E-Pub Articles Ahead of Print ::: Current Medicinal Chemistry

ISSN: 1875-533X (Online)
ISSN: 0929-8673 (Print)

Volume 21, 38 Issues, 2014

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Current Medicinal Chemistry

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  • 9th of 58 in Chemistry & Medicinal
  • 49th of 254 in Pharmacology & Pharmacy
  • 96th of 291 in Biochemistry & Molecular Biology

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Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge

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E-Pub Articles Ahead of Print

Purinergic P2X Receptors: Physiological and Pathological Roles and Potential as Therapeutic Targets
Diego Dal Ben
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Bioactivation of Drugs: Enzymes, Reactive Metabolites and Adverse Reactions
Hilmi Orhan
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Multi-Modal Imaging And Cancer Therapy Using Lanthanide Oxide Nanoparticles: Current Status And Perspectives
Ja Young Park, Yongmin Chang and Gang Ho Lee
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Polymers and Formulation Strategies of Nanofibrous Systems for Drug Delivery Application and Tissue Engineering
István Sebe, Barnabás Kállai-Szabó, Romána Zelkó and Dóra Szabó
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Contribution of Microglial Activation as Compelling Target for the Treatment of Acute Trauatic Brain Injury
Chung-Ching Chio, Mao-Tsun Lin and Ching-Ping Chang
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Endless Peptides – Circular forms in Nature
Anna Adamska and Anna Janecka
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New Antihypertensive Drugs Under Development
J Tamargo, J Duarte and Luis Miguel Ruilope
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Cardio-Vascular Activity of Catestatin: Interlocking the Puzzle Pieces
R. Mazza, B. Tota and A. Gattuso
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Recent Development Of Multifunctional Agents As Potential Drug Candidates For The Treatment Of Alzheimer’s Disease
Natalia Guzior, Anna Więckowska, Dawid Panek and Barbara Malawska
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Oxidative Stress in COPD: Molecular Background and Clinical Monitoring
Balazs Antus and Zsuzsanna Kardos
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Glucocorticoids In Patients With Rheumatic Diseases: Friends Or Enemiesof Bone?
Fedra Ciccarelli, Massimo De Martinis and Lia Ginaldi
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An Overview of the Selectivity and Efficiency of the Bacterial Carbonic Anhydrase Inhibitors
C. Capasso and C. T. Supuran
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Emerging Roles of P2X Receptors in Cancer
Elena Adinolfi, Marina Capece, Francesca Amoroso, Elena De Marchi and Alessia Franceschini
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Biotransformation of Endocrine Disrupting Compounds by Selected Phase I and Phase II Enzymes – Formation of Estrogenic and Chemically Reactive Metabolitesby Cytochromes P450 and Sulfotransferases
Jelle Reinen and Nico P.E. Vermeulen
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Idiosyncratic Drug Hepatotoxicity: Strategy for Prevention and Proposed Mechanism
Toshihiko Ikeda
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Role of MicroRNAs in Osteoblasts Differentiation and Bone Disorders
Yasir Arfat, Wei-Zhong Xiao, Munazza Ahmad, Fan Zhao, Di-Jie Li, Yu-Long Sun, Lifang Hu, Chen Zhihao, Ge Zhang, Peng Shang and Ai-Rong Qian
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Reactive Metabolites in Early Drug Development: Predictive In vitro Tools
Olavi Pelkonen, Markku Pasanen, Ari Tolonen, Mikko Koskinen, Jukka Hakkola, Khaled Abass, Jaana Laine, Merja Häkkinen, Risto Juvonen, Seppo Auriola, Markus Storvik, Pasi Huuskonen, Timo Rousu and Maiju Rahikkala
