E-Pub Articles Ahead of Print ::: Current Medicinal Chemistry

ISSN: 1875-533X (Online)
ISSN: 0929-8673 (Print)


Volume 23, 42 Issues, 2016


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Current Medicinal Chemistry

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 6th of 59 in Chemistry & Medicinal
  • 47th of 254 in Pharmacology & Pharmacy
  • 81st of 289 in Biochemistry & Molecular Biology

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Editor-in-Chief:
Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK


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Current: 3.853
5 - Year: 4.115

E-Pub Articles Ahead of Print

Vaccination to Alzheimer Disease. Is it a Promising Tool or a Blind Way?


Miroslav Pohanka.


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Monocyclic and Fused Azines and Azoles as Histamine H4 Receptor Ligands


Dorota Łażewska, Enrique Domínguez-Álvarez, Katarzyna Kamińska, Kamil Kuder and Katarzyna Kieć-Kononowicz.


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Identifying S100B as a Biomarker and a Therapeutic Target For Brain Injury and Multiple Diseases


Zhao Zhong Chong, Benjarat Changyaleket, Haoliang Xu, Randy O. Dull and David E Schwartz.


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Cyclic Opioid Peptides


Michael Remesic, Yeon Sun Lee and Victor J Hruby.


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Natural AMPK Activators: An Alternative Approach for the Treatment and Management of Metabolic Syndrome


Hitender Sharma and Sunil Kumar.


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Management of Inflammation by Natural Polyphenols: a Comprehensive Mechanistic Update


Souvik Sarkar, Somnath Mazumder, Shubhra J. Saha and Uday Bandyopadhyay.


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Enzymology of Pyrimidine Metabolism and Neurodegeneration


S. Vincenzetti, V. Polzonetti, D. Micozzi and S Pucciarelli.


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Preclinical Models of Multiple Sclerosis: Advantages and Limitations towards Better Therapies


Alessandro Didonna.


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Mesenchymal Stem Cells for Ischemic Stroke: Progress and Possibilities


Anna Lucia Maria Ferri, Anna Bersano, Daniela Lisini, Giorgio Boncoraglio, Simona Frigerio and Eugenio Parati.


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Role of the Receptor Tyrosine Kinase Axl and its Targeting in Cancer Cells


Cristina Corno, Laura Gatti, Cinzia Lanzi, Nadia Zaffaroni, Diego Colombo and Paola Perego.


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Insights into the Structural Features Essential for JAK2 Inhibition and Selectivity


Chao Zhao, Daulat Bikram Khadka and Won-Jea Cho.


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Effect of Dipeptidyl Peptidase-4 Inhibitors on Plasma Adiponectin: A Systematic Review and Meta-Analysis of Randomized Controlled Trials


Amirhossein Sahebkar, Valentina Ponzo and Simona Bo.


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Immunoproteasome-Selective Inhibitors: A Promising Strategy to Treat Hematologic Malignancies, Autoimmune and Inflammatory Diseases


Roberta Ettari, Santo Previti, Alessandra Bitto, Silvana Grasso and Maria Zappalà.


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Biochemical Markers of Renal Function


Danijela Krstić, Nenad Tomić, Branimir Radosavljević, Nataša Avramović, Vesna Dragutinović, Sanja Radojević Škodrić and Mirjana Čolović.


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Molecular Dissection of Renal Ischemia-Reperfusion: Oxidative Stress and Cellular Events


Branislav Rovcanin, Branislava Medic, Gordana Kocic, Tatjana Cebovic, Marko Ristic and Milica Prostran.


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Prevention of Renal Complications Induced by Non-Steroidal Anti- Inflammatory Drugs


Sonja Vučković, Katarina Savić Vujović, Branislava Medić, Dragana Srebro and Danka Mostić.


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Evaluation of Novel Biomarkers of Acute Kidney Injury: The Possibilities and Limitations


Branislava Medić, Branislav Rovčanin, Katarina Savić Vujović, Danilo Obradović, Dušan Đurić and Milica Prostran.


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Non-Vitamin K Oral Anticoagulant Drugs for Stroke Prevention in Patients with Atrial Fibrillation and Chronic Kidney Disease


Tatjana S. Potpara, Vera Jokic, Nikolaos Dagres, Torben B. Larsen, Deirdre A. Lane, Gerhard Hindricks and Gregory YH Lip.


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Fight against H1N1 Influenza A Virus: Recent Insights towards the Development of Druggable Compounds


Michele Tonelli and Elena Cichero.


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Angiotensin II Type 1 Receptor Binding Molecule ATRAP as a Possible Modulator of Renal Sodium Handling and Blood Pressure in Pathophysiology


K. Tamura, H. Wakui, K. Azushima, K. Uneda, S. Haku, R. Kobayashi, K. Ohki, K. Haruhara, S. Kinguchi, M. Matsuda, A. Yamashita and S Umemura.


