Introduction to Metabolic Genetic Engineering for the Production of Valuable Secondary Metabolites in in vivo and in vitro Plant Systems

ISSN: 2212-4012 (Online)
ISSN: 1872-2083 (Print)


Volume 8, 3 Issues, 2014


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Editor-in-Chief:
Rongling Wu
Departments of Public Health Sciences and Statistics
Pennsylvania State College of Medicine
Hershey, PA
USA


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Introduction to Metabolic Genetic Engineering for the Production of Valuable Secondary Metabolites in in vivo and in vitro Plant Systems

Author(s): Vagner A. Benedito and Luzia V. Modolo

Affiliation: Genetics and Developmental Biology Program, Plant and Soil Sciences Division, West Virginia University, Morgantown, WV, USA 26506-6108.

Abstract

Plants are capable of producing a myriad of chemical compounds. While these compounds serve specific functions in the plant, many have surprising effects on the human body, often with positive action against diseases. These compounds are often difficult to synthesize ex vivo and require the coordinated and compartmentalized action of enzymes in living organisms. However, the amounts produced in whole plants are often small and restricted to single tissues of the plant or even cellular organelles, making their extraction an expensive process. Since most natural products used in therapeutics are specialized, secondary plant metabolites, we provide here an overview of the classification of the main classes of these compounds, with its biochemical pathways and how this information can be used to create efficient in and ex planta production pipelines to generate highly valuable compounds. Metabolic genetic engineering is introduced in light of physiological and genetic methods to enhance production of high-value plant secondary metabolites.

Keywords: Alkaloid, callus, cell suspension, hairy root, jasmonic acid, phenylpropanoid, promoter, terpenoid, tissue culture, transcription factor, trichome.

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Article Details

Volume: 8
Issue Number: 1
First Page: 61
Last Page: 75
Page Count: 15
DOI: 10.2174/1872208307666131218125801
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