E-Pub Articles Ahead of Print ::: Current Pharmaceutical Design

ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)


Volume 22, 46 Issues, 2016


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Current Pharmaceutical Design

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  • 73rd of 253 in Pharmacology & Pharmacy

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Editor-in-Chief:
William A. Banks
VAPSHCS/GRECC S-182
Building 1, Room 810A
1600 S. Columbian Way
Seattle, WA 98108
USA


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E-Pub Articles Ahead of Print

Editorial: Immune Modulation


Juan B De Sanctis.


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The Role of Microbiota and Intestinal Permeability in the Pathophysiology of Autoimmune and Neuroimmune Processes with an Emphasis on Inflammatory Bowel Disease Type 1 Diabetes and Chronic Fatigue Syndrome


Gerwyn Morris, Michael Berk, André F. Carvalho, Javier R. Caso, Yolanda Sanz and Michael Maes.


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An Updated Review of Iscoms™ and Iscomatrix™ Vaccines


Alexis Garcia and Diego Lema.


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Asthma COPD Overlap Syndrome: An Approach to A Real -World Endotype in Obstructive Lung Disease?


Maria E. Laucho-Contreras, Maria Montes de Oca and Caroline A Owen.


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Carrier Mediated Systemic Delivery of Protein and Peptide Therapeutics


Rahela Zaman, Iekhan Othman and Ezharul Hoque Chowdhury.


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A Review of Clinical Trials of Belimumab In The Management of Systemic Lupus Erythematosus


Alexis Garcia and Juan B De Sanctis.


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The Synthetic Cannabinoids Phenomenon


Laurent Karila, Amine Benyamina, Lisa Blecha, Olivier Cottencin and Joël Billieux.


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Editorial: Current Research on Cannabis Use Disorder


Aviv Weinstein.


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Editorial: Measurements of ABC Transporters at the Blood-Brain Barrier: Novel Methods and Applications


Gert Luurtsema.


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Multiple Sclerosis, Gut Microbiota and Permeability: Role of Tryptophan Catabolites, Depression and the Driving Down of Local Melatonin


Moses Rodriguez, Bharath Wootla and George Anderson.


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Gut Permeability and Microbiota in Parkinson’s Disease: Role of Depression, Tryptophan Catabolites, Oxidative and Nitrosative Stress and Melatoninergic Pathways


George Anderson, M Seo, M Berk, AF Carvalho and M Maes.


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Enteric Ecosystem Disruption in Autism Spectrum Disorder: Can the Microbiota and Macrobiota be Restored?


John Slattery, Derrick F. MacFabe, Stephen G. Kahler and Richard E Frye.


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Neuronutrient Amino-Acid Therapy Protects Against Reward Deficiency Syndrome: Dopaminergic Key to Homeostasis and Neuroplasticity


Kenneth Blum, Marcelo Febo, Rajendra D. Badgaiyan, Eric R. Braverman, Kristina Dushaj, Mona Li, Sangmin You and Zsolt Demetrovics.


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The Microbiota and Gut-Brain Axis: Contributions to the Immunopathogenesis of Schizophrenia


Javier R. Caso, Vicent Balanzá-Martínez, Tomás Palomo and Borja García-Bueno.


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The Gut-Brain Axis, Including the Microbiome, Leaky Gut and Bacterial Translocation: Mechanisms and Pathophysiological Role in Alzheimer’s Disease


Cristiano A. Köhler, Michael Maes, Anastasiya Slyepchenko, Michael Berk, Marco Solmi, Krista L. Lanctôt and André F Carvalho.


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Editorial: Pharmacological Targeting of Biological Barriers


Imola Wilhelm.


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Editorial: Advances in the Diagnosis and Treatment of Polycystic Ovarian Syndrome


Alicia Beatriz Motta.


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Editorial: Molecular Pharmaceutics and Solid-state Chemistry of Drugs


Arcadius V Krivoshein.


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From Cannabis to Cannabidiol to Treat Epilepsy, Where Are We?


Pellegrino Lippiello, Simona Balestrini, Antonio Leo, Antonietta Coppola, Rita Citraro, Maurizio Elia, Emilio Russo and Giovambattista De Sarro.