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Population Pharmacokinetic Approach of Immunosuppressive Therapy in Kidney Transplant Patients


Bojana Golubović, Milica Prostran, Branislava Miljković, Katarina Vučićević, Dragana Radivojević and Iztok Grabnar.


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Unfolded Protein Response and PERK Kinase as a New Therapeutic Target in the Pathogenesis of Alzheimer’s Disease


Wioletta Rozpędek, Łukasz Markiewicz, J. Alan Diehl, Dariusz Pytel and Ireneusz Majsterek.


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Editorial: Inflammation and Atherosclerosis: The Role of Novel Biomarkers (Part-I)


Gerasimos Siasos, Athanasios G. Papavassiliou and Dimitris Tousoulis.


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Editorial: Metabolic Diseases: Drugs and Mitochondrial Targets


Carlos M. Palmeira and Anabela P Rolo.


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Editorial: Mechanisms and Therapeutic Strategies for Major Neurological Disorders: Current Advances and Future Perspectives


Weihai Ying.


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Tissue-specific Glucocorticoid Signaling May Determine the Resistance Against Glucocorticoids in Autoimmune Diseases


Á. Szappanos, Z. Nagy, B. Kovács, G. Poór, M. Tóth, K. Rácz, E. Kiss and A Patócs.


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Purinergic P2X Receptors: Structural and Functional Features Depicted by X-Ray and Molecular Modelling Studies


Leanne Grimes and Mark T Young.


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Polymers and Formulation Strategies of Nanofibrous Systems for Drug Delivery Application and Tissue Engineering


I. Sebe, B. Kállai-Szabó, R. Zelkó and D Szabó.


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Glucocorticoids in Patients with Rheumatic Diseases: Friends or Enemies of Bone?


Fedra Ciccarelli, Massimo De Martinis and Lia Ginaldi.


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Bioactivation of Drugs: Enzymes, Reactive Metabolites and Adverse Reactions


Hilmi Orhan.


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p38 MAPK: A Potential Target of Chronic Pain


X. Lin, M. Wang, J. Zhang and R Xu.


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Editorial: Emerging biomarkers for drug development in Amyotrophic Lateral Sclerosis


Sebastiano Cavallaro.


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A Glimpse of Matrix Metalloproteinases in Diabetic Nephropathy


X. Xu, L. Xiao, P. Xiao, S. Yang, G. Chen, F. Liu, Y.S. Kanwar and L Sun.


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Disturbed Tryptophan Metabolism in Cardiovascular Disease


H. Mangge, I. Stelzer, E.Z. Reininghaus, D. Weghuber, T.T. Postolache and D Fuchs.


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Editorial: Cardiovascular drug therapy in paediatric age: from metabolomics to clinical practice


Bassareo PP and Fanos V.


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Editorial: Prevention of microbial biofilms - the contribution of micro and nanostructured materials


Alexandru Mihai Grumezescu and Carmen Mariana Chifiriuc.


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EDITORIAL: New Insight into Lipid Disorders


Valentina Pallottini.


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Adipocytes Contribute to Resistance of Human Melanoma Cells to Chemotherapy and Targeted Therapy


M. Chi, J. Chen, Y. Ye, Hsin-Yi Tseng, F. Lai, K.H. Tay, L. Jin, S.T. Guo, C.C. Jiang and XD Zhang.


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P38 MAPK Contributes to Resistance and Invasiveness of HER2- Overexpressing Breast Cancer


S.M. Donnelly, E. Paplomata, B.M. Peake, E. Sanabria, Z. Chen and R Nahta.


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The Functional Logic of Cytosolic 5’-Nucleotidases


Piero L Ipata and Francesco Balestri.


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Biophysical Characterization of Glycodendrimers As Nano-carriers for HIV Peptides


M. Ionov, K. Ciepluch, B.R. Moreno, D. Appelhans, J. Sánchez-Nieves, R. Gómez, F.J. de la Mata, M.A. Muñoz-Fernández and M Bryszewska.


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Human Galectin-3 Selective and High Affinity Inhibitors. Present State and Future Perspectives


R. Téllez-Sanz, L. García-Fuentes and A Vargas-Berenguel.


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Nanoparticles Loaded with Nutlin-3 Display Cytotoxicity Towards p53wildtype JVM-2 But Not Towards p53mutated BJAB Leukemic Cells


R. Voltan, P. Secchiero, B. Ruozi, L. Caruso, F. Forni, M. Palomba, G. Zauli and MA Vandelli.


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MEK Inhibition Increases Lapatinib Sensitivity Via Modulation of FOXM1


S.S. Gayle, R.C. Castellino, M.C. Buss and R Nahta.


