E-Pub Articles Ahead of Print ::: Current Pharmaceutical Design

ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)


Volume 20, 42 Issues, 2014


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Current Pharmaceutical Design

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E-Pub Articles Ahead of Print

Pharmacological Management of Hypertension in the Elderly Certitudes and Controversies
Karolina Piotrowicz, Ewa Kucharska, Anna Skalska, Aleksander Kwater, Seetha Bhagavatula and Jerzy Gasowski
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Telomere-Dependent Genomic Integrity: Evolution of the Fusion-Bridge-Breakage Cycle Concept
Purificación Feijoo, Daniel Domínguez, Laura Tusell and Anna Genescà
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Telomere Recombination and the ALT Pathway: a Therapeutic Perspective for Cancer
Irena Draskovic and Arturo Londono-Vallejo
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Telomerase Modulation in Therapeutic Approach
Aleksandra Romaniuk, Przemysław Kopczynski, Krzysztof Książek and Błażej Rubiś
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Telomeric G-Quadruplex Architecture and Interactions with Potential Drugs
Claudia Sissi and Manlio Palumbo
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Extra-telomeric Functions of Human Telomerase: Cancer, Mitochondria and Oxidative Stress
G. Saretzki
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MicroRNA-dependent Regulation of Telomere Maintenance Mechanisms: a Field as Much Unexplored as Potentially Promising
Francesca Santambrogio, Paolo Gandellini, Graziella Cimino-Reale, Nadia Zaffaroni and Marco Folini
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Conventional Anticancer Therapeutics and Telomere Maintenance Mechanisms
Orit Uziel and Meir Lahav
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Oligonucleotides and G-quadruplex Stabilizers: Targeting Telomeres and Telomerase in Cancer Therapy
Zachary Crees, Jennifer Girard, Zechary Rios, Gregory M. Botting, Kymberly Harrington, Caleb Shearrow, Luke Wojdyla, Amanda L. Stone, Srijayaprakash B. Uppada, Joseph T. Devito and Neelu Puri
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Tankyrases: Structure, Function and Therapeutic Implications in Cancer
Teemu Haikarainen, Stefan Krauss and Lari Lehtio
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Telomere Maintenance Mechanisms in Cancer: Clinical Implications
Roger R. Reddel
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Editorial: Targeting Telomere Maintenance Mechanisms in Cancer Therapy
M. Folini
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Glutamate-Mediated Signaling and Autism Spectrum Disorders: Emerging Treatment Targets
Pinchen Yang and Chen-Lin Chang
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Dyslipidaemia Related to Insulin Resistance and Cardiovascular Disease in South Asian and West African Populations
Mfon Ewang-Emukowhate, Dilinika Perera and Anthony S. Wierzbicki
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Combination of Statin plus Renin Angiotensin System Inhibition for the Prevention or the Treatment of Atherosclerotic Cardiovascular Disease
Vasilios G. Athyros, Niki Katsiki, Asterios Karagiannis and Dimitri P Mikhailidis
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Hypertriglyceridaemia, Postprandial Lipaemia And Non-Hdl Cholesterol
Claudia Stefanutti, Giancarlo Labbadia and Vasilios G. Athyros
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Apolipoprotein B and Apolipopotein A-I in Vascular Risk Prediction – a Review
C Schmidt and G Bergström
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HDL Genetic Defects
Devaki R Nair, Arun Nair and Anjly Jain
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Familial Hypercholesterolemia: Etiology, Diagnosis and New Treatment Options
Ioanna Gouni-Berthold and Heiner K. Berthold
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Alcohol and the Cardiovascular System: a Double-Edged Sword
Niki Katsiki, Konstantinos Tziomalos and Dimitri P Mikhailidis
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LDL and HDL Subfractions, Dysfunctional HDL: Treatment Options
Antonio García Ríos, Dragana Nikolic, Pablo Perez-Martinez, Jose Lopez-Miranda, Manfredi Rizzo and Ron C. Hoogeveen
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Hypolipidaemic Drug Treatment: Yesterday is Not Gone Yet, Today is Challenging and Tomorrow is Coming Soon; let us Combine them all