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Subcutaneous Immunoglobulins: A Promising Alternative for Immunomodulation?


Silvia Sánchez-Ramón, Ángel L. Corbí, Águeda García Fidalgo and Ángeles Domínguez-Soto.


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Genetic Influences in Cannabis Use Disorder and Psychosis: Dopamine and Beyond


Amine Benyamina, Laurent Karila, Geneviève Lafaye and Lisa Blecha.


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A Narrative Review of Psychological Cannabis Use Treatments With And Without Pharmaceutical Adjunct


Jan Copeland, Peter Gates and Izabella Pokorski.


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New Biological Insights in the Immunomodulatory Effects of Mucosal Polybacterial Vaccines in Clinical Practice


Marta Tejera-Alhambra, Oscar Palomares, Rebeca Pérez de Diego, Ignacio Díaz-Lezcano and Silvia Sánchez-Ramón.


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Role of Salmonella Typhi Vi Antigen and Secretory Systems on Immune Response


Ermin Schadich, Petr Džubák and Marián Hajdúch.


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Allergic Asthma. A Summary from Genetic Basis, Mouse Studies, to Diagnosis and Treatment


Cynthia Kanagaratham and Danuta Radzioch.


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Understanding Tumor-Antigen Presentation in the New Era of Cancer Immunotherapy


Daniela Cerezo-Wallis and Marisol Soengas.


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Therapeutic Potential of Targeting TREM-1 in Inflammatory Diseases and Cancer


Maria Carla Bosco, Federica Raggi and Luigi Varesio.


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Cannabinoids and Psychosis


Deepak Cyril D`Souza, Rajiv Radhakrishnan, Mohamed Sherif, Jose Cortes-Briones, John Cahill, Swapnil Gupta, Patrick D. Skosnik and Mohini Ranganathan.


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Brain imaging studies on the cognitive, pharmacological and neurobiological effects of cannabis in humans: Evidence from studies of adult users


A. Weinstein, A. Livny-Ezer and A Weizman.


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Pharmacological Treatment of Cannabis-Related Disorders: A Narrative Review


David A Gorelick.


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Targeting Mitochondria in Cardiovascular Diseases


Filomena S.G. Silva, Rui F. Simões, Renata Couto and Paulo J Oliveira.


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Effects of Blood Pressure Control in Cardiovascular Prevention


Nathan Artom, Alessandra Vecchié and Aldo Pende.


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Cholesterol Lowering Therapy: Treat To Target Or Reduce The Global Risk? The Unresolved Problem of Residual Risk


Giulia Bruzzone, Giorgia Corbelli, Paola Belci, Annalaura Cremonini, Aldo Pende and Livia Pisciotta.


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Cardiovascular Prevention in Obese Patients


Manuel F. Landecho, Rafael Moncada, Víctor Valentí and Gema Frühbeck.


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Targeting Inflammation in Primary Cardiovascular Prevention


Federico Carbone, Luca Liberale, Aldo Bonaventura, Michele Cea and Fabrizio Montecucco.


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Lipid-Based Nanocarriers for Cutaneous Leishmaniais and Buruli Ulcer Management


Sandra Simões, Manuela Carvalheiro and Maria Manuela Gaspar.


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Shear Stress-sensitive Carriers for Localized Drug Delivery


Xia Yu, Chun-Yang Shi, Wei Xiong, Xiao-Long Hou, Jian-Guo Fang and Wen-Qing Wang.


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Editorial: Cardiovascular Prevention: Can We Do Any Better?


Aldo Pende.


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Importance of ABC Transporters in Drug Development


Marcel Benadiba and Yehoshua Maor.


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Follicular Cysts: A Single Sign and Different Diseases. A View from Comparative Medicine


Hugo H. Ortega, Pablo U. Diaz, Natalia R. Salvetti, Gustavo J. Hein, Belkis E. Marelli, Fernanda M. Rodríguez, Antonela Stassi and Florencia Rey.


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PET tracers for imaging of ABC transporters at the blood-brain barrier: Principles and Strategies


Gert Luurtsema, Philip Elsinga, Rudi Dierckx, Ronald Boellaard and Aren van Waarde.


