Recent Advances in Gene Therapy of Endometriosis
Anastasia N. Shubina, Anna A. Egorova, Vladislav S. Baranov and Anton V. KiselevAffiliation:
Ott's Institute for Obstetrics and Gynecology RAMS Saint-Petersburg Russia, 199034 Mendeleevskaya line, 3.
AbstractEndometriosis is a gynecological disease that affects up to 10%-15% of all reproductive-age women worldwide. It is characterized by the presence of endometrial tissues outside the uterine cavity. Endometriosis is a complex disease; its pathogenesis includes altered steroid metabolism and immune system abnormalities such as inflammation, increased angiogenic activity in the peritoneal fluid and impaired recognition of ectopic endometrial cells. The development of endometriosis also depends on genetic, anatomical and environmental factors. Numerous surgical and medical approaches to treat endometriosis have been developed to date. However, complete resolution of the problem has not been achieved so far. Gene therapy holds exciting promise for the treatment of numerous disorders and current studies have indicated it can also be applied to endometriosis. The focus of this review is to summarize the pathogenetic background of the disease and to highlight current gene therapy approaches for this common gynecological disorder.
Angiogenesis, endometriosis, gene delivery, gene therapy, inflammation.
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