Recent Advances in the Treatment of Neurogenic Erectile Dysfunction

ISSN: 2212-3954 (Online)
ISSN: 1574-8898 (Print)

Volume 10, 2 Issues, 2015

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Recent Patents on CNS Drug Discovery

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Vincenzo Di Marzo
Istituto di Chimica Biomolecolare (I.C.B.)
Consiglio Nazionale delle Ricerche (C.N.R.)
Via Campi Flegrei 34
Pozzuoli, Napoli 80078

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Recent Advances in the Treatment of Neurogenic Erectile Dysfunction

Recent Patents on CNS Drug Discovery, 9(1): 41-53.

Author(s): Rocco S. Calabro, Giovanni Polimeni and Placido Bramanti.

Affiliation: Neurorehabilitation Unit, IRCCS Centro Neurolesi “Bonino Pulejo” , via Palermo, S.S. 113, C.da Casazza, 98124 Messina, Italy.


Neurogenic erectile dysfunction (ED) can be broadly defined as an inability to sustain or maintain a penile erection owing to a neurological impairment, either centrally or peripherally or both. Although significant advances in the pharmacological treatment of ED have occurred in recent years, especially after the introduction of oral selective phosphodiesterase type 5 inhibitor, the treatment of neurological patients with ED may be challenging for prescribers, given poor data available on this topic and the variety of etiologic factors (iatrogenic, endocrine, psychiatric and psychosocial) to consider. At the same time, several, new oral, local and surgical treatments are available and their efficacy and safety depend on the specific cases. This review provides a comprehensive and updated description of current and future ED therapies, including assigned patents, with a special focus on the treatment of neurogenic erectile dysfunction.


Dopaminergic agonists, guanylate-cyclase activators, melanocortins, neurogenic erectile dysfunction, patents, PDEi, potassium channel inhibitors.

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Article Details

Volume: 9
Issue Number: 1
First Page: 41
Last Page: 53
Page Count: 13
DOI: 10.2174/2212798406666140131122641

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