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Prediction of aquatic toxicity of benzene derivatives to Tetrahymena pyriformis


Juan A. Castillo-Garit, Concepción Abad, Gerardo M. Casañola-Martin, Stephen Jones-Barigye, Francisco Torrens and Amparo Torreblanca.


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Cannabis Epidemiology: A Selective Review


James C. Anthony, Catalina Lopez-Quintero and Omayma Alshaarawy.


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Design and synthesis of new selective P-gp substrates and inhibitors


Mariangela Cantore, Marcello Leopoldo, Francesco Berardi, Roberto Perrone and Nicola Antonio Colabufo.


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Adolescent cannabis use: What is the evidence for functional brain alteration?


V. Lorenzetti, S. Alonso-Lana, G.J. Youssef, A. Verdejo-Garcia, C. Suo, J Cousijn, M. Takagi, M. Yücel and N Solowij.


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In vitro and ex vivo model systems to measure ABC transporter activity at the blood-brain barrier


NM de Wit, G Kooij and HE de Vries.


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ABC Transporters And Drug Resistance In Patients With Epilepsy


Maria Feldmann and Matthias Koepp.


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Detection of quinolone resistance in Salmonella Typhimurium pig isolates determined by gyrA gene mutation using PCR- and sequence-based techniques within the gyrA gene


Guadalupe Patricia Macías Farrera, Esvieta Tenorio Borroto, Fabiola Rivera Ramírez, Juan Carlos Vázquez Chagoyán, Martín Talavera Rojas, Gilberto Yong Ange and Roberto Montes de Oca Jimenez2.


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Experimental-Theoretic Approach to Drug-Lymphocyte Interactome Networks with Flow Cytometry and Spectral Moments Perturbation Theory


Humberto González-Díaz, Esvieta Tenorio-Borroto, Fabiola Rivera Ramírez, Juan Carlos Vázquez Chagoyán and Roberto Montes de Oca Jiménez.


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Importance of P-gp PET Imaging in Pharmacology


Jun Toyohara.


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Approaches to Improve Efficiency of Dendritic Cell-Based Therapy of High Grade Gliomas


Dimitry A. Chistiakov, Ivan V. Chekhonin, Olga I. Gurina, Yuri V. Bobryshev and Vladimir P Chekhonin.


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Antiepileptic Drugs Based on the α-Substituted Amide Group Pharmacophore: From Chemical Crystallography to Molecular Pharmaceutics


Arcadius V Krivoshein.


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Structural Aspects of Solid Solutions of Enantiomers


Clément Brandel, Samuel Petit, Yohann Cartigny and Gérard Coquerel.


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Benefits and Limitations of Polymorphic and Amorphous Forms of Active Pharmaceutical Ingredients


Alicja Talaczyńska, Jakub Dzitko and Judyta Cielecka-Piontek.


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Non-ambient Conditions in the Investigation and Manufacturing of Drug Forms


Elena Boldyreva.


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Altered Steroid Metabolism And Insulin Signaling In Pcos Endometria: Impact In Tissue Function


Lorena Oróstica, Carlos Rosas, Francisca Plaza-Parrochia, Isis Astorga, Fernando Gabler, Víctor García, Carmen Romero and Margarita Vega.


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Advanced Applications of Raman Imaging for Deeper Understanding and Better Quality Control of Formulations


Kei Moriyama.


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The Role of Solid State Characterization in Predicting Stability of Solid Dosage Forms


Péter Szabó, Romána Zelkó and István Antal.


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Solid Dispersions for Oral Administration: An Overview of the Methods for their Preparation


François Hallouard, Lyes Mehenni, Malika Lahiani-Skiba, Youssef Anouar and Mohamed Skiba.


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Investigation of Polymorphism and Cocrystallization of Active Pharmaceutical Ingredients using Vibrational Spectroscopic Techniques


Yong Du and Jiadan Xue.


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Application of Vibrational Spectroscopy to Study Solid-state Transformations of Pharmaceuticals


Andrea Erxleben.


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Mechanochemical Approaches to Pharmaceutical Cocrystal Formation and Stability Analysis


Shan-Yang Lin.