Vasilios G. Athyros, Konstantinos Tziomalos, Asterios Karagiannis and Dimitri P. Mikhailidis
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Halting arterial aging in Patients with Cardiovascular Disease: Hypolipidemic and Antihypertensive Therapy
Vasilios Papademetriou, Niki Katsiki, Michael Doumas and Charles Faselis
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Statin Treatment Non-adherence and Discontinuation: Clinical Implications and Potential Solutions
Kim Phan, Yessica-Haydee Gomez, Laura Elbaz and Stella S. Daskalopoulou
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Medications not Intended for Treatment of Dyslipidemias and with a Variable Effect on Lipids
Thomas F Whayne and Debabrata Mukherjee
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Pathophysiological Role and Clinical Significance of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Bound to LDL and HDL
Constantinos C. Tellis and Alexandros D. Tselepis
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Effects of Lipid-Lowering Agents on Inflammation, Haemostasis and Blood Pressure
Konstantinos Tziomalos, Asterios Karagiannis and Vasilios G. Athyros
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Editorial : Novel Data on the Pathogenesis of Atherosclerosis, Treatment Targets, and New Therapeutic Interventions in Lipid-Related Cardiovascular Risk Factors
Vasilios G. Athyros, Konstantinos Tziomalos, Niki Katsiki and Dimitri P. Mikhailidis
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Mitochondrial Biogenesis: a Therapeutic Target for Neurodevelopmental Disorders and Neurodegenerative Diseases
Martine Uittenbogaard and Anne Chiaramello
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Possible Role of Vascular Risk Factors in Alzheimer's Disease and Vascular Dementia
Mehrul Hasnain and W. Victor R. Vieweg
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Osteoprotegerin in Cardiovascular Disease:Ally or Enemy?
Giacomo Buso, Elisabetta Faggin, Paolo Pauletto and Marcello Rattazzi
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Attention Deficit Hyperactivity Disorder and N-methyl-D-aspartate (NMDA) Dysregulation
Jane Pei-Chen Chang, Hsien-Yuan Lane and Guochuan E. Tsai
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Hypertension and Atrial Fibrillation: Any Change with the New Anticoagulants
Lorenzo Ghiadoni, Stefano Taddei and Agostino Virdis
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Psoriasis and Vascular Risk: an Update
Niki Katsiki, Panagiotis Anagnostis, Vasilios G. Athyros, Asterios Karagiannis and Dimitri P. Mikhailidis
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Is Time To Change To Halogenated Drugs In Cardiac Surgery, What Do We Have To Do With Propofol?
Landoni Giovanni, Pasin Laura, Borghi Giovanni and Zangrillo Alberto
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System Medicine Approaches for the Definition of Complex Phenotypes in Chronic Diseases and Ageing. From Concept to Implementation and Policies
Jean Bousquet, Christian Jorgensen, Michel Dauzat, Alfredo Cesario, Thierry Camuzat, Rodolphe Bourret, Nicolas Best, Josep M Anto, Frederic Abecassis, Pierre Aubas, Antoine Avignon, Melanie Badin, Hubert Blain, Arnaud Bourdin, Jacques Bringer, William Camu, Guilhaume Cayla, David J Costa, Philippe Courtet, Jean Paul Cristol, Pascal Demoly, Jean Emmanuel de la Coussaye, Pierre Fesler, Fares Gouzi, Jean Christophe Gris, Bernard Guillot, Maurice Hayot, Claude Jeandel, Olivier Jonquet, Laurent Journot, Gwenanelle Mathieu, Jacques Morel, Gregory Ninot, Jean Yvon Pelissier, Marie Christine Picot, Françoise Rabier-Pontal, Jean Marie Robine, Michel Rodier, Ariane Sultan, Anne Wojtusciszyn, Charles Auffray, Rudi Balling, Cristina Barbara, Anne Cambon-Thomsen, Niels H Chavannes, Alexander Chuchalin, George Crooks, Antoni Dedeu, Leonardo M Fabbri, Judith Garcia-Aymeric, Jawad Hassan, Elisabete Melo Gomes, Susana Palkonen, François Piette, Christophe Pison, David Price, Boleslaw Samolinski, Holger J Schunemann, Peter J Sterk, Panayitakis Yiallouros, Josep Roca, Philippe Vande Perre and Jacques Mercier
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Interventions Against Sarcopenia In Older Persons
Zanandrea Valeria, Giua Renato, Costanzo Luisa, Vellas Bruno, Zamboni Mauro and Cesari Matteo
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Neuroprotective Effects of Intravenous Anesthetics: A New Critical Perspective
Federico Bilotta, Elisabetta Stazi, Alexander Zlotnik, Shaun E. Guenbaum and Giovanni Rosa