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P2X Receptors, Sensory Neurons and Pain
Tanja Bele and Elsa Fabbretti
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p38 MAPK: A Potential Target of Chronic Pain
X. Lin, M. Wang, J. Zhang and R. Xu
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Extrahepatic Targets and Cellular Reactivity of Drug Metabolites
Hilmi Orhan
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Editorial: Emerging biomarkers for drug development in Amyotrophic Lateral Sclerosis
Sebastiano Cavallaro
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Smoking and Atherosclerosis: Mechanisms of Disease and New Therapeutic Approaches
Gerasimos Siasos, Dimitris Tousoulis, Stavroula Michalea, Evangelos Oikonomou, Manolis Vavuranakis, Dimitris Athanasiou, Panagiotis Tourikis, Nikolaos Gouliopoulos, Antigoni Miliou, Savvas Mazaris, Athanasios G. Papavassiliou and Christodoulos Stefanadis
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A Glimpse of Matrix Metalloproteinases in Diabetic Nephropathy
X. Xu, L. Xiao, P. Xiao, S. Yang, G. Chen, F. Liu, Y.S. Kanwar and L. Sun
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Physiopathological Roles of P2X Receptors in the Central Nervous System
Geoffrey Burnstock
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Disturbed Tryptophan Metabolism in Cardiovascular Disease
H. Mangge, I. Stelzer, E.Z. Reininghaus, D. Weghuber, T.T. Postolache and D. Fuchs
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Editorial: Cardiovascular drug therapy in paediatric age: from metabolomics to clinical practice
Bassareo PP and Fanos V
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Editorial: Prevention of microbial biofilms - the contribution of micro and nanostructured materials
Alexandru Mihai Grumezescu and Carmen Mariana Chifiriuc
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EDITORIAL: New Insight into Lipid Disorders
Valentina Pallottini
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Adipocytes Contribute to Resistance of Human Melanoma Cells to Chemotherapy and Targeted Therapy
M. Chi, J. Chen, Y. Ye, Hsin-Yi Tseng, F. Lai, K.H. Tay, L. Jin, S.T. Guo, C.C. Jiang and X.D. Zhang
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P38 MAPK Contributes to Resistance and Invasiveness of HER2- Overexpressing Breast Cancer
S.M. Donnelly, E. Paplomata, B.M. Peake, E. Sanabria, Z. Chen and R. Nahta
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The Functional Logic of Cytosolic 5’-Nucleotidases
Piero L Ipata and Francesco Balestri
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Biophysical Characterization of Glycodendrimers As Nano-carriers for HIV Peptides
M. Ionov, K. Ciepluch, B.R. Moreno, D. Appelhans, J. Sánchez-Nieves, R. Gómez, F.J. de la Mata, M.A. Muñoz-Fernández and M. Bryszewska
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Human Galectin-3 Selective and High Affinity Inhibitors. Present State and Future Perspectives
R. Téllez-Sanz, L. García-Fuentes and A. Vargas-Berenguel
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Nanoparticles Loaded with Nutlin-3 Display Cytotoxicity Towards p53wildtype JVM-2 But Not Towards p53mutated BJAB Leukemic Cells
R. Voltan, P. Secchiero, B. Ruozi, L. Caruso, F. Forni, M. Palomba, G. Zauli and M.A. Vandelli
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MEK Inhibition Increases Lapatinib Sensitivity Via Modulation of FOXM1
S.S. Gayle, R.C. Castellino, M.C. Buss and R. Nahta
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1,2,4-Oxadiazoles Identified by Virtual Screening and their Non-Covalent Inhibition of the Human 20S Proteasome
X. Maréchal, E. Genin, L. Qin, O. Sperandio, M. Montes, N. Basse, N. Richy, M.A. Miteva, M. Reboud-Ravaux, J. Vidal and B.O. Villoutreix
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Insulin Secretion and Interleukin-1β Dependent Mechanisms in Human Diabetes Remission After Metabolic Surgery