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Blood-Brain Barrier ABC-transporter P-glycoprotein in Alzheimer’s Disease: still a suspect?


D.M.E. van Assema and BNM van Berckel.


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Kinetic models for measuring P-glycoprotein function at the blood-brain barrier with Positron Emission Tomography


Mark Lubberink.


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Potential Pathways for CNS Drug Delivery across the Blood-Cerebrospinal Fluid Barrier


Nathalie Strazielle and Jean-François Ghersi-Egea.


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Formation, Physicochemical Characterization, and Thermodynamic Stability of the Amorphous State of Drugs and Excipients


Piera Di Martino, Federico Magnoni, Dolores Vargas Peregrina, Maria Rosa Gigliobianco, Roberta Censi and Ledjan Malaj.


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Pharmacological Targeting of the Epidermal Barrier


L. Kemény, N. Nagy, Zs. Csoma, K. Szabó and G Erős.


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Membrane Transporters in Physiological Barriers of Pharmacological Importance


Ildikó Nagy, Beáta Tóth, Zsuzsanna Gáborik, Franciska Erdő and Péter Krajcsi.


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Plant-Derived Biomolecules and Drug Delivery Systems in the Treatment of Liver and Kidney Diseases


Anca Hermenean, Claudia Ghiozdan, Sami Gharbia, Istvan A. Krizbai and Aurel Ardelean.


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Strategies that Target Tight Junctions for Enhanced Drug Delivery


Lorenza González-Mariscal, Yanahi Posadas-Torrentera, Jael Miranda, Perla Uc, José Mario Ortega-Olvera and Sandra Hernández.


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Pharmacological Targeting of the Inflamed Intestinal Barrier


Attila E. Farkas and Asma Nusrat.


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Pharmaceutical Targeting of the Brain


István A. Krizbai, Ádám Nyúl-Tóth, Hans-Christian Bauer, Attila E. Farkas, Andreas Traweger, János Haskó, Hannelore Bauer and Imola Wilhelm.


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Targeted Vascular Drug Delivery in Cerebral Cancer


Nanna Humle, Kasper Bendix Johnsen, Gitte Abildgaard Arendt, Rikke Paludan Nielsen, Torben Moos and Louiza Bohn Thomsen.


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Polycystic Ovary Syndrome as a Proinflammatory State: The Role of Adipokines


Georgios K. Dimitriadis, Ioannis Kyrou and Harpal S Randeva.


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Metabolic Features Across The Female Life Span In Women With PCOS


Teresa Sir-Petermann, Bárbara Echiburú, Nicolás Crisosto, Manuel Maliqueo and Francisco Pérez Bravo.


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Cardiovascular Risk in the Different Phenotypes of Polycystic Ovary Syndrome


Konstantinos Tziomalos.


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Current Insights about Inositol Isoforms, Mediterranean and Ketogenic Diets for Polycystic Ovary Syndrome: From Bench to Beside


Giovanna Muscogiuri, Stefano Palomba, Antonio Simone Laganà and Francesco Orio.


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Insulin Resistance and Polycystic Ovary Syndrome


Paolo Moghetti.


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Hirsutism in Polycystic Ovary Syndrome: Pathophysiology and Management


Poli Mara Spritzer, Carolina Rocha Barone and Fabiana Bazanella de Oliveira.


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Adrenal Hyperandrogenism and Polycystic Ovary Syndrome


Manuel Luque-Ramírez and Héctor F Escobar-Morreale.


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Cubic Phases, Cubosomes and Ethosomes for Cutaneous Application


Elisabetta Esposito, Markus Drechsler, Claudio Nastruzzi and Rita Cortesi.


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Advances in the Diagnosis and Treatment of PCOS


Enrico Carmina, Ettore Guastella and Rosa Alba Longo.


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Quinolones in the Search for New Anticancer Agents


Pedro Netto Batalha Netto Batalha, Maria Cecília Bastos Vieira de Souza, Eduardo Peña-Cabrera, David Cruz Cruz and Fernanda da Costa Santos Boechat.