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1,2,4-Oxadiazoles Identified by Virtual Screening and their Non-Covalent Inhibition of the Human 20S Proteasome


X. Maréchal, E. Genin, L. Qin, O. Sperandio, M. Montes, N. Basse, N. Richy, M.A. Miteva, M. Reboud-Ravaux, J. Vidal and BO Villoutreix.


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Insulin Secretion and Interleukin-1β Dependent Mechanisms in Human Diabetes Remission After Metabolic Surgery


Chih-Yen Chen, Wei-Jei Lee, A. Asakawa, N. Fujitsuka, Keong Chong, Shu-Chun Chen, Shou-Dong Lee and A Inui.


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Serenoa Repens, Lycopene and Selenium: A Triple Therapeutic Approach to Manage Benign Prostatic Hyperplasia


L. Minutoli, A. Bitto, F. Squadrito, H. Marini, N. Irrera, G. Morgia, A. Passantino and D Altavilla.


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Anti-Inflammatory and Antioxidant Effects of Resveratrol in Healthy Smokers A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial


S. Bo, G. Ciccone, A. Castiglione, R. Gambino, F. De Michieli, P. Villois, M. Durazzo, P. Cavallo-Perin and M Cassader.


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Developing FGFR4 Inhibitors As Potential Anti-Cancer Agents Via In Silico Design, Supported by In Vitro and Cell-Based Testing


H.K. Ho, G. Németh, Y.R. Ng, E. Pang, C. Szántai-Kis, L. Zsákai, N. Breza, Z. Greff, Z. Horváth, J. Pató, I. Szabadkai, B. Szokol, F. Baska, L. Orfi, A. Ullrich, G. Kéri and BT Chua.


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Design, SAR, Angiogenic Activities Evaluation and Pro-Angiogenic Mechanism of New Marine Cyclopeptide Analogs


J. Li, X. Lu, Q. Wu, G. Yu, Z. Xu, L. Qiu, Z. Pei, Y. Lin and J Pang.


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Prostate Cancer, miRNAs, Metallothioneins and Resistance to Cytostatic Drugs


V. Pekarik, J. Gumulec, M. Masarik, R. Kizek and V Adam.


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Increased Akt Signaling Resulting from the Loss of Androgen Responsiveness in Prostate Cancer


J. Dulinska-Litewka, J.A. McCubrey and P Laidler.


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Inhaled Muscarinic Acetylcholine Receptor Antagonists for Treatment of COPD


P. Montuschi, F. Macagno, S. Valente and L Fuso.


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State of the Art of the Therapeutic Perspective of Sorafenib Against Hematological Malignancies


G. Zauli, R. Voltan, V. Tisato and P Secchiero.


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Therapeutic Monoclonal Antibodies: Strategies and Challenges for Biosimilars Development


Begoña Calvo and Leyre Zuñiga.


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Physico-Chemical Properties Mediating Reproductive and Developmental Toxicity of Engineered Nanomaterials


Luisa Campagnolo, Micol Massimiani, Andrea Magrini, Antonella Camaioni and Antonio Pietroiusti.


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Alkyl Hydroxybenzoic Acid Derivatives that Inhibit HIV-1 Protease Dimerization


O.A. Flausino Jr., L. Dufau, L.O. Regasini, M.S. Petrônio, D.H.S. Silva, T. Rose, V.S. Bolzani and M Reboud-Ravaux.


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Oxidized-LDL and Paraoxonase-1 As Biomarkers of Coronary Artery Disease in Patients with Sleep-Disordered Breathing


F.S. Hackenhaar, D. Martinez, T.M. Medeiros, C. Klein, P.V.G. Alabarse, M.V. Wainstein, S.C. Gonçalves and MS Benfato.


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pKa, Zinc- and Serum Albumin-Binding of Curcumin and Two Novel Biologically- Active Chemically-Modified Curcumins


Yu Zhang, Lorne M. Golub, Francis Johnson and Arnold Wishnia.


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Design, Synthesis and Biological Activity of New Polyenolic Inhibitors of Matrix Metalloproteinases: A Focus on Chemically-Modified Curcumins


Yu Zhang, Ying Gu, Hsi-Ming Lee, Elena Hambardjieva, Kveta Vrankova, Lorne M. Golub and Francis Johnson.


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Subtype-Selective Dopamine Receptor Radioligands for PET Imaging: Current Status and Recent Developments


A. Banerjee and O Prante.


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Targeting DNA Topoisomerase I with Non-Camptothecin Poisons


G.L. Beretta, V. Zuco, P. Perego and N Zaffaroni.


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