Chih-Yen Chen, Wei-Jei Lee, A. Asakawa, N. Fujitsuka, Keong Chong, Shu-Chun Chen, Shou-Dong Lee and A. Inui
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Serenoa Repens, Lycopene and Selenium: A Triple Therapeutic Approach to Manage Benign Prostatic Hyperplasia
L. Minutoli, A. Bitto, F. Squadrito, H. Marini, N. Irrera, G. Morgia, A. Passantino and D. Altavilla
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Anti-Inflammatory and Antioxidant Effects of Resveratrol in Healthy Smokers A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial
S. Bo, G. Ciccone, A. Castiglione, R. Gambino, F. De Michieli, P. Villois, M. Durazzo, P. Cavallo-Perin and M. Cassader
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Developing FGFR4 Inhibitors As Potential Anti-Cancer Agents Via In Silico Design, Supported by In Vitro and Cell-Based Testing
H.K. Ho, G. Németh, Y.R. Ng, E. Pang, C. Szántai-Kis, L. Zsákai, N. Breza, Z. Greff, Z. Horváth, J. Pató, I. Szabadkai, B. Szokol, F. Baska, L. Orfi, A. Ullrich, G. Kéri and B.T. Chua
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Design, SAR, Angiogenic Activities Evaluation and Pro-Angiogenic Mechanism of New Marine Cyclopeptide Analogs
J. Li, X. Lu, Q. Wu, G. Yu, Z. Xu, L. Qiu, Z. Pei, Y. Lin and J. Pang
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Prostate Cancer, miRNAs, Metallothioneins and Resistance to Cytostatic Drugs
V. Pekarik, J. Gumulec, M. Masarik, R. Kizek and V. Adam
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Increased Akt Signaling Resulting from the Loss of Androgen Responsiveness in Prostate Cancer
J. Dulinska-Litewka, J.A. McCubrey and P. Laidler
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Inhaled Muscarinic Acetylcholine Receptor Antagonists for Treatment of COPD
P. Montuschi, F. Macagno, S. Valente and L. Fuso
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State of the Art of the Therapeutic Perspective of Sorafenib Against Hematological Malignancies
G. Zauli, R. Voltan, V. Tisato and P. Secchiero
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Therapeutic Monoclonal Antibodies: Strategies and Challenges for Biosimilars Development
Begoña Calvo and Leyre Zuñiga
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Physico-Chemical Properties Mediating Reproductive and Developmental Toxicity of Engineered Nanomaterials
Luisa Campagnolo, Micol Massimiani, Andrea Magrini, Antonella Camaioni and Antonio Pietroiusti
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Alkyl Hydroxybenzoic Acid Derivatives that Inhibit HIV-1 Protease Dimerization
O.A. Flausino Jr., L. Dufau, L.O. Regasini, M.S. Petrônio, D.H.S. Silva, T. Rose, V.S. Bolzani and M. Reboud-Ravaux
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Oxidized-LDL and Paraoxonase-1 As Biomarkers of Coronary Artery Disease in Patients with Sleep-Disordered Breathing
F.S. Hackenhaar, D. Martinez, T.M. Medeiros, C. Klein, P.V.G. Alabarse, M.V. Wainstein, S.C. Gonçalves and M.S. Benfato
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pKa, Zinc- and Serum Albumin-Binding of Curcumin and Two Novel Biologically- Active Chemically-Modified Curcumins
Yu Zhang, Lorne M. Golub, Francis Johnson and Arnold Wishnia
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Design, Synthesis and Biological Activity of New Polyenolic Inhibitors of Matrix Metalloproteinases: A Focus on Chemically-Modified Curcumins
Yu Zhang, Ying Gu, Hsi-Ming Lee, Elena Hambardjieva, Kveta Vrankova, Lorne M. Golub and Francis Johnson
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Subtype-Selective Dopamine Receptor Radioligands for PET Imaging: Current Status and Recent Developments
A. Banerjee and O. Prante
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Targeting DNA Topoisomerase I with Non-Camptothecin Poisons
G.L. Beretta, V. Zuco, P. Perego and N. Zaffaroni
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