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Regulation and Function of Rankl in Arterial Calcification
Belinda A. Di Bartolo and Mary M. Kavurma
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Editorial: Modifying Cardiovascular Risk Factors: Newer Advances in Cardiovascular Metabolism and Diagnostic Technologies
Aurelio Leone
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Targeting Mitochondrial Biogenesis to Treat Insulin Resistance
Mònica Zamora and Josep A. Villena
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The Effects of Sevoflurane or Remifentanil on the Stress Response to Surgical Stimulus
Estíbaliz Alsina, Emilio Matute, Ana Dominguez Ruiz-Huerta and Fernando Gilsanz
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Pharmacological Strategies For The Prevention Of Acute Kidney Injury Following Cardiac Surgery: An Overview Of Systematic Reviews
Nishith N Patel and Gianni D Angelini
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Assessing and Treating Cognitive Impairments in Schizophrenia: Current and Future
Chun-Yuan Lin, Guochuan E. Tsai and Hsien-Yuan Lane
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New Treatments for COPD in the Elderly
Maria Gabriella Matera, Luigino Calzetta, Paola Rogliani, Alfredo Cesario and Mario Cazzola
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A Systems Medicine Clinical Platform for Understanding and Managing Non-Communicable Diseases
Cesario Alfredo, Auffray Charles, Agusti Alvar, Apolone Giovanni, Balling Rudi, Barbanti Piero, Bellia Alfonso, Boccia Stefania, Bousquet Jean, Cardaci Vittorio, Cazzola Mario, Dall Armi Valentina, Daraselia Nikolai, Da Ros Lucio, Del Bufalo Alessandra, Ducci Giuseppe, Ferri Luigi, Fini Massimo, Fossati Chiara, Gensini Gianfranco, Granone Pierluigi Maria, Kinross James, Lauro Davide, Lo Cascio Gerland, Lococo Filippo, Lococo Achille, Maier Dieter, Marcus Frederick, Margaritora Stefano, Marra Camillo, Minati Gianfranco, Neri Monica, Pasqua Franco, Pison Christophe, Pristipino Christian, Roca Joseph, Rosano Giuseppe, Rossini Paolo Maria, Russo Patrizia, Salinaro Gianluca, Shenhar Shani, Soreq Hermona, J Sterk Peter, Stocchi Fabrizio, Torti Margherita, Volterrani Maurizio, Wouters Emiel FM, Frustaci Alessandra and Bonassi Stefano
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Preoperative Levosimendan. A New Way For Organoprotection"
L Guerrero Orriach Jose, A Ramirez Fernandez, P Iglesias, M Galan, A Florez, JJ Escalona, MJ Rodriguez, M Ramirez, M Rubio and J Cruz
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Alpha9Alpha10 Nicotinic Acetylcholine Receptors as Target for the Treatment of Chronic Pain
Alessandra Del Bufalo, Alfredo Cesario, Gianluca Salinaro, Massimo Fini and Patrizia Russo
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Editorial: Perioperative Organoprotection, Something New And Something Wrong
Jose Luis Guerrero Orriach
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Editorial: Disease control and active and healthy ageing: New paradigms of therapeutic strategy
Patrizia Russo, Massimo Fini and Alfredo Cesario
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Role of Bone-Type Tissue-Nonspecific Alkaline Phosphatase and PHOSPO1 in Vascular Calcification
Yuri V. Bobryshev, Alexander N. Orekhov, Igor Sobenin and Dimitry A. Chistiakov
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Modulators of Networks: Molecular Targets of Arterial Calcification Identified in Man and Mice
Yvonne Nitschke and Frank Rutsch
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Ocular Involvement in Fetal Alcohol Spectrum Disorder: a Review
Deirdre Brennan and Seamus Giles
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Teratogenic Activity of HDAC Inhibitors
Erminio Giavini and Elena Menegola
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Ovarian Toxicity: from Environmental Exposure to Chemotherapy
Roberto Iorio, Annalisa Castellucci, Giovanni Ventriglia, Flavia Teoli, Valerio Cellini, Guido Macchiarelli and Sandra Cecconi
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The Male Peripubertal Phase as a Developmental Window for Reproductive Toxicology Studies
Juliana Elaine Perobelli
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Nitric Oxide and Teratogenesis: an Update
Gian Mario Tiboni and Adalisa Ponzano
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Therapeutic Drugs that Slow the Heart Rate of Early Rat Embryos. Is there a Risk for the Human?