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Translational Insight Into Polycystic Ovary Syndrome (PCOS) From Female Monkeys With PCOS-like Traits


David H. Abbott, Levine JE and Dumesic DA.


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Editorial: Recent Advances in Cancer Research: Targets and New Ligands


Marcela Cristina de Moraes and Fernando de Carvalho da Silva.


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Gastric Cancer: Nanoparticles as Tools to Improve Treatment Efficacy


Ariel R. Guerrero, Felipe Oyarzún-Ampuero, Natalia Hassan, Alejandro H. Corvalán, Andrew F.G. Quest and Marcelo J Kogan.


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Determinants of Anti-Cancer Effect of Mitochondrial Electron Transport Chain Inhibitors: Bioenergetic Profile and Metabolic Flexibility of Cancer Cells


Félix A. Urra, Boris Weiss-López and Ramiro Araya-Maturana.


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Targeting the EGF/HER Ligand-Receptor System in Cancer


Azucena Esparís-Ogando, Juan Carlos Montero, Joaquín Arribas, Alberto Ocaña and Atanasio Pandiella.


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Gut-Brain Axis and Metabolism in Polycystic Ovary Syndrome


Basak Ozgen Saydam and Bulent O Yildiz.


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Targeted Nanosystems to Prostate Cancer


Luiz Cláudio Rodrigues Pereira da Silva, Flávia Almada do Carmo, Luiz Eurico Nasciutti, Patrícia Zancan, Plínio Cunha Sathler and Lucio Mendes Cabral.


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Latest Results for Anti-Angiogenic Drugs in Cancer Treatment


Sofie Frandsen, Sascha Kopp, Markus Wehland, Jessica Pietsch, Manfred Infanger and Daniela Grimm.


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Writers and Erasers of Histone Lysine Methylation with Clinical Applied Modulators: Promising Target for Cancer Therapy


Yi-Chao Zheng, Jin-Lian Ma, Ying Liu and Hong M Liu.


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Do Advanced Glycation End Products (AGEs) Contribute to the Comorbidities of Polycystic Ovary Syndrome (PCOS)?


Aleksandra Zofia Rutkowska and Evanthia Diamanti-Kandarakis.


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Insulin-Like Growth Factor 2 – The Oncogene and its Accomplices


Sonja M. Kessler, Johannes Haybaeck and Alexandra K Kiemer.


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The 9p21 Locus and its Potential Role in Atherosclerosis Susceptibility; Molecular Mechanisms and Clinical Implications


Amir Tajbakhsh, Seyed Mahdi Hassanian, Mohammad Sadegh Khorrami, Alireza Pasdar, Ehsan Tabatabai, Seyed Mohammad Reza Parizadeh, Mostafa Fazeli, Sharareh Gholamin, Gordon A. Ferns, Majid Ghayour-Mobarhan and Amir Avan.


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Natalizumab Modifies Catecholamines Levels Present in Patients with Relapsing-Remitting Multiple Sclerosis


Begoña M. Escribano, Macarena Aguilar, Carmen Bahamonde, Cristina Conde, Rafael Lillo, Fernando Sánchez-López, Ana I. Giraldo, Antonio H. Cruz, Evelio Luque, Félix Gascón, Eduardo Agüera and Isaac Tunez.


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Emerging Role for RBM20 and Its Splicing Substrates in Cardiac Function and Heart Failure


Jipeng Ma, Linhe Lu, Jun Ren and Jian Yang.


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The Novel Antipsychotic Cariprazine (RGH-188): State-of-the-Art in the Treatment of Psychiatric Disorders


Domenico De Berardis.


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Energy Remodeling, Mitochondrial Disorder and Heart Failure


Peng Wang, Lei Xu and Aijun Sun.


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Targeting Mitochondrial Dysfunction in Chronic Heart Failure: Current Evidence and Potential Approaches


A Aimo, C Borrelli, G Vergaro, MF Piepoli, AR De Caterina, G Mirizzi, A Valleggi, V Raglianti, C Passino, M Emdin and A Giannoni.


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Lipids, Statins and Heart Failure: An update


Niki Katsiki, Michael Doumas and Dimitris P Mikhailidis.


