Young-Dan Cho, Sung-Jun Kim, Han-Sol Bae, Won-Joon Yoon, Kyung-Hwa Kim, Hyun-Mo Ryoo, Yang-Jo Seol, Yong-Moo Lee, In-Chul Rhyu and Young Ku.


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Oral Antiplatelet Treatment in STEMI: Current Practice and Future Considerations


Ioanna Xanthopoulou and Dimitrios Alexopoulos.


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Role of Colloidal Drug Delivery Carriers in Taxane-mediated Chemotherapy: A Review


Pramod Kumar, Kaisar Raza, Lokesh Kaushik, Ruchi Malik, Shweta Arora and Om Prakash Katare.


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Models for Self-Assembly of Nanoscale Systems with Biomedical Applications


Paula V. Messina, Ramon Rial and Juan M Ruso.


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Systems Medicine approaches to improving understanding, treatment, and clinical management of Neuroendocrine Prostate Cancer


Kamlesh K Yadav, Shameer Khader, Ben Readhead, Shalini S Yadav, Li Li, Andrew Kasarksis, Ashutosh K Tewari and Joel T Dudley.


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Computational Modeling and Experimental Facts of Mixed Self-Assembly Systems


Paula V. Messina, Jose Miguel Besada-Porto, Ramón Rial, Humberto González-Díaz and Juan M Ruso.


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Cell cycle kinases in osteosarcoma: potential for therapeutic intervention


Li Cheng, Chongchong Wang and Juehua Jing.


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Current status of ethosomes and elastic liposomes in dermal and transdermal drug delivery


Kevin Ita.


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Circulating microRNAs in hepatocellular carcinoma: potential diagnostic and prognostic biomarkers


Hamid Reza Mirzaei, Amirhossein Sahebkar, Foad Yazdi, Hosein Salehi, Mohammad Hasan Jafari, Afshin Namdar, Ehsan Khabazian, Mahmoud Reza Jaafri and Hamed Mirzaei.


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ABC transporters in the development of multidrug resistance in cancer therapy


Angelika Długosz and Anna Janecka.


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Targeting inflammatory bowel diseases by nanocarriers loaded with small and biopharmaceutical anti-inflammatory drugs


Ana Beloqui, Régis Coco and Véronique Préat.


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Passive targeting of cyclophosphamide-loaded carbonate apatite nanoparticles to liver impedes breast tumor growth in a syngeneic model


S Tiash and EH Chowdhury.


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MicroRNA-208a Potentiates Angiotensin II-triggered Cardiac Myoblasts Apoptosis via Inhibiting Nemo-like kinase (NLK)


Ying Huang, Yang Yang, Yong He, Cheng Huang, Xiaoming Meng and Jun Li.


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Site-Specific Thiol-mediated PEGylation of Streptokinase Leads to Improved Properties with Clinical Potential


Pooja Sawhney, Shekhar Kumar, Neeraj Maheshwari, Sumeet Singh Guleria, Neelam Dhar, Radhika Kashyup and Girish Sahni.


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Aptamers to hemagglutinin: a novel tool for influenza virus recognition and neutralization


Elena Zavyalova and Alexey Kopylov.


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Αlpha-2 adrenergic and opioids receptors participation in mice gastroprotection of Abelmoschus esculentus lectin


Kátia A. Ribeiro, Hellíada V. Chaves, Samuel Mateus Pereira Filho, Isabela Ribeiro Pinto, Dina Andressa Martins Monteiro, Samuel Oliveira Matos, Tatiane Santi-Gadelha, Carlos Alberto de Almeida Gadelha, José Thalles Jocelino Gomes de Lacerda, Lissiana M. V. Aguiar, Karuza M. A. Pereira, Norma M. B. Benevides, Vicente de Paulo T. Pinto, Gerardo Cristino Filho, Mirna M. Bezerra and Antonio A R Silva.


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Type 2 Diabetes Mellitus and Alzheimer`s disease: Bridging the Pathophysiology and Management


Fahmida Alam, Md. Asiful Islam, Teguh Haryo Sasongko and Siew Hua Gan.


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Statins in Stroke Prevention: Present and Future


Luis Castilla-Guerra, María del Carmen Fernandez-Moreno and Miguel Angel Colmenero- Camacho.


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Bcl-2 Family Proteins Regulate Apoptosis and Epithelial to Mesenchymal Transition by Calcium Signals


Yanjiao Wu and Liling Tang.


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Evolution of Chemosensitivity and Resistance Assays as Predictors of Clinical Outcomes in Epithelial Ovarian Cancer Patients


Bradley J. Monk, Thomas J. Herzog and Krishnansu S Tewari.


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Editorial: Metabolic Disorders, Drug Development, Drug Design and Biomarkers


Gjumrakch Aliev, Ramon Cacabelos and V Prakash Reddy.


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Nanotechnology for Drug Delivery: Part III


Jian Zhong.


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Editorial: The Pathogenesis of Inflammation and Cancer in the Gastrointestinal Tract: From Basic Science to Translational Medicine


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