William S Webster, Mats Nilsson and Helen Ritchie
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Mechanisms of Action of Anesthetics for the Modulation of Perioperative Thrombosis: Evidence for Immune Mechanisms from Basic and Clinical Studies
Toshiharu Azma, Florin Tuluc, Taishin Ito, Chikako Aoyama-Mani, Shinji Kawahito and Hiroyuki Kinoshita
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Anesthetic Cardioprotection: The Role of Adenosine
Stephanie Bonney, Kelly Hughes and Tobias Eckle
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Anesthetic Cardioprotection in Relation to Mitochondria: Basic Science
Yasushi Mio, Shoichi Uezono and Hiroshi Kitahata
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Signaling Epicenters: The Role of Caveolae and Caveolins in Volatile Anesthetic Induced Cardiac Protection
Yousuke T. Horikawa, Yasuo M. Tsutsumi, Hemal H. Patel and David M. Roth
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Anesthetic Neuroprotection: Antecedents and An Appraisal of Preclinical and Clinical Data Quality
Kazuyoshi Ishida, Miles Berger, Jacob Nadler and David S. Warner
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Spinal Cord Ischemia/Injury
T Ishikawa, H Suzuki, K Ishikawa, S Yasuda, T Matsui, M Yamamoto, T Kakeda, S Yamamoto, Y Owada and T L Yaksh
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Protective Effects of Anesthetics on the Spinal Cord
MANAB KAKINOHANA
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Protective Effects of Anesthetics on Vascular Function Related to K+ Channels
Shinji Kawahito, Katsutoshi Nakahata, Toshiharu Azma, Yasuhiro Kuroda, David J. Cook and Hiroyuki Kinoshita
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Cardioprotection with Opioids– Trusted Old Friends -Clinical Science –
Hisanari Ishii
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Targeting MiRNAs for Pancreatic Cancer Therapy
Min Shi, Dacheng Xie, Yong Gao and Keping Xie
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Dexamethasone Use During Pregnancy: Potential Adverse Effects on Embryonic Skeletogenesis
Xin Cheng, Guang Wang, Kenneth Ka Ho Lee and Xuesong Yang
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Editorial: Mitochondrial Biogenesis: Pharmacological Approaches
Teresa Valero
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Zebrafish Model in Drug Safety Assessment
Jyotshna Kanungo, Elvis Cuevas, Syed F. Ali and Merle G. Paule
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MicroRNAs as Anti-Cancer Therapy
Michela Garofalo, Gianpiero Di Leva and Carlo M. Croce
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Anesthetic Cardioprotection in Clinical Practice From Proof-of-Concept to Clinical Applications
Michael Zaugg, Eliana Lucchinetti, Said Behmanesh and Alexander S. Clanachan
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Opioid-Induced Cardioprotection
Katsuya Tanaka, Judy R. Kersten and Matthias L. Riess
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MicroRNAs in Cancer: Lessons from Melanoma
Eyal Greenberg, Yael Nemlich and Gal Markel
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Mechanisms of Inflammatory Response and Organ Dysfunction: Organ-Protective Strategy by Anesthetics
Noboru Hatakeyama and Naoyuki Matsuda
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Editorial : Regulating the CNS Grand Regulators; N-methyl-D-aspartate Receptor-Mediated Neurotransmission
Guochuan Emil Tsai
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Editorial: Advances in Developmental and Reproductive Toxicology
Gian Mario Tiboni
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Interrelationships of Circulating Tumor Cells with Metastasis and Thrombosis: Role of MicroRNAs
Junli Xue, Victoria K. Xie, Peipei Wang, Jiujie Cui, Yong Gao and Zhimin Lu
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Editorial: Advances with MicroRNAs in Tumorigenesis and Cancer Therapy
Zhiwei Wang
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NMDA Pathology and Treatment of Schizophrenia
Huey-Jen Chang, Hsien-Yuan Lane and Guochuan E. Tsai
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Targeting of NMDA Receptors in the Treatment of Major Depression
Yong-Hui Dang, Xian-Cang Ma, Ji-Chun Zhang, Qian Ren, Jin Wu, Cheng-Ge Gao and Kenji Hashimoto
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VEGF and Colon Cancer Growth Beyond Angiogenesis: Does VEGF Directly Mediate Colon Cancer Growth Via a Non-angiogenic Mechanism?