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Design and Synthesis of 2-(Arylmethylideneamino) Isoindolines as New Potential Analgesic and Anti-Inflammatory Agents: A Molecular Hybridization Approach


Maryam Iman, Hamed Shafaroodi, Asghar Davood, Masoud Abedini, Pouyan Pishva, Mehrnoush Taherkhani, Ahmad Reza Dehpour and Abbas Shafiee.


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Application of Mitochondria-Targeted Pharmaceuticals for the Treatment of Heart Disease


Ryan J Mailloux.


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Development of a Mouse Model of Shiga Toxin 2 (STX2) Intoxication for Testing Therapeutic Agents against Hemolytic Uremic Syndrome (HUS)


Maria Pilar Mejias, Romina Jimena Fernandez-Brando, Maria Victoria Ramos, Maria Jimena Abrey-Recalde, Elsa Zotta, Roberto Meiss and Marina Sandra Palermo.


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Generalized Molecular Descriptors Derived From Event-Based Discrete Derivative


Oscar Martínez-Santiago, Reisel Millán Cabrera, Yovani Marrero-Ponce, Stephen J. Barigye, Huong Le-Thi-Thu, Javier F. Torres, Cesar H. Zambrano, Ivan Yaber-Goenaga, Maykel Cruz-Monteagudo, Yoan Martínez López, Facundo Perez and Francisco Torrens.


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The Past, Current Studies and Future of Organometallic 99mTc(CO)3 Labeled Peptides And Proteins


Majid Piramoon and Seyed Jalal Hosseinimehr.


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From Fangs to Pharmacology: The Future of Snakebite Envenoming Therapy


Andreas H. Laustsen, Mikael Engmark, Christina Milbo, Jónas Johannesen, Bruno Lomonte, José María Gutiérrez and Brian Lohse.


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Pharmacological Approaches in an Experimental Model of Non-Small Cell Lung Cancer: Effects on Tumor Biology


Mercè Mateu-Jimenez, Clara Fermoselle, Federico Rojo, Javier Mateu, Raúl Peña, Alejandro J. Urtreger, Miriam J. Diament, Elisa D. Bal de Kier Joffé, Lara Pijuan, Antonio García de Herreros and Esther Barreiro.


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Common SAR Derived from Multiple QSAR Models on Vorinostat Derivatives Targeting HDACs in Tumor Treatment


Sugathan Praseetha, Srinivas Bandaru, Mukesh Yadav, Anuraj Nayarisseri and Sivanpillai Sureshkumar.


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Targeting cancer cells with photoactive silica nanoparticles


Wioleta Borzęcka, Tito Trindade, Tomás Torres and João Tomé.


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Editorial: Mitochondrial and Metabolism: Novel Targets for Heart Failure


Lei Xu and Aijun Sun.


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Triggering PIK3CA mutations in PI3K/AKT/mTOR axis: Exploration of newer inhibitors and rational preventive strategies


Vivek Asati, Sanjay K. Bharti, Debarshi Kar Mahapatra, Vikas Asati and Ashok Kumar Budhwani.


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Energetic Metabolic Roles in Pulmonary Arterial Hypertension and Right Ventricular Remodeling


Rui Zhang and Zhi-Cheng Jing.


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Targeting Anti-Cancer Active Compounds: Affinity-Based Chromatographic Assays


Marcela Cristina de Moraes, Carmen Lucia Cardoso, Claudia Seidl, Ruin Moaddel and Quezia Bezerra Cass.


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Strategies for Increasing the Solubility and Bioavailability of Anticancer Compounds: β-Lapachone and Other Naphthoquinones


Caroline Deckmann Nicoletti, Vitor Francisco Ferreira, Patricia Garcia Ferreira, Debora Omena Futuro and Fernando de Carvalho da Silva.


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Effects and Role of Multikinase Inhibitors in Thyroid Cancer.


Rasmus Laursen, Markus Wehland, Sascha Kopp, Jessica Pietsch, Manfred Infanger, Jirka Grosse and Daniela Grimm.


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The Role of Mitochondrial Dysfunction in Heart Failure and Potential Therapeutic Targets


Marko Banović and Arsen D Ristić.