Amrita Ahluwalia, Michael K. Jones, Tamara Matysiak-Budnik and Andrzej S. Tarnawski
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Supplementation of Creatine and Ribose Prevents Apoptosis and Right Ventricle Hypertrophy in Hypoxic Hearts
Anna Caretti, Paola Bianciardi, Marina Marini, Provvidenza M. Abruzzo, Alessandra Bolotta, Carlo Terruzzi, Franco Lucchina and Michele Samaja
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The Impact of Computational Structure-Based Methods on Drug Discovery
Charles H. Reynolds
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Human Use of Leucoselect® Phytosome® with Special Reference to Inflammatoryallergic Pathologies in Frail Elderly Patients
Thea Magrone, Vittorio Pugliese, Sergio Fontana and Emilio Jirillo
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Editorial: The SNAP-tag Technology – A Versatile Tool with many Applications
Stefan Barth
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Gender Based Differences in Stress-induced Gastric Ulcer Formation and its Regulation by Nitric Oxide (NO): An Experimental Study
Kavita Gulati, Ayanabha Chakraborti and Arunabha Ray
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Probiotics for the Prevention and Treatment of Allergies, with an Emphasis on Mode of Delivery and Mechanism of Action
Satya Prakash, Catherine Tomaro-Duchesneau, Shyamali Saha, Laetitia Rodes, Imen Kahouli and Meenakshi Malhotra
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Consumption of Mixed Fruit-juice Drink and Vitamin C Reduces Postprandial Stress Induced by a High Fat Meal in Healthy Overweight Subjects
Ilaria Peluso, Debora V. Villano, Susan A. Roberts, Eleonora Cesqui, Anna Raguzzini, Gina Borges, Alan Crozier, Giovina Catasta, Elisabetta Toti and Mauro Serafini
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Immunomodulating and Anti-allergic Effects of Negroamaro and Koshu Vitis vinifera Fermented Grape Marc (FGM)
Giuseppe Marzulli, Thea Magrone, Luisa Vonghia, Masahiro Kaneko, Hiroaki Takimoto, Yoshio Kumazawa and Emilio Jirillo
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Potential Use of Dietary Natural Products, Especially Polyphenols, for Improving Type-1 Allergic Symptoms
Kumazawa Y, Takimoto H, Matsumoto T and Kawaguchi K
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Omega-6 and Omega-3 Polyunsaturated Fatty Acids and Allergic Diseases in Infancy and Childhood
Elizabeth A. Miles and Philip C. Calder
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What Fans the Fire: Insights into Mechanisms of Leptin in Metabolic Syndrome- Associated Heart Diseases
Maolong Dong and Jun Ren
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Transactivation of ErbB Receptors by Leptin in the Cardiovascular System: Mechanisms, Consequences and Target for Therapy
Jerzy Bełtowski and Anna Jazmroz-Wiśniewska
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Structural Insights into Chitinolytic Enzymes and Inhibition Mechanisms of Selective Inhibitors
Tian Liu, Lei Chen, Qiang Ma, Xu Shen and Qing Yang
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Structure-based Design of Conformationally Flexible Reverse Transcriptase Inhibitors to Combat Resistant HIV
Ge-Fei Hao, Sheng-Gang Yang and Guang-Fu Yang
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Structural Basis of Resistance to Anti-Cytochrome bc1 Complex Inhibitors: Implication for Drug Improvement
Lothar Esser, Chang-An Yu and Di Xia
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ABC Transporters in Multidrug Resistance and Pharmacokinetics, and Strategies for Drug Development
Young Hee Choi, Ai-Ming Yu and Ai-Ming Yu
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Structure-Based Drug Design to Overcome Drug Resistance: Challenges and Opportunities
Rafaela S. Ferreira1, Adriano D. Andricopulo and Adriano D. Andricopulo
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Novel Next-Generation Sequencing and Networks-Based Therapeutic Targets: Realistic and More Effective Drug Design and Discovery
Dimitrios H. Roukos, Giannis G. Baltogiannis, Christos S. Katsouras, Aris Bechlioulis, Katerina K. Naka, Charalambos Batsis, Theodore Liakakos and Lampros K. Michalis
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Endothelial Dysfunction and the Effects of TNF Inhibitors on the Endothelium in Psoriasis and Psoriatic Arthritis: A Systematic Review
Elizabeth A. Brezinski, Matthew R. Follansbee, Ehrin J. Armstrong and April W. Armstrong
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Effects of Biologic Agents and Other Disease-Modifying Antirheumatic Drugs on Cardiovascular Outcomes in Psoriasis and Psoriatic Arthritis: A Systematic Review
April W. Armstrong, Elizabeth A. Brezinski, Matthew R. Follansbee and Ehrin J. Armstrong
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