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Polyketide Natural Products, Acetogenins from Graviola (Annona muricata L), its Biochemical, Cytotoxic Activity and Various Analyses Through Computational and Bio-Programming Methods


Keerthana Prabhakaran, Gnanam Ramasamy, Uma Doraisamy, Jayakanthan Mannu, K Rajamani and Jayadeepa Rajamani Murugesan.


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De novo design of new inhibitor of mutated tyrosine-kinase for the myeloid leukemia treatment


W. Pereira and I Camps.


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Identification of Small Molecule as a High Affinity β2 Agonist Irrespectively Targeting Wild and Mutated (Thr164Ile) β 2 Adrenergic Receptor in the Treatment of Bronchial Asthma


Srinivas Bandaru, Mallika Alvala, Jyothy Akka, Someshwar Rao Sagurthi, Anuraj Nayarisseri, Sanjeev Kumar Singh and Hema Prasad Mundluru.


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How the Protein Architecture of RNases III Influences their Substrate Specificity?


Guillermin Agüero-Chapin, Gisselle Pérez-Machado, Juan Collí Mull, Evys Ancede-Gallardo, Agostinho Antunes and Gustavo A de la Riva de la Riva.


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Probing the Hypothesis of SAR Continuity Restoration by the Removal of Activity Cliffs Generators in QSAR


Maykel Cruz-Monteagudo, José L. Medina-Franco, Yunier Perera-Sardiña, Fernanda Borges, Eduardo Tejera, Cesar Paz-y-Miño, Yunierkis Pérez-Castillo, Aminael Sánchez-Rodríguez, Zuleidys Contreras-Posada and M Natália D S Cordeiro.


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A Case Report of IgG4-related Syndrome and Literature Review


Antonino Tuttolomondo, Irene Simonetta, Domenico Di Raimondo, Roberta Conigliaro, Francesca Corpora, Valerio Vassallo and Antonio Pinto.


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Discriminating Drug-like Compounds by Partition Trees with Quantum Similarity Indices and Graph Invariants.


Jesus V. de Julián-Ortiz, Rafael Gozalbes and Emili Besalú.


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Structure- and Ligand-Based Approaches to Evaluate Aporphynic Alkaloids from Annonaceae as Multi-Target Agent Against Leishmania donovani


Vitor Prates Lorenzo, Ana Silvia Suassuna Carneiro Lúcio, Luciana Scotti, Josean Fechine Tavares, José Maria Barbosa Filho, Tatjana Keesen de Souza Lima Clemente, Juliana da Câmara Rocha and Marcus Tullius Scotti.


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Role of Colloidal Drug Delivery Carriers in Taxane-mediated Chemotherapy: A Review


Pramod Kumar, Kaisar Raza, Lokesh Kaushik, Ruchi Malik, Shweta Arora and Om Prakash Katare.


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Models for Self-Assembly of Nanoscale Systems with Biomedical Applications


Paula V. Messina, Ramon Rial and Juan M Ruso.


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Systems Medicine approaches to improving understanding, treatment, and clinical management of Neuroendocrine Prostate Cancer


Kamlesh K Yadav, Shameer Khader, Ben Readhead, Shalini S Yadav, Li Li, Andrew Kasarksis, Ashutosh K Tewari and Joel T Dudley.


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Computational Modeling and Experimental Facts of Mixed Self-Assembly Systems


Paula V. Messina, Jose Miguel Besada-Porto, Ramón Rial, Humberto González-Díaz and Juan M Ruso.


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Cell cycle kinases in osteosarcoma: potential for therapeutic intervention


Li Cheng, Chongchong Wang and Juehua Jing.


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Current status of ethosomes and elastic liposomes in dermal and transdermal drug delivery


Kevin Ita.


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Circulating microRNAs in hepatocellular carcinoma: potential diagnostic and prognostic biomarkers


Hamid Reza Mirzaei, Amirhossein Sahebkar, Foad Yazdi, Hosein Salehi, Mohammad Hasan Jafari, Afshin Namdar, Ehsan Khabazian, Mahmoud Reza Jaafri and Hamed Mirzaei.


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